KEGG   ORTHOLOGY: K15981
Entry
K15981                      KO                                     
Symbol
CYP125A
Name
cholest-4-en-3-one 26-monooxygenase [EC:1.14.15.29]
Pathway
map00984  Steroid degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K15981  CYP125A; cholest-4-en-3-one 26-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K15981  CYP125A; cholest-4-en-3-one 26-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.29  cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]
     K15981  CYP125A; cholest-4-en-3-one 26-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP125 family
   K15981  CYP125A; cholest-4-en-3-one 26-monooxygenase
Other DBs
RN: R11357
COG: COG2124
Genes
AFUS: EYZ66_06325
MSD: MYSTI_04828
PAUU: E8A73_015680
MTU: Rv3545c(cyp125)
MTV: RVBD_3545c
MTC: MT3649
MRA: MRA_3584(cyp125)
MTF: TBFG_13578
MTB: TBMG_03584
MTK: TBSG_03611
MTUR: CFBS_3761(cyp125)
MTO: MTCTRI2_3609(cyp125)
MTD: UDA_3545c(cyp125)
MTN: ERDMAN_3890(cyp125)
MTUC: J113_24790
MTUE: J114_18960
MTUL: TBHG_03485
MTUT: HKBT1_3746(cyp125)
MTUU: HKBT2_3755(cyp125)
MTQ: HKBS1_3758(cyp125)
MBO: BQ2027_MB3575C(cyp125)
MBB: BCG_3609c(cyp125)
MBT: JTY_3610(cyp125)
MBM: BCGMEX_3607c(cyp125)
MBX: BCGT_3411
MAF: MAF_35570(cyp125)
MMIC: RN08_3921
MCE: MCAN_35561(cyp125)
MCQ: BN44_110037(cyp)
MCV: BN43_90043(cyp)
MCX: BN42_90040(cyp)
MCZ: BN45_100040(cyp)
MLP: MLM_0760
MUL: MUL_4106(cyp125A7)
MMI: MMAR_2783(cyp125A6) MMAR_5032(cyp125A7)
MMAE: MMARE11_27030(cyp125A6) MMARE11_48420(cyp125A7)
MLI: MULP_02541(cyp125A6) MULP_05284(cyp125A7)
MNM: MNVM_23840(cyp125_1) MNVM_23850(cyp125_2) MNVM_23940(cyp125_3) MNVM_24710 MNVM_32450
MPSE: MPSD_28660 MPSD_52310(cyp125)
MSHO: MSHO_05050(cyp125) MSHO_41800
MLJ: MLAC_18500 MLAC_47630(cyp125)
MSHJ: MSHI_38950(cyp125)
MSG: MSMEI_3443(cyp125) MSMEI_5695(cyp125) MSMEI_5834(cyp125)
MJD: JDM601_2803(cyp125A7) JDM601_3609(cyp125A7) JDM601_3682(cyp125A7) JDM601_3692(cyp125A7) JDM601_3693(cyp125A7)
MTER: 4434518_02769(cyp125A7_1) 4434518_03588(cyp125A7_2) 4434518_03654(cyp125A7_3) 4434518_03664(cyp125A7_4) 4434518_03665(cyp125A7_5)
ASD: AS9A_0965
CSUR: N24_0159
GOR: KTR9_3902(cyp125A1)
TPR: Tpau_3821
SMA: SAVERM_5841(cyp22)
SGR: SGR_5169
SGB: WQO_09525
SMAL: SMALA_2275
SCT: SCAT_1444(cyp)
SBH: SBI_07560(cyp37)
SVE: SVEN_2047
SDV: BN159_6030(cyp125)
SFI: SFUL_1917
SALU: DC74_2810
SALL: SAZ_15430
STRE: GZL_06167
SLD: T261_5756
STRM: M444_11810
SPRI: SPRI_5168
SNR: SNOUR_28615(cyp125)
SLAU: SLA_1953
SALJ: SMD11_4755
SFK: KY5_2401
SRJ: SRO_5110
NCA: Noca_2739
PSIM: KR76_14335
TCU: Tcur_3656
AMD: AMED_2551
AMN: RAM_12965
AMM: AMES_2524
AMZ: B737_2525
AOI: AORI_2528
AJA: AJAP_26185(cyp125)
AMYY: YIM_14520
AORI: SD37_13695
KAL: KALB_3393
ALO: CRK59579
SAQ: Sare_2811
CAI: Caci_0773
AG: ACU30137(CYP125)
 » show all
Reference
  Authors
Capyk JK, Kalscheuer R, Stewart GR, Liu J, Kwon H, Zhao R, Okamoto S, Jacobs WR Jr, Eltis LD, Mohn WW
  Title
Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
  Journal
J Biol Chem 284:35534-42 (2009)
DOI:10.1074/jbc.M109.072132
  Sequence
[mtu:Rv3545c]
Reference
  Authors
Rosloniec KZ, Wilbrink MH, Capyk JK, Mohn WW, Ostendorf M, van der Geize R, Dijkhuizen L, Eltis LD
  Title
Cytochrome P450 125 (CYP125) catalyses C26-hydroxylation to initiate sterol side-chain degradation in Rhodococcus jostii RHA1.
  Journal
Mol Microbiol 74:1031-43 (2009)
DOI:10.1111/j.1365-2958.2009.06915.x
  Sequence
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