KEGG   ORTHOLOGY: K16249
Entry
K16249                      KO                                     
Symbol
dmpK, poxA, tomA0
Name
phenol/toluene 2-monooxygenase (NADH) P0/A0
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Reaction
R03560  toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R03608  o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R10042  benzene,NADH:oxygen oxidoreductase
R10043  phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16249  dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16249  dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
   00623 Toluene degradation
    K16249  dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
Genes
PSD: DSC_04440
RTH: LRK53_10135
RBD: ALSL_0901
PRE: PCA10_06960(dmpK)
PFUW: KF707C_6690(dmpK)
PCQ: PcP3B5_25300
PPG: PputGB1_3311
PPJ: RK21_04248
PVR: PverR02_14655
PKC: PKB_1741
PALK: PSAKL28_05870
PALL: UYA_20205
PUM: HGP31_14965
PLAL: FXN65_03410
PPHN: HU825_05020
PIZ: LAB08_R22480
PKM: PZ739_17315
PKK: QQ992_10210
AVN: Avin_08860(dmpK) Avin_30760(lapK)
AVL: AvCA_08860(dmpK) AvCA_30760(lapK)
AVD: AvCA6_08860(dmpK) AvCA6_30760(lapK)
HPEG: EAO82_09375
HAES: LO767_17620
PPHA: BVH74_06105
MAD: HP15_4024
MSR: AU15_09280 AU15_20715
MLQ: ASQ50_09265
MSQ: BKP64_13900
MARJ: MARI_05330
MALL: PBN92_01620
MSHE: MAALD49_03330 MAALD49_03760(mphK)
MANP: EHN06_02395
PSPG: AK823_07325
PSYG: AK825_07420
ABK: LX00_05890
ABAU: IX87_04535
ACC: BDGL_000476(mphK)
ALC: OTEC02_12940
ASEI: I8T81_12955
ACD: AOLE_13295
AJO: RZ95_18665
ACW: A0J50_11595
ALA: BFG52_10995
ADV: DJ533_01840 DJ533_10990
AWU: BEN71_12680
AGU: AS4_16460(dsoA)
ABER: BSR55_16085
ACHI: CDG60_14295
ATG: J4G44_06360
APOT: MZO21_14060
AFUS: EYZ66_02650
CZA: CYCME_2112
BLEP: AL038_01345
THIS: HZT40_13270
TBN: TBH_C0905
MARS: A8C75_10390
MGEO: CFI10_13985
MSEC: LN244_11625
MRZ: KDW95_03630
NCU: F0U83_03000
NJP: NEJAP_0662(dmpK)
NIK: F5I99_10155
AJP: AMJAP_3011(dmpK)
SINI: GT972_13675
NZO: SAMEA4504057_0437
NCI: NCTC10296_00924
NWD: H3L96_04810
NDU: LVJ88_00545
VFF: VITFI_CDS1381
PTES: JQU52_04815
USU: LVJ78_03615
AQL: BXU06_12750 BXU06_16815
RPI: Rpic_4631
RPF: Rpic12D_3555
RPJ: N234_08105
REH: H16_B0539(poxA)
CNC: CNE_2c04850(poxA)
REU: Reut_A1699 Reut_B5680
RME: Rmet_1331(tomA0) Rmet_1787
CBW: RR42_s2493
CCUP: BKK81_27045
CUP: BKK80_29275
CUU: BKK79_35225
COX: E0W60_07730
CCAX: KZ686_09940
CUK: KB879_20145
BVI: Bcep1808_7593
BUR: Bcep18194_B2971
BCEN: DM39_4844
BCT: GEM_5413
BCED: DM42_5003
BCON: NL30_24650
BDF: WI26_15935
BTEI: WS51_00510
BPSL: WS57_12215
BSTL: BBJ41_10460
BANN: JFN94_19075
BAEN: L3V59_30345
BYI: BYI23_C000570
BUE: BRPE67_CCDS12500
PARB: CJU94_38065
PTER: C2L65_07805
PPK: U875_01950
PRB: X636_07520
CABK: NK8_49930
LIMN: HKT17_03905
BOJ: CBF45_04565
APES: FOC84_00380
AFA: UZ73_17830
AFQ: AFA_08515
AAQU: D3M96_09735
AAMM: FE795_07730
PIG: EGT29_26560
KGY: EHF36_04950
AJS: Ajs_0206
ACID: CBP33_01025
ACIP: CBP36_01135
ACIN: CBP34_01045
ACIS: CBP35_17815
AMON: H9L24_14260
VEI: Veis_2796
VBO: CKY39_28555
CTT: CtCNB1_3162
COF: FOZ74_08250
ADN: Alide_0323
ADK: Alide2_0270
OTD: J1M35_00105
HYL: LPB072_18125
HPSE: HPF_01930
HYN: F9K07_02695
HTN: KI616_02020
DIH: G7047_01730
DRG: H9K76_11585
SIMP: C6571_13565
MELA: C6568_07910
MJE: LVC68_00950
STHM: IS481_10475
SAQA: OMP39_09055
MPT: Mpe_A2285(dmpK) Mpe_A3309(dmpK)
METP: C1M51_06300 C1M51_15460
SNN: EWH46_19270
IDC: LRM40_19510
LCH: Lcho_3363
TMJ: P0M04_30710
DAR: Daro_3797
DEY: HYN24_14275
DDEN: KI615_16945
DECH: GBK02_02775
QAU: KI612_13885
FLE: KI610_15525
AZO: azo1845(lapK) azo2444(poxA)
AOA: dqs_1995 dqs_2588
AZD: CDA09_10250 CDA09_10405
AZR: CJ010_12190 CJ010_15270
TMZ: Tmz1t_3116
THU: AC731_001760
THAU: C4PIVTH_2792
THK: CCZ27_04530 CCZ27_10805
AZQ: G3580_00465 G3580_08205
MTUN: MTUNDRAET4_3880
MLUT: JET14_11640
BVY: NCTC9239_03023
SJP: SJA_C1-11980(tomA0)
SINB: SIDU_08275
SYB: TZ53_09065
SUFL: FIL70_18950
