KEGG   ORTHOLOGY: K16172
Entry
K16172                      KO                                     
Symbol
IRS1
Name
insulin receptor substrate 1
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04213  Longevity regulating pathway - multiple species
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04935  Growth hormone synthesis, secretion and action
map04960  Aldosterone-regulated sodium reabsorption
map05010  Alzheimer disease
map05206  MicroRNAs in cancer
map05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04022 cGMP-PKG signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04151 PI3K-Akt signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04152 AMPK signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04150 mTOR signaling pathway
    K16172  IRS1; insulin receptor substrate 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16172  IRS1; insulin receptor substrate 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04923 Regulation of lipolysis in adipocytes
    K16172  IRS1; insulin receptor substrate 1
   04920 Adipocytokine signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04935 Growth hormone synthesis, secretion and action
    K16172  IRS1; insulin receptor substrate 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K16172  IRS1; insulin receptor substrate 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
  09149 Aging
   04211 Longevity regulating pathway
    K16172  IRS1; insulin receptor substrate 1
   04212 Longevity regulating pathway - worm
    K16172  IRS1; insulin receptor substrate 1
   04213 Longevity regulating pathway - multiple species
    K16172  IRS1; insulin receptor substrate 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K16172  IRS1; insulin receptor substrate 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K16172  IRS1; insulin receptor substrate 1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K16172  IRS1; insulin receptor substrate 1
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K16172  IRS1; insulin receptor substrate 1
   04932 Non-alcoholic fatty liver disease
    K16172  IRS1; insulin receptor substrate 1
   04931 Insulin resistance
    K16172  IRS1; insulin receptor substrate 1
Genes
HSA: 3667(IRS1)
PTR: 459985(IRS1)
PPS: 100971596(IRS1)
GGO: 101132740(IRS1)
PON: 100442255(IRS1)
PPYG: 129031768(IRS1)
NLE: 100607873(IRS1)
HMH: 116810145(IRS1)
SSYN: 129488521(IRS1)
MCC: 707870(IRS1)
MCF: 102117978(IRS1)
MTHB: 126932885
MNI: 105473988(IRS1)
CSAB: 103217981(IRS1)
CATY: 105586974(IRS1)
PANU: 100999369(IRS1)
TGE: 112636552(IRS1)
MLEU: 105543176(IRS1)
RRO: 104656078(IRS1)
RBB: 108538753(IRS1)
TFN: 117094439(IRS1)
PTEH: 111527547(IRS1)
CANG: 105518803(IRS1)
CJC: 100387742(IRS1)
SBQ: 101035868(IRS1)
CIMI: 108304802(IRS1)
ANAN: 105712891(IRS1)
CSYR: 103259285(IRS1)
MMUR: 105862871(IRS1)
LCAT: 123643492(IRS1)
PCOQ: 105808835(IRS1)
OGA: 100958778(IRS1)
MMU: 16367(Irs1)
MCAL: 110292727(Irs1)
MPAH: 110321270(Irs1)
RNO: 25467(Irs1)
MCOC: 116088647(Irs1)
ANU: 117722352(Irs1)
MUN: 110547502(Irs1)
CGE: 100755710(Irs1)
MAUA: 101832053(Irs1)
PROB: 127226500(Irs1)
PLEU: 114696438(Irs1)
MORG: 121446925(Irs1)
MFOT: 126512943
AAMP: 119820738(Irs1)
NGI: 103727788(Irs1)
HGL: 101708189(Irs1)
CPOC: 100716939(Irs1)
CCAN: 109696750(Irs1)
DORD: 105982400(Irs1)
DSP: 122107464(Irs1)
PLOP: 125350245(Irs1)
NCAR: 124979751
MMMA: 107138750(Irs1)
OCU: 100339981
OPI: 101526197(IRS1)
TUP: 102496620(IRS1)
GVR: 103586161(IRS1)
CFA: 486148(IRS1)
CLUD: 112669817(IRS1)
VVP: 112925532(IRS1)
VLG: 121496830(IRS1)
NPO: 129523419(IRS1)
AML: 100477645(IRS1)
UMR: 103662712(IRS1)
UAH: 113250390(IRS1)
UAR: 123778092(IRS1)
ELK: 111143995
LLV: 125095145
MPUF: 101684695(IRS1)
MNP: 132013605(IRS1)
MLK: 131827381(IRS1)
NVS: 122902369(IRS1)
ORO: 101367978(IRS1)
EJU: 114210848(IRS1)
ZCA: 113920032(IRS1)
MLX: 118011983(IRS1)
NSU: 110574308(IRS1)
LWW: 102729040(IRS1)
FCA: 101087257(IRS1)
PYU: 121014485(IRS1)
PBG: 122481851(IRS1)
PVIV: 125172805(IRS1)
LRUF: 124516592
PTG: 102965599(IRS1)
PPAD: 109264970(IRS1)
PUC: 125911117
AJU: 106972296
HHV: 120249142(IRS1)
BTA: 538598(IRS1)
BOM: 102284664(IRS1)
BIU: 109571355(IRS1)
BBUB: 102416637(IRS1)
BBIS: 104986454(IRS1)
CHX: 102184858(IRS1)
OAS: 101102293(IRS1)
BTAX: 128069000(IRS1)
ODA: 120854447(IRS1)
CCAD: 122426865(IRS1)
MBEZ: 129537506(IRS1)
SSC: 100512686(IRS1)
CFR: 102512682(IRS1)
CBAI: 105064075(IRS1)
CDK: 105088301(IRS1)
VPC: 102533840(IRS1)
BACU: 103011761(IRS1)
BMUS: 118897871(IRS1)
LVE: 103074278(IRS1)
OOR: 101271463(IRS1)
DLE: 111171885(IRS1)
PCAD: 102992290(IRS1)
PSIU: 116756739(IRS1)
NASI: 112396733(IRS1)
ECB: 100061987(IRS1)
EPZ: 103547143(IRS1)
EAI: 106827854(IRS1)
MYB: 102247525(IRS1)
MYD: 102752666(IRS1)
MMYO: 118661524(IRS1)
MLF: 102442509(IRS1)
MDT: 132238297(IRS1)
PKL: 118709201(IRS1)
EFUS: 103289256(IRS1)
MNA: 107525521(IRS1)
DRO: 112307950(IRS1)
SHON: 118975374(IRS1)
AJM: 119044737(IRS1)
PDIC: 114494358(IRS1)
PHAS: 123828676(IRS1)
MMF: 118625363(IRS1)
PPAM: 129080305(IRS1)
HAI: 109396328(IRS1)
