KEGG   ORTHOLOGY: K16305
Entry
K16305                      KO                                     
Symbol
K16305
Name
fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Pathway
map00010  Glycolysis / Gluconeogenesis
map00030  Pentose phosphate pathway
map00051  Fructose and mannose metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Reaction
R01068  D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
R01070  beta-D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
R02568  D-fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
R10049  2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
R10050  2-oxopropanal:D-fructose 1-phosphate glycerone-phosphotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00030 Pentose phosphate pathway
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
   00051 Fructose and mannose metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.11  6-deoxy-5-ketofructose 1-phosphate synthase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.13  fructose-bisphosphate aldolase
     K16305  K16305; fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Other DBs
COG: COG1830
GO: 0004332
Genes
AAEO: BJI67_06825
AFY: BW247_04500
TIN: Tint_0447
THI: THI_0524
AFR: AFE_1802
AFE: Lferr_1479
ACU: Atc_1531
ACZ: Acaty_c1299
AFI: Acife_0795 Acife_2018
AFJ: AFERRID_27730
AFP: K1Y48_06025 K1Y48_10460
ACIY: MQE22_05275
SUA: Saut_0463
SPAL: FM071_05630
SSEI: FJR45_02715
HYO: NNO_1235
HCJ: HCR_00780
NSA: Nitsa_0969
SUN: SUN_1211(fbaB)
SLH: YH65_05870
NIS: NIS_0927
NAP: C3L23_03955
CPAF: C6V80_04545
DPS: DP2457
AAUT: ACETAC_00835
CCU: Ccur_03540
SHI: Shel_19790
ELE: Elen_2983
EYY: EGYY_28100
EGD: GS424_017090
AEQ: AEQU_1983
AHAT: ADCFC_22570
DDT: AAY81_07945
CBAC: JI75_01080
BWA: HLV38_04495
RTS: CE91St31_04870
EBZ: J7S26_07675
MIN: Minf_2129(fbaB)
MKC: kam1_189
MFH: MFUM_0234
MCAO: IT6_05205
MEAP: MTHMO_0280(fba)
BVO: Pan97_15820(fbaB)
GAX: Pan161_52870(fbaB)
HYA: HY04AAS1_0176
HHO: HydHO_0183
HYS: HydSN_0190
ASAC: ATHSA_0473
LFC: LFE_2179
LFI: LFML04_1323
LFP: Y981_06425
LEG: ABH19_06865
FBN: HY931_01465
MJA: MJ_1585
MFE: Mefer_0658
MVU: Metvu_0368
MFS: MFS40622_0194
MIF: Metin_0355
MJH: JH146_0289
MESG: MLAUSG7_0763
MESA: MLASG1_0429
MIG: Metig_0068
MMP: MMP0293
MMQ: MmarC5_1380
MMX: MmarC6_0660
MMZ: MmarC7_1296
MMD: GYY_01500
MMAK: MMKA1_03000(fba)
MMAO: MMOS7_03270(fba)
MMAD: MMJJ_07650(fbaB)
MAE: Maeo_0690
MVN: Mevan_1304
MVO: Mvol_1341
MOK: Metok_1121
MBA: Mbar_A0176 Mbar_A2224
MBY: MSBRM_2208 MSBRM_2781
MBW: MSBRW_0821 MSBRW_2524
MBAR: MSBR2_2738
MBAK: MSBR3_2683
MAC: MA_2666 MA_3889
MMA: MM_0714
MMAZ: MmTuc01_0735
MMJ: MSMAS_0603
MMAC: MSMAC_0605
MVC: MSVAZ_0963
MEK: MSKOL_0932
MLS: MSLAZ_0625
METM: MSMTP_0658
MEF: MSWH1_0770
MEQ: MSWHS_0822
MSJ: MSSAC_1781 MSSAC_3626
MSZ: MSSIH_3164
MSW: MSSIT_3238
MTHR: MSTHT_2315
MTHE: MSTHC_0965
MHOR: MSHOH_0711
MFZ: AOB57_003890
MPY: Mpsy_1203
MZI: HWN40_02565
MMAV: RE476_07655
MSEB: RE474_03950
MHZ: Metho_0427
MEHF: MmiHf6_17900(fbaB)
MEES: MmiEs2_09970(fbaB)
MTP: Mthe_0380
MHI: Mhar_2267
MHU: Mhun_1466
MRTJ: KHC33_07445
MLA: Mlab_1135
MEM: Memar_1367
MBG: BN140_2246
MEMA: MMAB1_2969
MCHK: MchiMG62_15630
MSUM: OH143_01060
MPI: Mpet_1339
MEND: L6E24_12595
MEFW: F1737_04070
MAQE: RJ40_00525
MFK: E2N92_01880
MOU: OU421_10940
MESB: L1S32_02930
MANQ: L1994_04885
MPL: Mpal_0799
 » show all
Reference
PMID:17014089
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
LinkDB

