KEGG   ORTHOLOGY: K15998
Entry
K15998            Tight     KO                                     
Symbol
megDI
Name
TDP-megosamine glycosyltransferase
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01110  Biosynthesis of secondary metabolites
Reaction
R06506  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K15998  megDI; TDP-megosamine glycosyltransferase
Genes
AG: AAG13908(megDI)
Reference
PMID:10972798
  Authors
Volchegursky Y, Hu Z, Katz L, McDaniel R
  Title
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
  Journal
Mol Microbiol 37:752-62 (2000)
DOI:10.1046/j.1365-2958.2000.02059.x
  Sequence
[ag:AAG13908]
LinkDB

KEGG   REACTION: R06506
Entry
R06506                      Reaction                               
Definition
Erythromycin C + dTDP-L-megosamine <=> Megalomicin A + dTDP
Equation
C06616 + C11919 <=> C11985 + C00363
Comment
TDP-megosamine glycosyltransferase,MegD1
Reaction class
RC00005  C00363_C11919
RC00028  C06616_C11985
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01110  Biosynthesis of secondary metabolites
Orthology
K15998  TDP-megosamine glycosyltransferase
K19698  TDP-megosamine glycosyltransferase auxiliary protein
LinkDB

DBGET integrated database retrieval system