KEGG   ORTHOLOGY: K15226
Entry
K15226                      KO                                     
Symbol
tyrAa
Name
arogenate dehydrogenase (NADP+) [EC:1.3.1.78]
Pathway
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K15226  tyrAa; arogenate dehydrogenase (NADP+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.78  arogenate dehydrogenase (NADP+)
     K15226  tyrAa; arogenate dehydrogenase (NADP+)
Other DBs
RN: R00733
COG: COG0287
GO: 0033730
Genes
SYN: slr2081(tyrA)
SYZ: MYO_114060(tyrA)
SYY: SYNGTS_1394(tyrA)
SYT: SYNGTI_1394(tyrA)
SYS: SYNPCCN_1393(tyrA)
SYQ: SYNPCCP_1393(tyrA)
SYJ: D082_12010(tyrA)
SYO: C7I86_07220
SYC: syc0868_c(tyrA)
SYU: M744_13510
SYG: sync_0447(tyrA)
SYR: SynRCC307_2107(tyrA)
SYX: SynWH7803_0443(tyrA)
SYP: SYNPCC7002_A0677(tyrA)
CYA: CYA_2300(tyrA)
CYB: CYB_0624(tyrA)
SYNR: KR49_10995
SYND: KR52_00505
SYNW: SynWH8103_02365(tyrA)
SYW: SYNW2058
PMA: Pro_1719(tyrA)
PMM: PMM1565
PMT: PMT_1724
PMB: A9601_17721(tyrA)
PMC: P9515_17521(tyrA)
PMF: P9303_22941(tyrA)
PMG: P9301_17561(tyrA)
PMH: P9215_18371(tyrA)
PMJ: P9211_16841(tyrA)
PME: NATL1_20101(tyrA)
PRC: EW14_1923
PRM: EW15_2083
AMR: AM1_2942(tyrA)
TVN: NIES2134_101300(tyrA)
TEL: tll2435(tyrA)
THN: NK55_00825(tyrA)
LET: O77CONTIG1_00666(tyrA)
LBO: LBWT_6830
HHG: XM38_009440(tyrA)
PSER: ABRG53_1798(tyrA)
MAR: MAE_55280
MPK: VL20_422
CYL: AA637_05210(tyrAa)
CYT: cce_4463(tyrA)
TER: Tery_2701
ARP: NIES39_N00690(tyrA)
PAGH: NIES204_34900(tyrA)
GVI: glr0406(tyrA)
GLJ: GKIL_4393(tyrAa)
ANA: all1141
NSH: GXM_06625
AVA: Ava_4397
NAZ: Aazo_3900
CALH: IJ00_23290
DOU: BMF77_02823(tyrA_2)
CTHE: Chro_0609
CEO: ETSB_0416(tyrA)
CER: RGRSB_0377(tyrA)
 » show all
Reference
  Authors
Bonner CA, Jensen RA, Gander JE, Keyhani NO
  Title
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis.
  Journal
Biochem J 382:279-91 (2004)
DOI:10.1042/BJ20031809
  Sequence
[syn:slr2081]
LinkDB

KEGG   ORTHOLOGY: K15227
Entry
K15227                      KO                                     
Symbol
TYRAAT
Name
arogenate dehydrogenase (NADP+), plant [EC:1.3.1.78]
Pathway
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K15227  TYRAAT; arogenate dehydrogenase (NADP+), plant
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.78  arogenate dehydrogenase (NADP+)
     K15227  TYRAAT; arogenate dehydrogenase (NADP+), plant
Other DBs
RN: R00733
GO: 0033730
Genes
MMER: 123543817
ATH: AT1G15710 AT5G34930
ALY: 9304474 9328938
CRB: 111832551 17878621
CSAT: 104719228 104728176 104732493 104732495 104740255 104755882 104774398
EUS: EUTSA_v10008067mg EUTSA_v10020287mg
BRP: 103842888 103858107
BNA: 106367072 106414620 106438203 111200313
BOE: 106311520 106335007
RSZ: 108811778 108847856 108857986
MINC: 123227930
GMX: 100787362(PDH1) 100801552(ADH1) 100803931(TYRA-A) 100809027(ADH3) 100810896(PDH2)
LJA: Lj4g3v1936580.1(Lj4g3v1936580.1) Lj6g3v0452120.1(Lj6g3v0452120.1)
MDM: 108173469
CSV: 101214147
CMO: 103496957
BHJ: 120080457
MCHA: 111013055
QLO: 115954823
DCR: 108215982
DOSA: Os06t0542200-01(Os06g0542200) Os06t0708832-00(Os06g0708832) Os06t0709000-01(Os06g0709000)
VCN: VOLCADRAFT_78949(agd1)
MNG: MNEG_1533
APRO: F751_6083
OLU: OSTLU_119548(ardH)
FCY: FRACYDRAFT_191710(tyrC)
 » show all
Reference
  Authors
Rippert P, Matringe M
  Title
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana.
