KEGG   ORTHOLOGY: K14372
Entry
K14372            Tight     KO                                     
Symbol
aveE, CYP171A
Name
cytochrome P450 hydroxylase [EC:1.14.-.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06465  
R06467  
R06468  
R06470  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
   00199 Cytochrome P450
    K14372  aveE, CYP171A; cytochrome P450 hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14372  aveE, CYP171A; cytochrome P450 hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP171 family
   K14372  aveE, CYP171A; cytochrome P450 hydroxylase
Other DBs
COG: COG2124
Genes
SMA: SAVERM_941(aveE)
Reference
PMID:11851473
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_941]
LinkDB

KEGG   REACTION: R06470
Entry
R06470                      Reaction                               
Definition
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
Equation
C11961 + C00005 + C00007 <=> C11962 + C00006 + C00001
Comment
cytochrome P450 hydroxylase,AveE
Reaction class
RC00001  C00005_C00006
RC01527  C11961_C11962
Enzyme
1.14.-.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-
     R06470  6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''1b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''1b'' aglycone + NADP+ + H2O
Orthology
K14372  cytochrome P450 hydroxylase [EC:1.14.-.-]
LinkDB

KEGG   REACTION: R06468
Entry
R06468                      Reaction                               
Definition
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''2b'' aglycone + NADP+ + H2O
Equation
C11953 + C00005 + C00007 <=> C11954 + C00006 + C00001
Comment
cytochrome P450 hydroxylase,AveE
Reaction class
RC00001  C00005_C00006
RC01527  C11953_C11954
Enzyme
1.14.-.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.-  Acting on paired donors, with incorporation or reduction of molecular oxygen
    1.14.-.-
     R06468  6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone + NADPH + Oxygen <=> 5-Oxoavermectin ''2b'' aglycone + NADP+ + H2O
Orthology
K14372  cytochrome P450 hydroxylase [EC:1.14.-.-]
LinkDB

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