KEGG   ORTHOLOGY: K15944
Entry
K15944                      KO                                     
Symbol
snoaF, dnrE, dauE, aknU
Name
nogalaviketone/aklaviketone reductase [EC:1.1.1.- 1.1.1.362]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Reaction
R06677  auramycinone:NADP+ 7-oxidoreductase
R06682  aklavinone:NADP+ 7-oxidoreductase
R09329  nogalavinone:NADP+ 7-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.362  aklaviketone reductase
     K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K15944  snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase
Genes
SPRI: SPRI_0205 SPRI_7148
SPHW: NFX46_24955
SKA: CP970_39835
SGAL: CP966_29005
STSU: B7R87_22060
SCOE: CP976_32935
SXN: IAG42_36850
SDD: D9753_08660
SNIG: HEK616_47440
SJN: RI060_18340
SHAU: K9S39_40700
SKG: KJK29_16140
TALX: FOF52_07460
ACTQ: OG417_36645
ACYN: ORV05_34120
MAU: Micau_4000
MIL: ML5_4421
MFEU: H1D33_25720
DMAT: Dmats_05325
AG: AAA65202(dnrE) AAB08021(dauE) AAF01806(snoaF) AAF73457(aknU)
 » show all
Reference
PMID:11683270
  Authors
Torkkell S, Kunnari T, Palmu K, Mantsala P, Hakala J, Ylihonko K
  Title
The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures.
  Journal
Mol Genet Genomics 266:276-88 (2001)
DOI:10.1007/s004380100554
  Sequence
[ag:AAF01806]
Reference
PMID:8655529
  Authors
Dickens ML, Ye J, Strohl WR
  Title
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
  Journal
J Bacteriol 178:3384-8 (1996)
DOI:10.1128/JB.178.11.3384-3388.1996
  Sequence
[ag:AAB08021]
Reference
PMID:11016846
  Authors
Raty K, Kunnari T, Hakala J, Mantsala P, Ylihonko K
  Title
A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.
  Journal
Mol Gen Genet 264:164-72 (2000)
DOI:10.1007/s004380000306
  Sequence
[ag:AAF73457]
LinkDB

KEGG   REACTION: R09329
Entry
R09329                      Reaction                               
Name
nogalavinone:NADP+ 7-oxidoreductase
Definition
Nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+
Equation
C18630 + C00005 + C00080 <=> C18631 + C00006
Comment
C7-ketoreductase, snoaF
Reaction class
RC00001  C00005_C00006
RC00234  C18630_C18631
Enzyme
1.1.1.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00781  Nogalavinone/aklavinone biosynthesis, deoxynogalonate/deoxyaklanonate => nogalavinone/aklavinone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R09329  Nogalaviketone + NADPH + H+ <=> Nogalavinone + NADP+
Orthology
K15944  nogalaviketone/aklaviketone reductase [EC:1.1.1.- 1.1.1.362]
LinkDB

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