KEGG   ORTHOLOGY: K15760
Entry
K15760                      KO                                     
Symbol
tmoA, tbuA1, touA
Name
toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15760  tmoA, tbuA1, touA; toluene monooxygenase system protein A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15760  tmoA, tbuA1, touA; toluene monooxygenase system protein A
    1.14.13.-
     K15760  tmoA, tbuA1, touA; toluene monooxygenase system protein A
Other DBs
RN: R02550 R03562 R05666
Genes
PSD: DSC_04405
MSR: AU15_20735
CZA: CYCME_2098
THIS: HZT40_03325
SINI: GT972_13790
TBN: TBH_C0915
VFF: VITFI_CDS2830
RPI: Rpic_4632
RPF: Rpic12D_3556
CNC: CNE_BB1p12360(tmoA)
RME: Rmet_1316(tmoA)
CTI: pRALTA_0461(tmoA)
BCON: NL30_24535
BUG: BC1001_PA6410(tmoA)
BPX: BUPH_08274(tmoA)
BHO: D560_1531(tmoA)
BHM: D558_1522(tmoA)
HPSE: HPF_01805(tmoA1)
MPT: Mpe_A0814(tbuA1)
DAR: Daro_3820
ACIB: ACBT_0273(tmoA)
BBT: BBta_1598
AOL: S58_10670
HMC: HYPMC_2245(tmoA)
BTS: Btus_2069
SAY: TPY_0635
MSHG: MSG_02600(mphN)
MSTO: MSTO_08260
MSAK: MSAS_06380
MPHL: MPHLCCUG_04541(tmoA)
MHAS: MHAS_04833(tmoA)
MMAG: MMAD_01710
MMOR: MMOR_05370
MANY: MANY_23670
MTER: 4434518_03550(tmoA)
MHIB: MHIB_29700
CCYC: SCMU_04700
NFR: ERS450000_00312(tmoA)
TRO: trd_A0919
SSO: SSO1227(tmoA) SSO1228(tmoA)
SOL: Ssol_2196
SSOA: SULA_2229
SSOL: SULB_2230
SSOF: SULC_2227
POG: Pogu_1801
AG: AAA25999(tmoA)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15761
Entry
K15761                      KO                                     
Symbol
tmoB, tbuU, touB
Name
toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15761  tmoB, tbuU, touB; toluene monooxygenase system protein B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15761  tmoB, tbuU, touB; toluene monooxygenase system protein B
    1.14.13.-
     K15761  tmoB, tbuU, touB; toluene monooxygenase system protein B
Other DBs
RN: R02550 R03562 R05666
Genes
PSD: DSC_04400
MSR: AU15_20740
CZA: CYCME_2097
THIS: HZT40_03320
SINI: GT972_13795
TBN: TBH_C0916
VFF: VITFI_CDS2831
RPI: Rpic_4633
RPF: Rpic12D_3557
CNC: CNE_BB1p12350(tmoB)
RME: Rmet_1315(tmoB)
CTI: pRALTA_0462(tmoB)
BCON: NL30_24540
BUG: BC1001_PA6409(tmoB)
BHO: D560_1530
BHM: D558_1521
HPSE: HPF_01800(tmoB)
MPT: Mpe_A0815(tbuU) Mpe_A2540(tbuU)
DAR: Daro_3819
ACIB: ACBT_0272(tmoB)
BBT: BBta_1597
AOL: S58_10660
BTS: Btus_2068
SAY: TPY_0636
MSHG: MSG_02601(tmoB)
MSTO: MSTO_08250
MSAK: MSAS_06390
MPHL: MPHLCCUG_04540(tmoB)
MHAS: MHAS_04834(tmoB)
MMOR: MMOR_05360
MANY: MANY_23680
MTER: 4434518_03549(tmoB)
MHIB: MHIB_29690
CCYC: SCMU_04690
NFR: ERS450000_00313(tmoB)
TRO: trd_A0920
AG: AAA26000(tmoB)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15762
Entry
K15762                      KO                                     
Symbol
tmoC, tbuB, touC
Name
toluene monooxygenase system ferredoxin subunit
Pathway
map00623  Toluene degradation
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15762  tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15762  tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit
Other DBs
