KEGG   ORTHOLOGY: K15240
Entry
K15240                      KO                                     
Symbol
linE
Name
hydroquinone 1,2-dioxygenase [EC:1.13.11.66]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K15240  linE; hydroquinone 1,2-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.66  hydroquinone 1,2-dioxygenase
     K15240  linE; hydroquinone 1,2-dioxygenase
Other DBs
RN: R05246
GO: 0018569
Genes
SPHM: G432_21695
SJP: SJA_P1-01430(linE)
SINB: SIDU_18535
SPMI: K663_19943 K663_22998
SPHT: K426_30065
Reference
  Authors
Nagata Y, Miyauchi K, Takagi M.
  Title
Complete analysis of genes and enzymes for gamma-hexachlorocyclohexane degradation in Sphingomonas paucimobilis UT26.
  Journal
J Ind Microbiol Biotechnol 23:380-390 (1999)
DOI:10.1038/sj/jim/2900736
  Sequence
Reference
  Authors
Kumari R, Subudhi S, Suar M, Dhingra G, Raina V, Dogra C, Lal S, van der Meer JR, Holliger C, Lal R
  Title
Cloning and characterization of lin genes responsible for the degradation of Hexachlorocyclohexane isomers by Sphingomonas paucimobilis strain B90.
  Journal
Appl Environ Microbiol 68:6021-8 (2002)
DOI:10.1128/AEM.68.12.6021-6028.2002
LinkDB

KEGG   ENZYME: 1.13.11.66
Entry
EC 1.13.11.66               Enzyme                                 
Name
hydroquinone 1,2-dioxygenase;
hydroquinone dioxygenase;
benzene-1,4-diol:oxygen 1,2-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
benzene-1,4-diol:oxygen 1,2-oxidoreductase (ring-opening)
Reaction(IUBMB)
benzene-1,4-diol + O2 = (2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate [RN:R05246]
Reaction(KEGG)
R05246
Substrate
benzene-1,4-diol [CPD:C00530];
O2 [CPD:C00007]
Product
(2Z,4E)-4-hydroxy-6-oxohexa-2,4-dienoate
Comment
The enzyme is an extradiol-type dioxygenase, and is a member of the nonheme-iron(II)-dependent dioxygenase family. It catalyses the ring cleavage of a wide range of hydroquinone substrates to produce the corresponding 4-hydroxymuconic semialdehydes.
History
EC 1.13.11.66 created 2012
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K15240  hydroquinone 1,2-dioxygenase
Genes
SPHMG432_21695
SJPSJA_P1-01430(linE)
SINBSIDU_18535
SPMIK663_19943 K663_22998
SPHTK426_30065
Reference
1  [PMID:10542173]
  Authors
Miyauchi K, Adachi Y, Nagata Y, Takagi M
  Title
Cloning and sequencing of a novel meta-cleavage dioxygenase gene whose product is involved in degradation of gamma-hexachlorocyclohexane in Sphingomonas paucimobilis.
  Journal
J Bacteriol 181:6712-9 (1999)
DOI:10.1128/JB.181.21.6712-6719.1999
  Sequence
Reference
2  [PMID:18502867]
  Authors
Moonen MJ, Synowsky SA, van den Berg WA, Westphal AH, Heck AJ, van den Heuvel RH, Fraaije MW, van Berkel WJ
  Title
Hydroquinone dioxygenase from pseudomonas fluorescens ACB: a novel member of the  family of nonheme-iron(II)-dependent dioxygenases.
  Journal
J Bacteriol 190:5199-209 (2008)
DOI:10.1128/JB.01945-07
Reference
3  [PMID:20466541]
  Authors
Shen W, Liu W, Zhang J, Tao J, Deng H, Cao H, Cui Z
  Title
Cloning and characterization of a gene cluster involved in the catabolism of p-nitrophenol from Pseudomonas putida DLL-E4.
  Journal
Bioresour Technol 101:7516-22 (2010)
DOI:10.1016/j.biortech.2010.04.052
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.66
IUBMB Enzyme Nomenclature: 1.13.11.66
ExPASy - ENZYME nomenclature database: 1.13.11.66
BRENDA, the Enzyme Database: 1.13.11.66
LinkDB

KEGG   REACTION: R05246
Entry
R05246                      Reaction                               
Definition
Hydroquinone + Oxygen <=> cis,cis-4-Hydroxymuconic semialdehyde
Equation
Reaction class
RC01307  C00530_C06603
Enzyme
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K15240  hydroquinone 1,2-dioxygenase [EC:1.13.11.66]
Other DBs
RHEA: 34166
LinkDB

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