KEGG ORTHOLOGY: K16049

ORTHOLOGY: K16049

Entry

K16049                      KO

Symbol

hsaC

Name

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25]

Pathway

map00984

Steroid degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Reaction

R04597

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16049  hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.25  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
     K16049  hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

Other DBs

COG:

COG0346

GO:

0047071

Genes

VAF:	D1115_22660

PRE:	PCA10_13380

PFUW:

PLAL:

PPUT:

PPUN:

PVR:	PverR02_11720

PPUU:

PputUW4_01687

PKC:	PKB_4267(hsaC)

PFZ:	AV641_10715

PLQ:	AA042_19960

PPSY:

AOC04_08020

PSET:

THL1_1410

PSIL:

PMA3_11800

PKE:	DLD99_14645

PUM:	HGP31_20700

PPSH:

G5J76_13970

PAZE:

KSS91_19160

PTAE:

NCTC10697_02092(hsaC)

PCAV:

D3880_17225

PPHN:

HU825_14510

PIZ:	LAB08_R40730

PKM:	PZ739_11710

PSHS:

PLAU:

PFOU:

PBEJ:

PSKP:

PDEU:

PBUB:

PSML:

PSMZ:

PSWO:

PMOR:

PSAO:

SK095_03465 SK095_03705

PKH:	JLK41_05795

SDEG:

HARR:

PPHA:

HASM:

KAK:	Kalk_07830

PSYK:

SPL:

SHL:

COLW:

CBER:

PHA:	PSHAa0900(tesB)

PTN:	PTRA_a1032(hsaC)

PNG:	PNIG_a1084(hsaC)

SNAN:

I6N98_01460 I6N98_10755

ZAL:	AZF00_12080

MSPN:

M8T91_14335

HJA:	BST95_13315

HALC:

AFUS:

PAQM:

MSEC:

MRZ:	KDW95_01125

ENW:	MJO57_22800

EMP:	EZMO1_1285(tesB)

SOK:	D0B54_05280

SINI:

GT972_08460

FCE:	JN531_005450

GPB:	HDN1F_27360(bphC1)

RIN:	ACS15_4384(hsaC)

REH:	H16_B0654(bphC)

CNC:	CNE_2c06010(bphC)

CUH:	BJN34_30715

REU:	Reut_A1557

CTI:	RALTA_B0496(bphC)

CBW:	RR42_s2336

COX:	E0W60_08215

CUK:	KB879_20715

CUPP:

CTP10_R38850

CUPA:

LPA45_24000

BUR:	Bcep18194_B1431

BCJ:

BCAM1637

BCEN:

DM39_6216(hsaC)

BCEO:

I35_5498

BCT:

GEM_4079

BCED:

DM42_6321(hsaC)

BCEP:

APZ15_31025

BPYR:

ABD05_27685

BCON:

NL30_03995

BDF:	WI26_21320

BTEI:

BPSL:

BMEC:

BSTL:

BANN:

BARI:

BAEN:

BURK:

BURF:

BFN:

PBRY:

PPAI:

PVE:	UC34_06925

CABA:

SBC2_48810(hsaC)

CTT:	CtCNB1_1275

CTES:

O987_07285

CRJ:	QMY55_06795

DIH:	G7047_10915

SMIO:

CATMQ487_32170(hsaC)

AZD:	CDA09_09620

THU:	AC731_008515

THAU:

C4PIVTH_4232(hsaC)

THAG:

CKCBHOJB_02322(hsaC)

FRB:	AB6B37_08170

NAR:	Saro_3647 Saro_3750

NPP:	PP1Y_Mpl3065

NOV:	TQ38_027275

NOT:	C7W88_20680 C7W88_20750

NOVO:

IM701_18085 IM701_20245

SPHM:

G432_04775

SSAN:

NX02_14735

SPKC:

KC8_01090 KC8_05325 KC8_16655 KC8_19655

SPHA:

D3Y57_15480

SLAN:

GV829_01880

SBIN:

SBA_ch2_4330(hsaC)

SPCL:

F9288_18825

SPOG:

EEB18_002690

SWI:	Swit_1826 Swit_1848 Swit_3298

SPHD:

HY78_09060 HY78_16340 HY78_16450

RDI:	CMV14_16840

SPHB:

EP837_03390(hsaC)

SPCA:

GL174_15750

PHAO:

HF685_05540

SMIC:

SmB9_10410(hsaC)

ERR:	DVR09_05400

PHZ:	CHX26_05295

NTD:	EGO55_13435 EGO55_13700

CAEN:

K5X80_14715 K5X80_14970

MTU:	Rv3568c(hsaC)

MTV:	RVBD_3568c

MTC:

MT3673

MRA:	MRA_3607(bphC)

MTF:	TBFG_13601

MTB:	TBMG_03607

MTK:	TBSG_03634

MTZ:	TBXG_003582

MTG:	MRGA327_22030

MTI:	MRGA423_22550

MTE:	CCDC5079_3309

MTUR:

CFBS_3785(bphC)

MTL:	CCDC5180_3261

MTO:	MTCTRI2_3633(bphC)

MTD:	UDA_3568c(bphC)

MTN:	ERDMAN_3915(bphC)

MTJ:	J112_19215

MTUB:

MT7199_3631

MTUC:

J113_24990

MTUE:

J114_19085

MTX:	M943_18350

MTUL:

TBHG_03509

MTUT:

HKBT1_3770(bphC)

MTUU:

HKBT2_3779(bphC)

MTQ:	HKBS1_3782(bphC)

MBO:	BQ2027_MB3599C(hsac)

MBB:	BCG_3633c(bphC)

MBT:	JTY_3634(bphC)

MBM:	BCGMEX_3631c(bphC)

MBK:	K60_037060

MBX:

BCGT_3435

MAF:	MAF_35810(bphC)

MMIC:

RN08_3945

MCE:	MCAN_35811(bphC)

MCQ:	BN44_110063(hsaC)

MCV:	BN43_90069(hsaC)

MCX:	BN42_90066(hsaC)

MCZ:	BN45_100082(hsaC)

MORY:

MO_003727(hsaC)

MPA:

MAO:

MAVI:

MAVU:

MAV:	MAV_0593 MAV_3021

MAVM:

MAA44156_00512(hsaC_1) MAA44156_01423(hsaC_2)

MIT:	OCO_05020 OCO_28570

MIA:	OCU_05060 OCU_28440

MID:	MIP_00943 MIP_03717

MYO:	OEM_05080 OEM_27030

MCHI:

AN480_02505 AN480_14935

MIR:	OCQ_05170 OCQ_27150

MMAL:

CKJ54_02435 CKJ54_12980(bphC)

MLP:	MLM_0737 MLM_2413

MMAN:

MMAN_10310 MMAN_21330 MMAN_47960(hsaC)