RN: R02550 R03562 R05666 R09513
Genes
PSD: DSC_04395
MCA: MCA0225 MCA0586
METU: GNH96_03875 GNH96_15290
MMAI: sS8_4250 sS8_5417 sS8_5458
CZA: CYCME_2096
THIS: HZT40_03315
HAZ: A9404_01470
SINI: GT972_13800
TBN: TBH_C0917
VFF: VITFI_CDS2832
RPI: Rpic_4634
CNC: CNE_BB1p12340(tbcC)
RME: Rmet_1314(tmoC)
BCON: NL30_24545
BUG: BC1001_PA6408(tmoC)
BHO: D560_1527
BHM: D558_1518
PNA: Pnap_2045
HPSE: HPF_01795(tmoC)
MPT: Mpe_A0816(tbuB) Mpe_A0922(msmC) Mpe_A2541(tbuB)
DAR: Daro_3818
AZO: azo2601
AOA: dqs_2762
ACIB: ACBT_0271(tmoC)
BRA: BRADO3598
XAU: Xaut_4301
BID: Bind_2847
HMC: HYPMC_2243(tmoC)
MSC: BN69_2679
BTS: Btus_2067
SAY: TPY_0637
MSHG: MSG_02602
MSTO: MSTO_08240
MSAK: MSAS_06400
MPHL: MPHLCCUG_04539(tmoC)
MHAS: MHAS_04835(tmoC)
MMAG: MMAD_01690(nirD)
MMOR: MMOR_05350
MANY: MANY_23690
MTER: 4434518_03548(tmoC)
MHIB: MHIB_29680
CCYC: SCMU_04680
NFR: ERS450000_00317(tmoC)
TRO: trd_A0921
SSO: SSO1230(tmoC)
SOL: Ssol_2198
SSOA: SULA_2231
SSOL: SULB_2232
SSOF: SULC_2229
SID: M164_0422
SII: LD85_0413
SIH: SiH_0429
SIR: SiRe_0387
PAS: Pars_0544
AG: AAA26001(tmoC)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15763
Entry
K15763                      KO                                     
Symbol
tmoD, tbuV, touD
Name
toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15763  tmoD, tbuV, touD; toluene monooxygenase system protein D
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15763  tmoD, tbuV, touD; toluene monooxygenase system protein D
    1.14.13.-
     K15763  tmoD, tbuV, touD; toluene monooxygenase system protein D
Other DBs
RN: R02550 R03562 R05666
Genes
PSD: DSC_04390
MSR: AU15_20750
CZA: CYCME_2095
SINI: GT972_13805
TBN: TBH_C0918
VFF: VITFI_CDS2833
RPI: Rpic_4635
RPF: Rpic12D_3559
CNC: CNE_BB1p12330(tmoD)
REU: Reut_B5676
RME: Rmet_1313(tmoD)
CTI: pRALTA_0465(tmoD)
BCON: NL30_24550
BUG: BC1001_PA6407(tmoD)
BHO: D560_1529
BHM: D558_1520
HPSE: HPF_01790(tmoD)
MPT: Mpe_A0817(tbuV) Mpe_A2542(tbuV)
DAR: Daro_3817
ACIB: ACBT_0270(tmoD)
BBT: BBta_1595
AOL: S58_10640
HMC: HYPMC_2242(tmoD)
BTS: Btus_2066
SAY: TPY_0638
MSHG: MSG_02603(tmoD)
MSTO: MSTO_08230
MSAK: MSAS_06410
MPHL: MPHLCCUG_04538(tmoD)
MHAS: MHAS_04836(tmoD)
MMAG: MMAD_01680
MMOR: MMOR_05340
MANY: MANY_23700
MTER: 4434518_03547(tmoD)
MHIB: MHIB_29670
NFR: ERS450000_00314(tmoD)
TRO: trd_A0922
SSO: SSO1231(tmoD)
SOL: Ssol_2199
SSOA: SULA_2232
SSOL: SULB_2233
SSOF: SULC_2230
SID: M164_0423
SII: LD85_0414
SIH: SiH_0430
SIR: SiRe_0388
PAS: Pars_0543
AG: AAA26002(tmoD)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15764
Entry
K15764                      KO                                     
Symbol
tmoE, tbuA2, touE
Name
toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15764  tmoE, tbuA2, touE; toluene monooxygenase system protein E
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.236  toluene 4-monooxygenase
     K15764  tmoE, tbuA2, touE; toluene monooxygenase system protein E
    1.14.13.-
     K15764  tmoE, tbuA2, touE; toluene monooxygenase system protein E
Other DBs
RN: R02550 R03562 R05666
Genes
PSD: DSC_04385