SBAR: H5V43_20600
HTL: HPTL_0057
ACIB: ACBT_0280(dmpK)
AFC: AFAEC_1858(dmpK)
AAQI: AAQM_0969(dmpK)
ACLO: ACLO_a0155(dmpK)
ADZ: ADFLV_2569(dmpK)
ARC: ABLL_2460
AROS: NJU99_01590
ALK: ALEK_0370(dmpK)
AANA: AANAER_1245(dmpK)
AG: BAA23330(dsoA)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
[ppj:RK21_04248]
Reference
PMID:11751810
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence
[bvi:Bcep1808_7593]
LinkDB

KEGG   ORTHOLOGY: K16243
Entry
K16243                      KO                                     
Symbol
dmpL, poxB, tomA1
Name
phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Reaction
R03560  toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R03608  o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R10042  benzene,NADH:oxygen oxidoreductase
R10043  phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
   00623 Toluene degradation
    K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16243  dmpL, poxB, tomA1; phenol/toluene 2-monooxygenase (NADH) P1/A1
Genes
PSD: DSC_04435
RTH: LRK53_10140
RBD: ALSL_0900
PRE: PCA10_06970(dmpL)
PFUW: KF707C_6700(dmpL)
PCQ: PcP3B5_25310(mphL)
PPG: PputGB1_3310
PPJ: RK21_04247
PVR: PverR02_14660
PKC: PKB_1742(dmpL)
PALK: PSAKL28_05880
PALL: UYA_20200
PUM: HGP31_14970
PLAL: FXN65_03415
PPHN: HU825_05015
PIZ: LAB08_R22490
PKM: PZ739_17310
PKK: QQ992_10215
AVN: Avin_08850(dpmL) Avin_30750(lapL)
AVL: AvCA_08850(dpmL) AvCA_30750(lapL)
AVD: AvCA6_08850(dpmL) AvCA6_30750(lapL)
HPEG: EAO82_09380
HAES: LO767_17625
PPHA: BVH74_06110
MAD: HP15_4025
MSR: AU15_09285 AU15_20710
MLQ: ASQ50_09260
MSQ: BKP64_13895
MARJ: MARI_05340(mphL)
MALL: PBN92_01625
MSHE: MAALD49_03340(mphL) MAALD49_03770(mphL)
MANP: EHN06_02400
PSPG: AK823_07320
PSYG: AK825_07415
ABK: LX00_05885
ABAU: IX87_04540
ACC: BDGL_000474(mphL)
ALC: OTEC02_12945
ASEI: I8T81_12960
ACD: AOLE_13300
AJO: RZ95_18660
ACW: A0J50_11600
ALA: BFG52_11000
ADV: DJ533_01835 DJ533_10995
AWU: BEN71_12685
AGU: AS4_16450(dsoB)
ABER: BSR55_16090
ACHI: CDG60_14300
ATG: J4G44_06365
AFUS: EYZ66_02645
CZA: CYCME_2111
THIS: HZT40_13275
TBN: TBH_C0906
MARS: A8C75_10395
MGEO: CFI10_13980
MSEC: LN244_11620
MRZ: KDW95_03635
NCU: F0U83_03005
NJP: NEJAP_0663(dmpL)
NIK: F5I99_10150
AJP: AMJAP_3010(dmpL)
SINI: GT972_13680
NZO: SAMEA4504057_0438(mphL)
NCI: NCTC10296_00923(mphL)
NWD: H3L96_04805
NDU: LVJ88_00550
VFF: VITFI_CDS1382
PTES: JQU52_04820
USU: LVJ78_03620
AQL: BXU06_12755 BXU06_16820
RPI: Rpic_4630
RPF: Rpic12D_3554
RPJ: N234_08110
REH: H16_B0540(poxB)
CNC: CNE_2c04860(poxB)
REU: Reut_A1700 Reut_B5681
RME: Rmet_1330(tomA1) Rmet_1786(phyA)
CBW: RR42_s2492
CCUP: BKK81_27050
CUP: BKK80_29270
CUU: BKK79_35220
COX: E0W60_07735
CCAX: KZ686_09945
CUK: KB879_20150
BVI: Bcep1808_7594
BUR: Bcep18194_B2970
BCEN: DM39_4843(mphL)
BCT: GEM_5412
BCED: DM42_5002(phL)
BCON: NL30_24645
BDF: WI26_15940
BTEI: WS51_00515
BPSL: WS57_12210
BSTL: BBJ41_10465
BANN: JFN94_19080
BAEN: L3V59_30350
BYI: BYI23_C000560
BUE: BRPE67_CCDS12510
BUZ: AYM40_16215
PARB: CJU94_38070
PTER: C2L65_07810
PPK: U875_01945
PRB: X636_07525
CABK: NK8_49940
LIMN: HKT17_03900
BOJ: CBF45_04560
APES: FOC84_00375
CDN: BN940_04361
AFA: UZ73_17835
AFQ: AFA_08520
AAQU: D3M96_09740
AAMM: FE795_07735
PIG: EGT29_26555
KGY: EHF36_04945
AJS: Ajs_0207
ACIP: CBP36_01140
ACIN: CBP34_01050
ACIS: CBP35_17810
AMON: H9L24_14255
VEI: Veis_2795
VBO: CKY39_28550
CTT: CtCNB1_3161
COF: FOZ74_08255
ADN: Alide_0324
ADK: Alide2_0271
OTD: J1M35_00100
HYL: LPB072_18130
HPSE: HPF_01925(mphL)
HYN: F9K07_02700
HTN: KI616_02015
DIH: G7047_01725
DRG: H9K76_11590
SIMP: C6571_13570
MELA: C6568_07905
MJE: LVC68_00955
STHM: IS481_10480
SAQA: OMP39_09060
MPT: Mpe_A2284(dmpL) Mpe_A3308(dmpL)
METP: C1M51_06265 C1M51_06295 C1M51_15455
SNN: EWH46_19265
IDC: LRM40_19515
LCH: Lcho_3362
MASW: AM586_18610
TMJ: P0M04_30705
RBU: PG1C_06905
DAR: Daro_3796
DEY: HYN24_14155 HYN24_14270
