KEGG   ORTHOLOGY: K14448
Entry
K14448                      KO                                     
Symbol
mcd
Name
(2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00373  Ethylmalonyl pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K14448  mcd; (2S)-methylsuccinyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.12  (2S)-methylsuccinyl-CoA dehydrogenase
     K14448  mcd; (2S)-methylsuccinyl-CoA dehydrogenase
Other DBs
RN: R09293
COG: COG1960
Genes
PSET: THL1_4233
MARI: ACP86_19405
ALKM: NKI27_11390
ASEM: NNL22_07745
STAW: NCG89_13780
GAI: IMCC3135_16910(mcd)
KAK: Kalk_01775
OME: OLMES_2174
GBI: PG2T_00815
GPB: HDN1F_16010
HYB: Q5W_20085
PLA: Plav_1613
RBS: RHODOSMS8_02653(mcd)
XAU: Xaut_0310
AZC: AZC_4648
MEA: Mex_1p2223(ibd2)
MDI: METDI3005(msd)
MEX: Mext_2228
MCH: Mchl_2504
MPO: Mpop_2186
MET: M446_4575
MNO: Mnod_4511
MOR: MOC_5019
META: Y590_10710
MAQU: Maq22A_c07055(ibd2)
MIND: mvi_48210
HDN: Hden_0214
HMC: HYPMC_0100(msd)
RVA: Rvan_2966
MCG: GL4_3336
BVR: BVIR_182
BLAG: BLTE_34660
MSC: BN69_1942
PLEO: OHA_1_02835(ibd2)
HDI: HDIA_3966(mmgC_1)
RBM: TEF_03545
PSF: PSE_0035
LABT: FIU93_08975(mmgC1)
CCR: CC_3087
CAK: Caul_1059
CSE: Cseg_3655
PZU: PHZ_c3145
TSV: DSM104635_01226(mmgC_3)
SIL: SPO0693
RUT: FIU92_02785(mmgC1)
JAN: Jann_0530
RDE: RD1_1372(ibd2)
DSH: Dshi_0204(mmgC)
PGD: Gal_00245
OTM: OSB_02210(mmgC_1)
LAQU: R2C4_16280
CID: P73_0612
MALG: MALG_03387
SINL: DSM14862_03067(mcd)
SPSE: SULPSESMR1_02661(mcd)
RMM: ROSMUCSMR3_01322(mcd)
RID: RIdsm_00183(mmgC_3)
ROH: FIU89_16755(mmgC5)
MARU: FIU81_13010(mmgC4)
ROT: FIV09_15425(mmgC3)
MALU: KU6B_08810
RSP: RSP_1679
PDE: Pden_2840
PMAU: CP157_02762(mcd)
RSU: NHU_01021
RHC: RGUI_2888
PAMO: BAR1_16245
PALW: PSAL_022590(mcd)
HNE: HNE_3379
HBA: Hbal_0249
NAR: Saro_3795
SAL: Sala_2897
SPHP: LH20_06640
SMAZ: LH19_02450
SGI: SGRAN_3010(ibd2)
SPHD: HY78_18255
SPHT: K426_13845
BLAS: BSY18_3598
ELI: ELI_00035
SHUM: STHU_50800
STEL: STAQ_45970
RRU: Rru_A3064
RRF: F11_15695
MAG: amb0308
MGY: MGMSRv2__2675(mmgC)
MGRY: MSR1_36910(mmgC_5)
MAGX: XM1_1236(mmgC)
MAGN: WV31_14295
TMO: TMO_0120
TXI: TH3_17600
MAGQ: MGMAQ_3099
SCL: sce0587
AFO: Afer_1770
LIL: LA_0560(caiA)
LIE: LIF_A0461(caiA)
LIC: LIC_13009
LIS: LIL_13118(caiA9)
LBJ: LBJ_2405
LBL: LBL_0703
LBI: LEPBI_I3317(acdA3)
LBF: LBF_3202
LST: LSS_06909
LKB: LPTSP3_g34580(caiA_8)
 » show all
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
LinkDB

KEGG   ENZYME: 1.3.8.12
Entry
EC 1.3.8.12                 Enzyme                                 
Name
(2S)-methylsuccinyl-CoA dehydrogenase;
Mcd
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase
Reaction(IUBMB)
(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein [RN:R09293]
Reaction(KEGG)
R09293
Substrate
(2S)-methylsuccinyl-CoA [CPD:C18324];
electron-transfer flavoprotein [CPD:C04253]
Product
2-methylfumaryl-CoA [CPD:C06028];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD.