MSR: AU15_20755
CZA: CYCME_2094
THIS: HZT40_03305
SINI: GT972_13810
TBN: TBH_C0919
VFF: VITFI_CDS2834
RPI: Rpic_4636
RPF: Rpic12D_3560
CNC: CNE_BB1p12320(tmoE)
RME: Rmet_1312(tmoE)
CTI: pRALTA_0466(tmoE)
BCON: NL30_24555
BUG: BC1001_PA6406(tmoE)
BHO: D560_1528(touE)
BHM: D558_1519(touE)
HPSE: HPF_01785(tmoE)
MPT: Mpe_A0818(tbuA2) Mpe_A2543(tbuA2)
DAR: Daro_3816
ACIB: ACBT_0269(tmoE)
BBT: BBta_1594
AOL: S58_10630
HMC: HYPMC_2241(tmoE)
BTS: Btus_2065
SAY: TPY_0639
MSHG: MSG_02604
MSTO: MSTO_08220
MSAK: MSAS_06420
MPHL: MPHLCCUG_04537(tmoE)
MHAS: MHAS_04837(tmoE)
MMAG: MMAD_01670
MMOR: MMOR_05330
MANY: MANY_23710
MTER: 4434518_03546(tmoE)
MHIB: MHIB_29660
CCYC: SCMU_04660
NFR: ERS450000_00315(tmoE)
TRO: trd_A0923
SSO: SSO1233(tmoE)
SOL: Ssol_2200
SSOA: SULA_2233
SSOL: SULB_2234
SSOF: SULC_2231
SID: M164_0424
SII: LD85_0415
SIH: SiH_0431
SIR: SiRe_0389
SIC: SiL_0415
PAS: Pars_0542
AG: AAA26003(tmoE)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15765
Entry
K15765                      KO                                     
Symbol
tmoF, tbuC, touF
Name
toluene monooxygenase electron transfer component [EC:1.18.1.3]
Pathway
map00623  Toluene degradation
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.3  ferredoxin---NAD+ reductase
     K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
Other DBs
RN: R02550 R03562 R05666 R09513
Genes
PSD: DSC_04380
PPSE: BN5_3604
MBS: MRBBS_1308(tmoF)
MSR: AU15_20760
CYQ: Q91_2220
CZA: CYCME_2538
CYY: CPC19_01700
THIS: HZT40_03300
APAC: S7S_13335
MGEO: CFI10_14575 CFI10_17775
TBN: TBH_C0920
RPI: Rpic_4637
CNC: CNE_BB1p12310(tmoF)
RME: Rmet_1311
BCT: GEM_5810
BCON: NL30_24560
BUG: BC1001_PA6405(tmoF)
PPNO: DA70_22375
BPE: BP0066
BPC: BPTD_0064
BPER: BN118_3398
BPET: B1917_0069
BPEU: Q425_690
BPA: BPP0517
BBR: BB0522
BTRM: SAMEA390648701722(dmpP_1)
PUT: PT7_2459
LIM: L103DPR2_00189(carAd)
HPSE: HPF_01780(tmoF)
MPT: Mpe_A0819(tbuC) Mpe_A0921(msmD)
DAR: Daro_3815
BBT: BBta_1593
AOL: S58_10620
OCA: OCAR_6789
FIL: BN1229_v1_3546(msmD)
FIY: BN1229_v1_2377(msmD)
HDI: HDIA_4247(carAd)
SGI: SGRAN_2803(thnA4)
BTS: Btus_2064
NFR: ERS450000_00316(tmoF)
TRO: trd_A0924
AG: AAA26004(tmoF)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
  Sequence
LinkDB

KEGG   ENZYME: 1.14.13.236
Entry
EC 1.14.13.236              Enzyme                                 
Name
toluene 4-monooxygenase;
TMO
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Reaction(IUBMB)
toluene + NADH + H+ + O2 = 4-methylphenol + NAD+ + H2O [RN:R05666]
Reaction(KEGG)
R05666
Substrate
toluene [CPD:C01455];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
4-methylphenol [CPD:C01468];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
This bacterial enzyme belongs to a family of soluble diiron hydroxylases that includes toluene-, benzene-, xylene- and methane monooxygenases, phenol hydroxylases, and alkene epoxidases. The enzyme comprises a four-component complex that includes a hydroxylase, NADH-ferredoxin oxidoreductase, a Rieske-type [2Fe-2S] ferredoxin, and an effector protein.