DDEN: KI615_16940
DECH: GBK02_02780
QAU: KI612_13880
FLE: KI610_15405 KI610_15520
AZO: azo1846(lapL) azo2443(poxB)
AOA: dqs_1996 dqs_2587
AZD: CDA09_10255 CDA09_10410
AZR: CJ010_12195 CJ010_15265
TMZ: Tmz1t_3115
THU: AC731_001765
THAU: C4PIVTH_2793(dmpL)
THK: CCZ27_04535 CCZ27_10665 CCZ27_10800
AZQ: G3580_00470 G3580_01295 G3580_08210
MTUN: MTUNDRAET4_3881(dmpL)
MAAD: AZF01_11200
MLUT: JET14_11645
BVY: NCTC9239_03024(mphL)
SMY: BJP26_18670
SHAN: PPZ50_08275
SJP: SJA_C1-11990(tomA1)
SINB: SIDU_08270
SYB: TZ53_09070
SUFL: FIL70_18945
SBAR: H5V43_20595
ACIB: ACBT_0279(dmpL)
AFC: AFAEC_1857(dmpL)
AAQI: AAQM_0970(dmpL)
ACLO: ACLO_a0154(dmpL)
ADZ: ADFLV_2568(dmpL)
ARC: ABLL_2459
AROS: NJU99_01595
ALK: ALEK_0371(dmpL)
AANA: AANAER_1246(dmpL)
BACI: B1NLA3E_08455
ASOC: CB4_02441(mphL)
BTS: Btus_0959
KYR: CVV65_10620 CVV65_11340
SAY: TPY_0628
SAP: Sulac_3011
MSA: Mycsm_01964
MLL: B1R94_25115
GOQ: ACH46_03525
GOC: CXX93_06730
GAM: GII34_22060
GSI: P5P27_15510
TOY: FO059_13965
JTE: ASJ30_00060
JLI: EXU32_15405
JME: EEW87_015365
JAY: H7A72_00060
JCR: O9K63_12545
PHW: G7075_13225
AUS: IPK37_11610
RAIN: Rai3103_07195
TCU: Tcur_0524
AACD: LWP59_26125 LWP59_38115
PDX: Psed_0770
PSUU: Psuf_068230(mphL)
AG: BAA23331(dsoB)
 » show all
Reference
PMID:22885747
  Authors
Dalvi S, Azetsu S, Patrauchan MA, Aktas DF, Fathepure BZ
  Title
Proteogenomic elucidation of the initial steps in the benzene degradation pathway of a novel halophile, Arhodomonas sp. strain Rozel, isolated from a hypersaline environment.
  Journal
Appl Environ Microbiol 78:7309-16 (2012)
DOI:10.1128/AEM.01327-12
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
[ppj:RK21_04247]
Reference
PMID:11751810
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence
[bvi:Bcep1808_7594]
LinkDB

KEGG   ORTHOLOGY: K16244
Entry
K16244                      KO                                     
Symbol
dmpM, poxC, tomA2
Name
phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Reaction
R03560  toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R03608  o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R10042  benzene,NADH:oxygen oxidoreductase
R10043  phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
   00623 Toluene degradation
    K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16244  dmpM, poxC, tomA2; phenol/toluene 2-monooxygenase (NADH) P2/A2
Genes
PSD: DSC_04430
RTH: LRK53_10145
RBD: ALSL_0899
PRE: PCA10_06980(dmpM)
PFUW: KF707C_6710(dmpM)
PCQ: PcP3B5_25320(dmpM)
PPG: PputGB1_3309
PPJ: RK21_04246
PVR: PverR02_14665
PKC: PKB_1743
PALK: PSAKL28_05890
PALL: UYA_20195
PUM: HGP31_14975
PLAL: FXN65_03420
PPHN: HU825_05010
PIZ: LAB08_R22500
PKM: PZ739_17305
PKK: QQ992_10220
AVN: Avin_08840(dmpM) Avin_30740(lapM)
AVL: AvCA_08840(dmpM) AvCA_30740(lapM)
AVD: AvCA6_08840(dmpM) AvCA6_30740(lapM)
HPEG: EAO82_09385
HAES: LO767_17630
PPHA: BVH74_06115
MAD: HP15_4026
MSR: AU15_09290 AU15_20705
MLQ: ASQ50_09255
MSQ: BKP64_13890
MARJ: MARI_05350(dmpM)
MALL: PBN92_01630
MSHE: MAALD49_03350(mphM) MAALD49_03780(mphM)
MANP: EHN06_02405
PSPG: AK823_07315
PSYG: AK825_07410
ABK: LX00_05880
ABAU: IX87_04545
ACC: BDGL_000473(mphM)
ALC: OTEC02_12950
ASEI: I8T81_12965
ACD: AOLE_13305
AJO: RZ95_18655
ACW: A0J50_11605
ALA: BFG52_11005
ADV: DJ533_01830 DJ533_11000
AWU: BEN71_12690
AGU: AS4_16440(dsoC)
ABER: BSR55_16095
ACHI: CDG60_14305
ATG: J4G44_06370
AFUS: EYZ66_02640
CZA: CYCME_2110
THIS: HZT40_13280
TBN: TBH_C0907
MARS: A8C75_10400
MGEO: CFI10_13975
MSEC: LN244_11615
MRZ: KDW95_03640
NCU: F0U83_03010
NJP: NEJAP_0664(dmpM)
NIK: F5I99_10145
AJP: AMJAP_3009(dmpM)
SINI: GT972_13685
NZO: SAMEA4504057_0439(dmpM)
NCI: NCTC10296_00922(dmpM)
NWD: H3L96_04800
NDU: LVJ88_00555
VFF: VITFI_CDS1383
PTES: JQU52_04825
USU: LVJ78_03625
AQL: BXU06_12760 BXU06_16825
RPI: Rpic_4629
RPF: Rpic12D_3553
RPJ: N234_08115
REH: H16_B0541(poxC)
CNC: CNE_2c04870(poxC)
REU: Reut_A1701 Reut_B5682