RFQ: 117025871(IRS1)
PALE: 102891583(IRS1)
PGIG: 120597107(IRS1)
PVP: 105294748(IRS1)
RAY: 107497246(IRS1)
MJV: 108397189(IRS1)
TOD: 119256266(IRS1)
SARA: 101542323(IRS1)
SETR: 126001122(IRS1)
LAV: 100664968(IRS1)
TMU: 101356151
ETF: 101650216(IRS1)
DNM: 101437367(IRS1)
MDO: 100021838(IRS1)
GAS: 123242758(IRS1)
SHR: 100918116(IRS1)
AFZ: 127553038
PCW: 110200253(IRS1)
TVP: 118845823(IRS1)
OAA: 103170729(IRS1)
GGA: 107051846
PCOC: 116230914(IRS1)
MGP: 100539255(IRS1)
CJO: 107318049(IRS1)
TPAI: 128081773(IRS1)
LMUT: 125697843(IRS1)
NMEL: 110397421(IRS1)
APLA: 101796950(IRS1)
ACYG: 106036186(IRS1)
CATA: 118247238(IRS1)
AFUL: 116492767(IRS1)
TGU: 105759506(IRS1)
LSR: 110483660(IRS1)
SCAN: 103815658(IRS1)
PMOA: 120508576(IRS1)
OTC: 121341146(IRS1)
PRUF: 121357951(IRS1)
GFR: 102044407(IRS1)
FAB: 101810426(IRS1)
OMA: 130256705(IRS1)
PHI: 102101540(IRS1)
PMAJ: 107208936(IRS1)
CCAE: 111933626(IRS1)
CCW: 109145556(IRS1)
CBRC: 103614638
ETL: 114068746(IRS1)
ZAB: 102067323(IRS1)
ZLE: 135451675(IRS1)
SVG: 106854141(IRS1)
MMEA: 130573986(IRS1)
HRT: 120757352(IRS1)
SATI: 136365646(IRS1)
FPG: 101922249(IRS1)
FCH: 102052001(IRS1)
CCRI: 104164059(IRS1)
NNT: 104412554(IRS1)
SHAB: 115611753(IRS1)
ACUN: 113483461(IRS1)
TALA: 116964778(IRS1)
ACHC: 115347412(IRS1)
HLE: 104832290(IRS1)
AGEN: 126039537
GCL: 127020000
CSTI: 104557822
LDI: 104339929(IRS1)
MNB: 103773776(IRS1)
DPUB: 104296507(IRS1)
BRHI: 104487845(IRS1)
EGZ: 104127063(IRS1)
NNI: 104016496(IRS1)
PADL: 103917904(IRS1)
AFOR: 103905134(IRS1)
FGA: 104073643(IRS1)
CLV: 102083619(IRS1)
MUI: 104533222(IRS1)
PGUU: 104466655
PLET: 104614146(IRS1)
EHS: 104502575(IRS1)
CUCA: 104063698(IRS1)
TEO: 104369678(IRS1)
BREG: 104639857(IRS1)
OHA: 104337997(IRS1)
ACAR: 104527276(IRS1)
CPEA: 104392276(IRS1)
CVF: 104291056(IRS1)
RTD: 128911036(IRS1)
AAM: 106485843(IRS1)
AROW: 112976098(IRS1)
NPD: 112947867(IRS1)
TGT: 104566717(IRS1)
DNE: 112988889(IRS1)
SCAM: 104144662(IRS1)
ASN: 102372136(IRS1)
AMJ: 102574179(IRS1)
CPOO: 109308621(IRS1)
GGN: 109288184(IRS1)
PSS: 102455771 102463626(IRS1)
CMY: 102945843(IRS1) 119565054
CCAY: 125628580 125642789(IRS1)
DCC: 119861884(IRS1)
CPIC: 101931522(IRS1)
TST: 117882685(IRS1)
CABI: 116829822(IRS1)
MRV: 120372250(IRS1)
ACS: 100565100(irs1) 103282162
ASAO: 132770665(IRS1) 132777483
PVT: 110078456(IRS1) 110082325
SUND: 121925778(IRS1) 121934423
PBI: 103048511 103055013(IRS1)
PMUR: 107286667(IRS1)
CTIG: 120299722 120311443(IRS1)
TSR: 106542051(IRS1) 106556223
PGUT: 117678362(IRS1)
APRI: 131197369 131200818(IRS1)
PTEX: 113436854(IRS1)
NSS: 113409938(IRS1)
VKO: 123024780(IRS1)
PMUA: 114582338 114597807(IRS1)
PRAF: 128399792 128414584(IRS1)
ZVI: 118093487(IRS1) 118095226
HCG: 128329046 128351639(IRS1)
GJA: 107116003(IRS1)
STOW: 125437863(IRS1) 125444504
EMC: 129332056(IRS1) 129340365
XLA: 108711802(irs2.L) 108718134 399299(irs1.L)
XTR: 100495320(irs1) 394823(irs2)
NPR: 108796838(IRS1) 108800291
RTEM: 120933665 120936639(IRS1)
BBUF: 120986661 120997794(IRS1)
BGAR: 122924053 122934374(IRS1)
MUO: 115458282 115479023(IRS1)
GSH: 117350893 117366964(IRS1)
DRE: 559281(irs1)
SRX: 107730864 107751987
SANH: 107683387 107704743
SGH: 107577679 107582225(irs1) 107587795
CCAR: 109045228 109104127
CAUA: 113078802 113114960
CGIB: 127972745 128028964
PTET: 122359362(irs1)
LROH: 127177122(irs1)
OMC: 131520610(irs1)
PPRM: 120478817(irs1)
RKG: 130077911(irs1)
MAMB: 125248458(irs1)
CIDE: 127495986
CERY: 137005426(irs1)
MASI: 127422333 127430169
TROS: 130564634(irs1)
TDW: 130428812(irs1)
MANU: 129438351(irs1)
IPU: 108267519(si:ch73-335l21.1) 108278298
IFU: 128621416(irs1)
PHYP: 113539873 113544564(irs1)
SMEO: 124394801(irs1)
TFD: 113642529(irs1)
TVC: 132857878(irs1)
AMEX: 103025632(irs1) 103042975(si:ch73-335l21.1)
CMAO: 118798903(irs1)
EEE: 113588983(irs1) 113591002
CHAR: 105909303(irs1)
TRU: 101069368 101072794
TFS: 130522307(si:ch73-335l21.1) 130537259(si:ch211-284e13.4)
TNG: GSTEN00022133G001
LCO: 104923989
NCC: 104944906 104949454
TBEN: 117488102(si:ch73-335l21.1) 117490546(si:ch211-284e13.4)
CGOB: 115019302 115023495
PGEO: 117458793(si:ch211-284e13.4) 117463936(si:ch73-335l21.1)
GACU: 117534032(si:ch211-284e13.4) 117552674(si:ch73-335l21.1)
EMAC: 134871912(si:ch211-284e13.4) 134876328(si:ch73-335l21.1)
ELY: 117246218(si:ch73-335l21.1) 117263376(si:ch211-284e13.4)
EFO: 125883633(si:ch73-335l21.1) 125898921(si:ch211-284e13.4)
PLEP: 121939025(si:ch73-335l21.1) 121952980(si:ch211-284e13.4)
SLUC: 116048982(si:ch73-335l21.1) 116064954(si:ch211-284e13.4)
ECRA: 117955928(si:ch211-284e13.4) 117962219(si:ch73-335l21.1)
ESP: 116686365 116700901
PFLV: 114545606 114567028
GAT: 120822124(si:ch73-335l21.1) 120822445(si:ch211-284e13.4)
PPUG: 119215070(si:ch211-284e13.4) 119222532(si:ch73-335l21.1)
AFB: 129093522(si:ch73-335l21.1) 129113916(si:ch211-284e13.4)
CLUM: 117742765(si:ch211-284e13.4) 117747750(si:ch73-335l21.1)
PSWI: 130191646(si:ch211-284e13.4) 130212275(si:ch73-335l21.1)
MSAM: 119896161(si:ch211-284e13.4) 119911745(si:ch73-335l21.1)
SCHU: 122870633(si:ch73-335l21.1) 122888843(si:ch211-284e13.4)
