KEGG   ORTHOLOGY: K14449
Entry
K14449                      KO                                     
Symbol
mch, mcd
Name
2-methylfumaryl-CoA hydratase [EC:4.2.1.148]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map00660  C5-Branched dibasic acid metabolism
map00720  Carbon fixation pathways in prokaryotes
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
M00740  Methylaspartate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K14449  mch, mcd; 2-methylfumaryl-CoA hydratase
   00660 C5-Branched dibasic acid metabolism
    K14449  mch, mcd; 2-methylfumaryl-CoA hydratase
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K14449  mch, mcd; 2-methylfumaryl-CoA hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.148  2-methylfumaryl-CoA hydratase
     K14449  mch, mcd; 2-methylfumaryl-CoA hydratase
Other DBs
RN: R05076
COG: COG2030
GO: 0043881
Genes
PAGR: E2H98_04135
THT: E2K93_09440
THAP: FNC98_15555
CYQ: Q91_1214
CZA: CYCME_1214
CYY: CPC19_06535
THIP: N838_00820
KAK: Kalk_01780
KKO: Kkor_1561
KGE: TQ33_0883
GPB: HDN1F_16000(maoC)
REH: H16_B0354(h16_B0354)
RME: Rmet_4428
MMB: Mmol_0752
MEH: M301_0690
GCA: Galf_0005
URU: DSM104443_01837(mch)
UPL: DSM104440_01704(mch)
ABU: Abu_1926
ABT: ABED_1735
ATP: ATR_1699
ACIB: ACBT_0661
ACRE: ACRYA_0277
APOC: APORC_0472
ATHR: ATH_0463
AELL: AELL_2338
AAQI: AAQM_2072
ASUI: ASUIS_2143
ACLO: ACLO_2181
ARC: ABLL_2357
PACO: AACT_2435
ALK: ALEK_2814
AMYT: AMYT_1371
AMAR: AMRN_1288
ACAA: ACAN_1329
AMOL: AMOL_1357
APAI: APAC_2032
HBV: ABIV_1149
HEBR: AEBR_1424
SCL: sce0588
PLA: Plav_1430
RBS: RHODOSMS8_02865(mch)
BOS: BSY19_19
XAU: Xaut_1970
AZC: AZC_3739(maoC)
MEA: Mex_1p4153(meaC)
MDI: METDI4744(mcd)
MEX: Mext_3781
MCH: Mchl_4075
MPO: Mpop_4037
MET: M446_3940
MNO: Mnod_3627
MOR: MOC_5123
META: Y590_18780
MAQU: Maq22A_c24130(meaC)
MIND: mvi_45470
HDN: Hden_3241
HMC: HYPMC_4595(meaC)
RVA: Rvan_0096
MCG: GL4_0095
BVR: BVIR_2665
BLAG: BLTE_30930
MSC: BN69_0351
PLEO: OHA_1_03194(meaC)
HDI: HDIA_0200
RBM: TEF_04290
PSF: PSE_4924
CCR: CC_3656
CAK: Caul_5003
CSE: Cseg_4148
SIL: SPO0355
JAN: Jann_0813
RDE: RD1_1623
DSH: Dshi_2871
PGD: Gal_03131
OTM: OSB_04790
LAQU: R2C4_13620
CID: P73_3865
MALG: MALG_02742
SINL: DSM14862_02489(mch)
SPSE: SULPSESMR1_00397(mch)
RMM: ROSMUCSMR3_02502(mch)
AHT: ANTHELSMS3_02130(mch)
MALU: KU6B_41810(mch)
RSP: RSP_0973
RCP: RCAP_rcc00730(maoC)
PDE: Pden_0566
PMAU: CP157_01936(mch)
RSU: NHU_00727(maoC)
RHC: RGUI_0619
PAMO: BAR1_14380
PALW: PSAL_019000(mch)
HNE: HNE_3531
HBA: Hbal_0271
RAP: RHOA_5786(mch)
RRU: Rru_A1201
RRF: F11_06220
MGRY: MSR1_22170
MAGX: XM1_1405
MAGN: WV31_15110
HTQ: FRZ44_48910(mch)
HADH: FRZ61_47240(mch)
TMO: TMO_3272
TXI: TH3_18445
MAGQ: MGMAQ_3595
NBE: Back2_07760(mch)
PSIM: KR76_08755
RCA: Rcas_0913
CAU: Caur_0173
CAG: Cagg_1326
