KEGG   ORTHOLOGY: K16173
Entry
K16173                      KO                                     
Symbol
acd
Name
glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]
Pathway
map00362  Benzoate degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16173  acd; glutaryl-CoA dehydrogenase (non-decarboxylating)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.32  glutaryl-CoA dehydrogenase (acceptor)
     K16173  acd; glutaryl-CoA dehydrogenase (non-decarboxylating)
Other DBs
RN: R05579
Genes
TIG: THII_2206
GBI: PG2T_13310
BFN: OI25_7305
GEM: GM21_2801
GEO: Geob_0237
GBM: Gbem_1452
GBN: GEOBRER4_29700
GSUB: KP001_01975
DML: Dmul_25030(acdA5) Dmul_34900(acdA13)
DAL: Dalk_0058
DAT: HRM2_38550(acd11) HRM2_38670(acd12)
DTO: TOL2_C38270(acdA5)
DOV: DSCO28_15290 DSCO28_44640(acdB_2) DSCO28_67840(acdB_3)
DWD: DSCW_66360(acdB)
DALK: DSCA_21130(acdB_1) DSCA_32440(acdB_2) DSCA_37830
DLI: dnl_54690(acdA5)
DMM: dnm_014610(acdA1)
HOH: Hoch_1175
SAT: SYN_00480
DBR: Deba_2447
BMYC: DJ92_4005
BAG: Bcoa_0791
OIH: OB0864
GKA: GK0445
GTN: GTNG_0452
GEA: GARCT_00480(acdA_1)
PCAL: BV455_01302(acdA_2)
AFL: Aflv_1240(acdA)
LSP: Bsph_0858
HLI: HLI_20160
VPN: A21D_02347(acdA_3)
PSYO: PB01_02630
ASOC: CB4_03627(acdA_4)
AAC: Aaci_1850
AAD: TC41_1948(acd)
BTS: Btus_0350
SIV: SSIL_3577
AACX: DEACI_1885
CHY: CHY_1737
LPIL: LIP_0806
HHG: XM38_019870(anaB_1)
RCA: Rcas_3165
CAG: Cagg_0741
HAU: Haur_1248
TRO: trd_0039
PBF: CFX0092_A0325(acdA)
TTR: Tter_0362
ABAC: LuPra_03850(acdA_2)
MOX: DAMO_3029(acdA)
AG: ACP50614(acd)
 » show all
Reference
  Authors
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M
  Title
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria.
  Journal
J Bacteriol 191:4401-9 (2009)
DOI:10.1128/JB.00205-09
  Sequence
LinkDB

