KEGG   ORTHOLOGY: K14374
Entry
K14374            Tight     KO                                     
Symbol
aveD
Name
avermectin B 5-O-methyltransferase [EC:2.1.1.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06476  
R06477  
R06478  
R06479  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14374  aveD; avermectin B 5-O-methyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14374  aveD; avermectin B 5-O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14374  aveD; avermectin B 5-O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K14374  aveD; avermectin B 5-O-methyltransferase
Genes
SMA: SAVERM_937(aveD)
Reference
PMID:11851473
  Authors
Ikeda H, Omura S
  Title
Avermectin Biosynthesis.
  Journal
Chem Rev 97:2591-2610 (1997)
DOI:10.1021/cr960023p
Reference
PMID:9469930
  Authors
Ikeda H, Wang LR, Ohta T, Inokoshi J, Omura S
  Title
Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis.
  Journal
Gene 206:175-80 (1998)
DOI:10.1016/S0378-1119(97)00581-7
LinkDB

KEGG   REACTION: R06479
Entry
R06479                      Reaction                               
Definition
Avermectin B1b aglycone + S-Adenosyl-L-methionine <=> Avermectin A1b aglycone + S-Adenosyl-L-homocysteine
Equation
C11963 + C00019 <=> C11964 + C00021
Comment
C5-O-methyltransferase,AveD
Reaction class
RC00003  C00019_C00021
RC00466  C11963_C11964
Enzyme
2.1.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-
     R06479  Avermectin B1b aglycone + S-Adenosyl-L-methionine <=> Avermectin A1b aglycone + S-Adenosyl-L-homocysteine
Orthology
K14374  avermectin B 5-O-methyltransferase [EC:2.1.1.-]
LinkDB

KEGG   REACTION: R06478
Entry
R06478                      Reaction                               
Definition
Avermectin B2b aglycone + S-Adenosyl-L-methionine <=> Avermectin A2b aglycone + S-Adenosyl-L-homocysteine
Equation
C11955 + C00019 <=> C11956 + C00021
Comment
C5-O-methyltransferase,AveD
Reaction class
RC00003  C00019_C00021
RC00466  C11955_C11956
Enzyme
2.1.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-
     R06478  Avermectin B2b aglycone + S-Adenosyl-L-methionine <=> Avermectin A2b aglycone + S-Adenosyl-L-homocysteine
Orthology
K14374  avermectin B 5-O-methyltransferase [EC:2.1.1.-]
LinkDB

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