LIL: LA_2627
LIE: LIF_A2151
LIC: LIC_11359(maoC)
LIS: LIL_11480
LBJ: LBJ_1640(maoC)
LBL: LBL_1859(maoC)
LBF: LBF_0760(maoC)
LST: LSS_02729
SALI: L593_04665
HMA: rrnAC0688
HHI: HAH_1340
HMU: Hmuk_2983
HALL: LC1Hm_2320(mch3)
HTU: Htur_1591
NMG: Nmag_3337(msh)
NAT: NJ7G_3290
MSE: Msed_1216
VDI: Vdis_0232
 » show all
Reference
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
  Sequence
[cau:Caur_0173] [rsp:RSP_0973]
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC0688]
LinkDB

KEGG   ENZYME: 4.2.1.148
Entry
EC 4.2.1.148                Enzyme                                 
Name
2-methylfumaryl-CoA hydratase;
Mcd;
erythro-beta-methylmalonyl-CoA hydrolyase;
mesaconyl-coenzyme A hydratase (ambiguous);
mesaconyl-C1-CoA hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(2R,3S)-2-methylmalyl-CoA hydro-lyase (2-methylfumaryl-CoA-forming)
Reaction(IUBMB)
(2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O [RN:R05076]
Reaction(KEGG)
R05076
Substrate
(2R,3S)-2-methylmalyl-CoA [CPD:C06027]
Product
2-methylfumaryl-CoA [CPD:C06028];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 4.2.1.148 created 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00660  C5-Branched dibasic acid metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14449  2-methylfumaryl-CoA hydratase
Genes
PAGRE2H98_04135
THTE2K93_09440
THAPFNC98_15555
CYQQ91_1214
CZACYCME_1214
CYYCPC19_06535
THIPN838_00820
KAKKalk_01780
KKOKkor_1561
KGETQ33_0883
KSDKS2013_924
KPDCW740_07365
GPBHDN1F_16000(maoC)
RPJN234_23790
REHH16_B0354(h16_B0354)
CUHBJN34_06615 BJN34_32795
REUReut_B4149
RMERmet_4428
COXE0W60_35065
AXYAXYL_04959
MMBMmol_0752
MEHM301_0690
MBACBN1209_0534
MEUACJ67_09150
GCAGalf_0005
URUDSM104443_01837(mch)
UPLDSM104440_01704(mch)
APPCAP2UW1_2498 CAP2UW1_2509
BEBAEM42_12675
BEBABWI17_17565
ABUAbu_1926
ABTABED_1735
ABLA7H1H_1860
ASKEI285_07625
ATPATR_1699
ACIBACBT_0661
ACREACRYA_0277
ALANALANTH_1851
APOCAPORC_0472
AFCAFAEC_0403
ATHRATH_0463
ANTArnit_2997
AELLAELL_2338
AAQIAAQM_2072
ASUIASUIS_2143
ACLOACLO_2181
AVPAVENP_2538
ADZADFLV_2468
ARCABLL_2357
PACOAACT_2435
ALKALEK_2814
ALPLPB137_11165
AHSAHALO_1280
AMYTAMYT_1371
AMARAMRN_1288
ACAAACAN_1329
AMOLAMOL_1357
APAIAPAC_2032
HBVABIV_1149
HEBRAEBR_1424
AANAAANAER_1375
SCLsce0588
SCUSCE1572_04070
PAUUE8A73_012220
MRMA7982_10445
HOEIMCC20628_00131
PLAPlav_1430
PMOBHG718_14780
KMNHW532_11385
RBSRHODOSMS8_02865(mch)
BOPAXW83_18685
BOSBSY19_19
BVVBHK69_04050
BOIBLM15_22575
BOFFQV39_20495
XAUXaut_1970
XDIEZH22_04685
AZCAZC_3739(maoC)
MEAMex_1p4153(meaC)
MDIMETDI4744(mcd)
MEXMext_3781
MCHMchl_4075
MPOMpop_4037
MZAB2G69_00715
MRDMrad2831_4465
METM446_3940
MNOMnod_3627
MORMOC_5123
METAY590_18780
MAQUMaq22A_c24130(meaC)
MPHYMCBMB27_03974
MEEDA075_14875
METDC0214_21035
METXA3862_09080