KEGG   ENZYME: 1.3.99.32
Entry
EC 1.3.99.32                Enzyme                                 
Name
glutaryl-CoA dehydrogenase (acceptor);
GDHDes;
nondecarboxylating glutaryl-coenzyme A dehydrogenase;
nondecarboxylating glutaconyl-coenzyme A-forming GDH;
glutaryl-CoA dehydrogenase (non-decarboxylating)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With unknown physiological acceptors
Sysname
glutaryl-CoA:acceptor 2,3-oxidoreductase (non-decarboxylating)
Reaction(IUBMB)
glutaryl-CoA + acceptor = (E)-glutaconyl-CoA + reduced acceptor [RN:R05579]
Reaction(KEGG)
R05579
Substrate
glutaryl-CoA [CPD:C00527];
acceptor [CPD:C00028]
Product
(E)-glutaconyl-CoA [CPD:C02411];
reduced acceptor [CPD:C00030]
Comment
The enzyme contains FAD. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (EC 1.3.8.6), and a nondecarboxylating enzyme (this entry). The two enzymes cause different structural changes around the glutaconyl carboxylate group, primarily due to the presence of either a tyrosine or a valine residue, respectively, at the active site.
History
EC 1.3.99.32 created 2012, modified 2013
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating)
Genes
TIGTHII_2206
GBIPG2T_13310
BFNOI25_7305
GEMGM21_2801
GEOGeob_0237
GBMGbem_1452
GBNGEOBRER4_29700
GSUBKP001_01975
DMLDmul_25030(acdA5) Dmul_34900(acdA13)
DALDalk_0058
DATHRM2_38550(acd11) HRM2_38670(acd12)
DTOTOL2_C38270(acdA5)
DOVDSCO28_15290 DSCO28_44640(acdB_2) DSCO28_67840(acdB_3)
DWDDSCW_66360(acdB)
DALKDSCA_21130(acdB_1) DSCA_32440(acdB_2) DSCA_37830
DLIdnl_54690(acdA5)
DMMdnm_014610(acdA1)
HOHHoch_1175
SATSYN_00480
DTIDesti_2252 Desti_4873
DBRDeba_2447
BMYCDJ92_4005
BACIB1NLA3E_10900
BACOOXB_1160 OXB_1320
BSMBSM4216_2477
BFDNCTC4823_01481
BDAFSZ17_11390
BAGBcoa_0791
OIHOB0864
OCNCUC15_05285
GKAGK0445
GTEGTCCBUS3UF5_5600
GTKGT3570_02200
GTMGT3921_16995
GLIGLN3_12655
GTNGTNG_0452
GWCGWCH70_0441
GYCGYMC61_1327
GYAGYMC52_0449
GCTGC56T3_3025
GMCGY4MC1_3338
GGHGHH_c04660
GJFM493_02635
GEAGARCT_00480(acdA_1)
GELIB49_12835
GSEGT50_12030
GSRGS3922_13450
GEJA0V43_18040
GZAIC807_15965
GTHGeoth_3392
PTLAOT13_05790
PTBDER53_06815
PCALBV455_01302(acdA_2)
AFLAflv_1240(acdA)
AGNAFK25_08310
LSPBsph_0858
LGYT479_02025
LFUHR49_21765
LYSLBYS11_02065
LYBC3943_02640
LYZDCE79_01535
LPAKGDS87_02110
LAGRFJQ98_02205
HHDHBHAL_1540 HBHAL_1901
HMNHM131_06360 HM131_13220
HLIHLI_20160
VIRX953_03845
VHLBME96_03075
VIGBKP57_05365
VILCFK37_02280
VNECFK40_18785
VPNA21D_02347(acdA_3)
VIMGWK91_11900
VPTKBP50_16850
LAOAOX59_10470
BSJUP17_06235
BMURABE28_006370
PBUTDTO10_18935
PPSRI6J18_08855
BTHVCQJ30_09055
PSYHD0S48_09750
PSYOPB01_02630
RUEDT065_08935
SALEEPH95_09035
POFGS400_06975
NMKCHR53_17165
NTMBTDUT50_09765
MDGK8L98_08040
BVJI5776_14965
BOUI5818_18385
CTHUHUR95_05845
ANXACH33_15645
ASOCCB4_03627(acdA_4)
ATHEK3F53_03215
AACAaci_1850
AADTC41_1948(acd)
AFXJZ786_01490
BTSBtus_0350
KYRCVV65_03285
TUMCBW65_03605
TABCIG75_03285
EFFskT53_18330
SIVSSIL_3577
SSILSOLI23_00490
SOBCSE16_01720
PLNPlano_0640
PKUAUO94_13135
PRTAUC31_13565
PLLI858_003975
PANABBH88_17360
PDGBCM40_12500
PHCBBI08_16240
PMARB0X71_15560
PPLABBI15_08740
PFAEAJGP001_04045
PLXCW734_14790
PMATBBI11_14370
PDECH1Q58_13670
KURASO14_2659
SPSYAZE41_20075
SPORSporoP33_11030
SPOPSporoP37_11435
SURESporoP32a_11700
SPOSDV702_15645
SPAEE2C16_04195
PAEKD3873_01845
PANCE2636_09140 E2636_14105
PLAYDNR44_007170
VIJJNUCC6_16920
NTRB0W44_03260
TVUAB849_000355
PABSJIR001_23680
CCBClocel_3947
CLBClo1100_2634
DORDesor_1180 Desor_1198 Desor_2984
DAIDesaci_1830
DKUDesku_0803 Desku_2606
AACXDEACI_1885
DGIDesgi_0512 Desgi_4610
CHYCHY_1737
LPILLIP_0806
ACITHPK19_11375 HPK19_20125
HHGXM38_019870(anaB_1)
MICMic7113_1750
NOSNos7107_3476
NFLCOO91_09462
NEDHUN01_32175
CSGCylst_6469
NCNBZZ01_15490 BZZ01_17415
RRSRoseRS_2300
RCARcas_3165
CHLChy400_2879
CAGCagg_0741
HAUHaur_1248
TROtrd_0039
STISthe_0821 Sthe_1077
CAPCLDAP_05970
PBFCFX0092_A0325(acdA)
THUGKNN16_14240
TTRTter_0362
FGIOP10G_4175
NPYNPRO_17230
ABACLuPra_03850(acdA_2)
MOXDAMO_3029(acdA)
 » show all
Reference
1  [PMID:19395484]
  Authors
Wischgoll S, Taubert M, Peters F, Jehmlich N, von Bergen M, Boll M
  Title
Decarboxylating and nondecarboxylating glutaryl-coenzyme A dehydrogenases in the aromatic metabolism of obligately anaerobic bacteria.
  Journal
J Bacteriol 191:4401-9 (2009)
DOI:10.1128/JB.00205-09
  Sequence
Reference
2  [PMID:20486657]
  Authors
Wischgoll S, Demmer U, Warkentin E, Gunther R, Boll M, Ermler U
  Title
Structural basis for promoting and preventing decarboxylation in glutaryl-coenzyme a dehydrogenases.
  Journal
Biochemistry 49:5350-7 (2010)
DOI:10.1021/bi100317m
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.99.32
IUBMB Enzyme Nomenclature: 1.3.99.32
ExPASy - ENZYME nomenclature database: 1.3.99.32
BRENDA, the Enzyme Database: 1.3.99.32
LinkDB

KEGG   REACTION: R05579
Entry
R05579                      Reaction                               
Name
glutaryl-CoA:(acceptor) 2,3-oxidoreductase (non-decarboxylating)
Definition
Glutaryl-CoA + Acceptor <=> Glutaconyl-1-CoA + Reduced acceptor
Equation
Reaction class
RC00052  C00527_C02411
Enzyme
Pathway
rn00362  Benzoate degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]
Other DBs
RHEA: 47423
LinkDB

DBGET integrated database retrieval system