History
EC 1.3.8.12 created 2015
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14448  (2S)-methylsuccinyl-CoA dehydrogenase
Genes
PSETTHL1_4233
MARIACP86_19405
ALKMNKI27_11390
ASEMNNL22_07745
STAWNCG89_13780
GAIIMCC3135_16910(mcd)
KAKKalk_01775
OMEOLMES_2174
GBIPG2T_00815
GPBHDN1F_16010
ADNAlide_3214
ADKAlide2_1233
HYBQ5W_20085
XYKGT347_20760
APPCAP2UW1_2497
MESWA9K65_031175
PLAPlav_1613
PMOBHG718_00340
KMNHW532_17100
RBSRHODOSMS8_02653(mcd)
EMXFKV68_30905
RFVRFYW14_04019
BOPAXW83_03455
BOSBSY19_2144
BVVBHK69_16360
BOIBLM15_14085
BOFFQV39_08880
XAUXaut_0310
XDIEZH22_06665
AZCAZC_4648
APOLK9D25_22030
MEAMex_1p2223(ibd2)
MDIMETDI3005(msd)
MEXMext_2228
MCHMchl_2504
MPOMpop_2186
MZAB2G69_18750
MRDMrad2831_4351
METM446_4575
MNOMnod_4511
MORMOC_5019
METAY590_10710
MAQUMaq22A_c07055(ibd2)
MPHYMCBMB27_03874
MEEDA075_26015
METDC0214_12585
METXA3862_09600
METSDK389_01585
METIDK427_01745
MMESMMSR116_04950
MTEADK419_07360
MINDmvi_48210
MOGMMB17_24190
MTADM6G65_24885
RHJHZY79_04285
CDQBOQ54_02770
HDNHden_0214
HDTHYPDE_23628
HMCHYPMC_0100(msd)
HNIW911_17390
RVARvan_2966
FILBN1229_v1_1376
FIYBN1229_v1_1375
RHZRHPLAN_11820
MCGGL4_3336
METGHT051_03010
BVRBVIR_182
BLAGBLTE_34660
MSCBN69_1942
MBRYB1812_14845
MROSEHO51_15530
MHEYH2LOC_017850
MPARF7D14_06305
MTWCQW49_16350
CMETK6K41_15570
PLEOOHA_1_02835(ibd2)
HDIHDIA_3966(mmgC_1)
BRND1F64_21120
PSINCAK95_11900
NOHG5V57_10340
RBMTEF_03545
PSFPSE_0035
PPHRAPZ00_08230
LAPACP90_03340
LABRCHH27_17300
LABPFJ695_06860
LABTFIU93_08975(mmgC1)
LAGGB0E33_14815
SIWGH266_11160
PHRC6569_20730
PSTGE8M01_09815
ACUTMRB58_00795
CCRCC_3087
CCSCCNA_03184
CAKCaul_1059
CSECseg_3655
CHQAQ619_02845
CMBCSW64_19025
CFHC1707_03575
CAUFCSW63_19600
PZUPHZ_c3145
PHBHYN04_01310
TSVDSM104635_01226(mmgC_3)
SILSPO0693
SITTM1040_2444
RUAD1823_10490
RUTFIU92_02785(mmgC1)
RCONK3740_04120
JANJann_0530
RDERD1_1372(ibd2)
RLIRLO149_c034140
RPONG3256_02665
DSHDshi_0204(mmgC)
PGAPGA1_c01110
PGLPGA2_c29780
PGDGal_00245
PHPPhaeoP97_00338
PPICPhaeoP14_02942
PHQD1820_10540
OATOAN307_c03080
OAROA238_c02240
OTMOSB_02210(mmgC_1)
OCTFTO60_01335
LMDMETH_00815
LEJETW24_00805
LAQUR2C4_16280
LCAEK3721_00960
REDroselon_01508
CIDP73_0612
CMARIMCC12053_1518