MSER:

MTY59_24300(hsaC) MTY59_44560

MSA:	Mycsm_04159 Mycsm_05838

MUL:	MUL_4139(bphC)

MMI:	MMAR_5063(bphC)

MMAE:

MMARE11_48780(bphC)

MLI:	MULP_05321(bphC)

MPSE:

MPSD_52640(hsaC)

MSHO:

MSHO_05470(hsaC)

MMC:	Mmcs_0317 Mmcs_4707

MKM:	Mkms_0327 Mkms_4793

MJL:	Mjls_0308 Mjls_5092

MMM:	W7S_02450 W7S_13845

MKN:	MKAN_12120

MYV:	G155_04250 G155_26475

MYE:	AB431_15175 AB431_15235 AB431_26550

MHAD:

B586_04455

MDX:	BTO20_04385

MSHG:

MSG_02471 MSG_04561(hsaC)

MFJ:	MFLOJ_07940 MFLOJ_40670(hsaC)

MSTO:

MSTO_09180 MSTO_44620(hsaC)

MSIM:

MSIM_29110(hsaC) MSIM_53020

MSAK:

MSAS_05590 MSAS_29150(hsaC)

MKU:	I2456_25675

MLW:	MJO58_13015(bphC) MJO58_25090

MXE:	MYXE_05080(hsaC) MYXE_06660

MNV:	MNVI_11570 MNVI_12510(hsaC)

MPAG:

C0J29_19280 C0J29_27825

MNM:	MNVM_19350 MNVM_23440(hsaC)

MGOR:

H0P51_17855 H0P51_25865

MCOO:

MCOO_26120 MCOO_27310(hsaC)

MBAI:

MB901379_04452(hsaC)

MSEO:

MSEO_12710 MSEO_34550(hsaC)

MHEK:

JMUB5695_00469(hsaC_1) JMUB5695_00575

MGAU:

MGALJ_22850 MGALJ_38560

MLJ:	MLAC_47240(hsaC)

MBRD:

MBRA_20010(hsaC) MBRA_21120

MSHJ:

MSHI_38540(hsaC)

MMAM:

K3U93_11795(bphC) K3U93_22685

MSPG:

F6B93_20485

MOT:	LTS72_27920

MPAA:

MKK62_02395 MKK62_02910(bphC)

MKY:	IWGMT90018_22860 IWGMT90018_57490(hsaC)

MADI:

A7U43_06665

MWU:	PT015_15055(bphC) PT015_15560

MYW:	BVC93_09275

MYJ:	BCA37_02635

MHAF:

ACEL92_02990(hsaC) ACEL92_14455(bphC)

MSM:	MSMEG_2891 MSMEG_6036

MSG:	MSMEI_2817(bphC) MSMEI_5875(bphC)

MSB:	LJ00_14380 LJ00_29840

MSN:	LI99_14385 LI99_29845

MSH:	LI98_14390 LI98_29850

MVA:	Mvan_2891 Mvan_5306

MAUS:

JN090_13650(bphC) JN090_26580

MGI:	Mflv_1465 Mflv_4549

MSP:	Mspyr1_39490 Mspyr1_47020

MCB:	Mycch_1590 Mycch_4673

MNE:	D174_24700

MYN:	MyAD_24235

MFT:	XA26_08070 XA26_53610

MPHL:

MPHLCCUG_00493(hsaC_1) MPHLCCUG_02627(hsaC_2)

MVQ:	MYVA_1664 MYVA_5216

MLL:	B1R94_12250 B1R94_20085 B1R94_25460

MRH:	MycrhN_2245 MycrhN_4259

MTHN:

4412656_00959(bphC) 4412656_04092(hsaC)

MHAS:

MHAS_02457(hsaC_1) MHAS_03777(hsaC_2)

MDU:	MDUV_26660 MDUV_49010

MCHT:

MCHIJ_12760 MCHIJ_19310

MAUU:

NCTC10437_02739(hsaC_2) NCTC10437_05067(hsaC_3)

MMAG:

MMAD_48570

MMOR:

MMOR_11760 MMOR_26800

MFX:	MFAL_32600

MAIC:

MAIC_05180 MAIC_26790 MAIC_26930

MIJ:	MINS_00690

MALV:

MALV_29230 MALV_42140

MTY:	MTOK_22000

MPSC:

MPSYJ_15770

MARZ:

MARA_47440

MGAD:

MGAD_01100 MGAD_37680

MHEV:

MHEL_27650 MHEL_50120 MHEL_50220

MSAR:

MSAR_10970 MSAR_41300 MSAR_41350

MANY:

MANY_12800 MANY_33050

MAUB:

MAUB_27090 MAUB_54790

MPOF:

MPOR_53990

MPHU:

MPHO_14370 MPHO_43380

MMUC:

C1S78_011095(bphC) C1S78_019250(bphC) C1S78_025610

MMAT:

MMAGJ_33780

MBOK:

MBOE_04960 MBOE_20110

MFG:	K6L26_05345 K6L26_16790 K6L26_27685(bphC)

MSEI:

MSEDJ_02510

MFLV:

NCTC10271_00467(hsaC_1) NCTC10271_02187(hsaC_2)

MCEE:

MCEL_06120 MCEL_37740

MMON:

EWR22_01690(bphC) EWR22_25460

MGO:	AFA91_10590

MHOL:

K3U96_03080 K3U96_09635(bphC)

MSEN:

K3U95_12875 K3U95_25510

MPAE:

K0O64_14655(bphC) K0O64_14700(bphC) K0O64_26060

MRF:	MJO55_24175

MDF:	K0O62_15785(bphC) K0O62_25965

MCRO:

MI149_15510(bphC) MI149_15560(bphC) MI149_26360

MGRO:

FZ046_02940

MFRE:

EXE63_18695

MBUG:

MU0053_000395 MU0053_004905(bphC)

MYQ:	TUM20985_06420

MFLU:

HZU40_33065

MYH:	QU592_07270 QU592_07985 QU592_13070(bphC) QU592_27460

MPAT:

MPNTM1_01922 MPNTM1_05338

MKR:	MKOR_35330(hsaC) MKOR_36400

MPAK:

MIU77_01970

MAB:	MAB_0076 MAB_0585

MMV:	MYCMA_0047 MYCMA_0298

MABB:

MASS_0078 MASS_0554

MABL:

MMASJCM_0079 MMASJCM_0574

MCHE:

BB28_00370 BB28_02790

MIZ:	BAB75_00670 BAB75_03540

MSTE:

MSTE_00542(hsaC)

MSAO:

MYCSP_02495

MSAL:

DSM43276_00503(hsaC)

MJD:	JDM601_3853(bphC) JDM601_4250(bphC)

MTER:

4434518_03728(bphC)

MMIN:

