KEGG   ORTHOLOGY: K15971
Entry
K15971                      KO                                     
Symbol
tcmP, elmP
Name
O-methyltransferase [EC:2.1.1.-]
Pathway
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Reaction
R06703  S-adenosyl-L-methionine:tetracenomycin-E O-methyltransferase
R06713  S-adenosyl-L-methionine:tetracenomycin-B3 O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K15971  tcmP, elmP; O-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15971  tcmP, elmP; O-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K15971  tcmP, elmP; O-methyltransferase
Other DBs
COG: COG3315
Genes
SGU: SGLAU_26330(tcmP)
AG: CAP12605(elmP)
Reference
PMID:8509339
  Authors
Decker H, Motamedi H, Hutchinson CR
  Title
Nucleotide sequences and heterologous expression of tcmG and tcmP, biosynthetic genes for tetracenomycin C in Streptomyces glaucescens.
  Journal
J Bacteriol 175:3876-86 (1993)
DOI:10.1128/JB.175.12.3876-3886.1993
  Sequence
Reference
  Authors
Ramos A, Lombo F, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.
  Journal
Microbiology 154:781-8 (2008)
DOI:10.1099/mic.0.2007/014035-0
  Sequence
LinkDB

KEGG   REACTION: R06703
Entry
R06703                      Reaction                               
Name
S-adenosyl-L-methionine:tetracenomycin-E O-methyltransferase
Definition
Tetracenomycin E + S-Adenosyl-L-methionine <=> Tetracenomycin A2 + S-Adenosyl-L-homocysteine
Equation
Comment
O-methyltransferase, tcmP
Reaction class
RC00003  C00019_C00021
RC00460  C12370_C12371
Enzyme
2.1.1.-
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00783  Tetracenomycin C/8-demethyltetracenomycin C biosynthesis, tetracenomycin F2 => tetracenomycin C/8-demethyltetracenomycin C
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-
     R06703  Tetracenomycin E + S-Adenosyl-L-methionine <=> Tetracenomycin A2 + S-Adenosyl-L-homocysteine
Orthology
K15971  O-methyltransferase [EC:2.1.1.-]
LinkDB

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