KEGG   ORTHOLOGY: K15246
Entry
K15246            Tight     KO                                     
Symbol
tftD
Name
chlorophenol-4-monooxygenase [EC:1.14.14.173 1.14.14.-]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K15246  tftD; chlorophenol-4-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.173  2,4,6-trichlorophenol monooxygenase
     K15246  tftD; chlorophenol-4-monooxygenase
    1.14.14.-
     K15246  tftD; chlorophenol-4-monooxygenase
Other DBs
RN: R05446 R05447 R05449
GO: 0018642
Genes
AG: AAC23548(tftD)
Reference
PMID:9603818
  Authors
Hubner A, Danganan CE, Xun L, Chakrabarty AM, Hendrickson W
  Title
Genes for 2,4,5-trichlorophenoxyacetic acid metabolism in Burkholderia cepacia AC1100: characterization of the tftC and tftD genes and locations of the tft operons on multiple replicons.
  Journal
Appl Environ Microbiol 64:2086-93 (1998)
DOI:10.1128/AEM.64.6.2086-2093.1998
  Sequence
Reference
  Authors
Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun L, Kang C
  Title
Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100.
  Journal
J Biol Chem 285:2014-27 (2010)
DOI:10.1074/jbc.M109.056135
LinkDB

KEGG   ORTHOLOGY: K15245
Entry
K15245                      KO                                     
Symbol
tftC, tcpX
Name
flavin reductase [EC:1.5.1.37]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00740  Riboflavin metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K15245  tftC, tcpX; flavin reductase
  09111 Xenobiotics biodegradation and metabolism
   00361 Chlorocyclohexane and chlorobenzene degradation
    K15245  tftC, tcpX; flavin reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.37  FAD reductase (NADH)
     K15245  tftC, tcpX; flavin reductase
Other DBs
RN: R05446 R05447 R05449 R09748
COG: COG1853
Genes
RPJ: N234_22410
CNC: CNE_BB1p03430(rutF)
REU: Reut_A1584
COX: E0W60_29400
PHS: C2L64_40515
PTER: C2L65_19200
AG: AAC23547(tftC) AGC65457(tcpX)
Reference
  Authors
Webb BN, Ballinger JW, Kim E, Belchik SM, Lam KS, Youn B, Nissen MS, Xun L, Kang C
  Title
Characterization of chlorophenol 4-monooxygenase (TftD) and NADH:FAD oxidoreductase (TftC) of Burkholderia cepacia AC1100.
  Journal
J Biol Chem 285:2014-27 (2010)
DOI:10.1074/jbc.M109.056135
  Sequence
Reference
  Authors
Li J, Huang Y, Hou Y, Li X, Cao H, Cui Z
  Title
Novel gene clusters and metabolic pathway involved in 3,5,6-trichloro-2-pyridinol degradation by Ralstonia sp. strain T6.
  Journal
Appl Environ Microbiol 79:7445-53 (2013)
DOI:10.1128/AEM.01817-13
  Sequence
LinkDB

KEGG   REACTION: R05446
Entry
R05446                      Reaction                               
Definition
2,5-Dichlorohydroquinone + FADH2 + Oxygen <=> 5-Chloro-2-hydroxy-p-benzoquinone + FAD + H2O + Cl-
Equation
Comment
chlorophenol 4-monooxygenase
Reaction class
RC00126  C00016_C01352
RC03350  C06600_C21105
Enzyme
1.14.14.-
Pathway
rn00361  Chlorocyclohexane and chlorobenzene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K15245  flavin reductase [EC:1.5.1.37]
K15246  chlorophenol-4-monooxygenase [EC:1.14.14.173 1.14.14.-]
LinkDB

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