KEGG   ORTHOLOGY: K16086
Entry
K16086                      KO                                     
Symbol
E3.1.7.10
Name
(13E)-labda-7,13-dien-15-ol synthase [EC:3.1.7.10]
Pathway
map00904  Diterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09874  geranylgeranyl-diphosphate diphosphohydrolase [(13E)-labda-7,13-dien-15-ol-forming]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K16086  E3.1.7.10; (13E)-labda-7,13-dien-15-ol synthase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.10  (13E)-labda-7,13-dien-15-ol synthase
     K16086  E3.1.7.10; (13E)-labda-7,13-dien-15-ol synthase
Genes
SMO: SELMODRAFT_112927 SELMODRAFT_120716
Reference
PMID:21751328
  Authors
Mafu S, Hillwig ML, Peters RJ
  Title
A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.
  Journal
Chembiochem 12:1984-7 (2011)
DOI:10.1002/cbic.201100336
  Sequence
[smo:SELMODRAFT_120716]
LinkDB

KEGG   ENZYME: 3.1.7.10
Entry
EC 3.1.7.10                 Enzyme                                 
Name
(13E)-labda-7,13-dien-15-ol synthase;
labda-7,13E-dien-15-ol synthase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
Sysname
geranylgeranyl-diphosphate diphosphohydrolase [(13E)-labda-7,13-dien-15-ol-forming]
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate [RN:R09874]
Reaction(KEGG)
R09874
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
(13E)-labda-7,13-dien-15-ol [CPD:C20158];
diphosphate [CPD:C00013]
Comment
The enzyme from the lycophyte Selaginella moellendorffii is bifunctional, initially forming (13E)-labda-7,13-dien-15-yl diphosphate, which is hydrolysed to the alcohol.
History
EC 3.1.7.10 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K16086  (13E)-labda-7,13-dien-15-ol synthase
Genes
SMO: SELMODRAFT_112927 SELMODRAFT_120716
Reference
1  [PMID:21751328]
  Authors
Mafu S, Hillwig ML, Peters RJ
  Title
A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.
  Journal
Chembiochem 12:1984-7 (2011)
DOI:10.1002/cbic.201100336
  Sequence
[smo:SELMODRAFT_120716]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.10
IUBMB Enzyme Nomenclature: 3.1.7.10
ExPASy - ENZYME nomenclature database: 3.1.7.10
BRENDA, the Enzyme Database: 3.1.7.10
LinkDB

KEGG   REACTION: R09874
Entry
R09874                      Reaction                               
Name
geranylgeranyl-diphosphate diphosphohydrolase [(13E)-labda-7,13-dien-15-ol-forming]
Definition
Geranylgeranyl diphosphate + H2O <=> (13E)-Labda-7,13-dien-15-ol + Diphosphate
Equation
C00353 + C00001 <=> C20158 + C00013
Reaction class
RC02590  C00353_C20158
Enzyme
3.1.7.10
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.10
     R09874  Geranylgeranyl diphosphate + H2O <=> (13E)-Labda-7,13-dien-15-ol + Diphosphate
Orthology
K16086  (13E)-labda-7,13-dien-15-ol synthase [EC:3.1.7.10]
Other DBs
RHEA: 32078
LinkDB

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