KEGG   ORTHOLOGY: K14371
Entry
K14371                      KO                                     
Symbol
aveA1
Name
avermectin polyketide synthase AveA1
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06480  
R06481  
R06482  
R06483  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14371  aveA1; avermectin polyketide synthase AveA1
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14371  aveA1; avermectin polyketide synthase AveA1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14371  aveA1; avermectin polyketide synthase AveA1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Avermectin PKS
     K14371  aveA1; avermectin polyketide synthase AveA1
Genes
SMA: SAVERM_938(aveA1)
Reference
PMID:11780788
  Authors
Ikeda H, Nonomiya T, Omura S
  Title
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
  Journal
J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_938]
LinkDB

KEGG   ORTHOLOGY: K24567
Entry
K24567            Tight     KO                                     
Symbol
aveA2
Name
avermectin polyketide synthase AveA2
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06480  
R06481  
R06482  
R06483  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24567  aveA2; avermectin polyketide synthase AveA2
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24567  aveA2; avermectin polyketide synthase AveA2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24567  aveA2; avermectin polyketide synthase AveA2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Avermectin PKS
     K24567  aveA2; avermectin polyketide synthase AveA2
Genes
SMA: SAVERM_939(aveA2)
Reference
PMID:11780788
  Authors
Ikeda H, Nonomiya T, Omura S
  Title
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
  Journal
J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_939]
LinkDB

KEGG   ORTHOLOGY: K24568
Entry
K24568                      KO                                     
Symbol
aveA3
Name
avermectin polyketide synthase AveA3
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06480  
R06481  
R06482  
R06483  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24568  aveA3; avermectin polyketide synthase AveA3
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24568  aveA3; avermectin polyketide synthase AveA3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24568  aveA3; avermectin polyketide synthase AveA3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Avermectin PKS
     K24568  aveA3; avermectin polyketide synthase AveA3
Genes
SMA: SAVERM_942(aveA3)
Reference
PMID:11780788
  Authors
Ikeda H, Nonomiya T, Omura S
  Title
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
  Journal
J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_942]
LinkDB

KEGG   ORTHOLOGY: K24569
Entry
K24569            Tight     KO                                     
Symbol
aveA4
Name
avermectin polyketide synthase AveA4
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06480  
R06481  
R06482  
R06483  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24569  aveA4; avermectin polyketide synthase AveA4
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24569  aveA4; avermectin polyketide synthase AveA4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24569  aveA4; avermectin polyketide synthase AveA4
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Avermectin PKS
     K24569  aveA4; avermectin polyketide synthase AveA4
Genes
SMA: SAVERM_943(aveA4)
Reference
PMID:11780788
  Authors
Ikeda H, Nonomiya T, Omura S
  Title
Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis: analysis of enzymatic domains in four polyketide synthases.
  Journal
J Ind Microbiol Biotechnol 27:170-6 (2001)
DOI:10.1038/sj.jim.7000092
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_943]
LinkDB

KEGG   REACTION: R06483
Entry
R06483                      Reaction                               
Definition
2-Methylpropanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + 12 CO2 + 13 CoA + 6 H2O + 9 NADP+
Equation
C00630 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11961 + 12 C00011 + 13 C00010 + 6 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00630  C00010_C02557
RC02913  C00630_C11961
RC02915  C02557_C11961
RC02920  C02557_C11961
RC02921  C02557_C11961
RC02922  C02557_C11961
RC02924  C00083_C11961
RC02925  C00083_C11961
RC02926  C00083_C11961
RC02927  C00083_C11961
RC02928  C00083_C11961
RC02929  C00083_C11961
RC02930  C00083_C11961
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4
LinkDB

KEGG   REACTION: R06482
Entry
R06482                      Reaction                               
Definition
2-Methylpropanoyl-CoA + 5 Methylmalonyl-CoA + 7 Malonyl-CoA + 9 NADPH + 9 H+ <=> 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone + 12 CO2 + 13 CoA + 5 H2O + 9 NADP+
Equation
C00630 + 5 C02557 + 7 C00083 + 9 C00005 + 9 C00080 <=> C11953 + 12 C00011 + 13 C00010 + 5 C00001 + 9 C00006
Comment
type I polyketide synthase, AveA1-4
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C00630  C00010_C02557
RC02913  C00630_C11953
RC02914  C02557_C11953
RC02915  C02557_C11953
RC02920  C02557_C11953
RC02921  C02557_C11953
RC02922  C02557_C11953
RC02923  C00083_C11953
RC02924  C00083_C11953
RC02925  C00083_C11953
RC02926  C00083_C11953
RC02927  C00083_C11953
RC02928  C00083_C11953
RC02929  C00083_C11953
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Orthology
K14371  avermectin polyketide synthase AveA1
K24567  avermectin polyketide synthase AveA2
K24568  avermectin polyketide synthase AveA3
K24569  avermectin polyketide synthase AveA4
LinkDB

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