KEGG   ORTHOLOGY: K16049
Entry
K16049                      KO                                     
Symbol
hsaC
Name
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25]
Pathway
map00984  Steroid degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K16049  hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.25  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
     K16049  hsaC; 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
Other DBs
RN: R04597
COG: COG0346
GO: 0047071
Genes
VAF: D1115_22660
PRE: PCA10_13380
PFUW: KF707C_11930
PPUT: L483_14230
PPUN: PP4_26930
PVR: PverR02_11720
PPUU: PputUW4_01687
PKC: PKB_4267(hsaC)
PFZ: AV641_10715
PLQ: AA042_19960
PPSY: AOC04_08020
PSET: THL1_1410
PSIL: PMA3_11800
PKE: DLD99_14645
PUM: HGP31_20700
PPSH: G5J76_13970
PLAL: FXN65_06300
PKH: JLK41_05795
PAZE: KSS91_19160
PPHA: BVH74_17675
PTAE: NCTC10697_02092(hsaC)
SPL: Spea_2153
SHL: Shal_2124
COLW: A3Q33_18685
CBER: B5D82_11140
PHA: PSHAa0900(tesB)
PTN: PTRA_a1032(hsaC)
PNG: PNIG_a1084(hsaC)
SNAN: I6N98_01460 I6N98_10755
ZAL: AZF00_12080
HJA: BST95_13315
HALC: EY643_09155
AFUS: EYZ66_12950
KAK: Kalk_07830
MSEC: LN244_05120
SOK: D0B54_05280
SINI: GT972_08460
FCE: JN531_005450
GPB: HDN1F_27360(bphC1)
RIN: ACS15_4384(hsaC)
REH: H16_B0654(bphC)
CNC: CNE_2c06010(bphC)
CUH: BJN34_30715
REU: Reut_A1557
CTI: RALTA_B0496(bphC)
CBW: RR42_s2336
COX: E0W60_08215
BUR: Bcep18194_B1431
BCJ: BCAM1637
BCEN: DM39_6216(hsaC)
BCEO: I35_5498
BCT: GEM_4079
BCED: DM42_6321(hsaC)
BCEP: APZ15_31025
BPYR: ABD05_27685
BCON: NL30_03995
BDF: WI26_21320
BTEI: WS51_05820
BPSL: WS57_05915
BMEC: WJ16_26910
BSTL: BBJ41_21475
BANN: JFN94_25820
BURK: DM992_32505
BFN: OI25_4609
PVE: UC34_06925
CABA: SBC2_48810(hsaC)
CTT: CtCNB1_1275
CTES: O987_07285
DIH: G7047_10915
AZD: CDA09_09620
THU: AC731_008515
NTD: EGO55_13435 EGO55_13700
NAR: Saro_3647 Saro_3750
NPP: PP1Y_Mpl3065
NOV: TQ38_027275
NOT: C7W88_20680 C7W88_20750
SWI: Swit_1826 Swit_1848 Swit_3298
SPHD: HY78_09060 HY78_16340 HY78_16450
RDI: CMV14_16840
SPHM: G432_04775
SSAN: NX02_14735
SPKC: KC8_01090 KC8_05325 KC8_16655 KC8_19655
SPHA: D3Y57_15480
SLAN: GV829_01880
SPHB: EP837_03390(hsaC)
PHAO: HF685_05540
SMIC: SmB9_10410(hsaC)
ERR: DVR09_05400
PHZ: CHX26_05295
MTU: Rv3568c(hsaC)
MTV: RVBD_3568c
MTC: MT3673
MRA: MRA_3607(bphC)
MTF: TBFG_13601
MTB: TBMG_03607
MTK: TBSG_03634
MTZ: TBXG_003582
MTG: MRGA327_22030
MTI: MRGA423_22550
MTE: CCDC5079_3309
MTUR: CFBS_3785(bphC)
MTL: CCDC5180_3261
MTO: MTCTRI2_3633(bphC)
MTD: UDA_3568c(bphC)
MTN: ERDMAN_3915(bphC)
MTJ: J112_19215
MTUB: MT7199_3631
MTUC: J113_24990
MTUE: J114_19085
MTX: M943_18350
