KEGG   ORTHOLOGY: K15988
Entry
K15988            Tight     KO                                     
Symbol
tylG1
Name
tylactone synthase 1
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15988  tylG1; tylactone synthase 1
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15988  tylG1; tylactone synthase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15988  tylG1; tylactone synthase 1
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K15988  tylG1; tylactone synthase 1
Genes
AG: AAB66504(tylG1)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:10322123
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
[ag:AAB66504]
LinkDB

KEGG   ORTHOLOGY: K24555
Entry
K24555                      KO                                     
Symbol
tylG2
Name
tylactone synthase 2
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24555  tylG2; tylactone synthase 2
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24555  tylG2; tylactone synthase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24555  tylG2; tylactone synthase 2
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K24555  tylG2; tylactone synthase 2
Genes
AG: AAB66505(tylG2)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:10322123
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
[ag:AAB66505]
LinkDB

KEGG   ORTHOLOGY: K24556
Entry
K24556                      KO                                     
Symbol
tylG3
Name
tylactone synthase 3
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24556  tylG3; tylactone synthase 3
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24556  tylG3; tylactone synthase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24556  tylG3; tylactone synthase 3
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K24556  tylG3; tylactone synthase 3
Genes
SCYG: S1361_05090(eryA2)
SCAE: IHE65_08850
SGK: PET44_28370
AG: AAB66506(tylG3)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:10322123
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
[ag:AAB66506]
LinkDB

KEGG   ORTHOLOGY: K24557
Entry
K24557                      KO                                     
Symbol
tylG4
Name
tylactone synthase 4
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24557  tylG4; tylactone synthase 4
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24557  tylG4; tylactone synthase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24557  tylG4; tylactone synthase 4
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K24557  tylG4; tylactone synthase 4
Genes
SGK: PET44_28375
AG: AAB66507(tylG4)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:10322123
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
[ag:AAB66507]
LinkDB

KEGG   ORTHOLOGY: K24558
Entry
K24558                      KO                                     
Symbol
tylG5
Name
tylactone synthase 5
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06448  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K24558  tylG5; tylactone synthase 5
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K24558  tylG5; tylactone synthase 5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K24558  tylG5; tylactone synthase 5
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Modular type I PKS
   cis-AT PKS
    Tylactone synthase
     K24558  tylG5; tylactone synthase 5
Genes
AG: AAB66508(tylG5)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:10322123
  Authors
Butler AR, Bate N, Cundliffe E
  Title
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.
  Journal
Chem Biol 6:287-92 (1999)
DOI:10.1016/S1074-5521(99)80074-X
  Sequence
[ag:AAB66508]
LinkDB

KEGG   REACTION: R06448
Entry
R06448                      Reaction                               
Definition
5 Methylmalonyl-CoA + 2 Malonyl-CoA + (2S)-Ethylmalonyl-CoA + 7 NADPH + 7 H+ <=> 8 CoA + Tylactone + 8 CO2 + 3 H2O + 7 NADP+
Equation
5 C02557 + 2 C00083 + C18026 + 7 C00005 + 7 C00080 <=> 8 C00010 + C12000 + 8 C00011 + 3 C00001 + 7 C00006
Comment
tylactone synthase,TylG1-5
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083  C00010_C02557  C00010_C18026
RC02829  C02557_C12000
RC02910  C02557_C12000
RC02911  C00083_C12000
RC02912  C00083_C12000
RC02914  C02557_C12000
RC02917  C02557_C12000
RC02919  C02557_C12000
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Orthology
K15988  tylactone synthase 1
K24555  tylactone synthase 2
K24556  tylactone synthase 3
K24557  tylactone synthase 4
K24558  tylactone synthase 5
LinkDB

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