CUD: 121504510(si:ch73-335l21.1) 121519283(si:ch211-284e13.4)
ALAT: 119027222(si:ch73-335l21.1) 119031913(si:ch211-284e13.4)
ASTR: 137590268(si:ch73-335l21.1) 137606448(si:ch211-284e13.4)
MZE: 101464741 101471414
ONL: 102078815 102079662
OAU: 116330213(si:ch211-284e13.4) 116330728(si:ch73-335l21.1)
OLA: 101163034 101165750
OML: 112142839(si:ch211-284e13.4) 112155960(si:ch73-335l21.1)
CSAI: 133419995(si:ch73-335l21.1) 133459682(si:ch211-284e13.4)
XMA: 102224423
XCO: 114157029
XHE: 116728752 116732244
PRET: 103480483
PFOR: 103137524 103145644
PLAI: 106934592 106938919
PMEI: 106904791 106934130
GAF: 122820335 122820623 122845027(si:ch211-284e13.4)
PPRL: 129368719(si:ch211-284e13.4) 129379495(si:ch73-335l21.1)
CVG: 107087768
CTUL: 119779217(si:ch211-284e13.4) 119783405(si:ch73-335l21.1)
GMU: 124876829(si:ch211-284e13.4) 124880703(si:ch73-335l21.1)
NFU: 107377348 107386495
KMR: 108241811(si:ch73-335l21.1) 108245231(si:ch211-284e13.4)
ALIM: 106529184
NWH: 119409467(si:ch73-335l21.1) 119420295(si:ch211-284e13.4)
AOCE: 111571694
MCEP: 125013716 125021007
CSEM: 103386951 103395409
POV: 109628480 109634880
SSEN: 122766369(si:ch73-335l21.1) 122779291(si:ch211-284e13.4)
HHIP: 117752039(si:ch73-335l21.1) 117774495(si:ch211-284e13.4)
HSP: 118102283(si:ch73-335l21.1) 124854838(si:ch211-284e13.4)
PPLT: 128430241(si:ch73-335l21.1) 128457429(si:ch211-284e13.4)
SMAU: 118287074(si:ch73-335l21.1) 118300864(si:ch211-284e13.4)
LCF: 108897056(si:ch73-335l21.1)
SDU: 111233019
SLAL: 111665735
XGL: 120797377(si:ch73-335l21.1) 120802170(si:ch211-284e13.4)
HCQ: 109508359 109512406
SSCV: 125982105(si:ch211-284e13.4) 125991305(si:ch73-335l21.1)
SBIA: 133491645(si:ch211-284e13.4) 133494546(si:ch73-335l21.1)
PEE: 133398112(si:ch73-335l21.1) 133416420(si:ch211-284e13.4)
PTAO: 133466883(si:ch211-284e13.4) 133472768(si:ch73-335l21.1)
BPEC: 110157680 110158597
MALB: 109966482
BSPL: 114851205(si:ch73-335l21.1) 114869594(si:ch211-284e13.4)
SJO: 128370926(si:ch211-284e13.4) 128383280(si:ch73-335l21.1)
SASA: 106567885 106577633 106603593 106608778 106612416(irs1)
STRU: 115148954 115154413 115194272 115198274 115205827(irs1)
OTW: 112216688(irs1) 112229124 112233838 112257780 112259956(si:ch73-335l21.1)
OMY: 110490060(irs1) 110500592 110531720(si:ch73-335l21.1) 110533721(si:ch211-284e13.4) 110537392
OGO: 123994816(irs1) 124000899 124008927(si:ch73-335l21.1) 124009869
ONE: 115105617 115106778 115133536 115136269 115138064
OKI: 109864467(irs1) 109875632 109891793 109897022 109906495
OKE: 118366019(irs1) 118368784 118390137(si:ch211-284e13.4) 118391224 118391996
SALP: 111950155 111953930 111960107 111960647(irs1) 111980351
SNH: 120028247(irs1) 120030427(si:ch73-335l21.1) 120043800 120049688 120057482(si:ch211-284e13.4)
CCLU: 121554386(si:ch73-335l21.1) 121567271(irs1) 121572107 121573626 121579823
ELS: 105020633 105023953
SFM: 108918671 108922166(irs1) 108922894
PKI: 111836028(irs1) 111854483 111860932
AANG: 118210068(irs1) 118229152
LOC: 102684310 102696987(irs1)
PSPA: 121305699 121306496 121322871 121327022
ARUT: 117404456 117417304 117422933 117968833
PSEX: 120533058(irs1)
LCM: 102366510(IRS1) 102367331
CMK: 103180489(irs1)
RTP: 109916967 109924087(irs1)
CPLA: 122547493 122556246(irs1)
HOC: 132821746(irs1) 132835327
LERI: 129703280(irs1) 129715098
PMRN: 116952540
LRJ: 133353767
BFO: 118404526
CIN: 100185541
SCLV: 120328915
SPU: 100890677
APLC: 110985759
SKO: 102809894
DME: Dmel_CG5686(chico)
DER: 6542588
DSE: 6611937
DSI: Dsimw501_GD22290(Dsim_GD22290)
DYA: Dyak_GE26285
DSR: 110183373
DPO: 4811653
DPE: 6589676
DMN: 108162201
DWI: 6652608
DGR: 6567010
DMO: Dmoj_GI10661
DAZ: 108610418
DNV: 115563042
DHE: 111603951
CCAT: 101459143
BOD: 118681405
BDR: 105225362(Irs1)
AOQ: 129247903
TDA: 119687796
GFS: 119642984
AAG: 5569675
AALB: 109411294
ASUA: 134212214
CPII: 120414058
CNS: 116338347
BCOO: 119082059
AME: 408438
ACER: 107999616
ALAB: 122712169
ADR: 102670752
AFLR: 100865952
BIM: 100742603
BBIF: 117213506
BVK: 117233579
BVAN: 117154788
BTER: 100644779
BAFF: 126922801
BPYO: 122574297
BPAS: 132911059
FVI: 122535913
CCAL: 108623285
OBB: 114878683
OLG: 117603591
MGEN: 117221395
NMEA: 116428644
CGIG: 122403420
SOC: 105202010
MPHA: 105833897
AEC: 105146271 105151362
ACEP: 105627057
PBAR: 105427691
VEM: 105562552
HST: 105180459
DQU: 106741422
CFO: 105251794
FEX: 115242179
LHU: 105679317(chico)
PGC: 109861371
OBO: 105280708
PCF: 106792141
PFUC: 122517592
VPS: 122637625
VCRB: 124432767
VVE: 124946770
NVI: 100119908
CSOL: 105368177
TPRE: 106649838
MDL: 103578429
CGLO: 123268301
DAM: 107037127
CCIN: 107268002
TCA: 103313904
SOY: 115879307
ATD: 109598230
CSET: 123318070
LDC: 111506503
DVV: 114330008
NVL: 108558535
APLN: 108734879
PPYR: 116178891
OTU: 111426727
BMOR: 101745072
BMAN: 114247063
MSEX: 115441776
BANY: 112053097
PMAC: 106718294
PXU: 106126509
PRAP: 110993911
ZCE: 119840245
AAGE: 121735233
HAW: 110376740
HZE: 124639152
TNL: 113497656
SLIU: 111354031
OFU: 114361067
ATRA: 106137782
GMW: 113516157
LGLY: 125231003
API: 100569479
DNX: 107161961