  Journal
Eur J Biochem 269:4753-61 (2002)
DOI:10.1046/j.1432-1033.2002.03172.x
  Sequence
Reference
  Authors
Rippert P, Puyaubert J, Grisollet D, Derrier L, Matringe M
  Title
Tyrosine and phenylalanine are synthesized within the plastids in Arabidopsis.
  Journal
Plant Physiol 149:1251-60 (2009)
DOI:10.1104/pp.108.130070
LinkDB

KEGG   ENZYME: 1.3.1.78
Entry
EC 1.3.1.78                 Enzyme                                 
Name
arogenate dehydrogenase (NADP+);
arogenic dehydrogenase (ambiguous);
pretyrosine dehydrogenase (ambiguous);
TyrAAT1;
TyrAAT2;
TyrAa
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-arogenate:NADP+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
L-arogenate + NADP+ = L-tyrosine + NADPH + CO2 [RN:R00733]
Reaction(KEGG)
R00733
Substrate
L-arogenate [CPD:C00826];
NADP+ [CPD:C00006]
Product
L-tyrosine [CPD:C00082];
NADPH [CPD:C00005];
CO2 [CPD:C00011]
Comment
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NADP+-dependent enzymes usually predominate in higher plants.The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly [2,3].
History
EC 1.3.1.78 created 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15226  arogenate dehydrogenase (NADP+)
K15227  arogenate dehydrogenase (NADP+), plant
Genes
MMER123543817
ATHAT1G15710 AT5G34930
ALY9304474 9328938
CRB111832551 17878621
CSAT104719228 104728176 104732493 104732495 104740255 104755882 104774398
EUSEUTSA_v10008067mg EUTSA_v10020287mg
BRP103842888 103858107
BNA106367072 106414620 106438203 111200313
BOE106311520 106335007
RSZ108811778 108847856 108857986
THJ104808204 104812465 104815295 104824345 104826560
CPAP110821063 110821065 110826128
CIT102607475 102611864 102624096
CICCICLE_v10007630mg CICLE_v10025846mg CICLE_v10032371mg
PVY116111666 116120968
MINC123227930
TCC18588852 18588854 18589809 18595336
GRA105766784 105772990 105799414
GHI107889341 107891395 107901339 107906447 107962573
GAB108450113 108453256 108454509
DZI111274419 111284814 111285339
EGR104421031 104424190 104438618 108955710
GMX100787362(PDH1) 100801552(ADH1) 100803931(TYRA-A) 100809027(ADH3) 100810896(PDH2)
GSJ114380866 114381698 114383862 114384263 114394141 114397647 114411741
PVUPHAVU_001G247200g PHAVU_003G178200g
VRA106756143 106765463
VAR108323774 108329078
VUN114179044 114179214
CCAJ109808128 109814142 109816588
APRC113846444 113847869 113850503
MTRMTR_3g071980 MTR_4g115980 MTR_5g083530
CAM101494521 101505291 101512316 101513967
LJALj4g3v1936580.1(Lj4g3v1936580.1) Lj6g3v0452120.1(Lj6g3v0452120.1)
ADU107469958 107494416 107496964
AIP107604805 107609247 107622828 107637161
AHF112696929 112702323 112707696 112715311 112742203 112744219 112754794 112765553 112783081
LANG109355921 109362216
FVE101305676 101311619
RCN112183586 112186297 112188560
PPER18770037 18778408 18783081
PMUM103328066 103342969
PAVI110756235 110769140
PDUL117620660 117623592 117634118
MDM108173469
PXB103928925 103928944 103930850 103953879
ZJU107407580 107408197 107413940
MNT21395503 21407648
CSV101214147
CMO103496957
BHJ120080457
MCHA111013055
CMAX111465461 111493711
CMOS111444329 111450314
CPEP111785711 111798049 111805854
RCU107261139 8259490 8263848
JCU105634814 105645529
HBR110648210 110650063 110671430