MMIN_06700 MMIN_12530

MHIB:

MHIB_23840 MHIB_31170(hsaC)

MHER:

K3U94_21025

MVM:	MJO54_20920

MKK:	MU0083_003479

ASD:

AS9A_0926

NFA:	NFA_40980 NFA_4720

NFR:	ERS450000_03764(hsaC_1) ERS450000_05815(hsaC_2)

NCY:	NOCYR_0501 NOCYR_2418(bphC)

NBR:	O3I_002665

NNO:	NONO_c05030(hsaC1) NONO_c44720 NONO_c58760(hsaC2)

NSL:	BOX37_02175 BOX37_11855

NSR:	NS506_01260(hsaC) NS506_06778(etbC)

NTP:	CRH09_03305

NOZ:	DMB37_23590

NOD:	FOH10_22595 FOH10_28745

NAH:	F5544_02630

NAD:	NCTC11293_01245(hsaC_1) NCTC11293_04394(hsaC_2)

NWL:	NWFMUON74_04930

NIE:	KV110_03025

NTC:	KHQ06_03675 KHQ06_24085 KHQ06_26960 KHQ06_35110

NHU:	H0264_03850 H0264_34220

NYA:	LTV02_28890 LTV02_38700

NGP:	LTT66_15420 LTT66_28770

NSPU:

IFM12276_01680 IFM12276_30830

NYU:	D7D52_04495 D7D52_09480

NVU:	V7968_10085(hsaC)

RHA:	RHA1_ro02488 RHA1_ro04541(hsaC) RHA1_ro05803 RHA1_ro09005

RER:	RER_07570 RER_13780 RER_51660

REY:	O5Y_03680 O5Y_06490 O5Y_24430

REB:	XU06_03920 XU06_06750 XU06_24850

RQI:	C1M55_04160 C1M55_06995(bphC) C1M55_26050(bphC)

ROP:	ROP_22150 ROP_44560 ROP_58640

ROA:	Pd630_LPD00993 Pd630_LPD02422 Pd630_LPD06714

RPY:	Y013_19035 Y013_19285

RBY:	CEJ39_05400 CEJ39_05650 CEJ39_21895(bphC)

RAV:	AAT18_03975 AAT18_22060

RHW:	BFN03_15190

RRZ:	CS378_10115(bphC) CS378_11825(bphC) CS378_19615

RHQ:	IM25_02765 IM25_08885

RHOD:

AOT96_05860 AOT96_14555 AOT96_17390

RRT:	4535765_00584(hsaC_1) 4535765_00631(hsaC_2) 4535765_04055(hsaC_4)

RCR:	NCTC10994_02089(hsaC_1) NCTC10994_02136(hsaC_2) NCTC10994_03239(hsaC_3) NCTC10994_03314(hsaC_4)

RTM:	G4H71_04575(bphC) G4H71_07385 G4H71_13740(bphC)

RKO:	JWS14_13060(bphC) JWS14_24495 JWS14_31735(bphC)

RGO:	KYT97_11700(bphC) KYT97_15280 KYT97_15685(bphC) KYT97_23245

ROZ:	CBI38_00790 CBI38_01330 CBI38_04180

RPSK:

JWS13_12175(bphC) JWS13_20430 JWS13_32825(bphC)

RGOR:

NMQ04_02525 NMQ04_02760(bphC) NMQ04_17480(bphC) NMQ04_17845(bphC) NMQ04_22185

RHOP:

D8W71_08095 D8W71_26905

RHOO:

RA302_04030 RA302_06880(bphC) RA302_25090(bphC)

RHOU:

KZJ41_03970 KZJ41_23490(bphC)

RHOW:

A4U64_02490 A4U64_20800

RHOJ:

JVH1_07345(bphC) JVH1_13625(hsaC) JVH1_24740(bphC) JVH1_39390

RHOS:

QWW67_10690(bphC) QWW67_12140(bphC) QWW67_21315

RHOQ:

QWW98_10695(bphC) QWW98_12150(bphC) QWW98_21325

RHOY:

QNA09_01525 QNA09_06855 QNA09_18265(bphC) QNA09_19340(bphC)

RHOH:

CPI83_04510(bphC) CPI83_22290(bphC) CPI83_25055

RHOX:

RBB84_23655 RBB84_23910

RHJS:

OYT95_07645(bphC) OYT95_14220 OYT95_26100(bphC)

RSF:	OED52_02305 OED52_17480(bphC)

RHZQ:

GO592_01985(bphC) GO592_20770(bphC) GO592_26985

RHZG:

BO226_15705 BO226_23450 BO226_23700

RHBH:

A0W34_03980 A0W34_06790 A0W34_24750

RHPD:

U9J23_02720 U9J23_02955 U9J23_19615(bphC) U9J23_20050(bphC)

RHON:

EHW12_03930 EHW12_06775(bphC) EHW12_25450(bphC)

RHWB:

FND50_04920 FND50_11315(bphC) FND50_30745(bphC)

RHPM:

E5769_01345 E5769_08240(bphC) E5769_21465

RHPC:

E5720_05775(bphC) E5720_12670 E5720_14055

RHSQ:

E7742_15690(bphC) E7742_16730 E7742_17280(bphC) E7742_22065

RHWY:

GFS60_00125(bphC) GFS60_00257(bphC) GFS60_00870(bphC)

RHDM:

HFP48_04065 HFP48_10010 HFP48_22700(bphC)

RHWQ:

HUN07_01025 HUN07_04015 HUN07_22770(bphC)

RHMM:

ISO16_10650(bphC) ISO16_12100(bphC) ISO16_21245

RHZP:

HYG77_11765 HYG77_14590(bphC) HYG77_15195(bphC)

RHRC:

P0M12_07640(bphC) P0M12_16385 P0M12_19235(bphC)

RHNY:

ACBG85_04155(hsaC) ACBG85_06870(bphC) ACBG85_24470(bphC)

RHRD:

RDE2_04980 RDE2_05460 RDE2_15170 RDE2_40090 RDE2_40610

RHDK:

PST05_12615(bphC) PST05_23205(hsaC) PST05_29545(bphC)

RHMZ:

QWU03_11335(bphC) QWU03_12790(bphC) QWU03_21980

RIO:	ACM26Y_03510(hsaC) ACM26Y_19740(bphC) ACM26Y_21105(bphC)

REQ:	REQ_01430 REQ_06820 REQ_40140 REQ_43800

PDEF:

P9209_05565(bphC) P9209_29065

PSOW:

ABI214_10410(hsaC) ABI214_15740(bphC) ABI214_17980(bphC)

WHR:	OG579_17640

GBR:

Gbro_0921

GPO:	GPOL_c41080(hsaC) GPOL_c41220

GOR:	KTR9_0821(hsaC)