AGS: 114131651
RMD: 113547937
BTAB: 109033713
CLEC: 106667510
HHAL: 106681977(chico)
NLU: 111053511
PHU: Phum_PHUM441290
FOC: 113218444
TPAL: 117647689
ZNE: 110835233
CSEC: 111867485
FCD: 110847979
DMK: 116921553
PJA: 122248311
PCLA: 123763636
PTRU: 123516473
EAF: 111716183
DSV: 119461122
VDE: 111246385
VJA: 111270069
TUT: 107366694
DPTE: 113791832
CSCU: 111622797
PTEP: 107438950 107446916
CEL: CELE_C54D1.3(ist-1)
CBR: CBG_10979(Cbr-ist-1)
CRQ: GCK72_024710
NAI: NECAME_10663
BMY: BM_BM2926(Bma-ist-1)
LOA: LOAG_16388
TSP: Tsp_03690
PCAN: 112561836
GAE: 121377759
HRF: 124139711
HRJ: 124291303
CRG: 105342662
MYI: 110464153
OSN: 115210869
NVE: 5517532
ATEN: 116300822
ADF: 107342456
AMIL: 114960550
 » show all
Reference
PMID:17591841
  Authors
Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Ando S, Surmacz E
  Title
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
  Journal
Ann Oncol 18 Suppl 6:vi81-5 (2007)
DOI:10.1093/annonc/mdm232
Reference
PMID:8513971
  Authors
Araki E, Sun XJ, Haag BL 3rd, Chuang LM, Zhang Y, Yang-Feng TL, White MF, Kahn CR
  Title
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
  Journal
Diabetes 42:1041-54 (1993)
DOI:10.2337/diab.42.7.1041
  Sequence
[hsa:3667]
Reference
PMID:1380456
  Authors
Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al.
  Title
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
  Journal
EMBO J 11:3469-79 (1992)
DOI:10.1002/j.1460-2075.1992.tb05426.x
  Sequence
[rno:25467]
LinkDB

KEGG   ORTHOLOGY: K07187
Entry
K07187                      KO                                     
Symbol
IRS2
Name
insulin receptor substrate 2
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04022 cGMP-PKG signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04152 AMPK signaling pathway
    K07187  IRS2; insulin receptor substrate 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07187  IRS2; insulin receptor substrate 2
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04923 Regulation of lipolysis in adipocytes
    K07187  IRS2; insulin receptor substrate 2
   04920 Adipocytokine signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04935 Growth hormone synthesis, secretion and action
    K07187  IRS2; insulin receptor substrate 2
  09149 Aging
   04211 Longevity regulating pathway
    K07187  IRS2; insulin receptor substrate 2
   04213 Longevity regulating pathway - multiple species
    K07187  IRS2; insulin receptor substrate 2
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07187  IRS2; insulin receptor substrate 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07187  IRS2; insulin receptor substrate 2
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07187  IRS2; insulin receptor substrate 2
   04932 Non-alcoholic fatty liver disease
    K07187  IRS2; insulin receptor substrate 2
   04931 Insulin resistance
    K07187  IRS2; insulin receptor substrate 2
Genes
HSA: 8660(IRS2)
PTR: 452657(IRS2)
PPS: 100982406(IRS2)
GGO: 101127585(IRS2)
PON: 100452233(IRS2)
PPYG: 129011530(IRS2)
NLE: 100583956(IRS2)
HMH: 116467557(IRS2)
SSYN: 129463687(IRS2)
MCC: 698536(IRS2)
MCF: 102122241(IRS2)
MTHB: 126940155
MNI: 105485304(IRS2)
CSAB: 103214788(IRS2)
CATY: 105584904(IRS2)
PANU: 101011176(IRS2)
TGE: 112610905(IRS2)
RRO: 104679253(IRS2)
RBB: 108527055(IRS2)
TFN: 117063516(IRS2)
PTEH: 111546313(IRS2)
CANG: 105505962(IRS2)
CJC: 100404822(IRS2)
SBQ: 101038649(IRS2)
CIMI: 108284872(IRS2)
ANAN: 105709100(IRS2)
MMUR: 105864251(IRS2)
LCAT: 123648877(IRS2)
PCOQ: 105805133(IRS2)
OGA: 100951299(IRS2)
MMU: 384783(Irs2)
MCAL: 110300614(Irs2)
MPAH: 110336729(Irs2)
RNO: 29376(Irs2)
MCOC: 116068902(Irs2)
ANU: 117721708(Irs2)
MUN: 110548880(Irs2)
CGE: 100771848(Irs2)
MAUA: 101839047(Irs2)
PROB: 127220248(Irs2)
PLEU: 114695106(Irs2)
MORG: 121462188(Irs2)
MFOT: 126498321
AAMP: 119813278(Irs2)
NGI: 103751690(Irs2)
HGL: 101719081(Irs2)
CCAN: 109700963(Irs2)
DSP: 122122851(Irs2)
PLOP: 125348108(Irs2)
NCAR: 124984569
MMMA: 107140739(Irs2)
OCU: 103349113
OPI: 101527103(IRS2)
GVR: 103597238(IRS2)
CFA: 485548(IRS2)
CLUD: 112655863(IRS2)
VVP: 112927496(IRS2)
VLG: 121476873(IRS2)
NPO: 129516510(IRS2)
AML: 100477685(IRS2)
UMR: 121101279(IRS2)
UAH: 113251536(IRS2)
UAR: 123776714(IRS2)
ELK: 111147115
LLV: 125094825
MPUF: 101689279(IRS2)
MNP: 132002951(IRS2)
MLK: 131813562(IRS2)
NVS: 122907240(IRS2)
ORO: 101381397(IRS2)
EJU: 114196636(IRS2)
ZCA: 113919723(IRS2)
NSU: 110585808(IRS2)
LWW: 102741876(IRS2)
FCA: 101095791(IRS2)
PYU: 121024217(IRS2)
PBG: 122484873(IRS2)
PVIV: 125171008(IRS2)
LRUF: 124513679
PPAD: 109264073(IRS2)
PUC: 125933954
AJU: 113601123
HHV: 120228369(IRS2)
BTA: 100300012(IRS2)
BIU: 109567100(IRS2)
BBUB: 102405314(IRS2)
BBIS: 104982211(IRS2)
CHX: 108637286(IRS2)
OAS: 106991367(IRS2)
BTAX: 128057660(IRS2)
ODA: 120883252(IRS2)
CCAD: 122447361(IRS2)
MBEZ: 129556507(IRS2)
SSC: 110255858(IRS2)
CFR: 116668634(IRS2)
CDK: 116157131(IRS2)
BACU: 103005810(IRS2)
BMUS: 118883967(IRS2)
LVE: 103088704(IRS2)
OOR: 101276950(IRS2)
DLE: 111176387(IRS2)
PCAD: 112064787(IRS2)