METSDK389_24235
METIDK427_20415
MMESMMSR116_09355
MTEADK419_24615
MINDmvi_45470
MOGMMB17_08775
MTADM6G65_23985
RHJHZY79_05500
CHELAL346_08910
CDQBOQ54_02010
HDNHden_3241
HDTHYPDE_39543
HMCHYPMC_4595(meaC)
HNIW911_01750
RVARvan_0096
FILBN1229_v1_1105
FIYBN1229_v1_1106
RHZRHPLAN_04430
MCGGL4_0095
METGHT051_02330
BVRBVIR_2665
BLAGBLTE_30930
MSCBN69_0351
MBRYB1812_00605
MROSEHO51_06320
MHEYH2LOC_003165
MPARF7D14_17160
MTWCQW49_03910
CMETK6K41_13785
PLEOOHA_1_03194(meaC)
HDIHDIA_0200
BRND1F64_22685
PSINCAK95_07805
NOHG5V57_10435
RBMTEF_04290
PSFPSE_4924
PPHRAPZ00_07775
LAPACP90_02630
LABRCHH27_17905
LABPFJ695_06270
LABTFIU93_08255
LAGGB0E33_14110
SIWGH266_13030
PHRC6569_01280
PSTGE8M01_18925
CCRCC_3656
CCSCCNA_03771
CAKCaul_5003
CSECseg_4148
CHQAQ619_17495
CMBCSW64_19910
CFHC1707_05910
CAUFCSW63_22650
TSVDSM104635_00255
SILSPO0355
SITTM1040_3523
RUAD1823_12155
RUTFIU92_01335
RCONK3740_01485
JANJann_0813
RDERD1_1623
RLIRLO149_c030850
RPONG3256_15350
DSHDshi_2871
PGAPGA1_c03710
PGLPGA2_c03270
PGDGal_03131
PHPPhaeoP97_02985
PPICPhaeoP14_00288
PHQD1820_14710
OATOAN307_c41490
OAROA238_c04280
OTMOSB_04790
OCTFTO60_03000
LMDMETH_03330
LEJETW24_04135
LAQUR2C4_13620
LEVETW23_16065
LCAEK3721_03450
REDroselon_01724
CIDP73_3865
CMARIMCC12053_3017
CEHCEW89_10085
MALGMALG_02742
CONTQ29_02455
YPACCEW88_11150
YANAYJ57_04535
TPROGa0080559_TMP1133
PABYGa0080574_TMP3145
SUAMBOO69_13695
SULZC1J03_18205
SULIC1J05_18095
SULDB5M07_04965
SPOTG6548_04130
SMEDJNX03_18035
SINLDSM14862_02489(mch)
SPSESULPSESMR1_00397(mch)
TOMBWR18_01040
RMMROSMUCSMR3_02502(mch)
ROKRAK1035_0680
RIDRIdsm_04535
ROMEI983_02915
ROHFIU89_19165
AHTANTHELSMS3_02130(mch)
SAGUCDO87_04375
THAACFI11_04370
OCDFHY55_05870
MARUFIU81_04130
ROTFIV09_01395
RMHLVO79_01070
MALUKU6B_41810(mch)
TGLHFZ77_08400
TMDKUV46_05985
HATRC74_09380
PALXGQA70_04805
LSALKBK07_01430
RSPRSP_0973
RSHRsph17029_2633
RSQRsph17025_0085
RSKRSKD131_2365
CAZTLV780_00430
RCPRCAP_rcc00730(maoC)
RHPLPB142_03430
RBLB6K69_07610
PDEPden_0566
PAMIJCM7686_2571
PYEA6J80_13315
PCONB0A89_09560
PZHCX676_05520
PAROCUV01_17705
PAMNJCM7685_2542
PMUTDPM13_11795
PARREOJ32_08555
PAAKFIU66_10015
PKDF8A10_02180
PPANESD82_12335
PLIAE4191_08460
PSANHGN31_04080
PMAUCP157_01936(mch)
PMEHJWJ88_02010
PTPRCA23_c14030
RSUNHU_00727(maoC)
RHMB5V46_04490
RHCRGUI_0619
RMBK529_020755
DAAAKL17_3640
DONBSK21_11425
RBZB9057_02190
THWBMG03_06685
TECAKL02_005540
LVSLOKVESSMR4R_02800(mch)
RBGBG454_13670
GEHHYN69_13100
GFUKM031_13950
TAWEI545_06960
SALOEF888_18555
SEDIEBB79_02265
BOOE2K80_01980
PSEBEOK75_09385
PPRUFDP22_03655
PAEDG5B38_15505
MONG8E03_14620
PAMOBAR1_14380
PSHQF3W81_20290
POZI0K15_13755
PALWPSAL_019000(mch)
PGVSL003B_0349
CACTHZ995_03645
THASC6Y53_10255
HDHG5B40_16095
CMAGCBW24_13070
GCEKYE46_04220
NSMJO391_19980
ACROK3J57_02785
SINRO5O51_12640
