KEGG ORTHOLOGY: K16438

ORTHOLOGY: K16438

Entry

K16438                      KO

Symbol

evaD, eryBVII, aveBV, megDIV, staE

Name

5-epimerase [EC:5.1.3.-]

Pathway

map00404

Staurosporine biosynthesis

map00523

Polyketide sugar unit biosynthesis

map01055

Biosynthesis of vancomycin group antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00798

dTDP-L-mycarose biosynthesis

M00799

dTDP-L-oleandrose biosynthesis

M00800

dTDP-L-megosamine biosynthesis

Reaction

R06433

dTDP-4-oxo-2,6-dideoxy-D-allose 5-epimerase

R06628

dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose 5-epimerase

R08934

dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose 5-epimerase

R11046

dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose 5-epimerase

R11138

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
   01055 Biosynthesis of vancomycin group antibiotics
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K16438  evaD, eryBVII, aveBV, megDIV, staE; 5-epimerase

Genes

NBR:	O3I_007430

NTP:	CRH09_07945

NIE:	KV110_35790

SALB:

XNR_0573

SMA:	SAVERM_949(aveBV)

SGR:

SGR_629

SANL:

KZO11_29595

SCYE:

R2B67_24665 R2B67_24675(rfbC)

SSOI:

I1A49_39385

SVE:

SVEN_5999

SLD:

T261_6856

SXI:	SXIM_35750

SPRI:

SPRI_0240 SPRI_7113

SLE:	sle_09270(sle_09270)

SRN:	A4G23_02283(rmlC) A4G23_02292(gerF)

SCLF:

BB341_29645

SGM:	GCM10017557_01760(rfbC) GCM10017557_73970(rfbC)

SCAD:

DN051_13670

SNR:	SNOUR_10130(eryBVII)

SALU:

DC74_6613

SALL:

SAZ_34380

SPUN:

BFF78_11210

SALF:

SMD44_08279(rfbC)

SGD:	ELQ87_08070

STIR:

DDW44_27805

SKA:	CP970_39805

SFIC:

EIZ62_04030 EIZ62_09595

SGAL:

CP966_29045

SSPO:

DDQ41_30665

SPAD:

DVK44_01720

SGF:	HEP81_07923

SCIN:

STSU:

SCHA:

SCOE:

SLIA:

SDW:	K7C20_32595

SAUH:

SU9_033050

SFB:	CP974_12565 CP974_12610

SMOB:

J7W19_00845

SPEU:

CGZ69_24390

SXN:	IAG42_35895

SGJ:	IAG43_33150

SANU:

K7396_04500 K7396_33610

SMAO:

SINE:

SRUG:

SAKB:

SNIG:

HEK616_47300(rfbC)

STUD:

STRTU_006750 STRTU_006761

SANT:

QR300_05475(rfbC)

SJN:	RI060_04590(rfbC) RI060_18305

SHAU:

K9S39_40780

SKG:	KJK29_16105

SFP:	QUY26_02155(rfbC)

SCHG:

NRO40_12720 NRO40_12765

STTN:

BSL84_24960

SPRF:

K4G22_02660 K4G22_25840

KCH:	O1G21_27115

FSB:	GCM10025867_37710(rfbC)

AARC:

G127AT_03385

AUT:	AINA4_11760(rfbC)

DERM:

H7F30_07395

ALX:	LVQ62_08355

TED:	U5C87_10905(rfbC)

AER:	AERYTH_15830

TALX:

FOF52_07500 FOF52_14825

NGV:	CDO52_02805

NEC:	KGD82_07555

NCG:	KGD84_13455

STRR:

EKD16_15530(novW)

SAIU:

J4H86_24140

TCU:

Tcur_2791

NOW:	GBF35_40095

NCX:	Nocox_25595(novW)

NFS:	OIE67_22415(rfbC)

SEN:	SACE_0714(eryBVII) SACE_6416(rmlC)

SACG:

FDZ84_06960

SVI:	Svir_30640

SACC:

EYD13_17005(rmlC)

AMD:	AMED_7962(rfbC)

AMN:

RAM_40920

AMM:	AMES_7844(rfbC)

AMZ:	B737_7844(rfbC)

AOI:	AORI_1501(rfbC)

AJA:	AJAP_32015(staE)

AMQ:	AMETH_5764(rfbC)

AMYC:

CU254_32330

AMYB:

BKN51_41545

AAB:	A4R43_01820 A4R43_23095

AMYY:

YIM_05675(novW) YIM_08365(rmlC1)

AORI:

SD37_06785 SD37_33615

AACD:

LWP59_33105

APRT:

MUY14_19250 MUY14_44490

AROO:

NQK81_15385 NQK81_32135

ATHM:

L1857_31765

ARHD:

VSH64_29135(rfbC)

ACYN:

ORV05_02990 ORV05_18120

ACOR:

LCL61_00285(rfbC) LCL61_13745

PSEQ:

PECQ:

APRE:

AMI:

SESP:

BN6_75510(rfbC3)

SSYI:

EKG83_32245 EKG83_42105

KAL:	KALB_6583(acuS3)

KUT:	JJ691_101270(rfbC_4) JJ691_101500 JJ691_31620(rfbC_1) JJ691_70300 JJ691_87810(rfbC_3)

KPHY:

AOZ06_22540 AOZ06_23380

LED:	BBK82_19555 BBK82_43755

AHM:	TL08_05630

ACTI:

UA75_05670 UA75_16855

ACAD:

UA74_05665

AHG:	AHOG_05430(novW1)

ACTA:

C1701_01565 C1701_14905

ALO:

CRK59671

PMAD:

BAY61_07765 BAY61_26015

SACE:

GIY23_18560

ACTU:

Actkin_00394(rmlC_1) Actkin_05461(rmlC_2)

CROS:

N8J89_05085

ACTY:

OG774_12535 OG774_26020

UME:	RM788_20385(rfbC)

STP:	Strop_2217

SAQ:	Sare_2018 Sare_2338

MAU:	Micau_4005

MIL:

ML5_4416

MCAB:

HXZ27_04133(evdS13)

MENO:

Jiend_53110(rfbC)

MPRN:

Q3V37_18390

AMS:	AMIS_50610

AOU:	ACTOB_006481(rfbC)

PRY:	Prubr_24740(rfbC)

DVC:	Dvina_17755

DAUR:

Daura_37960

CCAZ:

COUCH_15965

AEY:	CDG81_13220

EKE:	EK0264_16180

AG:	AAG13911(megDIV) BAC55217(staE)

» show all

Reference

PMID:24884615

Authors

Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W

Title

Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.

Journal

BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363

Sequence

[aoi:AORI_1501]

Reference

PMID:9353926

Authors

Summers RG, Donadio S, Staver MJ, Wendt-Pienkowski E, Hutchinson CR, Katz L.

Title

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production.

Journal

Microbiology 143:3251-62 (1997)
DOI:10.1099/00221287-143-10-3251

Sequence

[sen:SACE_0714]

Reference

PMID:11451669

Authors

Wohlert S, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, MacNeil DJ, Hutchinson CR

Title

Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans.

Journal

Chem Biol 8:681-700 (2001)
DOI:10.1016/S1074-5521(01)00043-6

Reference

PMID:10449723

Authors

Ikeda H, Nonomiya T, Usami M, Ohta T, Omura S

Title

Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.

Journal

Proc Natl Acad Sci U S A 96:9509-14 (1999)
DOI:10.1073/pnas.96.17.9509

Sequence

[sma:SAVERM_949]

Reference

PMID:12617516

Authors

Onaka H, Taniguchi S, Igarashi Y, Furumai T

Title

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

Journal

J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063

Sequence

[ag:BAC55217]

LinkDB

REACTION: R11046

Entry

R11046                      Reaction

Name

dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose 5-epimerase

Definition

dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose <=> dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose

Equation

C21073 <=> C21074

Reaction class

RC01518

C21073_C21074

Enzyme

5.1.3.-

Pathway

rn00523

Polyketide sugar unit biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

rn01250

Biosynthesis of nucleotide sugars

Module

M00800

dTDP-L-megosamine biosynthesis

Brite

Enzymatic reactions [BR:br08201]
5. Isomerase reactions
  5.1  Racemases and epimerases
   5.1.3  Acting on carbohydrates and derivatives
    5.1.3.-
     R11046  dTDP-3-N,N-dimethylamino-2,3,6-trideoxy-4-keto-D-glucose <=> dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-L-allose

Orthology

K16438

5-epimerase [EC:5.1.3.-]

LinkDB

DBGET integrated database retrieval system