PSIU: 116743032(IRS2)
NASI: 112405567(IRS2)
ECB: 100146249(IRS2)
EAI: 106838201(IRS2)
MYB: 102249810(IRS2)
MYD: 102753060(IRS2)
MMYO: 118651692(IRS2)
MLF: 102429074(IRS2)
MDT: 132228536(IRS2)
PKL: 118730740(IRS2)
EFUS: 103288306(IRS2)
MNA: 107530378(IRS2)
DRO: 112321408(IRS2)
SHON: 118981568(IRS2)
AJM: 119042698(IRS2)
PDIC: 114508468(IRS2)
PHAS: 123807405(IRS2)
MMF: 118622304(IRS2)
PPAM: 129071212(IRS2)
HAI: 109383948(IRS2)
RFQ: 117021767(IRS2)
PALE: 102898575(IRS2)
PGIG: 120605338(IRS2)
PVP: 105301327(IRS2)
RAY: 107511114(IRS2)
MJV: 108403230(IRS2)
TOD: 119259653(IRS2)
SARA: 101552515(IRS2)
SETR: 126015552(IRS2)
LAV: 100676904(IRS2)
TMU: 101345051
ETF: 101640484(IRS2)
DNM: 101425165(IRS2)
MDO: 100023831(IRS2) 100025395(IRS4)
GAS: 123242631(IRS2) 123253748
SHR: 100924829(IRS2) 100931354(IRS4)
AFZ: 127542628 127553464
PCW: 110194742(IRS4) 110196696(IRS2)
TVP: 118833028(IRS4) 118845896(IRS2)
OAA: 114805830(IRS2)
GGA: 101749060(IRS2) 422347(IRS4)
PCOC: 116229775(IRS4) 116242784(IRS2)
MGP: 100540702(IRS4) 100548754(IRS2)
CJO: 107307936(IRS2) 107312783(IRS4)
TPAI: 128075836(IRS4) 128092214(IRS2)
LMUT: 125693375(IRS2) 125699912(IRS4)
NMEL: 110391172 110403269(IRS4) 110407441(IRS2)
APLA: 101801905 101804723(IRS2)
ACYG: 106038523(IRS4) 106044455(IRS2)
CATA: 118245459(IRS4) 118257481(IRS2)
AFUL: 116493009(IRS2) 116494470(IRS4)
TGU: 100220894(IRS2) 100223674(IRS4)
LSR: 110478760(IRS2) 110480059(IRS4)
SCAN: 103812665(IRS2) 103816520(IRS4)
PMOA: 120504647(IRS2) 120506231(IRS4)
OTC: 121331759(IRS4) 121343099(IRS2)
PRUF: 121356275(IRS2) 121363155(IRS4)
GFR: 102041556(IRS4) 102044059(IRS2)
FAB: 101807499(IRS4) 101814066(IRS2)
OMA: 130252108(IRS2) 130253226(IRS4)
PHI: 102103569(IRS4) 102111858(IRS2)
PMAJ: 107203717(IRS4) 107208306(IRS2)
CCAE: 111928696(IRS4) 111945898
CCW: 104686328(IRS2) 104694453(IRS4)
CBRC: 103621654(IRS4)
ETL: 114059692(IRS4) 114073373(IRS2)
ZAB: 102061645(IRS4) 102068148(IRS2)
ZLE: 135445848(IRS2) 135447985(IRS4)
ACHL: 103802148
SVG: 106857269(IRS2) 106859351(IRS4)
MMEA: 130573325 130588974(IRS2)
HRT: 120748563(IRS2) 120761978(IRS4)
SATI: 136358030(IRS2) 136370597(IRS4)
FPG: 101918515(IRS4) 101924402(IRS2)
FCH: 102046894(IRS2) 102052095(IRS4)
CCRI: 104157181(IRS2)
NNT: 104413293
SHAB: 115604134(IRS2) 115613255(IRS4)
ACUN: 113478507(IRS2) 113479916(IRS4)
TALA: 104369142(IRS4) 116962659(IRS2)
ACHC: 115333517(IRS4) 115334514(IRS2)
HALD: 104320710
HLE: 104832692(IRS4) 104836952(IRS2)
AGEN: 126050220 126052839
GCL: 127019516 127022371
CSTI: 104554070
LDI: 104354435
MNB: 103774421
DPUB: 104298641(IRS2) 104299562(IRS4)
AVIT: 104269958
BRHI: 104493854
EGZ: 104133285(IRS4)
NNI: 104012562(IRS2) 104023330(IRS4)
PCRI: 104034411(IRS2)
PCAO: 104040909(IRS2)
PADL: 103920154(IRS4)
AFOR: 103895631(IRS4) 103896302(IRS2)
FGA: 104081894
GSTE: 104260229
CLV: 102089452(IRS2) 102090441
MUI: 104545604
PGUU: 104472464
PLET: 104628182
EHS: 104505637
CMAC: 104485024
CUCA: 104058372(IRS4) 128851265(IRS2)
TEO: 104380608
BREG: 104635578
OHA: 104339082(IRS4)
ACAR: 104520301
CPEA: 104388287(IRS4)
CVF: 104290216(IRS4)
RTD: 128901105(IRS2) 128914737(IRS4)
AAM: 106482668 106482669 106493916(IRS2)
AROW: 112976657(IRS2) 112977320(IRS4)
NPD: 112944527(IRS4) 112945131(IRS2)
TGT: 104579875
DNE: 112984528(IRS2) 112992577
SCAM: 104150940(IRS4)
ASN: 102374791(IRS2) 102382907(IRS4)
AMJ: 102558545(IRS4) 102565350(IRS2)
CPOO: 109306322(IRS2) 109313719(IRS4)
GGN: 109300745(IRS4) 109303148(IRS2)
PSS: 102457842(IRS4)
CMY: 102934421(IRS2) 102943497(IRS4)
CCAY: 125638833(IRS2) 125643230(IRS4)
DCC: 119849243(IRS2) 119861304(IRS4)
CPIC: 101945214(IRS2) 101951320(IRS4)
TST: 117870803(IRS2) 117882623(IRS4)
CABI: 116815629(IRS2) 116829393(IRS4)
MRV: 120371966(IRS4) 120404286(IRS2)
ACS: 100555020(irs4) 103279765(irs2)
ASAO: 132762950(IRS4) 132781035(IRS2)
PVT: 110074287(IRS4) 110090941(IRS2)
SUND: 121919404(IRS2) 121936111(IRS4)
PBI: 103051591(IRS2) 103052062
PMUR: 107296125(IRS2) 107298766
CTIG: 120300362(IRS2) 120310372(IRS4)
TSR: 106548513(IRS4) 106552209(IRS2)
PGUT: 117675956(IRS4)
APRI: 131198139(IRS2) 131205088(IRS4)
PTEX: 113437883(IRS4) 113440909(IRS2)
NSS: 113416615(IRS4) 113419573(IRS2)
VKO: 123022003(IRS4)
PMUA: 114588807(IRS4) 114593451(IRS2)
PRAF: 128406222(IRS4) 128409819(IRS2)
ZVI: 118082626(IRS2) 118084286(IRS4)
HCG: 128335495(IRS4) 128339990(IRS2)
GJA: 107114014(IRS4) 107120743
STOW: 125426447 125437816 125442689(IRS4)
EMC: 129325940(IRS2) 129341159(IRS4)
XLA: 108708462 108709741 399388(irs4.S) 495836(irs4.L)
XTR: 100196925(irs4) 100498409
NPR: 108787450(IRS2) 108788816
RTEM: 120913724(IRS4) 120926366(IRS2)
BBUF: 120995798(IRS2) 121009307(IRS4)
BGAR: 122919924 122931021(IRS2)
MUO: 115469177(IRS2) 115473747 115474385
GSH: 117360932(IRS4) 117362702(IRS2)
DRE: 100329897(irs4a) 393285(irs2a) 572001(irs2b) 794462
SRX: 107707846 107707924 107711568 107715923 107716007 107721603 107742428
SANH: 107654267 107661701 107677836 107684954 107688717 107692954 107702923
SGH: 107552371 107557498 107557930 107559513 107562168 107581880 107588831 107596473
