KEGG   ORTHOLOGY: K14375
Entry
K14375            Tight     KO                                     
Symbol
aveBI
Name
dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06484  
R06485  
R06486  
R06487  
R06488  
R06489  
R06490  
R06491  
R06492  
R06493  
R06494  
R06495  
R06496  
R06497  
R06498  
R06499  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14375  aveBI; dTDP-L-oleandrosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14375  aveBI; dTDP-L-oleandrosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14375  aveBI; dTDP-L-oleandrosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K14375  aveBI; dTDP-L-oleandrosyltransferase
Other DBs
CAZy: GT1
Genes
SMA: SAVERM_945(aveBI)
Reference
PMID:10449723
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
[sma:SAVERM_945]
Reference
PMID:17177349
  Authors
Zhang C, Albermann C, Fu X, Thorson JS
  Title
The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.
  Journal
J Am Chem Soc 128:16420-1 (2006)
DOI:10.1021/ja065950k
LinkDB

KEGG   REACTION: R06490
Entry
R06490                      Reaction                               
Definition
Avermectin A1a aglycone + dTDP-L-oleandrose <=> Avermectin A1a monosaccharide + dTDP
Equation
C11980 + C11921 <=> C11982 + C00363
Comment
glycosyl transferase,AveB1
Reaction class
RC00005  C00363_C11921
RC00049  C11980_C11982
Enzyme
2.4.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-
     R06490  Avermectin A1a aglycone + dTDP-L-oleandrose <=> Avermectin A1a monosaccharide + dTDP
Orthology
K14375  dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
LinkDB

KEGG   REACTION: R06486
Entry
R06486                      Reaction                               
Definition
Avermectin A2a aglycone + dTDP-L-oleandrose <=> Avermectin A2a monosaccharide + dTDP
Equation
C11972 + C11921 <=> C11974 + C00363
Comment
glycosyl transferase,AveB1
Reaction class
RC00005  C00363_C11921
RC00049  C11972_C11974
Enzyme
2.4.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-
     R06486  Avermectin A2a aglycone + dTDP-L-oleandrose <=> Avermectin A2a monosaccharide + dTDP
Orthology
K14375  dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
LinkDB

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