KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00902 Monoterpenoid biosynthesis
K15099 CYP76B6, G10H; geraniol 8-hydroxylase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K15099 CYP76B6, G10H; geraniol 8-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.83 geraniol 8-hydroxylase
K15099 CYP76B6, G10H; geraniol 8-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, plant type
CYP76 family
K15099 CYP76B6, G10H; geraniol 8-hydroxylase
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
A cytochrome P-450 (heme thiolate) protein found in plants. Also hydroxylates nerol and citronellol, cf. EC 1.14.14.84, linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.14.82, flavonoid 3'-monooxygenase) [3].
History
EC 1.14.14.83 created 2012 as EC 1.14.13.152, transferred 2018 to EC 1.14.14.83
Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.83
R08785 Geraniol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> (6E)-8-Hydroxygeraniol + [Oxidized NADPH---hemoprotein reductase] + H2O