RME: Rmet_1329(tomA2) Rmet_1785(phyB)
CBW: RR42_s2491
CCUP: BKK81_27055
CUP: BKK80_29265
CUU: BKK79_35215
COX: E0W60_07740
CCAX: KZ686_09950
CUK: KB879_20155
BVI: Bcep1808_7595
BUR: Bcep18194_B2969
BCEN: DM39_4842(dmpM)
BCT: GEM_5411
BCED: DM42_5001(dmpM)
BCON: NL30_24640
BDF: WI26_15945
BTEI: WS51_00520
BPSL: WS57_12205
BSTL: BBJ41_10470
BANN: JFN94_19085
BAEN: L3V59_30355
BYI: BYI23_C000550(mmoB_dmpM)
BUE: BRPE67_CCDS12520(mmoB_dmpM)
BUZ: AYM40_16210
PARB: CJU94_38075
PTER: C2L65_07815
PPK: U875_01940
PRB: X636_07530
CABK: NK8_49950
LIMN: HKT17_03895
BOJ: CBF45_04555
APES: FOC84_00370
CDN: BN940_04356
AFA: UZ73_17840
AFQ: AFA_08525
AAQU: D3M96_09745
AAMM: FE795_07740
PIG: EGT29_26550
KGY: EHF36_04940
AJS: Ajs_0208
ACID: CBP33_01035
ACIP: CBP36_01145
ACIN: CBP34_01055
ACIS: CBP35_17805
AMON: H9L24_14250
VEI: Veis_2794
VBO: CKY39_28545
CTT: CtCNB1_3160
COF: FOZ74_08260
ADN: Alide_0325
ADK: Alide2_0272
OTD: J1M35_00095
HYL: LPB072_18135
HPSE: HPF_01920(dmpM)
HYN: F9K07_02705
HTN: KI616_02010
DIH: G7047_01720
DRG: H9K76_11595
SIMP: C6571_13575
MELA: C6568_07900
MJE: LVC68_00960
STHM: IS481_10485
SAQA: OMP39_09065
MPT: Mpe_A2283(dmpM) Mpe_A3307(dmpM)
METP: C1M51_06290 C1M51_15450
SNN: EWH46_19260
IDC: LRM40_19520
LCH: Lcho_3361
MASW: AM586_18615
TMJ: P0M04_30700
RBU: PG1C_06900
DAR: Daro_3795
DEY: HYN24_14150 HYN24_14265
DDEN: KI615_16935
DECH: GBK02_02785
QAU: KI612_13875
FLE: KI610_15400 KI610_15515
AZO: azo1847(lapM) azo2442(poxC)
AOA: dqs_1997 dqs_2586
AZD: CDA09_10260 CDA09_10415
AZR: CJ010_12200 CJ010_15260
TMZ: Tmz1t_3114
THU: AC731_001770
THAU: C4PIVTH_2794(dmpM)
THK: CCZ27_04540 CCZ27_10670 CCZ27_10795
AZQ: G3580_00475 G3580_01300 G3580_08215
MTUN: MTUNDRAET4_3882(dmpM)
MAAD: AZF01_11205
MLUT: JET14_11650
BVY: NCTC9239_03025(dmpM)
SMY: BJP26_18675
SHAN: PPZ50_08280
SJP: SJA_C1-12000(tomA2)
SINB: SIDU_08265
SYB: TZ53_09075
SUFL: FIL70_18940
SBAR: H5V43_20590
ACIB: ACBT_0278(dmpM)
AFC: AFAEC_1856(dmpM)
AAQI: AAQM_0971(dmpM)
ACLO: ACLO_a0153(dmpM)
ADZ: ADFLV_2567(dmpM)
ARC: ABLL_2458
AROS: NJU99_01600
ALK: ALEK_0372(dmpM)
AANA: AANAER_1247(dmpM)
BACI: B1NLA3E_08460
ASOC: CB4_02442(dmpM)
BTS: Btus_0960
KYR: CVV65_10615 CVV65_11335
SAY: TPY_0629
SAP: Sulac_3010
MSA: Mycsm_01965
MLL: B1R94_25110
MMAG: MMAD_31790
MCRO: MI149_22720
GOQ: ACH46_03530
GOC: CXX93_06735
GAM: GII34_22055
GSI: P5P27_15505
TOY: FO059_13970
JTE: ASJ30_00065
JLI: EXU32_15400
JME: EEW87_015370
JAY: H7A72_00065
JCR: O9K63_12550
RAIN: Rai3103_07190
NMES: H9L09_04340
TCU: Tcur_0525
AACD: LWP59_26120 LWP59_38110
PDX: Psed_0769
PSUU: Psuf_068240
AG: BAA23332(dsoC)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
[ppj:RK21_04246]
Reference
PMID:11751810
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence
[bvi:Bcep1808_7595]
LinkDB

KEGG   ORTHOLOGY: K16242
Entry
K16242                      KO                                     
Symbol
dmpN, poxD, tomA3
Name
phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Reaction
R03560  toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R03608  o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R10042  benzene,NADH:oxygen oxidoreductase
R10043  phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
   00623 Toluene degradation
    K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16242  dmpN, poxD, tomA3; phenol/toluene 2-monooxygenase (NADH) P3/A3
Genes
PSD: DSC_04425
RTH: LRK53_10150
RBD: ALSL_0898
PRE: PCA10_06990(dmpN)
PFUW: KF707C_6720(dmpN)
PCQ: PcP3B5_25330(tmoA)
PPG: PputGB1_3308
PPJ: RK21_04244 RK21_04245
PVR: PverR02_14670
PKC: PKB_1744(dmpN)
PALK: PSAKL28_05900
PALL: UYA_20190
PUM: HGP31_14980
PLAL: FXN65_03425
PPHN: HU825_05005
PIZ: LAB08_R22510
PKM: PZ739_17300
PKK: QQ992_10225
AVN: Avin_08830(dmpN) Avin_30730(lapN)
AVL: AvCA_08830(dmpN) AvCA_30730(lapN)
AVD: AvCA6_08830(dmpN) AvCA6_30730(lapN)
HPEG: EAO82_09390
HAES: LO767_17635
PPHA: BVH74_06120