History
EC 1.14.13.236 created 2017
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15760  toluene monooxygenase system protein A
K15761  toluene monooxygenase system protein B
K15763  toluene monooxygenase system protein D
K15764  toluene monooxygenase system protein E
Genes
PSDDSC_04385 DSC_04390 DSC_04400 DSC_04405
MSRAU15_20735 AU15_20740 AU15_20750 AU15_20755
CZACYCME_2094 CYCME_2095 CYCME_2097 CYCME_2098
THISHZT40_03305 HZT40_03320 HZT40_03325
SINIGT972_13790 GT972_13795 GT972_13805 GT972_13810
TBNTBH_C0915 TBH_C0916 TBH_C0918 TBH_C0919
VFFVITFI_CDS2830 VITFI_CDS2831 VITFI_CDS2833 VITFI_CDS2834
RPIRpic_4632 Rpic_4633 Rpic_4635 Rpic_4636
RPFRpic12D_3556 Rpic12D_3557 Rpic12D_3559 Rpic12D_3560
CNCCNE_BB1p12320(tmoE) CNE_BB1p12330(tmoD) CNE_BB1p12350(tmoB) CNE_BB1p12360(tmoA)
REUReut_B5675 Reut_B5676 Reut_B5678 Reut_B5679
RMERmet_1312(tmoE) Rmet_1313(tmoD) Rmet_1315(tmoB) Rmet_1316(tmoA)
CTIpRALTA_0461(tmoA) pRALTA_0462(tmoB) pRALTA_0465(tmoD) pRALTA_0466(tmoE)
BVIBcep1808_7608
BCONNL30_24535 NL30_24540 NL30_24550 NL30_24555
BSTLBBJ41_10535 BBJ41_10540 BBJ41_10550 BBJ41_10555
BUGBC1001_PA6406(tmoE) BC1001_PA6407(tmoD) BC1001_PA6409(tmoB) BC1001_PA6410(tmoA)
BGEBC1002_6838 BC1002_6839 BC1002_6841 BC1002_6845
BPXBUPH_05041 BUPH_05042 BUPH_08274(tmoA) BUPH_08478
PARBCJU94_38140 CJU94_38145 CJU94_38155 CJU94_38160
PPKU875_01855 U875_01860 U875_01870 U875_01875
PRBX636_07595 X636_07600 X636_07610 X636_07615
BHOD560_1528(touE) D560_1529 D560_1530 D560_1531(tmoA)
BHMD558_1519(touE) D558_1520 D558_1521 D558_1522(tmoA)
HPSEHPF_01785(tmoE) HPF_01790(tmoD) HPF_01800(tmoB) HPF_01805(tmoA1)
HTNKI616_01905 KI616_01910 KI616_01920 KI616_01925
MPTMpe_A0814(tbuA1) Mpe_A0815(tbuU) Mpe_A0817(tbuV) Mpe_A0818(tbuA2) Mpe_A2540(tbuU) Mpe_A2542(tbuV) Mpe_A2543(tbuA2)
METPC1M51_16275 C1M51_16280 C1M51_16290 C1M51_16295
IDCLRM40_19610 LRM40_19615 LRM40_19625 LRM40_19630
RBUPG1C_06390 PG1C_06395 PG1C_06405 PG1C_06410 PG1C_06860 PG1C_06865 PG1C_06875 PG1C_06880
DARDaro_3816 Daro_3817 Daro_3819 Daro_3820
DEYHYN24_09680 HYN24_09685 HYN24_09695 HYN24_09700
FLEKI610_08735 KI610_08740 KI610_08750 KI610_08755
AZDCDA09_10195 CDA09_10200 CDA09_10210 CDA09_10215
AZRCJ010_11500 CJ010_11505 CJ010_11515 CJ010_11520
THKCCZ27_06370 CCZ27_06375 CCZ27_06385 CCZ27_06390
ACIBACBT_0269(tmoE) ACBT_0270(tmoD) ACBT_0272(tmoB) ACBT_0273(tmoA)
LLUAKJ09_01040 AKJ09_01043 AKJ09_01044
BBTBBta_1594 BBta_1595 BBta_1597 BBta_1598
AOLS58_10630 S58_10640 S58_10660 S58_10670
BROBRAD285_2998 BRAD285_2999 BRAD285_3001 BRAD285_3002
XDIEZH22_10090 EZH22_10095 EZH22_10105 EZH22_10110 EZH22_30900 EZH22_30905 EZH22_30915 EZH22_30920