MTUL: TBHG_03509
MTUT: HKBT1_3770(bphC)
MTUU: HKBT2_3779(bphC)
MTQ: HKBS1_3782(bphC)
MBO: BQ2027_MB3599C(hsac)
MBB: BCG_3633c(bphC)
MBT: JTY_3634(bphC)
MBM: BCGMEX_3631c(bphC)
MBK: K60_037060
MBX: BCGT_3435
MAF: MAF_35810(bphC)
MMIC: RN08_3945
MCE: MCAN_35811(bphC)
MCQ: BN44_110063(hsaC)
MCV: BN43_90069(hsaC)
MCX: BN42_90066(hsaC)
MCZ: BN45_100082(hsaC)
MPA: MAP_0499
MAO: MAP4_3368
MAVI: RC58_16705
MAVU: RE97_16740
MAV: MAV_0593 MAV_3021
MIT: OCO_05020 OCO_28570
MIA: OCU_05060 OCU_28440
MID: MIP_00943 MIP_03717
MYO: OEM_05080 OEM_27030
MCHI: AN480_02505 AN480_14935
MIR: OCQ_05170 OCQ_27150
MMAL: CKJ54_02435 CKJ54_12980(bphC)
MLP: MLM_0737 MLM_2413
MMAN: MMAN_10310 MMAN_21330 MMAN_47960(hsaC)
MSA: Mycsm_04159 Mycsm_05838
MUL: MUL_4139(bphC)
MMC: Mmcs_0317 Mmcs_4707
MKM: Mkms_0327 Mkms_4793
MJL: Mjls_0308 Mjls_5092
MMI: MMAR_5063(bphC)
MMAE: MMARE11_48780(bphC)
MMM: W7S_02450 W7S_13845
MLI: MULP_05321(bphC)
MKN: MKAN_12120
MYV: G155_04250 G155_26475
MYE: AB431_15175 AB431_15235 AB431_26550
MGO: AFA91_10590
MHAD: B586_04455
MDX: BTO20_04385
MSHG: MSG_02471 MSG_04561(hsaC)
MFJ: MFLOJ_07940 MFLOJ_40670(hsaC)
MSTO: MSTO_09180 MSTO_44620(hsaC)
MSIM: MSIM_29110(hsaC) MSIM_53020
MSAK: MSAS_05590 MSAS_29150(hsaC)
MKU: I2456_25675
MGRO: FZ046_02940
MXE: MYXE_05080(hsaC) MYXE_06660
MNV: MNVI_11570 MNVI_12510(hsaC)
MPAG: C0J29_19280 C0J29_27825
MNM: MNVM_19350 MNVM_23440(hsaC)
MGOR: H0P51_17855 H0P51_25865
MCOO: MCOO_26120 MCOO_27310(hsaC)
MBAI: MB901379_04452(hsaC)
MSEO: MSEO_12710 MSEO_34550(hsaC)
MPSE: MPSD_52640(hsaC)
MSHO: MSHO_05470(hsaC)
MHEK: JMUB5695_00469(hsaC_1) JMUB5695_00575
MGAU: MGALJ_22850 MGALJ_38560
MLJ: MLAC_47240(hsaC)
MBRD: MBRA_20010(hsaC) MBRA_21120
MSHJ: MSHI_38540(hsaC)
MKR: MKOR_35330(hsaC) MKOR_36400
MDF: K0O62_15785(bphC) K0O62_25965
MMAM: K3U93_11795(bphC) K3U93_22685
MHOL: K3U96_03080 K3U96_09635(bphC)
MHER: K3U94_21025
MSEN: K3U95_12875 K3U95_25510
MPAE: K0O64_14655(bphC) K0O64_14700(bphC) K0O64_26060
MSPG: F6B93_20485
MOT: LTS72_27920
MSM: MSMEG_2891 MSMEG_6036
MSG: MSMEI_2817(bphC) MSMEI_5875(bphC)
MSB: LJ00_14380 LJ00_29840
MSN: LI99_14385 LI99_29845
MSH: LI98_14390 LI98_29850
MVA: Mvan_2891 Mvan_5306
MGI: Mflv_1465 Mflv_4549
MSP: Mspyr1_39490 Mspyr1_47020
MCB: Mycch_1590 Mycch_4673
MNE: D174_24700
MYN: MyAD_24235
MFT: XA26_08070 XA26_53610
MPHL: MPHLCCUG_00493(hsaC_1) MPHLCCUG_02627(hsaC_2)
MVQ: MYVA_1664 MYVA_5216
MLL: B1R94_12250 B1R94_20085 B1R94_25460
MRH: MycrhN_2245 MycrhN_4259
MTHN: 4412656_00959(bphC) 4412656_04092(hsaC)
MHAS: MHAS_02457(hsaC_1) MHAS_03777(hsaC_2)
MDU: MDUV_26660 MDUV_49010
MCHT: MCHIJ_12760 MCHIJ_19310