MAD: HP15_4027
MLQ: ASQ50_09250
MSQ: BKP64_13885
MARJ: MARI_05360(tmoA)
MALL: PBN92_01635
MSHE: MAALD49_03360(mphN) MAALD49_03790(mphN)
MANP: EHN06_02410
PSPG: AK823_07310
PSYG: AK825_07405
ABK: LX00_05875
ABAU: IX87_04550
ACC: BDGL_000472(mphN)
ALC: OTEC02_12955
ASEI: I8T81_12970
ACD: AOLE_13310
AJO: RZ95_18650
ACW: A0J50_11610
ALA: BFG52_11010
ADV: DJ533_01825 DJ533_11005
AWU: BEN71_12695
AGU: AS4_16430(dsoD)
ABER: BSR55_16100
ACHI: CDG60_14310
ATG: J4G44_06375
AFUS: EYZ66_02635
CZA: CYCME_2109
BLEP: AL038_01335
THIS: HZT40_13285
TBN: TBH_C0908
MARS: A8C75_10405
MGEO: CFI10_13970
MSEC: LN244_11610
MRZ: KDW95_03645
NCU: F0U83_03015
NJP: NEJAP_0665(dmpN)
NIK: F5I99_10140
AJP: AMJAP_3008(dmpN)
SINI: GT972_13690
NZO: SAMEA4504057_0440(tmoA)
NCI: NCTC10296_00921(tmoA)
NWD: H3L96_04795
NDU: LVJ88_00560
VFF: VITFI_CDS1384
PTES: JQU52_04830
USU: LVJ78_03630
AQL: BXU06_12765 BXU06_16830
RPI: Rpic_4628
RPF: Rpic12D_3552
RPJ: N234_08120
REH: H16_B0542(poxD)
CNC: CNE_2c04880(poxD)
REU: Reut_A1702 Reut_B5683
RME: Rmet_1328(tomA3) Rmet_1784(phyC)
CBW: RR42_s2490
CCUP: BKK81_27060
CUP: BKK80_29260
CUU: BKK79_35210
COX: E0W60_07745
CCAX: KZ686_09955
CUK: KB879_20160
BVI: Bcep1808_7596
BUR: Bcep18194_B2968
BCEN: DM39_4841(phN)
BCT: GEM_5410
BCED: DM42_5000(phN)
BCON: NL30_24635
BDF: WI26_15950
BTEI: WS51_00525
BPSL: WS57_12200
BSTL: BBJ41_10475
BANN: JFN94_19090
BAEN: L3V59_30360
BYI: BYI23_C000540
BUE: BRPE67_CCDS12530
BUZ: AYM40_16205
PARB: CJU94_38080
PTER: C2L65_07820
PPK: U875_01935
PRB: X636_07535
CABK: NK8_49960
LIMN: HKT17_03890
BOJ: CBF45_04550
APES: FOC84_00365
CDN: BN940_04351
AFA: UZ73_17845
AFQ: AFA_08530
AAQU: D3M96_09750
AAMM: FE795_07745
PIG: EGT29_26545
KGY: EHF36_04935
AJS: Ajs_0209
ACIP: CBP36_01150
ACIN: CBP34_01060
ACIS: CBP35_17800
AMON: H9L24_14245
VEI: Veis_2793
VBO: CKY39_28540
CTT: CtCNB1_3159
COF: FOZ74_08265
ADN: Alide_0326
ADK: Alide2_0273
OTD: J1M35_00090
HYL: LPB072_18140
HPSE: HPF_01915(tmoA2)
HYN: F9K07_02710
HTN: KI616_02005
DIH: G7047_01715
DRG: H9K76_11600
SIMP: C6571_13580
MELA: C6568_07895
MJE: LVC68_00965
STHM: IS481_10490
SAQA: OMP39_09070
MPT: Mpe_A2282(dmpN) Mpe_A3306(dmpN)
METP: C1M51_06260 C1M51_06285 C1M51_15445
SNN: EWH46_19255
IDC: LRM40_19525
LCH: Lcho_3360
MASW: AM586_18620
TMJ: P0M04_30695
RBU: PG1C_06895
DAR: Daro_3794
DEY: HYN24_14145 HYN24_14260
DDEN: KI615_16930
DECH: GBK02_02790
QAU: KI612_13870
FLE: KI610_15395 KI610_15510
AZO: azo1848(lapN) azo2441(poxD)
AOA: dqs_1998 dqs_2585
AZD: CDA09_10265 CDA09_10420
AZR: CJ010_12205 CJ010_15255
TMZ: Tmz1t_3113
THU: AC731_001775
THAU: C4PIVTH_2795(dmpN)
THK: CCZ27_04545 CCZ27_10675 CCZ27_10790
AZQ: G3580_00480 G3580_01305 G3580_08220
MTUN: MTUNDRAET4_3883
MAAD: AZF01_11210
MLUT: JET14_11655
BVY: NCTC9239_03026(tmoA)
SMY: BJP26_18680
SHAN: PPZ50_08285
SJP: SJA_C1-12010(tomA3)
SINB: SIDU_08260
SYB: TZ53_09080
SUFL: FIL70_18935
SBAR: H5V43_20585
ACIB: ACBT_0277(dmpN)
AFC: AFAEC_1855(dmpN)
AAQI: AAQM_0972(dmpN)
ACLO: ACLO_a0152(dmpN)
ADZ: ADFLV_2566(dmpN)
ARC: ABLL_2457
AROS: NJU99_01605
ALK: ALEK_0373(dmpN)
AANA: AANAER_1248(dmpN)
BACI: B1NLA3E_08465
ASOC: CB4_02443(tmoA)
BTS: Btus_0961
KYR: CVV65_10610 CVV65_11330
SAY: TPY_0630
SAP: Sulac_3009
MSA: Mycsm_01966
MMAG: MMAD_31810(mphN)
MCRO: MI149_22730
GOQ: ACH46_03535
GOC: CXX93_06740
GAM: GII34_22050
GSI: P5P27_15500
TOY: FO059_13975
JTE: ASJ30_00070
JLI: EXU32_15395
JME: EEW87_015375
JAY: H7A72_00070
JCR: O9K63_12555
PHW: G7075_13215
AUS: IPK37_11620
RAIN: Rai3103_07185
TCU: Tcur_0526
AACD: LWP59_26115 LWP59_38105
PDX: Psed_0768
PSUU: Psuf_068250(mphN)
AG: BAA23333(dsoD)
 » show all
Reference
PMID:22885747
  Authors
Dalvi S, Azetsu S, Patrauchan MA, Aktas DF, Fathepure BZ
  Title
Proteogenomic elucidation of the initial steps in the benzene degradation pathway of a novel halophile, Arhodomonas sp. strain Rozel, isolated from a hypersaline environment.
