KEGG   ORTHOLOGY: K16305
Entry
K16305                      KO                                     
Symbol
K16305
Name
fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00030  Pentose phosphate pathway
map00051  Fructose and mannose metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00030 Pentose phosphate pathway
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00051 Fructose and mannose metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.11  6-deoxy-5-ketofructose 1-phosphate synthase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Other DBs
RN: R01068 R01070 R02568 R10049 R10050
COG: COG1830
GO: 0004332
Genes
SSEI: FJR45_02715
EGD: GS424_017090
AHAT: ADCFC_22570
RTS: CE91St31_04870
MKC: kam1_189
BVO: Pan97_15820(fbaB)
ASAC: ATHSA_0473
MJA: MJ_1585
MFE: Mefer_0658
MVU: Metvu_0368
MMP: MMP0293
MMD: GYY_01500
MMAK: MMKA1_03000(fba)
MMAO: MMOS7_03270(fba)
MMAD: MMJJ_07650(fbaB)
MAE: Maeo_0690
MVO: Mvol_1341
MBAR: MSBR2_2738
MBAK: MSBR3_2683
MMA: MM_0714
MMAC: MSMAC_0605
METM: MSMTP_0658
MTHR: MSTHT_2315
MTHE: MSTHC_0965
MHOR: MSHOH_0711
MPY: Mpsy_1203
MTP: Mthe_0380
MHI: Mhar_2267
MHU: Mhun_1466
MLA: Mlab_1135
MEMA: MMAB1_2969
MPI: Mpet_1339
MPL: Mpal_0799
 » show all
Reference
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
LinkDB

KEGG   ENZYME: 2.2.1.11
Entry
EC 2.2.1.11                 Enzyme                                 
Name
6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
Sysname
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Reaction(IUBMB)
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]
Reaction(KEGG)
R10049 R10050
Substrate
2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.11 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Genes
SSEIFJR45_02715
EGDGS424_017090
AHATADCFC_22570
RTSCE91St31_04870
MKCkam1_189
BVOPan97_15820(fbaB)
ASACATHSA_0473
MJAMJ_1585
MFEMefer_0658
MVUMetvu_0368
MFSMFS40622_0194
MIFMetin_0355
MJHJH146_0289
MESGMLAUSG7_0763
MESAMLASG1_0429
MIGMetig_0068
MMPMMP0293
MMQMmarC5_1380
MMXMmarC6_0660
MMZMmarC7_1296
MMDGYY_01500
MMAKMMKA1_03000(fba)
MMAOMMOS7_03270(fba)
MMADMMJJ_07650(fbaB)
MAEMaeo_0690
MVNMevan_1304
MVOMvol_1341
MOKMetok_1121
MBAMbar_A0176 Mbar_A2224
MBYMSBRM_2208 MSBRM_2781
MBWMSBRW_0821 MSBRW_2524
MBARMSBR2_2738
MBAKMSBR3_2683
MACMA_2666 MA_3889
MMAMM_0714
MMAZMmTuc01_0735
MMJMSMAS_0603
MMACMSMAC_0605
MVCMSVAZ_0963
MEKMSKOL_0932
MLSMSLAZ_0625
METMMSMTP_0658
MEFMSWH1_0770
MEQMSWHS_0822
MSJMSSAC_1781 MSSAC_3626
MSZMSSIH_3164
MSWMSSIT_3238
MTHRMSTHT_2315
MTHEMSTHC_0965
MHORMSHOH_0711
MFZAOB57_003890
MPYMpsy_1203
MZIHWN40_02565
MHZMetho_0427
MTPMthe_0380
MHIMhar_2267
MHUMhun_1466
MRTJKHC33_07445
MLAMlab_1135
MEMMemar_1367
MBGBN140_2246
MEMAMMAB1_2969
MCHKMchiMG62_15630
MPIMpet_1339
MPLMpal_0799
 » show all
Reference
1  [PMID:17014089]
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.11
IUBMB Enzyme Nomenclature: 2.2.1.11
ExPASy - ENZYME nomenclature database: 2.2.1.11
BRENDA, the Enzyme Database: 2.2.1.11
LinkDB

KEGG   REACTION: R10049
Entry
R10049                      Reaction                               
Name
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Definition
Methylglyoxal + D-Fructose 1,6-bisphosphate <=> D-Glyceraldehyde 3-phosphate + 6-Deoxy-5-ketofructose 1-phosphate
Equation
Reaction class
RC00439  C00118_C00354
RC02301  C00546_C16848
RC03034  C00354_C16848
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Other DBs
RHEA: 31914
LinkDB

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