GOQ:	ACH46_03105 ACH46_03245

GTA:	BCM27_04770 BCM27_05115

GOC:	CXX93_06465

GIT:	C6V83_04280

GRU:	GCWB2_04180(hsaC)

GOM:	D7316_02454(hsaC_1) D7316_02467(hsaC_2) D7316_02567(hsaC_3)

GAV:	C5O27_00855 C5O27_10720(bphC)

GOD:	GKZ92_03975 GKZ92_16410(bphC)

GOS:	QAD21_04130

GOJ:	GR168_04255

GAM:	GII34_18805

GPD:	GII33_03935 GII33_21760

GJI:	H1R19_03905 H1R19_04055 H1R19_12675(bphC)

GOI:	LK459_05080 LK459_05165(bphC)

GHN:	MVF96_04255

GAMI:

IHQ52_06835

GMG:	NWF22_15760

GSI:	P5P27_15785

GOO:	HUN08_03000

GOP:	ACE11G_03155(hsaC)

GON:	Q9K23_17925

SPIN:

KV203_17340

TPR:

Tpau_3843

TSM:	ASU32_21895

TPUL:

TPB0596_41840

TSD:	MTP03_43280

DTM:	BJL86_0699

DIT:	C3V38_09270

DIZ:	CT688_03190

DPC:	A6048_03135

DLU:	A6035_02405 A6035_03430

DKN:	NHB83_01965 NHB83_02980

DCD:	VYL96_02145 VYL96_03215

DID:	GJR88_01032

TOY:	FO059_01335(bphC) FO059_14005 FO059_16385

SGRF:

SGFS_022200 SGFS_025350

SSOI:

I1A49_45975

SVT:	SVTN_35915

SALU:

DC74_7447

SALL:

SAZ_38440

SLX:	SLAV_27440(hsaC)

SNK:	CP967_03280

SGX:	H4W23_38550

SROI:

IAG44_02090

SXN:	IAG42_26655

SDEC:

L3078_00990

SRUG:

F0345_00805

STAA:

LDH80_36410

SNIG:

HEK616_31480(hsaC)

SCAE:

IHE65_04670 IHE65_42050

STUB:

SLON:

SCYN:

SCAT:

STII:

STIC:

SPOF:

STBR:

SSOC:

SSLI:

SSTO:

STRK:

ARL:	AFL94_16970

ARY:	ATC04_01210

ASUN:

KG104_04195

ARTA:

OL239_16035

GPR:	JQN66_16975

PAEY:

KUF55_17985

NCA:

Noca_2774

NDK:	I601_0578(hsaC_1) I601_3468(hsaC_2)

NBE:	Back2_27220

NANO:

G5V58_09770

NARO:

CFH99_13520

NPI:	G7071_12490 G7071_15935

NPC:	KUV85_04290

NMAR:

HPC71_09525

NFC:	KG111_08325 KG111_15390(bphC)

NBI:	SHK19_12515

NOCR:

OSR43_09585 OSR43_13270

NOCW:

ABFU82_07545(hsaC) ABFU82_20940

NOCA:

ncot_02685 ncot_07840 ncot_09675

NOCL:

KM427_12565

NOCD:

QJ852_14490

NOCQ:

QI633_08545 QI633_11905 QI633_17890 QI633_22550

PSIM:

KR76_14470 KR76_27095

AEB:	C6I20_03270

TCU:

ACTW:

AMAZ:

ACIR:

AWS:	ACN3XK_49860 ACN3XK_50535

ACTQ:

AMD:

AMN:

AMM:

AMZ:

AOI:	AORI_2486(bphC)

AJA:	AJAP_26395(hsaC)

AMQ:	AMETH_4836

AMYC:

CU254_10470 CU254_23455

AMYB:

BKN51_05030

AAB:	A4R43_16035

AMYY:

YIM_14460(hsaC1) YIM_36675(hsaC2)

AORI:

AACD:

APRT:

AROO:

ATHM:

ARHD:

AMOG:

ACYN:

ACOR:

LCL61_01255(hsaC)

AMYZ:

HUW46_00280(hsaC)

ANW:	QP939_49820

AMYD:

ABAR:

AMYE:

AMYS:

ARHI:

AB5I40_14185(hsaC) AB5I40_44425

PSDS:

K1T35_06305

KAL:

KALB_5122

KUT:	JJ691_08350

KBR:	Q4V65_43215(hsaC)

KPHY:

AOZ06_42780

LED:	BBK82_38915

LXR:	ACRSBM_19110(hsaC) ACRSBM_27205

LENT:

JNUCC0626_04690(hsaC)

ALO:	CRK57812 CRK59592

PMAD:

BAY61_10965

SACE:

GIY23_13330

CROS:

N8J89_29365

STP:	Strop_2669

SAQ:

Sare_2877

AMS:	AMIS_19200

AIH:	Aiant_18870

ACTL:

L3i22_084450

ASIC:

Q0Z83_065570

AOU:	ACTOB_004121

ACTE:

ACTI_41230

DFU:	Dfulv_20760 Dfulv_33640

JCY:	M6B22_17705 M6B22_21585

AYM:	YM304_33710

DHI:	LH044_03935

» show all

Reference

PMID:17264217

Authors

Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD

Title

A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.

Journal

Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104

Reference

PMID:21924910

Authors

Ouellet H, Johnston JB, de Montellano PR

Title

Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.

Journal

Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009

Reference

PMID:19300498

Authors

Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD

Title

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

Journal

PLoS Pathog 5:e1000344 (2009)
DOI:10.1371/journal.ppat.1000344

Sequence

[mtu:Rv3568c]

LinkDB

ENZYME: 1.13.11.25

Entry

EC 1.13.11.25               Enzyme

Name

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase;
steroid 4,5-dioxygenase;
3-alkylcatechol 2,3-dioxygenase;
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (ring-opening)

Reaction(IUBMB)

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [RN:R04597]

Reaction(KEGG)

R04597

Substrate

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione [CPD:C04793];
O2 [CPD:C00007]

Product

3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate [CPD:C04844]

Comment

Requires Fe2+. Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.