HMCHYPMC_2241(tmoE) HYPMC_2242(tmoD) HYPMC_2244 HYPMC_2245(tmoA)
BTSBtus_2065 Btus_2066 Btus_2068 Btus_2069
SAYTPY_0635 TPY_0636 TPY_0638 TPY_0639
SAPSulac_3000 Sulac_3001 Sulac_3003 Sulac_3004
MSHGMSG_02600(mphN) MSG_02601(tmoB) MSG_02603(tmoD) MSG_02604
MFJMFLOJ_53260 MFLOJ_53270 MFLOJ_53290 MFLOJ_53300
MSTOMSTO_08220 MSTO_08230 MSTO_08250 MSTO_08260
MSAKMSAS_06380 MSAS_06390 MSAS_06410 MSAS_06420
MPHLMPHLCCUG_04537(tmoE) MPHLCCUG_04538(tmoD) MPHLCCUG_04540(tmoB) MPHLCCUG_04541(tmoA)
MLLB1R94_25125 B1R94_25130 B1R94_25140 B1R94_25145
MHASMHAS_04833(tmoA) MHAS_04834(tmoB) MHAS_04836(tmoD) MHAS_04837(tmoE)
MMAGMMAD_01670 MMAD_01680 MMAD_01710
MMORMMOR_05330 MMOR_05340 MMOR_05360 MMOR_05370
MANYMANY_23670 MANY_23680 MANY_23700 MANY_23710
MTER4434518_03546(tmoE) 4434518_03547(tmoD) 4434518_03549(tmoB) 4434518_03550(tmoA)
MHIBMHIB_29660 MHIB_29670 MHIB_29690 MHIB_29700
CCYCSCMU_04660 SCMU_04690 SCMU_04700
NFRERS450000_00312(tmoA) ERS450000_00313(tmoB) ERS450000_00314(tmoD) ERS450000_00315(tmoE)
ROAPd630_LPD03568 Pd630_LPD03569 Pd630_LPD03571 Pd630_LPD03572
RKOJWS14_48075 JWS14_48080 JWS14_48085 JWS14_48090
GPOGPOL_c08420 GPOL_c08430 GPOL_c08440 GPOL_c08450
PHWG7075_19675 G7075_19680 G7075_19690 G7075_19695
FRAFrancci3_0211 Francci3_0212 Francci3_0214 Francci3_0215
FSYFsymDg_1864
AMQAMETH_6107 AMETH_6108 AMETH_6109 AMETH_6110
AMYCCU254_12375 CU254_12380 CU254_12385 CU254_12390
AACDLWP59_25960 LWP59_25965 LWP59_25970 LWP59_25975 LWP59_38050 LWP59_38055 LWP59_38065 LWP59_38070
PDXPsed_0812 Psed_0813 Psed_0814 Psed_0815 Psed_1155 Psed_1156 Psed_1158 Psed_1159 Psed_1436 Psed_1437 Psed_1438 Psed_1439 Psed_6058 Psed_6059 Psed_6061 Psed_6062
PBROHOP40_29385 HOP40_29390 HOP40_29395 HOP40_29400
TROtrd_A0919 trd_A0920 trd_A0922 trd_A0923
NAJB1756_14060 B1756_14070 B1756_14075 B1756_14085
SSOSSO1227(tmoA) SSO1228(tmoA) SSO1231(tmoD) SSO1233(tmoE)
SOLSsol_2196 Ssol_2199 Ssol_2200
SSOASULA_2229 SULA_2232 SULA_2233
SSOLSULB_2230 SULB_2233 SULB_2234
SSOFSULC_2227 SULC_2230 SULC_2231
SSHIJ5U23_02013 J5U23_02014 J5U23_02017 J5U23_02018
SISLS215_0420 LS215_0421 LS215_0424 LS215_0425
SIDM164_0419 M164_0420 M164_0423 M164_0424
SINYN1551_2652 YN1551_2653 YN1551_2656 YN1551_2657
SIILD85_0410 LD85_0411 LD85_0414 LD85_0415
SIHSiH_0426 SiH_0427 SiH_0430 SiH_0431
SIRSiRe_0384 SiRe_0385 SiRe_0388 SiRe_0389
SICSiL_0415
SULABFU36_13245 BFU36_13250 BFU36_13265 BFU36_13270
SULEGFS03_03520 GFS03_03525 GFS03_03540 GFS03_03545
SULOGFS33_07675 GFS33_07680 GFS33_07695 GFS33_07700
SULLEWF20_11120 EWF20_11125 EWF20_11140 EWF20_11145