CEHCEW89_14850
MALGMALG_03387
CONTQ29_01745
YPACCEW88_03080
YANAYJ57_10165
TPROGa0080559_TMP1223
PABYGa0080574_TMP1791
SUAMBOO69_01730
SULZC1J03_02875
SULIC1J05_02105
SULDB5M07_15630
SPOTG6548_14190
SMEDJNX03_10970
SINLDSM14862_03067(mcd)
SFAVPL335_14690
SPSESULPSESMR1_02661(mcd)
TOMBWR18_13585
RMMROSMUCSMR3_01322(mcd)
ROKRAK1035_0274
RIDRIdsm_00183(mmgC_3)
ROMEI983_14390
ROHFIU89_16755(mmgC5)
AHTANTHELSMS3_01950
SAGUCDO87_13230
THAACFI11_02130
OCDFHY55_18290
MARUFIU81_13010(mmgC4)
ROTFIV09_15425(mmgC3)
RMHLVO79_13390
MALUKU6B_08810
TGLHFZ77_13930
TMDKUV46_07595
HATRC74_04475
PALXGQA70_15605
LSALKBK07_00695
RSPRSP_1679
RSHRsph17029_0312
RSQRsph17025_2567
RSKRSKD131_3079
CAZTLV780_11785
RCPRCAP_rcc03306
RHPLPB142_14090
RBLB6K69_12755
PDEPden_2840
PAMIJCM7686_0656
PYEA6J80_04750
PCONB0A89_08760
PZHCX676_16780
PAROCUV01_04620
PAMNJCM7685_1082
PARREOJ32_04100
PAAKFIU66_02420
PKDF8A10_17805
PPANESD82_07180
PLIAE4191_01960
PSANHGN31_12625
PMAUCP157_02762(mcd)
PMEHJWJ88_13515 JWJ88_18485
PSEWJHW44_02365
PSAPJHX88_05830
PFISJHX87_14200
PTPRCA23_c05210
RSUNHU_01021
RHMB5V46_13600
RHCRGUI_2888
RMBK529_011675
DAAAKL17_0387
DONBSK21_01045
RBZB9057_00825
TECAKL02_018800
LVSLOKVESSMR4R_00199(mcd)
RBGBG454_04115
GEHHYN69_01605
GFUKM031_11680
TAWEI545_08280
SALOEF888_00405
SEDIEBB79_01115
BOOE2K80_17425
PSEBEOK75_15210
PPRUFDP22_10630
PAEDG5B38_16425
MONG8E03_13660
PAMOBAR1_16245
PSHQF3W81_12655
POZI0K15_01150
PALWPSAL_022590(mcd)
PGVSL003B_0448
CACTHZ995_08795
THASC6Y53_12405
HDHG5B40_02075
CMAGCBW24_14615
GCEKYE46_00120
NSMJO391_18650
ACROK3J57_01055
SINRO5O51_02550
AALKLGT41_0000495
FAQG5B39_04545
AMAQGO499_18380
HNEHNE_3379
HBAHbal_0249
CBOTATE48_04215
HBCAEM38_11365
NARSaro_3795
NPPPP1Y_AT31373 PP1Y_AT31999
NPNJI59_17585
NOTC7W88_21090
NORFA702_12980
NGFFRF71_05160
NOGGKE62_14150
SALSala_2897
SPHKSKP52_19810
SPHPLH20_06640
SMAGAN936_15840
SMAZLH19_02450
STERAOA14_14405
SGISGRAN_3010(ibd2)
SPHQBWQ93_00925
SPHOC3E99_10420
SPHXE5675_00380
SPHUSPPYR_1404 SPPYR_3581
SPHDHY78_18255
SPHAD3Y57_03955
SLANGV829_02840
SPAPH3Z74_06280
SRADLLW23_12455
SCHSphch_1000
SYBTZ53_15780
SPHBEP837_00036
SPHTK426_13845
SYAA6768_05870
SCLOSCLO_1006500
SUFLFIL70_02615 FIL70_14440
