KEGG   ORTHOLOGY: K14375
Entry
K14375            Tight     KO                                     
Symbol
aveBI
Name
dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Reaction
R06484  
R06485  
R06486  
R06487  
R06488  
R06489  
R06490  
R06491  
R06492  
R06493  
R06494  
R06495  
R06496  
R06497  
R06498  
R06499  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14375  aveBI; dTDP-L-oleandrosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14375  aveBI; dTDP-L-oleandrosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14375  aveBI; dTDP-L-oleandrosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K14375  aveBI; dTDP-L-oleandrosyltransferase
Other DBs
CAZy: GT1
Genes
SMA: SAVERM_945(aveBI)
Reference
  Authors
Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S
  Title
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.
  Journal
Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509
  Sequence
Reference
  Authors
Zhang C, Albermann C, Fu X, Thorson JS
  Title
The in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibility.
  Journal
J Am Chem Soc 128:16420-1 (2006)
DOI:10.1021/ja065950k
LinkDB

KEGG   REACTION: R06499
Entry
R06499                      Reaction                               
Definition
Avermectin A1b monosaccharide + dTDP-L-oleandrose <=> Avermectin A1b + dTDP
Equation
Comment
glycosyl transferase,AveB1
Reaction class
RC00005  C00363_C11921
RC00049  C11966_C11968
Enzyme
2.4.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00777  Avermectin biosynthesis, 2-methylbutanoyl-CoA/isobutyryl-CoA => 6,8a-Seco-6,8a-deoxy-5-oxoavermectin 1a/1b aglycone => avermectin A1a/B1a/A1b/B1b
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-
     R06499  Avermectin A1b monosaccharide + dTDP-L-oleandrose <=> Avermectin A1b + dTDP
Orthology
K14375  dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
LinkDB

KEGG   REACTION: R06495
Entry
R06495                      Reaction                               
Definition
Avermectin A2b monosaccharide + dTDP-L-oleandrose <=> Avermectin A2b + dTDP
Equation
Comment
glycosyl transferase,AveB1
Reaction class
RC00005  C00363_C11921
RC00049  C11958_C11960
Enzyme
2.4.1.-
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.-
     R06495  Avermectin A2b monosaccharide + dTDP-L-oleandrose <=> Avermectin A2b + dTDP
Orthology
K14375  dTDP-L-oleandrosyltransferase [EC:2.4.1.-]
LinkDB

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