MAUU: NCTC10437_02739(hsaC_2) NCTC10437_05067(hsaC_3)
MMAG: MMAD_48570
MMOR: MMOR_11760 MMOR_26800
MFX: MFAL_32600
MAIC: MAIC_05180 MAIC_26790 MAIC_26930
MIJ: MINS_00690
MALV: MALV_29230 MALV_42140
MTY: MTOK_22000
MPSC: MPSYJ_15770
MARZ: MARA_47440
MGAD: MGAD_01100 MGAD_37680
MHEV: MHEL_27650 MHEL_50120 MHEL_50220
MSAR: MSAR_10970 MSAR_41300 MSAR_41350
MANY: MANY_12800 MANY_33050
MAUB: MAUB_27090 MAUB_54790
MPOF: MPOR_53990
MPHU: MPHO_14370 MPHO_43380
MMUC: C1S78_011095(bphC) C1S78_019250(bphC) C1S78_025610
MMAT: MMAGJ_33780
MBOK: MBOE_04960 MBOE_20110
MFG: K6L26_05345 K6L26_16790 K6L26_27685(bphC)
MSEI: MSEDJ_02510
MFLV: NCTC10271_00467(hsaC_1) NCTC10271_02187(hsaC_2)
MAB: MAB_0076 MAB_0585
MMV: MYCMA_0047 MYCMA_0298
MABB: MASS_0078 MASS_0554
MABL: MMASJCM_0079 MMASJCM_0574
MCHE: BB28_00370 BB28_02790
MIZ: BAB75_00670 BAB75_03540
MSTE: MSTE_00542(hsaC)
MSAO: MYCSP_02495
MSAL: DSM43276_00503(hsaC)
MJD: JDM601_3853(bphC) JDM601_4250(bphC)
MTER: 4434518_03728(bphC)
MMIN: MMIN_06700 MMIN_12530
MHIB: MHIB_23840 MHIB_31170(hsaC)
ASD: AS9A_0926
MPAK: MIU77_01970
NFA: NFA_40980 NFA_4720
NFR: ERS450000_03764(hsaC_1) ERS450000_05815(hsaC_2)
NCY: NOCYR_0501 NOCYR_2418(bphC)
NBR: O3I_002665
NNO: NONO_c05030(hsaC1) NONO_c44720 NONO_c58760(hsaC2)
NSL: BOX37_02175 BOX37_11855
NSR: NS506_01260(hsaC) NS506_06778(etbC)
NTP: CRH09_03305
NOZ: DMB37_23590
NOD: FOH10_22595 FOH10_28745
NAH: F5544_02630
NAD: NCTC11293_01245(hsaC_1) NCTC11293_04394(hsaC_2)
NWL: NWFMUON74_04930
NIE: KV110_03025
NTC: KHQ06_03675 KHQ06_24085 KHQ06_26960 KHQ06_35110
NHU: H0264_03850 H0264_34220
NYA: LTV02_28890 LTV02_38700
NGP: LTT66_15420 LTT66_28770
RHA: RHA1_ro02488 RHA1_ro04541(hsaC) RHA1_ro05803
RER: RER_07570 RER_13780 RER_51660
REY: O5Y_03680 O5Y_06490 O5Y_24430
REB: XU06_03920 XU06_06750 XU06_24850
RQI: C1M55_04160 C1M55_06995(bphC) C1M55_26050(bphC)
ROP: ROP_22150 ROP_44560 ROP_58640
ROA: Pd630_LPD00993 Pd630_LPD02422 Pd630_LPD06714
REQ: REQ_01430 REQ_06820 REQ_40140 REQ_43800
RPY: Y013_19035 Y013_19285
RBY: CEJ39_05400 CEJ39_05650 CEJ39_21895(bphC)
RAV: AAT18_03975 AAT18_22060
RHW: BFN03_15190
RRZ: CS378_10115(bphC) CS378_11825(bphC) CS378_19615
RHQ: IM25_02765 IM25_08885
RHOD: AOT96_05860 AOT96_14555 AOT96_17390
RRT: 4535765_00584(hsaC_1) 4535765_00631(hsaC_2) 4535765_04055(hsaC_4)
RCR: NCTC10994_02089(hsaC_1) NCTC10994_02136(hsaC_2) NCTC10994_03239(hsaC_3) NCTC10994_03314(hsaC_4)
RTM: G4H71_04575(bphC) G4H71_07385 G4H71_13740(bphC)
RKO: JWS14_13060(bphC) JWS14_24495 JWS14_31735(bphC)
RGO: KYT97_11700(bphC) KYT97_15280 KYT97_15685(bphC) KYT97_23245
GBR: Gbro_0921
GPO: GPOL_c41080(hsaC) GPOL_c41220