CCAR: 109045204 109083655 109093374 109093375 109094505 109096615 109096616 109113581
CAUA: 113038277 113044375 113051391 113053641 113063906 113106282 113108922
CGIB: 127942214 127949639 127961485 127965137 127986267 128017727 128019446
PTET: 122326567(irs4a) 122349609 122349701(irs2a) 122351325(irs2b)
LROH: 127152685(irs4a) 127168883 127170612(irs2b) 127180721(irs2a)
OMC: 131529070(irs4a) 131542623(irs2a) 131543823 131547069(irs2b)
PPRM: 120473670(irs4a) 120477286 120487082(irs2b) 120495327(irs2a)
RKG: 130085838(irs2b) 130087827(irs2a) 130091191 130096832(irs4a)
MAMB: 125252736(irs4a) 125265406 125269983(irs2b) 125272323(irs2a)
CIDE: 127509202 127515379 127518345
CERY: 137013086(irs4a) 137031178 137032045(irs2a) 137036496(irs2b)
MASI: 127429335 127430408 127432027 127443685 127447519 127448591 127451354
TROS: 130551433 130555712(irs2b) 130570466(irs4a)
TDW: 130407956(irs4a) 130420717 130427189(irs2b)
MANU: 129423659(irs4a) 129448490 129451750(irs2b)
IPU: 108258957(irs2a) 108266735(irs2b) 108267420 108278674(irs4a)
IFU: 128601981(irs2a) 128608673(irs2b) 128610183 128622068(irs4a)
PHYP: 113524486(irs2) 113537322 113540276 113541549
SMEO: 124377984(irs2a) 124382775(irs2b) 124387138 124398449(irs4a)
TFD: 113647569(irs4a) 113648782(irs2a) 113654441(irs2b) 113654717
TVC: 132839124(irs2a) 132848733 132850096(irs2b) 132859736(irs4a)
TRN: 134312368 134324749 134328265(irs2a) 134330332(irs4a)
AMEX: 103025363 103025582(irs4a) 103030138(irs2a) 103034135(irs2b)
CMAO: 118798413(irs2a) 118820113(irs4a) 118824744(irs2b) 118826746
EEE: 113576562 113578495 113582842 113591396
CHAR: 105892967(irs2b) 105895554 105902399(irs4a)
TRU: 101069496 101074788 101076043
TFS: 130522368 130522962 130527411(irs2b)
TNG: GSTEN00005624G001 GSTEN00019601G001 GSTEN00026006G001
LCO: 104928452(irs2) 104929883 104938872
NCC: 104955106 104961594 104961599
TBEN: 117481438(irs2b) 117497935 117498969
CGOB: 115017676 115023931 115024036 115026042(irs2)
PGEO: 117458168 117463556 117466789(irs2b)
GACU: 117546737 117556839(irs2b) 117560169
EMAC: 134860795 134867157(irs2b) 134875976
ELY: 117246063 117249939 117251133(irs2b)
EFO: 125884378 125884695 125899435(irs2b)
PLEP: 121949440(irs2b) 121961832 121962687
SLUC: 116044568(irs2a) 116046847(irs2b) 116053173
ECRA: 117934557 117939246 117953341(irs2b)
ESP: 116669528 116673813 116697727(irs2)
PFLV: 114546012 114550774 114563852(irs2)
GAT: 120822033 120825688 120833892(irs2b)
PPUG: 119213930 119222867 119228584(irs2b)
AFB: 129093242 129104830(irs2b) 129111725
CLUM: 117741504 117747932 117750188(irs2b)
PSWI: 130204504 130206764(irs2b) 130211779
MSAM: 119901737 119904232(irs2b) 119911576
SCHU: 122869974 122872245 122885444(irs2b)
CUD: 121504557 121506091 121522403(irs2b)
ALAT: 119015429 119025684(irs2b) 119027104
ASTR: 137590298 137591202 137604714(irs2b)
MZE: 101465453 101468614 101476715 101482705(irs2)
ONL: 100699855(irs2) 100704325 100709921 102081223
OAU: 116314366 116316072(irs2b) 116327581 116334013
OLA: 101162408(irs2) 101169068 101174984
OML: 112155149(irs2b) 112156084 112160084
CSAI: 133420029 133425068 133445857(irs2b)
XMA: 102226863 102227153 102236425 102237141
XCO: 114140419 114141249 114147878 114157700
XHE: 116715828 116722724 116732920
PRET: 103459734(irs2) 103474601 103476518 103480255
PFOR: 103140288(irs2) 103154686 103155838
PLAI: 106934562 106935256 106955663(irs2)
PMEI: 106906991 106927476(irs2) 106929252
GAF: 122820721 122827297 122839412(irs2b)
PPRL: 129352338 129361135(irs2b) 129379044
CVG: 107086777 107091522 107096497(irs2)
CTUL: 119786399(irs2b) 119788614 119790360
GMU: 124861643 124871251(irs2b) 124880406
NFU: 107377017 107380884 107381024 107389850(irs2)
KMR: 108232465(irs2b) 108247737 108248502
ALIM: 106519158 106523934 106524457
NWH: 119408688 119419666(irs2b) 119428803
AOCE: 111566540 111566595(irs2) 111575407 111580299
MCEP: 125000777 125010560 125017532(irs2b)
CSEM: 103386201 103389324 103389765 103392135(irs2)
POV: 109631417(irs2) 109640930 109641748
SSEN: 122761160(irs2a) 122763946(irs2b) 122767273
HHIP: 117751826 117755348(irs2b) 117774049
HSP: 118102549 118103209 118119877(irs2b)
PPLT: 128430135 128430802 128455815(irs2b)
SMAU: 118282585(irs2b) 118283436 118304743
LCF: 108899730(irs2b) 108900631 108902081
SDU: 111218308(irs2) 111222710 111233462
SLAL: 111646010 111662143(irs2) 111667114
XGL: 120797646 120798246 120801245(irs2b)
HCQ: 109507042 109507777 109524681(irs2)
SSCV: 125973487 125984053 125988346
SBIA: 133494718 133509775 133512079(irs2b)
PEE: 133398010 133406055 133410424(irs2b)
PTAO: 133472787 133483904 133486499(irs2b)
BPEC: 110153857 110165987 110173115(irs2)
MALB: 109955690 109965432(irs2) 109973872
BSPL: 114844848 114846348 114847157(irs2b)
SJO: 128354057 128368244(irs2b) 128384229
SASA: 106563716 106575127(irs2) 106582130 106586664 106609064
STRU: 115155832 115161187 115179428 115194642 115195908 115198586 115202642
OTW: 112214510 112220193 112225416 112230587 112236594 112241326 112266609
OMY: 110495980 110500338 110501605 110510164 110520474 110528824(irs2a) 110531423