History

EC 1.13.11.25 created 1972

Pathway

ec00984

Steroid degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K16049

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

Genes

VAF:	D1115_22660

PRE:	PCA10_13380

PFUW:

KF707C_11930

PLAL:

FXN65_06300

PPUT:

L483_14230

PPUN:

PP4_26930

PVR:	PverR02_11720

PPUU:

PputUW4_01687

PKC:	PKB_4267(hsaC)

PFZ:	AV641_10715

PLQ:	AA042_19960

PPSY:

AOC04_08020

PSET:

THL1_1410

PSIL:

PMA3_11800

PKE:	DLD99_14645

PUM:	HGP31_20700

PPSH:

G5J76_13970

PAZE:

KSS91_19160

PTAE:

NCTC10697_02092(hsaC)

PCAV:

D3880_17225

PPHN:

HU825_14510

PIZ:	LAB08_R40730

PKM:	PZ739_11710

PSHS:

JJN09_05530

PLAU:

I0D68_06285

PFOU:

OZ911_14245

PBEJ:

PSH84_15820

PSKP:

KU43P_19220

PDEU:

QEP73_19075

PBUB:

V6B39_14585

PSML:

V6P94_14210

PSMZ:

V6L79_14395

PSWO:

SD196_12815

PMOR:

PMm318_A52410

PSAO:

SK095_03465 SK095_03705

PKH:	JLK41_05795

SDEG:

GOM96_01505

HARR:

HV822_17740

PPHA:

BVH74_17675

HASM:

QAO71_12600

KAK:	Kalk_07830

PSYK:

AADH33_06585

SPL:

Spea_2153

SHL:

Shal_2124

COLW:

A3Q33_18685

CBER:

B5D82_11140

PHA:	PSHAa0900(tesB)

PTN:	PTRA_a1032(hsaC)

PNG:	PNIG_a1084(hsaC)

SNAN:

I6N98_01460 I6N98_10755

ZAL:	AZF00_12080

MSPN:

M8T91_14335

HJA:	BST95_13315

HALC:

EY643_09155

AFUS:

EYZ66_12950

PAQM:

E0F26_07490

MSEC:

LN244_05120

MRZ:	KDW95_01125

ENW:	MJO57_22800

EMP:	EZMO1_1285(tesB)

SOK:	D0B54_05280

SINI:

GT972_08460

FCE:	JN531_005450

GPB:	HDN1F_27360(bphC1)

RIN:	ACS15_4384(hsaC)

REH:	H16_B0654(bphC)

CNC:	CNE_2c06010(bphC)

CUH:	BJN34_30715

REU:	Reut_A1557

CTI:	RALTA_B0496(bphC)

CBW:	RR42_s2336

COX:	E0W60_08215

CUK:	KB879_20715

CUPP:

CTP10_R38850

CUPA:

LPA45_24000

BUR:	Bcep18194_B1431

BCJ:

BCAM1637

BCEN:

DM39_6216(hsaC)

BCEO:

I35_5498

BCT:

GEM_4079

BCED:

DM42_6321(hsaC)

BCEP:

APZ15_31025

BPYR:

ABD05_27685

BCON:

NL30_03995

BDF:	WI26_21320

BTEI:

WS51_05820

BPSL:

WS57_05915

BMEC:

WJ16_26910

BSTL:

BBJ41_21475

BANN:

JFN94_25820

BARI:

NLX30_30035

BAEN:

L3V59_21880

BURK:

DM992_32505

BURF:

Bsp3421_002140

BFN:

OI25_4609

PBRY:

NDK50_32980

PPAI:

E1956_37120

PVE:	UC34_06925

CABA:

SBC2_48810(hsaC)

CTT:	CtCNB1_1275

CTES:

O987_07285

CRJ:	QMY55_06795

DIH:	G7047_10915

SMIO:

CATMQ487_32170(hsaC)

AZD:	CDA09_09620

THU:	AC731_008515

THAU:

C4PIVTH_4232(hsaC)

THAG:

CKCBHOJB_02322(hsaC)

FRB:	AB6B37_08170

NAR:	Saro_3647 Saro_3750

NPP:	PP1Y_Mpl3065

NOV:	TQ38_027275

NOT:	C7W88_20680 C7W88_20750

NOVO:

IM701_18085 IM701_20245

SPHM:

G432_04775

SSAN:

NX02_14735

SPKC:

KC8_01090 KC8_05325 KC8_16655 KC8_19655

SPHA:

D3Y57_15480

SLAN:

GV829_01880

SBIN:

SBA_ch2_4330(hsaC)

SPCL:

F9288_18825

SPOG:

EEB18_002690

SWI:	Swit_1826 Swit_1848 Swit_3298

SPHD:

HY78_09060 HY78_16340 HY78_16450

RDI:	CMV14_16840

SPHB:

EP837_03390(hsaC)

SPCA:

GL174_15750

PHAO:

HF685_05540

SMIC:

SmB9_10410(hsaC)

ERR:	DVR09_05400

PHZ:	CHX26_05295

NTD:	EGO55_13435 EGO55_13700

CAEN:

K5X80_14715 K5X80_14970

MTU:	Rv3568c(hsaC)

MTV:	RVBD_3568c

MTC:

MT3673

MRA:	MRA_3607(bphC)

MTF:	TBFG_13601

MTB:	TBMG_03607

MTK:	TBSG_03634

MTZ:	TBXG_003582

MTG:	MRGA327_22030

MTI:	MRGA423_22550

MTE:	CCDC5079_3309

MTUR:

CFBS_3785(bphC)

MTL:	CCDC5180_3261

MTO:	MTCTRI2_3633(bphC)

MTD:	UDA_3568c(bphC)

MTN:	ERDMAN_3915(bphC)

MTJ:	J112_19215

MTUB:

MT7199_3631

MTUC:

J113_24990

MTUE:

J114_19085

MTX:	M943_18350

MTUL:

TBHG_03509

MTUT:

HKBT1_3770(bphC)

MTUU:

HKBT2_3779(bphC)

MTQ:	HKBS1_3782(bphC)

MBO:	BQ2027_MB3599C(hsac)

MBB:	BCG_3633c(bphC)

MBT:	JTY_3634(bphC)

MBM:	BCGMEX_3631c(bphC)

MBK:	K60_037060

MBX:

BCGT_3435

MAF:	MAF_35810(bphC)

MMIC:

RN08_3945

MCE:	MCAN_35811(bphC)

MCQ:	BN44_110063(hsaC)

MCV:	BN43_90069(hsaC)

MCX:	BN42_90066(hsaC)

MCZ:	BN45_100082(hsaC)

MORY:

MO_003727(hsaC)

MPA:

MAP_0499

MAO:

MAP4_3368

MAVI:

RC58_16705

MAVU:

RE97_16740

MAV:	MAV_0593 MAV_3021

MAVM:

MAA44156_00512(hsaC_1) MAA44156_01423(hsaC_2)

MIT:	OCO_05020 OCO_28570

MIA:	OCU_05060 OCU_28440

MID:	MIP_00943 MIP_03717

MYO:	OEM_05080 OEM_27030

MCHI:

AN480_02505 AN480_14935

MIR:	OCQ_05170 OCQ_27150

MMAL:

CKJ54_02435 CKJ54_12980(bphC)

MLP:	MLM_0737 MLM_2413

MMAN:

MMAN_10310 MMAN_21330 MMAN_47960(hsaC)

MSER:

MTY59_24300(hsaC) MTY59_44560

MSA:	Mycsm_04159 Mycsm_05838

MUL:	MUL_4139(bphC)

