KEGG   ORTHOLOGY: K16005
Entry
K16005            Tight     KO                                     
Symbol
desVIII
Name
narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Reaction
R06460  dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase
R06461  dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:narbonolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16005  desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K16005  desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16005  desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Glycosyltransferase
   K16005  desVIII; narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
Genes
AG: AAC68676(desVIII)
Reference
PMID:20695498
  Authors
Borisova SA, Liu HW
  Title
Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway.
  Journal
Biochemistry 49:8071-84 (2010)
DOI:10.1021/bi1007657
  Sequence
[ag:AAC68676]
Reference
PMID:17049185
  Authors
Hong JS, Park SJ, Parajuli N, Park SR, Koh HS, Jung WS, Choi CY, Yoon YJ
  Title
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation.
  Journal
Gene 386:123-30 (2007)
DOI:10.1016/j.gene.2006.08.021
  Sequence
[ag:AAC68676]
LinkDB

KEGG   REACTION: R06460
Entry
R06460                      Reaction                               
Name
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase
Definition
10-Deoxymethynolide + dTDP-D-desosamine <=> 10-Deoxymethymycin + dTDP
Equation
C11993 + C11911 <=> C11994 + C00363
Comment
glycosyl transferase,DesVII
Reaction class
RC00005  C00363_C11911
RC00049  C11993_C11994
Enzyme
2.4.1.277
Pathway
rn00522  Biosynthesis of 12-, 14- and 16-membered macrolides
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00776  Pikromycin/methymycin biosynthesis, methylmalonyl-CoA + malonyl-CoA => narbonolide/10-deoxymethynolide => pikromycin/methymycin
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.277
     R06460  10-Deoxymethynolide + dTDP-D-desosamine <=> 10-Deoxymethymycin + dTDP
Orthology
K16004  narbonolide/10-deoxymethynolide desosaminyltransferase [EC:2.4.1.277]
K16005  narbonolide/10-deoxymethynolide desosaminyltransferase auxiliary protein
Other DBs
RHEA: 31630
LinkDB

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