OGO: 124006799 124008468 124008660 124013757 124044147 124045618
ONE: 115101466 115118046 115124666 115127142 115133282 115134579
OKI: 109869859 109870927 109890724(irs2) 109896876 109906315 116358306
OKE: 118369199 118370111 118370511 118372756 118384960 118392214
SALP: 111952012 111953604 111959252 111964378 111971054 111979234 112072034
SNH: 120021068 120030198 120033714 120049809 120051209 120058456 120064167
CCLU: 121536490 121541307 121554744 121558766 121571273 121571627
ELS: 105009026 105016500(irs2) 105024652 105030862
SFM: 108920068 108922965 108933081(irs2) 108934127
PKI: 111841535 111843667 111846317 111851414
AANG: 118214118 118223060(irs2b) 118223117 118234975
LOC: 102682802(irs2) 102693755(irs4)
PSPA: 121295578 121318669 121320808 121327771
ARUT: 117407256(irs2b) 117412261
PSEX: 120524638(irs2b)
LCM: 102364884(IRS2) 102366705(IRS4)
CMK: 103178654(irs2b) 103179604
RTP: 109919326 109921559
CPLA: 122550450 122557378
HOC: 132816359 132820382
LERI: 129698328(irs2b) 129702352
PMRN: 116956300
LRJ: 133357147
BBEL: 109465793
ARUN: 117300700
FAS: 105265590
AGB: 108904873
PCHN: 125029151
LSM: 121129521
PPOI: 119100198
RSAN: 119396415
RMP: 119174621
DFR: 124495248
SDM: 118181644 118200332
PMAX: 117316183
 » show all
Reference
PMID:11114102
  Authors
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G
  Title
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
  Journal
Diabetes Metab Res Rev 16:434-41 (2000)
DOI:10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8
Reference
PMID:25277391
  Authors
Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, Nakaya K, Noda M, Ueki K, Kadowaki T
  Title
Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.
  Journal
Diabetes 64:876-86 (2015)
DOI:10.2337/db14-0432
  Sequence
[mmu:384783]
Reference
PMID:10077005
  Authors
Vassen L, Wegrzyn W, Klein-Hitpass L
  Title
Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene.
  Journal
Mol Endocrinol 13:485-94 (1999)
DOI:10.1210/mend.13.3.0256
  Sequence
[hsa:8660]
LinkDB

KEGG   ORTHOLOGY: K17445
Entry
K17445                      KO                                     
Symbol
IRS3
Name
insulin receptor substrate 3
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04022 cGMP-PKG signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04152 AMPK signaling pathway
    K17445  IRS3; insulin receptor substrate 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17445  IRS3; insulin receptor substrate 3
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04923 Regulation of lipolysis in adipocytes
    K17445  IRS3; insulin receptor substrate 3
   04920 Adipocytokine signaling pathway
    K17445  IRS3; insulin receptor substrate 3
   04935 Growth hormone synthesis, secretion and action
    K17445  IRS3; insulin receptor substrate 3
  09149 Aging
   04211 Longevity regulating pathway
    K17445  IRS3; insulin receptor substrate 3
   04213 Longevity regulating pathway - multiple species
    K17445  IRS3; insulin receptor substrate 3
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17445  IRS3; insulin receptor substrate 3
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K17445  IRS3; insulin receptor substrate 3
Genes
PANU: 101021880
MMUR: 105868385
LCAT: 123631629
PCOQ: 105806007
MMU: 16369(Irs3)
MCAL: 110293997
RNO: 84021(Irs3)
MCOC: 116068604
ANU: 117698147
MUN: 110556773
CGE: 100751390
MAUA: 101835091
PROB: 127237201
PLEU: 114686777
MORG: 121446140
MFOT: 126493980
AAMP: 119824895
NGI: 103733517
CCAN: 109698062
DORD: 106002856
DSP: 122113664
PLOP: 125367642
NCAR: 124970787
MMMA: 107146610
OCU: 100339305
OPI: 101525112
TUP: 106735628
AML: 100467269
UMR: 103670034
UAH: 113267858
UAR: 123777346
ELK: 111146232
LLV: 125090697
MPUF: 101671264
MNP: 132026555
MLK: 131820117
NVS: 122896052
ORO: 101378833
EJU: 114214389
ZCA: 113932642
MLX: 117999416
NSU: 110571849
LWW: 102749360
FCA: 101100432
PYU: 121017634
PCOO: 112859926
PBG: 122471292
PVIV: 125154378
LRUF: 124519412
PTG: 102952104
PPAD: 109251297
PUC: 125928238
AJU: 106987435
HHV: 120223687
BTA: 107131843(IRS3)
BIU: 109578427
BBUB: 102404040
BBIS: 104987149
OAS: 101121655
BTAX: 128043668
ODA: 120879389
CCAD: 122432714
MBEZ: 129545680
SSC: 100515824
CFR: 116657470
CBAI: 105078567
CDK: 105105271
VPC: 102538912
BACU: 103005013
BMUS: 118881371
OOR: 101279800
DLE: 111181964
PCAD: 102982336
PSIU: 116740211
NASI: 112399963
ECB: 100069009
EPZ: 103555632
EAI: 106839324
HAI: 109374927
RFQ: 117024512
MJV: 108409367
TOD: 119242334
SARA: 101548071
SETR: 126029954
LAV: 100660353
TMU: 101362072
MDO: 103100498
GAS: 123246324
OAA: 114808089
HRO: HELRODRAFT_171842
 » show all
Reference
PMID:9348224
  Authors
Sciacchitano S, Taylor SI
  Title
Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene.
  Journal
Endocrinology 138:4931-40 (1997)
DOI:10.1210/endo.138.11.5518
  Sequence
[mmu:16369]
Reference
PMID:11724774
  Authors
Kabuta T, Hakuno F, Asano T, Takahashi S
  Title
Insulin receptor substrate-3 functions as transcriptional activator in the nucleus.
