KEGG   ORTHOLOGY: K15993
Entry
K15993            Tight     KO                                     
Symbol
tylN
Name
O-mycaminosyltylonolide 6-deoxyallosyltransferase [EC:2.4.1.317]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Reaction
R06451  dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-beta-D-allosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.317  O-mycaminosyltylonolide 6-deoxyallosyltransferase
     K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K15993  tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase
Other DBs
CAZy: GT1
Genes
AG: CAA06512(tylN)
Reference
PMID:11476481
  Authors
Rawlings BJ.
  Title
Type I polyketide biosynthesis in bacteria (part B).
  Journal
Nat Prod Rep 18:231-81 (2001)
DOI:10.1039/B100191O
Reference
PMID:9651492
  Authors
Wilson VT, Cundliffe E
  Title
Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae.
  Journal
Gene 214:95-100 (1998)
DOI:10.1016/S0378-1119(98)00210-8
  Sequence
[ag:CAA06512]
LinkDB

KEGG   ENZYME: 2.4.1.317
Entry
EC 2.4.1.317                Enzyme                                 
Name
O-mycaminosyltylonolide 6-deoxyallosyltransferase;
tylN (gene name)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-alpha-D-allosyltransferase
Reaction(IUBMB)
5-O-beta-D-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose = dTDP + demethyllactenocin [RN:R06451]
Reaction(KEGG)
R06451
Substrate
5-O-beta-D-mycaminosyltylonolide [CPD:C12002];
dTDP-6-deoxy-alpha-D-allose [CPD:C11912]
Product
dTDP [CPD:C00363];
demethyllactenocin [CPD:C12003]
Comment
The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
History
EC 2.4.1.317 created 2014
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15993  O-mycaminosyltylonolide 6-deoxyallosyltransferase
Reference
1  [PMID:9651492]
  Authors
Wilson VT, Cundliffe E
  Title
Characterization and targeted disruption of a glycosyltransferase gene in the tylosin producer, Streptomyces fradiae.
  Journal
Gene 214:95-100 (1998)
DOI:10.1016/S0378-1119(98)00210-8
  Sequence
[ag:CAA06512]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.317
IUBMB Enzyme Nomenclature: 2.4.1.317
ExPASy - ENZYME nomenclature database: 2.4.1.317
BRENDA, the Enzyme Database: 2.4.1.317
LinkDB

KEGG   REACTION: R06451
Entry
R06451                      Reaction                               
Name
dTDP-6-deoxy-alpha-D-allose:5-O-beta-D-mycaminosyltylonolide 23-O-6-deoxy-beta-D-allosyltransferase
Definition
5-O-beta-D-Mycaminosyltylonolide + dTDP-6-deoxy-D-allose <=> Demethyllactenocin + dTDP
Equation
C12002 + C11912 <=> C12003 + C00363
Reaction class
RC00005  C00363_C11912
RC00059  C12002_C12003
Enzyme
2.4.1.317
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00773  Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.317
     R06451  5-O-beta-D-Mycaminosyltylonolide + dTDP-6-deoxy-D-allose <=> Demethyllactenocin + dTDP
Orthology
K15993  O-mycaminosyltylonolide 6-deoxyallosyltransferase [EC:2.4.1.317]
Other DBs
RHEA: 15360
LinkDB

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