KEGG   ENZYME: 2.2.1.11
Entry
EC 2.2.1.11                 Enzyme                                 
Name
6-deoxy-5-ketofructose 1-phosphate synthase;
DKFP synthase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
Sysname
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Reaction(IUBMB)
(1) 2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10049];
(2) 2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [RN:R10050]
Reaction(KEGG)
R10049 R10050
Substrate
2-oxopropanal [CPD:C00546];
D-fructose 1,6-bisphosphate [CPD:C00354];
D-fructose 1-phosphate [CPD:C01094]
Product
D-glyceraldehyde 3-phosphate [CPD:C00118];
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate [CPD:C16848];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
History
EC 2.2.1.11 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase
Genes
AAEO: BJI67_06825
AFY: BW247_04500
TIN: Tint_0447
THI: THI_0524
AFR: AFE_1802
AFE: Lferr_1479
ACU: Atc_1531
ACZ: Acaty_c1299
AFI: Acife_0795 Acife_2018
AFJ: AFERRID_27730
AFP: K1Y48_06025 K1Y48_10460
ACIY: MQE22_05275
SUA: Saut_0463
SPAL: FM071_05630
SSEI: FJR45_02715
HYO: NNO_1235
HCJ: HCR_00780
NSA: Nitsa_0969
SUN: SUN_1211(fbaB)
SLH: YH65_05870
NIS: NIS_0927
NAP: C3L23_03955
CPAF: C6V80_04545
DPS: DP2457
AAUT: ACETAC_00835
CCU: Ccur_03540
SHI: Shel_19790
ELE: Elen_2983
EYY: EGYY_28100
EGD: GS424_017090
AEQ: AEQU_1983
AHAT: ADCFC_22570
DDT: AAY81_07945
CBAC: JI75_01080
BWA: HLV38_04495
RTS: CE91St31_04870
EBZ: J7S26_07675
MIN: Minf_2129(fbaB)
MKC: kam1_189
MFH: MFUM_0234
MCAO: IT6_05205
MEAP: MTHMO_0280(fba)
BVO: Pan97_15820(fbaB)
GAX: Pan161_52870(fbaB)
HYA: HY04AAS1_0176
HHO: HydHO_0183
HYS: HydSN_0190
ASAC: ATHSA_0473
LFC: LFE_2179
LFI: LFML04_1323
LFP: Y981_06425
LEG: ABH19_06865
FBN: HY931_01465
MJA: MJ_1585
MFE: Mefer_0658
MVU: Metvu_0368
MFS: MFS40622_0194
MIF: Metin_0355
MJH: JH146_0289
MESG: MLAUSG7_0763
MESA: MLASG1_0429
MIG: Metig_0068
MMP: MMP0293
MMQ: MmarC5_1380
MMX: MmarC6_0660
MMZ: MmarC7_1296
MMD: GYY_01500
MMAK: MMKA1_03000(fba)
MMAO: MMOS7_03270(fba)
MMAD: MMJJ_07650(fbaB)
MAE: Maeo_0690
MVN: Mevan_1304
MVO: Mvol_1341
MOK: Metok_1121
MBA: Mbar_A0176 Mbar_A2224
MBY: MSBRM_2208 MSBRM_2781
MBW: MSBRW_0821 MSBRW_2524
MBAR: MSBR2_2738
MBAK: MSBR3_2683
MAC: MA_2666 MA_3889
MMA: MM_0714
MMAZ: MmTuc01_0735
MMJ: MSMAS_0603
MMAC: MSMAC_0605
MVC: MSVAZ_0963
MEK: MSKOL_0932
MLS: MSLAZ_0625
METM: MSMTP_0658
MEF: MSWH1_0770
MEQ: MSWHS_0822
MSJ: MSSAC_1781 MSSAC_3626
MSZ: MSSIH_3164
MSW: MSSIT_3238
MTHR: MSTHT_2315
MTHE: MSTHC_0965
MHOR: MSHOH_0711
MFZ: AOB57_003890
MPY: Mpsy_1203
MZI: HWN40_02565
MMAV: RE476_07655
MSEB: RE474_03950
MHZ: Metho_0427
MEHF: MmiHf6_17900(fbaB)
MEES: MmiEs2_09970(fbaB)
MTP: Mthe_0380
MHI: Mhar_2267
MHU: Mhun_1466
MRTJ: KHC33_07445
MLA: Mlab_1135
MEM: Memar_1367
MBG: BN140_2246
MEMA: MMAB1_2969
MCHK: MchiMG62_15630
MSUM: OH143_01060
MPI: Mpet_1339
MEND: L6E24_12595
MEFW: F1737_04070
MAQE: RJ40_00525
MFK: E2N92_01880
MOU: OU421_10940
MESB: L1S32_02930
MANQ: L1994_04885
MPL: Mpal_0799
 » show all
Reference
1  [PMID:17014089]
  Authors
White RH, Xu H
  Title
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii.
  Journal
Biochemistry 45:12366-79 (2006)
DOI:10.1021/bi061018a
  Sequence
[mja:MJ_1585]
Reference
2  [PMID:18318840]
  Authors
Samland AK, Wang M, Sprenger GA
  Title
MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity.
  Journal
FEMS Microbiol Lett 281:36-41 (2008)
DOI:10.1111/j.1574-6968.2008.01079.x
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.11
IUBMB Enzyme Nomenclature: 2.2.1.11
ExPASy - ENZYME nomenclature database: 2.2.1.11
BRENDA, the Enzyme Database: 2.2.1.11
LinkDB

KEGG   REACTION: R10049
Entry
R10049                      Reaction                               
Name
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
Definition
Methylglyoxal + D-Fructose 1,6-bisphosphate <=> D-Glyceraldehyde 3-phosphate + 6-Deoxy-5-ketofructose 1-phosphate
Equation
C00546 + C00354 <=> C00118 + C16848
Reaction class
RC00439  C00118_C00354
RC02301  C00546_C16848
RC03034  C00354_C16848
Enzyme
2.2.1.11
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.11
     R10049  Methylglyoxal + D-Fructose 1,6-bisphosphate <=> D-Glyceraldehyde 3-phosphate + 6-Deoxy-5-ketofructose 1-phosphate
Orthology
K16305  fructose-bisphosphate aldolase / 6-deoxy-5-ketofructose 1-phosphate synthase [EC:4.1.2.13 2.2.1.11]
Other DBs
RHEA: 31914
LinkDB

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