KEGG   ORTHOLOGY: K14045
Entry
K14045            Tight     KO                                     
Symbol
KSL11
Name
stemod-13(17)-ene synthase [EC:4.2.3.34]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09116  9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K14045  KSL11; stemod-13(17)-ene synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.34  stemod-13(17)-ene synthase
     K14045  KSL11; stemod-13(17)-ene synthase
Other DBs
GO: 0034283
Genes
OGL: 127755082
AG: AAZ76733(KSL11)
Reference
PMID:16256063
  Authors
Morrone D, Jin Y, Xu M, Choi SY, Coates RM, Peters RJ
  Title
An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase.
  Journal
Arch Biochem Biophys 448:133-40 (2006)
DOI:10.1016/j.abb.2005.09.001
  Sequence
[ag:AAZ76733]
LinkDB

KEGG   ENZYME: 4.2.3.34
Entry
EC 4.2.3.34                 Enzyme                                 
Name
stemod-13(17)-ene synthase;
OsKSL11;
stemodene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming]
Reaction(IUBMB)
9alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate [RN:R09116]
Reaction(KEGG)
R09116
Substrate
9alpha-copalyl diphosphate [CPD:C11902]
Product
stemod-13(17)-ene [CPD:C18224];
diphosphate [CPD:C00013]
Comment
This enzyme catalyses the committed step in the biosynthesis of the stemodane family of diterpenoid secondary metabolites, some of which possess mild antiviral activity. The enzyme also produces stemod-12-ene and stemar-13-ene as minor products.
History
EC 4.2.3.34 created 2008
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14045  stemod-13(17)-ene synthase
Genes
OGL: 127755082
Reference
1  [PMID:16256063]
  Authors
Morrone D, Jin Y, Xu M, Choi SY, Coates RM, Peters RJ
  Title
An unexpected diterpene cyclase from rice: functional identification of a stemodene synthase.
  Journal
Arch Biochem Biophys 448:133-40 (2006)
DOI:10.1016/j.abb.2005.09.001
  Sequence
[ag:AAZ76733]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.34
IUBMB Enzyme Nomenclature: 4.2.3.34
ExPASy - ENZYME nomenclature database: 4.2.3.34
BRENDA, the Enzyme Database: 4.2.3.34
LinkDB

KEGG   REACTION: R09116
Entry
R09116                      Reaction                               
Name
9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming]
Definition
9alpha-Copalyl diphosphate <=> Stemod-13(17)-ene + Diphosphate
Equation
C11902 <=> C18224 + C00013
Reaction class
RC02057  C11902_C18224
Enzyme
4.2.3.34
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.34
     R09116  9alpha-Copalyl diphosphate <=> Stemod-13(17)-ene + Diphosphate
Orthology
K14045  stemod-13(17)-ene synthase [EC:4.2.3.34]
Other DBs
RHEA: 25559
LinkDB

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