KEGG   ORTHOLOGY: K16038
Entry
K16038                      KO                                     
Symbol
asm10
Name
N-methyltransferase [EC:2.1.1.-]
Pathway
map01051  Biosynthesis of ansamycins
map01052  Type I polyketide structures
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K16038  asm10; N-methyltransferase
   01051 Biosynthesis of ansamycins
    K16038  asm10; N-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K16038  asm10; N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.-
     K16038  asm10; N-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K16038  asm10; N-methyltransferase
Other DBs
RN: R09856
Genes
APRE: CNX65_16190
AMI: Amir_3182
Reference
  Authors
Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L, Floss HG
  Title
N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis.
  Journal
Chembiochem 12:1759-66 (2011)
DOI:10.1002/cbic.201100062
Reference
  Authors
Spiteller P, Bai L, Shang G, Carroll BJ, Yu TW, Floss HG
  Title
The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
  Journal
J Am Chem Soc 125:14236-7 (2003)
DOI:10.1021/ja038166y
Reference
  Authors
Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG
  Title
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.
  Journal
Proc Natl Acad Sci U S A 99:7968-73 (2002)
DOI:10.1073/pnas.092697199
  Sequence
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