AMANB6F84_00770 B6F84_00790 B6F84_00795 B6F84_00810
ABRIDFR85_14340 DFR85_14345 DFR85_14360 DFR85_14370
PASPars_0542 Pars_0543 Pars_0546 Pars_0548
POGPogu_1801
 » show all
Reference
1  [PMID:2019563]
  Authors
Whited GM, Gibson DT
  Title
Toluene-4-monooxygenase, a three-component enzyme system that catalyzes the oxidation of toluene to p-cresol in Pseudomonas mendocina KR1.
  Journal
J Bacteriol 173:3010-6 (1991)
DOI:10.1128/JB.173.9.3010-3016.1991
Reference
2  [PMID:11297417]
  Authors
Hemmi H, Studts JM, Chae YK, Song J, Markley JL, Fox BG
  Title
Solution structure of the toluene 4-monooxygenase effector protein (T4moD).
  Journal
Biochemistry 40:3512-24 (2001)
DOI:10.1021/bi0013703
Reference
3  [PMID:18479085]
  Authors
Schwartz JK, Wei PP, Mitchell KH, Fox BG, Solomon EI
  Title
Geometric and electronic structure studies of the binuclear nonheme ferrous active site of toluene-4-monooxygenase: parallels with methane monooxygenase and  insight into the role of the effector proteins in O2 activation.
  Journal
J Am Chem Soc 130:7098-109 (2008)
DOI:10.1021/ja800654d
Reference
4  [PMID:22264099]
  Authors
Bailey LJ, Acheson JF, McCoy JG, Elsen NL, Phillips GN Jr, Fox BG
  Title
Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase.
  Journal
Biochemistry 51:1101-13 (2012)
DOI:10.1021/bi2018333
Reference
5  [PMID:24798294]
  Authors
Hosseini A, Brouk M, Lucas MF, Glaser F, Fishman A, Guallar V
  Title
Atomic picture of ligand migration in toluene 4-monooxygenase.
  Journal
J Phys Chem B 119:671-8 (2015)
DOI:10.1021/jp502509a
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.236
IUBMB Enzyme Nomenclature: 1.14.13.236
ExPASy - ENZYME nomenclature database: 1.14.13.236
BRENDA, the Enzyme Database: 1.14.13.236
LinkDB

KEGG   REACTION: R05666
Entry
R05666                      Reaction                               
Name
toluene,NADH:oxygen oxidoreductase (4-hydroxylating)
Definition
Toluene + NADH + H+ + Oxygen <=> 4-Cresol + NAD+ + H2O
Equation
Reaction class
RC00490  C01455_C01468
Enzyme
Pathway
rn00623  Toluene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K15760  toluene monooxygenase system protein A [EC:1.14.13.236 1.14.13.-]
K15761  toluene monooxygenase system protein B [EC:1.14.13.236 1.14.13.-]
K15762  toluene monooxygenase system ferredoxin subunit
K15763  toluene monooxygenase system protein D [EC:1.14.13.236 1.14.13.-]
K15764  toluene monooxygenase system protein E [EC:1.14.13.236 1.14.13.-]
K15765  toluene monooxygenase electron transfer component [EC:1.18.1.3]
Other DBs
RHEA: 41383
LinkDB

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