MESC110600150 110613841 110619090 110625567
POP18094861 18099902 7472451
PEU105111427 105113282 105122672 105139926
PALZ118032618 118040895 118055900
JRE108991826 108995634
QSU112008752 112027884 112027906
QLO115954823
TWL120007714 120011471 120013578
VVI100241212 100251480 100263817 104877397
VRI117921766 117922150 117922154 117927604
SLY101259263 101259361 101264432
SPEN107023185 107026479 107030600
SOT102579802 102587993 102605098
CANN107842110 107856230 107873327 107876377
NTA107764315 107779931 107782363 107798411 107805642 107813162
NSY104211780 104215149 104244162
NTO104084486 104084839 104116640
NAU109206432 109217460 109241120
INI109147944 109154996 109164138 109176464 109178775
ITR116000391 116002100 116013721 116019510 116032443
SIND105160837 105162242 105166429
OEU111368391 111368530 111389512 111390713 111402269 111407915
EGT105960662 105977769
SSPL121744294 121749586 121752428 121796173 121799916 121805634
HAN110904815 110928670
ECAD122599633 122602638
LSV111877801 111879836 111905077
CCAV112500022 112500788 112520080 112520254
DCR108215982
CSIN114293661 114309941
BVG104901924 104901927
SOE110789416 110789423
CQI110708031 110725557
NNU104588604 104592542 104602503 104610673 104611605 104613112
MING122057600 122058481 122059402 122066903 122081462
TSS122638751 122643325 122649727 122651020 122652194 122660366
PSOM113280966 113289961 113314277 113317376 113320481 113323165 113354339
NCOL116249701 116267039
OSA107277437 4341232 4342026
DOSAOs06t0542200-01(Os06g0542200) Os06t0708832-00(Os06g0708832) Os06t0709000-01(Os06g0709000)
OBR102706391 102716604 107304376
BDI100828973 100829970 100833753
ATS109757600 109758435 109758438
TDC119329742 119332287 119333642 119338030 119341594 119341880
TAES123147895 123148531 123148532 123156075 123160230 123161907 123163666 123166534 123169064
SBI8064968 8064969 8072682
ZMA100276497 100281038 100281078 100284089
SITA101769617 101776886 106804311
SVS117851285 117851355 117852217
PVIR120668758 120668760 120670683 120703645 120704437 120704440
PHAI112888356 112888411 112889471
PDA103709458 103710118 103715890 103721502
EGU105033050 105057363
MUS103985416 103986814 103990066 103990067
DCT110108381 110110004
PEQ110018080 110036088 110038143
AOF109835324 109835734 109843924
ATR18423492 18442140 18447759
SMOSELMODRAFT_147857 SELMODRAFT_34770
PPP112280496 112281008 112285748 112289182
CRECHLRE_06g278350v5
VCNVOLCADRAFT_78949(agd1)
MNGMNEG_1533
CSLCOCSUDRAFT_14797
CVRCHLNCDRAFT_18936
APROF751_6083
OLUOSTLU_119548(ardH)
OTAOT_ostta02g01980
BPGBathy14g02110
MISMICPUN_102217
MPPMICPUCDRAFT_4596
CMECYME_CMS326C
GSLGasu_01630
CCPCHC_T00003598001
FCYFRACYDRAFT_191710(tyrC)
AAFAURANDRAFT_3833
SYNslr2081(tyrA)
SYZMYO_114060(tyrA)
SYYSYNGTS_1394(tyrA)
SYTSYNGTI_1394(tyrA)
SYSSYNPCCN_1393(tyrA)
SYQSYNPCCP_1393(tyrA)
SYJD082_12010(tyrA)
SYOC7I86_07220
SYCsyc0868_c(tyrA)
SYUM744_13510
SYFSynpcc7942_0660
SYDSyncc9605_0385
SYESyncc9902_1945
SYGsync_0447(tyrA)
SYRSynRCC307_2107(tyrA)
SYXSynWH7803_0443(tyrA)
SYPSYNPCC7002_A0677(tyrA)
CYACYA_2300(tyrA)
CYBCYB_0624(tyrA)
SYNESyn6312_1438
SYNPSyn7502_00098
SYNKKR100_03435
SYNRKR49_10995
SYNDKR52_00505
SYHSyncc8109_0393
SYNWSynWH8103_02365(tyrA)
SYVAWQ23_03540
SYLAWQ21_04085
SYNCCB0101_10610
DSLDacsa_0703
SYWSYNW2058