SBARH5V43_02925
CIJWG74_11805
BLASBSY18_3598
TFVIDJ81_09110
ELIELI_00035
ELQGa0102493_112805
EMVHQR01_02800
PNSA9D12_00115
PORLBG023_111657
PHZCHX26_12895
POTE2E27_09260
SHUMSTHU_50800
SVCSTVA_50710
STELSTAQ_45970
ABSAZOBR_p410033
ABQABAZ39_30385
ABFAMK58_26085
ATIAL072_22095
AZTTSH58p_19350
AZMDM194_21400
AARED3093_29555
SKTIGS68_10650
SMUCJL100_016580
SROEJL101_015005
RRURru_A3064
RRFF11_15695
RPMRSPPHO_00637
MAGamb0308
MGYMGMSRv2__2675(mmgC)
MGRYMSR1_36910(mmgC_5)
MAGXXM1_1236(mmgC)
MAGNWV31_14295
FERFNB15_00570
HTQFRZ44_46300
HADHFRZ61_44230
DEXHWD60_01575
DVNHQ394_15005
TMOTMO_0120
TXITH3_17600
THACCSC3H3_16690
TIIDY252_04205
THAIIT893_16605
MAGQMGMAQ_3099
ECOGFIV45_15330
SNEANBZ79_17895
SCLsce0587
SCUSCE1572_04065
NOWGBF35_13605
ABAIIMCC26256_11419
AFOAfer_1770
AYMYM304_14140
ATQGH723_12935
AQZKSP35_23260
IAMHC251_17070
IMAPO878_07060
ERZER308_13570
EUZDVS28_a4047
LILLA_0560(caiA)
LIELIF_A0461(caiA)
LICLIC_13009
LISLIL_13118(caiA9)
LBJLBJ_2405
LBLLBL_0703
LBILEPBI_I3317(acdA3)
LBFLBF_3202
LSTLSS_06909
LAJA0128_02880
LMAYDPV73_01935
LKMEFP84_13705
LWLFHG68_15305
LKBLPTSP3_g34580(caiA_8)
LNOMAL08_02195
LKRFH602_03205
TPXTurpa_3980
 » show all
Reference
1  [PMID:19703103]
  Authors
Erb TJ, Fuchs G, Alber BE.
  Title
(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation.
  Journal
Mol Microbiol 73:992-1008 (2009)
DOI:10.1111/j.1365-2958.2009.06837.x
  Sequence
[rsp:RSP_1679]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.12
IUBMB Enzyme Nomenclature: 1.3.8.12
ExPASy - ENZYME nomenclature database: 1.3.8.12
BRENDA, the Enzyme Database: 1.3.8.12
LinkDB

KEGG   REACTION: R09293
Entry
R09293                      Reaction                               
Name
(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase
Definition
(2S)-Methylsuccinyl-CoA + Electron-transferring flavoprotein <=> 2-Methylfumaryl-CoA + Reduced electron-transferring flavoprotein
Equation
Reaction class
RC02483  C06028_C18324
Enzyme
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00373  Ethylmalonyl pathway
Orthology
K14448  (2S)-methylsuccinyl-CoA dehydrogenase [EC:1.3.8.12]
Other DBs
RHEA: 45031
LinkDB

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