  Journal
Appl Environ Microbiol 78:7309-16 (2012)
DOI:10.1128/AEM.01327-12
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
[ppj:RK21_04245]
Reference
PMID:11751810
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence
[bvi:Bcep1808_7596]
LinkDB

KEGG   ORTHOLOGY: K16245
Entry
K16245                      KO                                     
Symbol
dmpO, poxE, tomA4
Name
phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Reaction
R03560  toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R03608  o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R10042  benzene,NADH:oxygen oxidoreductase
R10043  phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
   00623 Toluene degradation
    K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16245  dmpO, poxE, tomA4; phenol/toluene 2-monooxygenase (NADH) P4/A4
Genes
PSD: DSC_04420
RTH: LRK53_10155
RBD: ALSL_0897
PRE: PCA10_07000(dmpO)
PFUW: KF707C_6730(dmpO)
PCQ: PcP3B5_25340
PPG: PputGB1_3307
PPJ: RK21_04243
PVR: PverR02_14675
PKC: PKB_1745
PALK: PSAKL28_05910
PALL: UYA_20185
PUM: HGP31_14985
PLAL: FXN65_03430
PPHN: HU825_05000
PIZ: LAB08_R22520
PKM: PZ739_17295
PKK: QQ992_10230
AVN: Avin_08820(dmpO) Avin_30720(lapO)
AVL: AvCA_08820(dmpO) AvCA_30720(lapO)
AVD: AvCA6_08820(dmpO) AvCA6_30720(lapO)
HPEG: EAO82_09395
HAES: LO767_17640
PPHA: BVH74_06125
MAD: HP15_4028
MSR: AU15_20695
MLQ: ASQ50_09245
MSQ: BKP64_13880
MARJ: MARI_05370
MALL: PBN92_01640
MSHE: MAALD49_03370(mphO) MAALD49_03800(mphO)
MANP: EHN06_02415
PSPG: AK823_07305
PSYG: AK825_07400
ABK: LX00_05870
ABAU: IX87_04555
ACC: BDGL_000471(mphO)
ALC: OTEC02_12960
ASEI: I8T81_12975
ACD: AOLE_13315
AJO: RZ95_18645
ACW: A0J50_11615
ALA: BFG52_11015
ADV: DJ533_01820 DJ533_11010
AWU: BEN71_12700
AGU: AS4_16420(dsoE)
ABER: BSR55_16105
ACHI: CDG60_14315
ATG: J4G44_06380
ACIU: A3K93_13810
AFUS: EYZ66_02630
CZA: CYCME_2108
BLEP: AL038_01330
THIS: HZT40_13290
TBN: TBH_C0909
MARS: A8C75_10410
MGEO: CFI10_13965
MSEC: LN244_11605
MRZ: KDW95_03650
NCU: F0U83_03020
NJP: NEJAP_0666(dmpO)
NIK: F5I99_10135
AJP: AMJAP_3007(dmpO)
SINI: GT972_13695
NZO: SAMEA4504057_0441
NCI: NCTC10296_00920
NWD: H3L96_04790
NDU: LVJ88_00565
VFF: VITFI_CDS1385
PTES: JQU52_04835
USU: LVJ78_03635
AQL: BXU06_12770 BXU06_16835
RPI: Rpic_4627
RPF: Rpic12D_3551
RPJ: N234_08125
REH: H16_B0543(poxE)
CNC: CNE_2c04890(poxE)
REU: Reut_A1703 Reut_B5684
RME: Rmet_1327(tomA4) Rmet_1783(phyD)
CBW: RR42_s2489
CCUP: BKK81_27065
CUP: BKK80_29255
CUU: BKK79_35205
COX: E0W60_07750
CCAX: KZ686_09960
CUK: KB879_20165
BVI: Bcep1808_7597
BUR: Bcep18194_B2967
BCEN: DM39_4840(phO)
BCT: GEM_5409
BCED: DM42_4999(phO)
BCON: NL30_24630
BDF: WI26_15955
BTEI: WS51_00530
BPSL: WS57_12195
BSTL: BBJ41_10480
BANN: JFN94_19095
BAEN: L3V59_30365
BYI: BYI23_C000530
BUE: BRPE67_CCDS12540
BUZ: AYM40_16200
PARB: CJU94_38085
PTER: C2L65_07825
PPK: U875_01930
PRB: X636_07540
CABK: NK8_49970
LIMN: HKT17_03885
BOJ: CBF45_04545
APES: FOC84_00360
CDN: BN940_04346
AFA: UZ73_17850
AFQ: AFA_08535
AAQU: D3M96_09755
AAMM: FE795_07750
PIG: EGT29_26540
KGY: EHF36_04930
AJS: Ajs_0210
ACID: CBP33_01055
ACIP: CBP36_01155
ACIN: CBP34_01065
ACIS: CBP35_17795
AMON: H9L24_14240
VEI: Veis_2792
CTT: CtCNB1_3158
COF: FOZ74_08270
ADN: Alide_0327
ADK: Alide2_0274
OTD: J1M35_00085
HYL: LPB072_18145
HPSE: HPF_01910(tbuD)
HYN: F9K07_02715
HTN: KI616_02000
DIH: G7047_01710
DRG: H9K76_11605
SIMP: C6571_13585
MELA: C6568_07890
MJE: LVC68_00970
STHM: IS481_10495
SAQA: OMP39_09075
MPT: Mpe_A2281(dmpO) Mpe_A3305(dmpO)
METP: C1M51_06255 C1M51_06280 C1M51_15440
SNN: EWH46_19250
IDC: LRM40_19530
LCH: Lcho_3359
MASW: AM586_18625
TMJ: P0M04_30690
RBU: PG1C_06890
DAR: Daro_3793
DEY: HYN24_14140 HYN24_14255
DDEN: KI615_16925
DECH: GBK02_02795
QAU: KI612_13865
FLE: KI610_15390 KI610_15505
AZO: azo1849(lapO) azo2440(poxE)