MMI:	MMAR_5063(bphC)

MMAE:

MMARE11_48780(bphC)

MLI:	MULP_05321(bphC)

MPSE:

MPSD_52640(hsaC)

MSHO:

MSHO_05470(hsaC)

MMC:	Mmcs_0317 Mmcs_4707

MKM:	Mkms_0327 Mkms_4793

MJL:	Mjls_0308 Mjls_5092

MMM:	W7S_02450 W7S_13845

MKN:	MKAN_12120

MYV:	G155_04250 G155_26475

MYE:	AB431_15175 AB431_15235 AB431_26550

MHAD:

B586_04455

MDX:	BTO20_04385

MSHG:

MSG_02471 MSG_04561(hsaC)

MFJ:	MFLOJ_07940 MFLOJ_40670(hsaC)

MSTO:

MSTO_09180 MSTO_44620(hsaC)

MSIM:

MSIM_29110(hsaC) MSIM_53020

MSAK:

MSAS_05590 MSAS_29150(hsaC)

MKU:	I2456_25675

MLW:	MJO58_13015(bphC) MJO58_25090

MXE:	MYXE_05080(hsaC) MYXE_06660

MNV:	MNVI_11570 MNVI_12510(hsaC)

MPAG:

C0J29_19280 C0J29_27825

MNM:	MNVM_19350 MNVM_23440(hsaC)

MGOR:

H0P51_17855 H0P51_25865

MCOO:

MCOO_26120 MCOO_27310(hsaC)

MBAI:

MB901379_04452(hsaC)

MSEO:

MSEO_12710 MSEO_34550(hsaC)

MHEK:

JMUB5695_00469(hsaC_1) JMUB5695_00575

MGAU:

MGALJ_22850 MGALJ_38560

MLJ:	MLAC_47240(hsaC)

MBRD:

MBRA_20010(hsaC) MBRA_21120

MSHJ:

MSHI_38540(hsaC)

MMAM:

K3U93_11795(bphC) K3U93_22685

MSPG:

F6B93_20485

MOT:	LTS72_27920

MPAA:

MKK62_02395 MKK62_02910(bphC)

MKY:	IWGMT90018_22860 IWGMT90018_57490(hsaC)

MADI:

A7U43_06665

MWU:	PT015_15055(bphC) PT015_15560

MYW:	BVC93_09275

MYJ:	BCA37_02635

MHAF:

ACEL92_02990(hsaC) ACEL92_14455(bphC)

MSM:	MSMEG_2891 MSMEG_6036

MSG:	MSMEI_2817(bphC) MSMEI_5875(bphC)

MSB:	LJ00_14380 LJ00_29840

MSN:	LI99_14385 LI99_29845

MSH:	LI98_14390 LI98_29850

MVA:	Mvan_2891 Mvan_5306

MAUS:

JN090_13650(bphC) JN090_26580

MGI:	Mflv_1465 Mflv_4549

MSP:	Mspyr1_39490 Mspyr1_47020

MCB:	Mycch_1590 Mycch_4673

MNE:	D174_24700

MYN:	MyAD_24235

MFT:	XA26_08070 XA26_53610

MPHL:

MPHLCCUG_00493(hsaC_1) MPHLCCUG_02627(hsaC_2)

MVQ:	MYVA_1664 MYVA_5216

MLL:	B1R94_12250 B1R94_20085 B1R94_25460

MRH:	MycrhN_2245 MycrhN_4259

MTHN:

4412656_00959(bphC) 4412656_04092(hsaC)

MHAS:

MHAS_02457(hsaC_1) MHAS_03777(hsaC_2)

MDU:	MDUV_26660 MDUV_49010

MCHT:

MCHIJ_12760 MCHIJ_19310

MAUU:

NCTC10437_02739(hsaC_2) NCTC10437_05067(hsaC_3)

MMAG:

MMAD_48570

MMOR:

MMOR_11760 MMOR_26800

MFX:	MFAL_32600

MAIC:

MAIC_05180 MAIC_26790 MAIC_26930

MIJ:	MINS_00690

MALV:

MALV_29230 MALV_42140

MTY:	MTOK_22000

MPSC:

MPSYJ_15770

MARZ:

MARA_47440

MGAD:

MGAD_01100 MGAD_37680

MHEV:

MHEL_27650 MHEL_50120 MHEL_50220

MSAR:

MSAR_10970 MSAR_41300 MSAR_41350

MANY:

MANY_12800 MANY_33050

MAUB:

MAUB_27090 MAUB_54790

MPOF:

MPOR_53990

MPHU:

MPHO_14370 MPHO_43380

MMUC:

C1S78_011095(bphC) C1S78_019250(bphC) C1S78_025610

MMAT:

MMAGJ_33780

MBOK:

MBOE_04960 MBOE_20110

MFG:	K6L26_05345 K6L26_16790 K6L26_27685(bphC)

MSEI:

MSEDJ_02510

MFLV:

NCTC10271_00467(hsaC_1) NCTC10271_02187(hsaC_2)

MCEE:

MCEL_06120 MCEL_37740

MMON:

EWR22_01690(bphC) EWR22_25460

MGO:	AFA91_10590

MHOL:

K3U96_03080 K3U96_09635(bphC)

MSEN:

K3U95_12875 K3U95_25510

MPAE:

K0O64_14655(bphC) K0O64_14700(bphC) K0O64_26060

MRF:	MJO55_24175

MDF:	K0O62_15785(bphC) K0O62_25965

MCRO:

MI149_15510(bphC) MI149_15560(bphC) MI149_26360

MGRO:

FZ046_02940

MFRE:

EXE63_18695

MBUG:

MU0053_000395 MU0053_004905(bphC)

MYQ:	TUM20985_06420

MFLU:

HZU40_33065

MYH:	QU592_07270 QU592_07985 QU592_13070(bphC) QU592_27460

MPAT:

MPNTM1_01922 MPNTM1_05338

MKR:	MKOR_35330(hsaC) MKOR_36400

MPAK:

MIU77_01970

MAB:	MAB_0076 MAB_0585

MMV:	MYCMA_0047 MYCMA_0298

MABB:

MASS_0078 MASS_0554

MABL:

MMASJCM_0079 MMASJCM_0574

MCHE:

BB28_00370 BB28_02790

MIZ:	BAB75_00670 BAB75_03540

MSTE:

MSTE_00542(hsaC)

MSAO:

MYCSP_02495

MSAL:

DSM43276_00503(hsaC)

MJD:	JDM601_3853(bphC) JDM601_4250(bphC)

MTER:

4434518_03728(bphC)

MMIN:

MMIN_06700 MMIN_12530

MHIB:

MHIB_23840 MHIB_31170(hsaC)

MHER:

K3U94_21025

MVM:	MJO54_20920

MKK:	MU0083_003479

ASD:

AS9A_0926

NFA:	NFA_40980 NFA_4720

NFR:	ERS450000_03764(hsaC_1) ERS450000_05815(hsaC_2)

NCY:	NOCYR_0501 NOCYR_2418(bphC)

NBR:	O3I_002665

NNO:	NONO_c05030(hsaC1) NONO_c44720 NONO_c58760(hsaC2)

NSL:	BOX37_02175 BOX37_11855

NSR:	NS506_01260(hsaC) NS506_06778(etbC)

NTP:	CRH09_03305

NOZ:	DMB37_23590

NOD:	FOH10_22595 FOH10_28745

NAH:	F5544_02630

NAD:	NCTC11293_01245(hsaC_1) NCTC11293_04394(hsaC_2)

NWL:	NWFMUON74_04930

NIE:	KV110_03025

NTC:	KHQ06_03675 KHQ06_24085 KHQ06_26960 KHQ06_35110

NHU:	H0264_03850 H0264_34220

NYA:	LTV02_28890 LTV02_38700

NGP:	LTT66_15420 LTT66_28770

NSPU:

IFM12276_01680 IFM12276_30830

NYU:	D7D52_04495 D7D52_09480

NVU:	V7968_10085(hsaC)

RHA:	RHA1_ro02488 RHA1_ro04541(hsaC) RHA1_ro05803 RHA1_ro09005

RER:	RER_07570 RER_13780 RER_51660

REY:	O5Y_03680 O5Y_06490 O5Y_24430

REB:	XU06_03920 XU06_06750 XU06_24850

RQI:	C1M55_04160 C1M55_06995(bphC) C1M55_26050(bphC)

ROP:	ROP_22150 ROP_44560 ROP_58640

ROA:	Pd630_LPD00993 Pd630_LPD02422 Pd630_LPD06714

RPY:	Y013_19035 Y013_19285

RBY:	CEJ39_05400 CEJ39_05650 CEJ39_21895(bphC)

RAV:	AAT18_03975 AAT18_22060

RHW:	BFN03_15190

RRZ:	CS378_10115(bphC) CS378_11825(bphC) CS378_19615

RHQ:	IM25_02765 IM25_08885

RHOD:

AOT96_05860 AOT96_14555 AOT96_17390

RRT:	4535765_00584(hsaC_1) 4535765_00631(hsaC_2) 4535765_04055(hsaC_4)

RCR:	NCTC10994_02089(hsaC_1) NCTC10994_02136(hsaC_2) NCTC10994_03239(hsaC_3) NCTC10994_03314(hsaC_4)

RTM:	G4H71_04575(bphC) G4H71_07385 G4H71_13740(bphC)

RKO:	JWS14_13060(bphC) JWS14_24495 JWS14_31735(bphC)

RGO:	KYT97_11700(bphC) KYT97_15280 KYT97_15685(bphC) KYT97_23245

ROZ:	CBI38_00790 CBI38_01330 CBI38_04180

RPSK:

JWS13_12175(bphC) JWS13_20430 JWS13_32825(bphC)

RGOR:

NMQ04_02525 NMQ04_02760(bphC) NMQ04_17480(bphC) NMQ04_17845(bphC) NMQ04_22185

RHOP:

D8W71_08095 D8W71_26905

RHOO:

RA302_04030 RA302_06880(bphC) RA302_25090(bphC)

RHOU:

KZJ41_03970 KZJ41_23490(bphC)

RHOW:

A4U64_02490 A4U64_20800

RHOJ:

JVH1_07345(bphC) JVH1_13625(hsaC) JVH1_24740(bphC) JVH1_39390

RHOS:

QWW67_10690(bphC) QWW67_12140(bphC) QWW67_21315

RHOQ:

QWW98_10695(bphC) QWW98_12150(bphC) QWW98_21325

RHOY:

QNA09_01525 QNA09_06855 QNA09_18265(bphC) QNA09_19340(bphC)

RHOH:

CPI83_04510(bphC) CPI83_22290(bphC) CPI83_25055

RHOX:

RBB84_23655 RBB84_23910

RHJS:

OYT95_07645(bphC) OYT95_14220 OYT95_26100(bphC)

RSF:	OED52_02305 OED52_17480(bphC)

RHZQ:

GO592_01985(bphC) GO592_20770(bphC) GO592_26985

RHZG:

BO226_15705 BO226_23450 BO226_23700

RHBH:

A0W34_03980 A0W34_06790 A0W34_24750

RHPD:

U9J23_02720 U9J23_02955 U9J23_19615(bphC) U9J23_20050(bphC)

RHON:

EHW12_03930 EHW12_06775(bphC) EHW12_25450(bphC)

RHWB:

FND50_04920 FND50_11315(bphC) FND50_30745(bphC)

RHPM:

E5769_01345 E5769_08240(bphC) E5769_21465

RHPC:

E5720_05775(bphC) E5720_12670 E5720_14055

RHSQ:

E7742_15690(bphC) E7742_16730 E7742_17280(bphC) E7742_22065

RHWY:

GFS60_00125(bphC) GFS60_00257(bphC) GFS60_00870(bphC)

RHDM:

HFP48_04065 HFP48_10010 HFP48_22700(bphC)

RHWQ:

HUN07_01025 HUN07_04015 HUN07_22770(bphC)

RHMM:

ISO16_10650(bphC) ISO16_12100(bphC) ISO16_21245

RHZP:

HYG77_11765 HYG77_14590(bphC) HYG77_15195(bphC)

RHRC:

P0M12_07640(bphC) P0M12_16385 P0M12_19235(bphC)

RHNY:

ACBG85_04155(hsaC) ACBG85_06870(bphC) ACBG85_24470(bphC)

RHRD:

RDE2_04980 RDE2_05460 RDE2_15170 RDE2_40090 RDE2_40610

RHDK:

PST05_12615(bphC) PST05_23205(hsaC) PST05_29545(bphC)

RHMZ:

QWU03_11335(bphC) QWU03_12790(bphC) QWU03_21980

RIO:	ACM26Y_03510(hsaC) ACM26Y_19740(bphC) ACM26Y_21105(bphC)

REQ:	REQ_01430 REQ_06820 REQ_40140 REQ_43800

PDEF:

P9209_05565(bphC) P9209_29065

PSOW:

ABI214_10410(hsaC) ABI214_15740(bphC) ABI214_17980(bphC)

WHR:	OG579_17640

GBR:

Gbro_0921

GPO:	GPOL_c41080(hsaC) GPOL_c41220

GOR:	KTR9_0821(hsaC)

GOQ:	ACH46_03105 ACH46_03245

GTA:	BCM27_04770 BCM27_05115

GOC:	CXX93_06465

GIT:	C6V83_04280

GRU:	GCWB2_04180(hsaC)

