KEGG   ORTHOLOGY: K15960
Entry
K15960            Tight     KO                                     
Symbol
mtmGIV
Name
glycosyltransferase [EC:2.4.1.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Reaction
R06716  dTDP-D-olivose:premithramycinone D-olivosyltransferase
R06718  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15960  mtmGIV; glycosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15960  mtmGIV; glycosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K15960  mtmGIV; glycosyltransferase
Other DBs
CAZy: GT1
Genes
AG: CAK50788(mtmGIV)
Reference
PMID:10660060
  Authors
Blanco G, Fernandez E, Fernandez MJ, Brana AF, Weissbach U, Kunzel E, Rohr J, Mendez C, Salas JA
  Title
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.
  Journal
Mol Gen Genet 262:991-1000 (2000)
DOI:10.1007/PL00008667
  Sequence
[ag:CAK50788]
LinkDB

KEGG   ORTHOLOGY: K15962
Entry
K15962            Tight     KO                                     
Symbol
mtmC
Name
D-mycarose 3-C-methyltransferase
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06718  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15962  mtmC; D-mycarose 3-C-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15962  mtmC; D-mycarose 3-C-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K15962  mtmC; D-mycarose 3-C-methyltransferase
Genes
AG: CAK50784(mtmC)
Reference
PMID:11254130
  Authors
Gonzalez A, Remsing LL, Lombo F, Fernandez MJ, Prado L, Brana AF, Kunzel E, Rohr J, Mendez C, Salas JA
  Title
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.
  Journal
Mol Gen Genet 264:827-35 (2001)
DOI:10.1007/s004380000372
  Sequence
[ag:CAK50784]
LinkDB

KEGG   REACTION: R06718
Entry
R06718                      Reaction                               
Definition
Premithramycin A2' + dTDP-D-mycarose <=> Premithramycin A3' + dTDP
Equation
C12385 + C12444 <=> C12386 + C00363
Comment
glycosyltransferase, mtmGIV and D-mycarose 3-C-methyltransferase
Reaction class
RC00005  C00363_C12444
RC00049  C12385_C12386
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00782  Mithramycin biosynthesis, 4-demethylpremithramycinone => mithramycin
Orthology
K15960  glycosyltransferase [EC:2.4.1.-]
K15962  D-mycarose 3-C-methyltransferase
LinkDB

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