AOA: dqs_1999 dqs_2584
AZD: CDA09_10270 CDA09_10425
AZR: CJ010_12210 CJ010_15250
TMZ: Tmz1t_3112
THU: AC731_001780
THAU: C4PIVTH_2796(dmpO)
THK: CCZ27_10680 CCZ27_10785
AZQ: G3580_00485 G3580_01310 G3580_08225
MTUN: MTUNDRAET4_3885
MAAD: AZF01_11215
MLUT: JET14_11660
SMY: BJP26_18685
SHAN: PPZ50_08290
SJP: SJA_C1-12020(tomA4)
SINB: SIDU_08255
SYB: TZ53_09085
SUFL: FIL70_18930
SBAR: H5V43_20580
ACIB: ACBT_0276(dmpO)
AFC: AFAEC_1854(dmpO)
AAQI: AAQM_0973(dmpO)
ACLO: ACLO_a0151(dmpO)
ADZ: ADFLV_2565(dmpO)
ARC: ABLL_2456
AROS: NJU99_01610
ALK: ALEK_0374(dmpO)
AANA: AANAER_1249(dmpO)
SAY: TPY_0631
SAP: Sulac_3008
MSA: Mycsm_01967
MLL: B1R94_25100
GOQ: ACH46_03540
GOC: CXX93_06745
GAM: GII34_22045
GSI: P5P27_15495
TOY: FO059_13980
JTE: ASJ30_00075
JLI: EXU32_15390
JME: EEW87_015380
JCR: O9K63_12560
PHW: G7075_13210
AUS: IPK37_11625
TCU: Tcur_0527
AACD: LWP59_26110 LWP59_38100
PDX: Psed_0767
AG: BAA23334(dsoE)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
[ppj:RK21_04243]
Reference
PMID:11751810
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence
[bvi:Bcep1808_7597]
LinkDB

KEGG   ORTHOLOGY: K16246
Entry
K16246                      KO                                     
Symbol
dmpP, poxF, tomA5
Name
phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
Pathway
map00361  Chlorocyclohexane and chlorobenzene degradation
map00362  Benzoate degradation
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00548  Benzene degradation, benzene => catechol
Reaction
R03560  toluene,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R03608  o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
R10042  benzene,NADH:oxygen oxidoreductase
R10043  phenol,NADH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
   00361 Chlorocyclohexane and chlorobenzene degradation
    K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
   00623 Toluene degradation
    K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243  toluene 2-monooxygenase
     K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
    1.14.13.244  phenol 2-monooxygenase (NADH)
     K16246  dmpP, poxF, tomA5; phenol/toluene 2-monooxygenase (NADH) P5/A5
Other DBs
COG: COG0543 COG0633
Genes
PSD: DSC_04415
RTH: LRK53_10245
RBD: ALSL_0896
PRE: PCA10_07010(dmpP)
PFUW: KF707C_6740(dmpP)
PCQ: PcP3B5_25350(dmpP)
PPG: PputGB1_3306
PPJ: RK21_04242
PVR: PverR02_14680
PKC: PKB_1746(dmpP)
PALK: PSAKL28_05920
PALL: UYA_20180
PUM: HGP31_14990
PLAL: FXN65_03435
PPHN: HU825_04995
PIZ: LAB08_R22530
PKM: PZ739_17290
PKK: QQ992_10235
AVN: Avin_08810(dmpP) Avin_30710(lapP)
AVL: AvCA_08810(dmpP) AvCA_30710(lapP)
AVD: AvCA6_08810(dmpP) AvCA6_30710(lapP)
HPEG: EAO82_09400
HAES: LO767_17645
PPHA: BVH74_06130
MAD: HP15_4029
MSR: AU15_09305 AU15_20690
MLQ: ASQ50_09240
MSQ: BKP64_13875
MARJ: MARI_05380(dmpP)
MALL: PBN92_01645
MSHE: MAALD49_03380(mphP) MAALD49_03810(mphP)
MANP: EHN06_02420
PSPG: AK823_07300
PSYG: AK825_07395
ABK: LX00_05865
ABAU: IX87_04560
ACC: BDGL_000470(mphP)
ALC: OTEC02_12965
ASEI: I8T81_12980
ACD: AOLE_13320
AJO: RZ95_18640
ACW: A0J50_11620
ALA: BFG52_11020
ADV: DJ533_01815 DJ533_11015
AWU: BEN71_12705
AGU: AS4_16410(dsoF)
ABER: BSR55_16110
ACHI: CDG60_14320
ATG: J4G44_06385
AFUS: EYZ66_02625
CZA: CYCME_2107
BLEP: AL038_01325
THIS: HZT40_13300
TBN: TBH_C0910
MARS: A8C75_10415
MGEO: CFI10_13960
MSEC: LN244_11600
MRZ: KDW95_03655
NCU: F0U83_03025
NJP: NEJAP_0667(dmpP)
NIK: F5I99_10130
AJP: AMJAP_3006(dmpP)
SINI: GT972_13700
NZO: SAMEA4504057_0442(mphP)
NCI: NCTC10296_00919(mphP)
NWD: H3L96_04785
NDU: LVJ88_00570
VFF: VITFI_CDS1386
PTES: JQU52_04840
USU: LVJ78_03640
AQL: BXU06_12775 BXU06_16840
RPI: Rpic_4626
RPF: Rpic12D_3550
RPJ: N234_08130
REH: H16_B0544(poxF)
CNC: CNE_2c04900(poxF)
REU: Reut_A1704 Reut_B5685
RME: Rmet_1326(tomA5) Rmet_1782(phyE)