GOM:	D7316_02454(hsaC_1) D7316_02467(hsaC_2) D7316_02567(hsaC_3)

GAV:	C5O27_00855 C5O27_10720(bphC)

GOD:	GKZ92_03975 GKZ92_16410(bphC)

GOS:	QAD21_04130

GOJ:	GR168_04255

GAM:	GII34_18805

GPD:	GII33_03935 GII33_21760

GJI:	H1R19_03905 H1R19_04055 H1R19_12675(bphC)

GOI:	LK459_05080 LK459_05165(bphC)

GHN:	MVF96_04255

GAMI:

IHQ52_06835

GMG:	NWF22_15760

GSI:	P5P27_15785

GOO:	HUN08_03000

GOP:	ACE11G_03155(hsaC)

GON:	Q9K23_17925

SPIN:

KV203_17340

TPR:

Tpau_3843

TSM:	ASU32_21895

TPUL:

TPB0596_41840

TSD:	MTP03_43280

DTM:	BJL86_0699

DIT:	C3V38_09270

DIZ:	CT688_03190

DPC:	A6048_03135

DLU:	A6035_02405 A6035_03430

DKN:	NHB83_01965 NHB83_02980

DCD:	VYL96_02145 VYL96_03215

DID:	GJR88_01032

TOY:	FO059_01335(bphC) FO059_14005 FO059_16385

SGRF:

SGFS_022200 SGFS_025350

SSOI:

I1A49_45975

SVT:	SVTN_35915

SALU:

DC74_7447

SALL:

SAZ_38440

SLX:	SLAV_27440(hsaC)

SNK:	CP967_03280

SGX:	H4W23_38550

SROI:

IAG44_02090

SXN:	IAG42_26655

SDEC:

L3078_00990

SRUG:

F0345_00805

STAA:

LDH80_36410

SNIG:

HEK616_31480(hsaC)

SCAE:

IHE65_04670 IHE65_42050

STUB:

MMF93_31675

SLON:

LGI35_13835

SCYN:

N8I84_00485

SCAT:

P8A18_03495

STII:

DRB96_33815

STIC:

DRB89_33175

SPOF:

P8A21_05580

STBR:

ABDE16_34480

SSOC:

ABZO31_07670

SSLI:

R2D22_27820

SSTO:

ACE1OC_30175

STRK:

R2B38_40775

ARL:	AFL94_16970

ARY:	ATC04_01210

ASUN:

KG104_04195

ARTA:

OL239_16035

GPR:	JQN66_16975

PAEY:

KUF55_17985

NCA:

Noca_2774

NDK:	I601_0578(hsaC_1) I601_3468(hsaC_2)

NBE:	Back2_27220

NANO:

G5V58_09770

NARO:

CFH99_13520

NPI:	G7071_12490 G7071_15935

NPC:	KUV85_04290

NMAR:

HPC71_09525

NFC:	KG111_08325 KG111_15390(bphC)

NBI:	SHK19_12515

NOCR:

OSR43_09585 OSR43_13270

NOCW:

ABFU82_07545(hsaC) ABFU82_20940

NOCA:

ncot_02685 ncot_07840 ncot_09675

NOCL:

KM427_12565

NOCD:

QJ852_14490

NOCQ:

QI633_08545 QI633_11905 QI633_17890 QI633_22550

PSIM:

KR76_14470 KR76_27095

AEB:	C6I20_03270

TCU:

Tcur_3516

ACTW:

F7P10_28360

AMAZ:

LUW76_36065

ACIR:

OG979_26445

AWS:	ACN3XK_49860 ACN3XK_50535

ACTQ:

OG417_40260

AMD:

AMED_2524

AMN:

RAM_12830

AMM:

AMES_2496

AMZ:

B737_2497

AOI:	AORI_2486(bphC)

AJA:	AJAP_26395(hsaC)

AMQ:	AMETH_4836

AMYC:

CU254_10470 CU254_23455

AMYB:

BKN51_05030

AAB:	A4R43_16035

AMYY:

YIM_14460(hsaC1) YIM_36675(hsaC2)

AORI:

SD37_13495

AACD:

LWP59_29190

APRT:

MUY14_23820

AROO:

NQK81_09920

ATHM:

L1857_26955

ARHD:

VSH64_01790

AMOG:

QRX60_26350

ACYN:

ORV05_07260

ACOR:

LCL61_01255(hsaC)

AMYZ:

HUW46_00280(hsaC)

ANW:	QP939_49820

AMYD:

K1T34_30675

ABAR:

AMYBAR_005561

AMYE:

MJQ72_04360

AMYS:

CVV72_16685

ARHI:

AB5I40_14185(hsaC) AB5I40_44425

PSDS:

K1T35_06305

KAL:

KALB_5122

KUT:	JJ691_08350

KBR:	Q4V65_43215(hsaC)

KPHY:

AOZ06_42780

LED:	BBK82_38915

LXR:	ACRSBM_19110(hsaC) ACRSBM_27205

LENT:

JNUCC0626_04690(hsaC)

ALO:	CRK57812 CRK59592

PMAD:

BAY61_10965

SACE:

GIY23_13330

CROS:

N8J89_29365

STP:	Strop_2669

SAQ:

Sare_2877

AMS:	AMIS_19200

AIH:	Aiant_18870

ACTL:

L3i22_084450

ASIC:

Q0Z83_065570

AOU:	ACTOB_004121

ACTE:

ACTI_41230

DFU:	Dfulv_20760 Dfulv_33640

JCY:	M6B22_17705 M6B22_21585

AYM:	YM304_33710

DHI:	LH044_03935

» show all

Reference

1 [PMID:5908121]

Authors

Gibson DT, Wang KC, Sih CJ, Whitlock H Jr.

Title

Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms.

Journal

J Biol Chem 241:551-9 (1966)

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.25

IUBMB Enzyme Nomenclature:

1.13.11.25

ExPASy - ENZYME nomenclature database:

1.13.11.25

UM-BBD (Biocatalysis/Biodegradation Database):

1.13.11.25

BRENDA, the Enzyme Database:

1.13.11.25

CAS:	37256-63-6

LinkDB

REACTION: R04597

Entry

R04597                      Reaction

Name

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)

Definition

3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + Oxygen <=> 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

Equation

C04793 + C00007 <=> C04844

Reaction class

RC01610

C04793_C04844

Enzyme

1.13.11.25

Pathway

rn00984

Steroid degradation

rn01100

Metabolic pathways

rn01120

Microbial metabolism in diverse environments

rn01220

Degradation of aromatic compounds

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.25
     R04597  3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + Oxygen <=> 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

Orthology

K16049

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25]

Other DBs

RHEA:

21355 43899

LinkDB

DBGET integrated database retrieval system