FAQG5B39_05130
AMAQGO499_14335
HNEHNE_3531
HBAHbal_0271
CBOTATE48_08620
HBCAEM38_13390
RAPRHOA_5786(mch)
SKTIGS68_03940
SMUCJL100_004090
SROEJL101_003845
RRURru_A1201
RRFF11_06220
RPMRSPPHO_01637
MGYMGMSRv2__2222
MGRYMSR1_22170
MAGXXM1_1405
MAGNWV31_15110
FERFNB15_04090
HTQFRZ44_48910(mch)
HADHFRZ61_47240(mch)
DEXHWD60_03945
DVNHQ394_01630
TMOTMO_3272
TXITH3_18445
THACCSC3H3_17630
TIIDY252_03095
THAIIT893_17685
MAGQMGMAQ_3595
ECOGFIV45_00800
SNEANBZ79_01560
TSMASU32_19295
ARSADJ73_08750
JTEASJ30_03560
JLIEXU32_11335
JMEEEW87_011215
JAYH7A72_03565
AUSIPK37_14060
NOIFCL41_11755
NSNEXE58_13390
NBEBack2_07760(mch)
NAROCFH99_08310
NPIG7071_09440
NOQLN652_19075
NPCKUV85_09000
PSIMKR76_08755
AERAERYTH_05815
AEZC3E78_13730
AEBC6I20_02560
AEFGEV26_03685
EKEEK0264_18180
ATQGH723_14180
RRSRoseRS_4172
RCARcas_0913
CAUCaur_0173
CHLChy400_0186
CAGCagg_1326
LILLA_2627
LIELIF_A2151
LICLIC_11359(maoC)
LISLIL_11480
LBJLBJ_1640(maoC)
LBLLBL_1859(maoC)
LBILEPBI_I0786
LBFLBF_0760(maoC)
LSTLSS_02729
LAJA0128_11715
LMAYDPV73_12235
LKMEFP84_03615
LWLFHG68_12355
LKBLPTSP3_g27670
LNOMAL08_06760
TPXTurpa_2138
GGRHKW67_06645
HALXM0R89_18085
SALIL593_04665
HMArrnAC0688
HHIHAH_1340
HHNHISP_06860
HABSG26_14705
HTABVU17_06530
HALJG9465_08580
HSINKDQ40_06770
HMUHmuk_2983
HALZE5139_02190
HALLLC1Hm_2320(mch3)
HAZPGBQ70_02190
HRRHZS55_19990
HPELHZS54_23490
HTUHtur_1591
HDABB347_04015
HSALJMJ58_00680
HLOJ0X27_02300
HAKZJ0X25_14765
NMGNmag_3337(msh)
HXAHalxa_3158
NATNJ7G_3290
NPENatpe_2591
NVRFEJ81_11885
NPLFGF80_10925
NAYHYG81_14695
HALYHYG82_17315
HJTDVR14_02940
NGENatgr_3385
HRUHalru_1549
HALVNGM15_00940
NOUNatoc_1510
HLRHALLA_10840
HLCCHINAEXTREME16080
NAJB1756_12020
NAGAArcMg_1646 AArcMg_4139
NANAArc1_1993 AArc1_5074
NBGDV706_12985
NASGCU68_13730
SAWLNGM29_08775
MSEMsed_1216
MPRUDFR88_00425
MTENGWK48_10815
VDIVdis_0232
 » show all
Reference
1  [PMID:18065535]
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
  Sequence
[cau:Caur_0173][rsp:RSP_0973]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.148
IUBMB Enzyme Nomenclature: 4.2.1.148
ExPASy - ENZYME nomenclature database: 4.2.1.148
BRENDA, the Enzyme Database: 4.2.1.148
LinkDB

KEGG   REACTION: R05076
Entry
R05076                      Reaction                               
Name
(2R,3S)-2-methylmalyl-CoA hydro-lyase (2-methylfumaryl-CoA-forming)
Definition
L-erythro-3-Methylmalyl-CoA <=> 2-Methylfumaryl-CoA + H2O
Equation
Reaction class
RC01984  C06027_C06028
Enzyme
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00660  C5-Branched dibasic acid metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
M00740  Methylaspartate cycle
Orthology
K14449  2-methylfumaryl-CoA hydratase [EC:4.2.1.148]
Other DBs
RHEA: 38266
LinkDB

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