GOR: KTR9_0821(hsaC)
GOQ: ACH46_03105 ACH46_03245
GTA: BCM27_04770 BCM27_05115
GOC: CXX93_06465
GIT: C6V83_04280
GRU: GCWB2_04180(hsaC)
GOM: D7316_02454(hsaC_1) D7316_02467(hsaC_2) D7316_02567(hsaC_3)
GAV: C5O27_00855 C5O27_10720(bphC)
GOD: GKZ92_03975 GKZ92_16410(bphC)
GAM: GII34_18805
GPD: GII33_03935
GJI: H1R19_04055 H1R19_12675(bphC)
GOI: LK459_05080 LK459_05165(bphC)
SPIN: KV203_17340
TPR: Tpau_3843
TSM: ASU32_21895
DTM: BJL86_0699
DIT: C3V38_09270
DIZ: CT688_03190
DPC: A6048_03135
DLU: A6035_02405 A6035_03430
TOY: FO059_01335(bphC) FO059_14005 FO059_16385
SSOI: I1A49_45975
SALU: DC74_7447
SALL: SAZ_38440
SVT: SVTN_35915
SLX: SLAV_27440(hsaC)
SNK: CP967_03280
SGX: H4W23_38550
SROI: IAG44_02090
SXN: IAG42_26655
ARL: AFL94_16970
ARY: ATC04_01210
GPR: JQN66_16975
PAEY: KUF55_17985
NCA: Noca_2774
NDK: I601_0578(hsaC_1) I601_3468(hsaC_2)
NBE: Back2_27220
NANO: G5V58_09770
NARO: CFH99_13520
NPI: G7071_12490 G7071_15935
PSIM: KR76_14470 KR76_27095
AEB: C6I20_03270
TCU: Tcur_3516
ACTW: F7P10_28360
AMD: AMED_2524
AMN: RAM_12830
AMM: AMES_2496
AMZ: B737_2497
AOI: AORI_2486(bphC)
AJA: AJAP_26395(hsaC)
AMQ: AMETH_4836
AMYC: CU254_10470 CU254_23455
AMYB: BKN51_05030
AAB: A4R43_16035
AMYY: YIM_14460(hsaC1) YIM_36675(hsaC2)
AORI: SD37_13495
AACD: LWP59_29190
KAL: KALB_5122
KPHY: AOZ06_42780
LED: BBK82_38915
ALO: CRK57812 CRK59592
PMAD: BAY61_10965
SACE: GIY23_13330
STP: Strop_2669
SAQ: Sare_2877
AMS: AMIS_19200
AIH: Aiant_18870
AYM: YM304_33710
 » show all
Reference
PMID:17264217
  Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
  Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
  Journal
Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104
Reference
PMID:21924910
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
Reference
PMID:19300498
  Authors
Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD
  Title
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
  Journal
PLoS Pathog 5:e1000344 (2009)
DOI:10.1371/journal.ppat.1000344
  Sequence
[mtu:Rv3568c]
LinkDB

KEGG   REACTION: R04597
Entry
R04597                      Reaction                               
Name
3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)
Definition
3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + Oxygen <=> 3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
Equation
C04793 + C00007 <=> C04844
Reaction class
RC01610  C04793_C04844
Enzyme
1.13.11.25
Pathway
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K16049  3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase [EC:1.13.11.25]
Other DBs
RHEA: 43899
LinkDB

DBGET integrated database retrieval system