  Journal
J Biol Chem 277:6846-51 (2002)
DOI:10.1074/jbc.M107058200
  Sequence
[rno:84021]
LinkDB

KEGG   ORTHOLOGY: K17446
Entry
K17446                      KO                                     
Symbol
IRS4
Name
insulin receptor substrate 4
Pathway
map04022  cGMP-PKG signaling pathway
map04068  FoxO signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04910  Insulin signaling pathway
map04920  Adipocytokine signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04930  Type II diabetes mellitus
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
Disease
H00250  Congenital nongoitrous hypothyroidism (CHNG)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04022 cGMP-PKG signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04152 AMPK signaling pathway
    K17446  IRS4; insulin receptor substrate 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K17446  IRS4; insulin receptor substrate 4
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04923 Regulation of lipolysis in adipocytes
    K17446  IRS4; insulin receptor substrate 4
   04920 Adipocytokine signaling pathway
    K17446  IRS4; insulin receptor substrate 4
   04935 Growth hormone synthesis, secretion and action
    K17446  IRS4; insulin receptor substrate 4
  09149 Aging
   04211 Longevity regulating pathway
    K17446  IRS4; insulin receptor substrate 4
   04213 Longevity regulating pathway - multiple species
    K17446  IRS4; insulin receptor substrate 4
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K17446  IRS4; insulin receptor substrate 4
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K17446  IRS4; insulin receptor substrate 4
Genes
HSA: 8471(IRS4)
PTR: 473846(IRS4)
PPS: 100991292(IRS4)
GGO: 109024862(IRS4)
PON: 100458662(IRS4)
PPYG: 129024624(IRS4)
NLE: 100588594(IRS4)
HMH: 116811948(IRS4)
SSYN: 129476056(IRS4)
MCC: 703846(IRS4)
MCF: 102128819(IRS4)
MTHB: 126945702
MNI: 105490457(IRS4)
CSAB: 103232472(IRS4)
CATY: 105598463(IRS4)
PANU: 101027041(IRS4)
TGE: 112616118(IRS4)
MLEU: 105541408(IRS4)
RRO: 104676250(IRS4)
RBB: 108541574(IRS4)
TFN: 117077563(IRS4)
PTEH: 111536706(IRS4)
CANG: 105518616(IRS4)
CJC: 100410200(IRS4)
SBQ: 101035392(IRS4)
CIMI: 108316556(IRS4)
ANAN: 105716928(IRS4)
CSYR: 103262177(IRS4)
MMUR: 105863379(IRS4)
LCAT: 123628131(IRS4)
PCOQ: 105810971(IRS4)
OGA: 100953605(IRS4)
MMU: 16370(Irs4)
MCAL: 110287491(Irs4)
MPAH: 110313986(Irs4)
RNO: 315350(Irs4)
MCOC: 116089083(Irs4)
ANU: 117695265(Irs4)
MUN: 110540163(Irs4)
CGE: 100773159
MAUA: 101840584(Irs4)
PROB: 127217141(Irs4)
PLEU: 114698331(Irs4)
MORG: 121436878 121437242
MFOT: 126489634
AAMP: 119805566(Irs4)
NGI: 103750027(Irs4)
HGL: 101719321(Irs4)
CPOC: 100717360(Irs4)
CCAN: 109675517(Irs4)
DORD: 105992800(Irs4)
DSP: 122116357(Irs4)
PLOP: 125344181(Irs4)
NCAR: 124972126
OCU: 103351932
OPI: 101528328(IRS4)
TUP: 102489416(IRS4)
GVR: 103603730(IRS4)
CFA: 492059(IRS4)
CLUD: 112649305(IRS4)
VVP: 112932035(IRS4)
VLG: 121483169(IRS4)
NPO: 129518021(IRS4)
AML: 105240373(IRS4)
UMR: 103679770(IRS4)
UAH: 113241174(IRS4)
UAR: 123780203(IRS4)
ELK: 111161266
LLV: 125092461
MPUF: 101680131(IRS4)
MNP: 132007037(IRS4)
MLK: 131821025(IRS4)
NVS: 122897407(IRS4)
ORO: 101371781(IRS4)
EJU: 114198362(IRS4)
ZCA: 113930850(IRS4)
MLX: 118010742(IRS4)
NSU: 110570454(IRS4)
LWW: 102737797(IRS4)
FCA: 101093251(IRS4)
PYU: 121025718(IRS4)
PCOO: 112871206(IRS4)
PBG: 122477260(IRS4)
PVIV: 125156854(IRS4)
LRUF: 124513799
PTG: 102952189(IRS4)
PPAD: 109253661(IRS4)
PUC: 125931893
AJU: 106973150
HHV: 120232651(IRS4)
BTA: 514607(IRS4)
BOM: 102273597(IRS4)
BIU: 109555543(IRS4)
BBUB: 102400715(IRS4)
BBIS: 104983354(IRS4)
CHX: 102179643(IRS4)
OAS: 101112456(IRS4)
BTAX: 128070573(IRS4)
ODA: 120881381(IRS4)
CCAD: 122435154(IRS4)
MBEZ: 129564117(IRS4)
SSC: 100622674(IRS4)
CFR: 102521714(IRS4)
CBAI: 105061987(IRS4)
CDK: 105099556(IRS4)
VPC: 102528920(IRS4)
BACU: 102998877(IRS4)
BMUS: 118888242(IRS4)
LVE: 103068740(IRS4)
OOR: 101290244(IRS4)
DLE: 111165800(IRS4)
PCAD: 102989579(IRS4)
PSIU: 116748068(IRS4)
NASI: 112401927(IRS4)
ECB: 100059954(IRS4)
EPZ: 103545515(IRS4)
EAI: 106839711(IRS4)
MYB: 102242347(IRS4)
MYD: 102753243(IRS4)
MMYO: 118654640(IRS4)
MLF: 102418401(IRS4)
MDT: 132224716(IRS4)
PKL: 118731903(IRS4)
EFUS: 103299461(IRS4)
MNA: 107526265(IRS4)
DRO: 112296869(IRS4)
SHON: 118984183(IRS4)
AJM: 119065177(IRS4)
PDIC: 114505548(IRS4)
PHAS: 123805137(IRS4)
MMF: 118636678(IRS4)
PPAM: 129076254(IRS4)
HAI: 109393345(IRS4)
RFQ: 117026277(IRS4)
PALE: 102895007(IRS4)
PGIG: 120616378(IRS4)
PVP: 105301581(IRS4)
RAY: 107506967(IRS4)
MJV: 108406099(IRS4)
TOD: 119245973(IRS4)
SARA: 101540547(IRS4)
SETR: 125999066(IRS4)
LAV: 100667324(IRS4)
TMU: 101350401
ETF: 101652949(IRS4)
DNM: 101416233(IRS4)
 » show all
Reference
PMID:9261155
  Authors
Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE
  Title
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.
  Journal
J Biol Chem 272:21403-7 (1997)
DOI:10.1074/jbc.272.34.21403
  Sequence
[hsa:8471]
Reference
PMID:12639902
  Authors
Schreyer S, Ledwig D, Rakatzi I, Kloting I, Eckel J
  Title
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
  Journal
Endocrinology 144:1211-8 (2003)
DOI:10.1210/en.2002-220723
  Sequence
[hsa:8471]
LinkDB

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