CGCCyagr_1800
CYICBM981_1843
PMAPro_1719(tyrA)
PMMPMM1565
PMTPMT_1724
PMNPMN2A_1136
PMIPMT9312_1657
PMBA9601_17721(tyrA)
PMCP9515_17521(tyrA)
PMFP9303_22941(tyrA)
PMGP9301_17561(tyrA)
PMHP9215_18371(tyrA)
PMJP9211_16841(tyrA)
PMENATL1_20101(tyrA)
PRCEW14_1923
PRMEW15_2083
CMPCha6605_5283
AMRAM1_2942(tyrA)
TVNNIES2134_101300(tyrA)
SLWBRW62_03525
TELtll2435(tyrA)
THNNK55_00825(tyrA)
THECFFX45_12545
LEPLepto7376_0061
LENLEP3755_15060
LETO77CONTIG1_00666(tyrA)
LBOLBWT_6830
KOVK9N68_19390
LSCKIK02_13145
LSKJ5X98_09300
HHGXM38_009440(tyrA)
PSEUPse7367_1830
PSERABRG53_1798(tyrA)
THEUHPC62_12710
GLPGlo7428_1710
GENGM3709_2701
GEEGM3708_1698
CHONNIES4102_24130
MARMAE_55280
MPKVL20_422
MIQB5D77_25225
MVZmyaer102_27660
CANCyan10605_0182
CSNCyast_1229
CYLAA637_05210(tyrAa)
HAOPCC7418_1433
ENNFRE64_00645
CYTcce_4463(tyrA)
CWACwatDRAFT_4419
CYPPCC8801_0596
CYHCyan8802_0611
CYCPCC7424_2019
CYJCyan7822_3353
CYNCyan7425_3574
TERTery_2701
ARPNIES39_N00690(tyrA)
PAGHNIES204_34900(tyrA)
OXYHCG48_09750
MVAGD0A34_12960
LFSHFV01_14730
MICMic7113_2359
GEIGEI7407_0094
OACOscil6304_3355
ONIOsc7112_4172
MPROBJP34_16235
CEPCri9333_1775
GVIglr0406(tyrA)
GLJGKIL_4393(tyrAa)
GMLISF26_20060
ANAall1141
NPUNpun_R0978
NOSNos7107_2223
NOPNos7524_2310
NONNOS3756_17370
NFLCOO91_07496
NOECLI64_15270
NSHGXM_06625
NEDHUN01_07750
AVAAva_4397
NAZAazo_3900
ANBANA_C20257
ACYAnacy_4791
AWAAA650_16670
ANNEH233_04250
CSGCylst_3355
RSINB6N60_01578
CALOCal7507_1077
CALTCal6303_4074
CALHIJ00_23290
RIVRiv7116_2767
FISFIS3754_49490
NSPBMF81_02506
DOUBMF77_02823(tyrA_2)
DFSHGD76_22110
CCURIAR63_13475
AFLOHEQ12_17930
TOQHCG51_07315
NCNBZZ01_11940
CTHEChro_0609
PLPPle7327_0729
SCSSta7437_4289
STANSTA3757_37290
CEOETSB_0416(tyrA)
CERRGRSB_0377(tyrA)
MBFBHV42_04645
 » show all
Reference
1  [PMID:24272471]
  Authors
Gaines CG, Byng GS, Whitaker RJ, Jensen RA
  Title
L-tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes.
  Journal
Planta 156:233-40 (1982)
DOI:10.1007/BF00393730
Reference
2  [PMID:12354106]
  Authors
Rippert P, Matringe M
  Title
Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana.
  Journal
Eur J Biochem 269:4753-61 (2002)
DOI:10.1046/j.1432-1033.2002.03172.x
  Sequence
Reference
3  [PMID:15171683]
  Authors
Bonner CA, Jensen RA, Gander JE, Keyhani NO
  Title
A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis.
  Journal
Biochem J 382:279-91 (2004)
DOI:10.1042/BJ20031809
  Sequence
[syn:slr2081]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.78
IUBMB Enzyme Nomenclature: 1.3.1.78
ExPASy - ENZYME nomenclature database: 1.3.1.78
BRENDA, the Enzyme Database: 1.3.1.78
CAS: 64295-75-6
LinkDB

KEGG   REACTION: R00733
Entry
R00733                      Reaction                               
Name
L-arogenate:NADP+ oxidoreductase
Definition
L-Arogenate + NADP+ <=> L-Tyrosine + CO2 + NADPH + H+
Equation
Comment
NAD+ (ec 1.3.1.79, see R00732)
Reaction class
RC00001  C00005_C00006
RC00125  C00082_C00826
Enzyme
1.3.1.78        1.3.1.79
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
Orthology
K15226  arogenate dehydrogenase (NADP+) [EC:1.3.1.78]
K15227  arogenate dehydrogenase (NADP+), plant [EC:1.3.1.78]
Other DBs
RHEA: 15420
LinkDB

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