CBW: RR42_s2488
CCUP: BKK81_27070
CUP: BKK80_29250
CUU: BKK79_35200
COX: E0W60_07755
CCAX: KZ686_09965
CUK: KB879_20170
BVI: Bcep1808_7598
BUR: Bcep18194_B2966
BCEN: DM39_4839(dmpP)
BCT: GEM_5408
BCED: DM42_4998(dmpP)
BCON: NL30_24625
BDF: WI26_15960
BTEI: WS51_00535
BPSL: WS57_12190
BSTL: BBJ41_10485
BANN: JFN94_19100
BAEN: L3V59_30370
BYI: BYI23_C000520
BUE: BRPE67_CCDS12550
BUZ: AYM40_16195
PARB: CJU94_38090
PTER: C2L65_07830
PPK: U875_01925
PRB: X636_07545
CABK: NK8_49980
LIMN: HKT17_03880
BOJ: CBF45_04540
APES: FOC84_00355
CDN: BN940_04341
AFA: UZ73_17855
AFQ: AFA_08540
AAQU: D3M96_09760
AAMM: FE795_07755
PIG: EGT29_26535
KGY: EHF36_04925
AJS: Ajs_0211
ACID: CBP33_01060
ACIP: CBP36_01160
ACIN: CBP34_01070
ACIS: CBP35_17790
AMON: H9L24_14235
VEI: Veis_2791
VBO: CKY39_28530
CTT: CtCNB1_3157
COF: FOZ74_08275
ADN: Alide_0328
ADK: Alide2_0275
OTD: J1M35_00080
HYL: LPB072_18150
HPSE: HPF_01905(dmpP)
HYN: F9K07_02720
HTN: KI616_01995
DIH: G7047_01705
DRG: H9K76_11610
SIMP: C6571_13590
MELA: C6568_07885
MJE: LVC68_00975
STHM: IS481_10500
SAQA: OMP39_09080
MPT: Mpe_A2280(dmpP)
METP: C1M51_06275
SNN: EWH46_19245
IDC: LRM40_19535
LCH: Lcho_3358
MASW: AM586_18630
TMJ: P0M04_30685
RBU: PG1C_06885
DAR: Daro_3792
DEY: HYN24_14250
DDEN: KI615_16920
DECH: GBK02_02800
QAU: KI612_13860
FLE: KI610_15500
AZO: azo1850(lapP) azo2439(poxF)
AOA: dqs_2000 dqs_2583
AZD: CDA09_10275 CDA09_10430
AZR: CJ010_12215 CJ010_15245
TMZ: Tmz1t_3111
THU: AC731_001785
THAU: C4PIVTH_2797(dmpP)
THK: CCZ27_04555 CCZ27_10685 CCZ27_10780
AZQ: G3580_00490 G3580_08230
STEG: QA637_22950
MTUN: MTUNDRAET4_3886(dmpP)
MAAD: AZF01_11220
MLUT: JET14_11665
SMY: BJP26_18690
SHAN: PPZ50_08295
SJP: SJA_C1-12030(tomA5)
SINB: SIDU_08250
SYB: TZ53_09090
SUFL: FIL70_18925
SBAR: H5V43_20575
ACIB: ACBT_0275(dmpP)
AFC: AFAEC_1853(dmpP)
AAQI: AAQM_0974(dmpP)
ACLO: ACLO_a0150(dmpP)
ADZ: ADFLV_2564(dmpP)
ARC: ABLL_2455
AROS: NJU99_01615
ALK: ALEK_0375(dmpP)
AANA: AANAER_1250(dmpP)
SAY: TPY_0634(benC)
SAP: Sulac_3005
MSA: Mycsm_01968
MHIB: MHIB_39890(mphP)
CCYC: SCMU_04650(mphP)
ROZ: CBI38_31750 CBI38_32160 CBI38_32255
GOQ: ACH46_03545
GOC: CXX93_06750
GAM: GII34_22040
GSI: P5P27_15490
TOY: FO059_13985
JTE: ASJ30_00080
JLI: EXU32_15385
JME: EEW87_015385
JAY: H7A72_00080
JCR: O9K63_12565
PHW: G7075_13205
AUS: IPK37_11640
RAIN: Rai3103_07175
TCU: Tcur_0530
AACD: LWP59_26105 LWP59_38095
PDX: Psed_0766
PSUU: Psuf_068280(mphP)
COY: HF329_27145
CFIL: MYF79_02125
CHOR: MKQ68_23840
NKF: Nkreftii_004063
AG: BAA23335(dsoF)
 » show all
Reference
PMID:2254258
  Authors
Nordlund I, Powlowski J, Shingler V
  Title
Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.
  Journal
J Bacteriol 172:6826-33 (1990)
DOI:10.1128/jb.172.12.6826-6833.1990
  Sequence
[ppj:RK21_04242]
Reference
PMID:11751810
  Authors
Canada KA, Iwashita S, Shim H, Wood TK
  Title
Directed evolution of toluene ortho-monooxygenase for enhanced 1-naphthol synthesis and chlorinated ethene degradation.
  Journal
J Bacteriol 184:344-9 (2002)
DOI:10.1128/jb.184.2.344-349.2002
  Sequence
[bvi:Bcep1808_7598]
LinkDB

KEGG   REACTION: R03608
Entry
R03608                      Reaction                               
Name
o-cresol,NADH:oxygen oxidoreductase (2,3-dihydroxylating)
Definition
o-Cresol + Oxygen + NADH + H+ <=> 2,3-Dihydroxytoluene + NAD+ + H2O
Equation
C01542 + C00007 + C00004 + C00080 <=> C02923 + C00003 + C00001
Reaction class
RC00001  C00005_C00006
RC00046  C01542_C02923
Enzyme
1.14.13.243
Pathway
rn00623  Toluene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.243
     R03608  o-Cresol + Oxygen + NADH + H+ <=> 2,3-Dihydroxytoluene + NAD+ + H2O
Orthology
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
K16249  phenol/toluene 2-monooxygenase (NADH) P0/A0
LinkDB

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