KEGG   ORTHOLOGY: K16792
Entry
K16792                      KO                                     
Symbol
aksD
Name
methanogen homoaconitase large subunit [EC:4.2.1.114]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16792  aksD; methanogen homoaconitase large subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16792  aksD; methanogen homoaconitase large subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16792  aksD; methanogen homoaconitase large subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K16792
Other DBs
RN: R03444 R04371 R09720 R10391 R10392 R10393 R10394 R10395 R10396
COG: COG0065
Genes
MMAX: LCQ47_06430
SSOI: I1A49_21970
AACD: LWP59_12505
RRS: RoseRS_1053
RCA: Rcas_3474
CAU: Caur_0329
CHL: Chy400_0354
CAG: Cagg_3602
HAU: Haur_3302
PMET: G4Y79_18425
DRA: DR_1610
DGE: Dgeo_1156
DDR: Deide_13470
DMR: Deima_1355
DGO: DGo_CA1306
DPD: Deipe_2764
DSW: QR90_09055
DCH: SY84_02060
DPU: SU48_08715
DEZ: DKM44_08505
DWU: DVJ83_05635
DFC: DFI_07080
DEIN: DAAJ005_11930
DGA: DEGR_14160(leuC1)
DPH: EHF33_05185
TRA: Trad_1389
TTH: TT_C1547
TTJ: TTHA1911(TTHA1911)
TTS: Ththe16_1911
TTL: TtJL18_1993
TSC: TSC_c01880(hacA)
THC: TCCBUS3UF1_21070
TOS: Theos_1937
TAQ: TO73_0094
TPAR: AV541_01240
TBC: A0O31_00874
TANT: KNN15_05110
MRB: Mrub_2728
MRE: K649_08895
MSV: Mesil_0442
MTAI: Mtai_v1c23270
OPR: Ocepr_1780
MHD: Marky_0672
SCOR: J3U87_19130
PPIO: CE91St28_02100 CE91St28_12480
MJA: MJ_1003
MFE: Mefer_1231
MVU: Metvu_1303
MFS: MFS40622_1618
MIF: Metin_0516
MJH: JH146_0954
MESG: MLAUSG7_0432(hacA)
MESA: MLASG1_0006(hacA)
MIG: Metig_0807
MMP: MMP1480
MMQ: MmarC5_0098
MMX: MmarC6_1194
MMZ: MmarC7_0724
MMD: GYY_08235
MMAK: MMKA1_17030(leuD)
MMAO: MMOS7_15860(leuD)
MMAD: MMJJ_13590(dmdA_1)
MAE: Maeo_0311
MVN: Mevan_0789
MVO: Mvol_1623
MOK: Metok_0062
METF: CFE53_05095
MTH: MTH_1631
MMG: MTBMA_c02160(leuC1)
METC: MTCT_1490
MWO: MWSIV6_0177(hacA)
METE: tca_01581(dmdA_2)
METZ: METMT2_1470
METK: FVF72_03470
MTHM: FZP57_00775
METJ: FZP68_05785
MST: Msp_1100(leuC2)
METB: AW729_10315
MRU: mru_0384(aksD)
MSI: Msm_0723
MEB: Abm4_0180(aksD)
MMIL: sm9_2161(aksD)
MEYE: TL18_01065
MOL: YLM1_0055
MARO: MarbSA_13800
MEL: Metbo_2070
MEW: MSWAN_0570
METH: MBMB1_0289(leuC2)
MFC: BRM9_1986(aksD)
MFI: DSM1535_0178(leuC2)
MCUB: MCBB_0567(hacA)
MSUB: BK009_11610
METN: BK008_07185
METT: CIT01_06840
METO: CIT02_05440
MEME: HYG87_07560
MFV: Mfer_0965
MKA: MK1208(leuC_2)
MBA: Mbar_A1961
MBY: MSBRM_0704
MBW: MSBRW_2776
MBAR: MSBR2_1672
MBAK: MSBR3_1673
MAC: MA_3085(leuC)
MMA: MM_0409
MMAZ: MmTuc01_0417
MMJ: MSMAS_0894
MMAC: MSMAC_0883
MVC: MSVAZ_1170
MEK: MSKOL_1122
MLS: MSLAZ_2100
METM: MSMTP_2281
MEF: MSWH1_0957
MEQ: MSWHS_1027
MSJ: MSSAC_2956
MSZ: MSSIH_2594
MSW: MSSIT_2634
MTHR: MSTHT_2523
MTHE: MSTHC_0762
MHOR: MSHOH_1131
MFZ: AOB57_002735
MBU: Mbur_2263(hacA)
MMET: MCMEM_0412
MELO: J7W08_00085
MMH: Mmah_0418
MHAZ: BHR79_01390
MEV: Metev_1371
MZH: Mzhil_0725
MPY: Mpsy_2821
MZI: HWN40_08640
MHZ: Metho_0694
MTP: Mthe_0788
MCJ: MCON_0444(leuC1)
MHI: Mhar_1525
MHU: Mhun_1800
MRTJ: KHC33_05410
MLA: Mlab_0233
MEM: Memar_0634
MBG: BN140_1717(leuC3)
MEMA: MMAB1_2209(leuC)
MCHK: MchiMG62_07640
MPI: Mpet_2489
MBN: Mboo_0599
MFO: Metfor_2592
MPL: Mpal_2143
MPD: MCP_1961
MEZ: Mtc_1559(leuC-2)
RCI: RCIX2646(leuC-2)
 » show all
Reference
PMID:18765671
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1003]
LinkDB

KEGG   ORTHOLOGY: K16793
Entry
K16793                      KO                                     
Symbol
aksE
Name
methanogen homoaconitase small subunit [EC:4.2.1.114]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16793  aksE; methanogen homoaconitase small subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16793  aksE; methanogen homoaconitase small subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16793  aksE; methanogen homoaconitase small subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K16793
Other DBs
RN: R03444 R04371 R09720 R10391 R10392 R10393 R10394 R10395 R10396
COG: COG0066
Genes
PASG: KSS96_22110
PEW: KZJ38_04415
BOH: AKI39_19115
RRS: RoseRS_1056
RCA: Rcas_3472
CAU: Caur_0330
CHL: Chy400_0355
CAG: Cagg_3601
HAU: Haur_3303
DRA: DR_1614(leuD)
DGE: Dgeo_1154
DDR: Deide_13460
DMR: Deima_1353
DGO: DGo_CA1308
DPD: Deipe_2762
DSW: QR90_07810
DCH: SY84_02050
DAB: AUC44_07725
DPU: SU48_08705
DEZ: DKM44_08520
DWU: DVJ83_05640
DFC: DFI_07070
DEIN: DAAJ005_09955
DGA: DEGR_14180(leuD1)
DPH: EHF33_03450
TRA: Trad_1390
TTH: TT_C1546
TTJ: TTHA1910(TTHA1910)
TTS: Ththe16_1910
TTL: TtJL18_1992
TSC: TSC_c01890(hacB)
THC: TCCBUS3UF1_21060
TOS: Theos_1936
TAQ: TO73_0095
TPAR: AV541_01245
TBC: A0O31_00873
TANT: KNN15_05115
MRB: Mrub_2727
MRE: K649_08900
MSV: Mesil_0441
MTAI: Mtai_v1c23260
OPR: Ocepr_1781
MHD: Marky_0671
SCOR: J3U87_19135
MJA: MJ_1271
MFE: Mefer_0048
MVU: Metvu_0677 Metvu_0864
MFS: MFS40622_0030 MFS40622_0660
MIF: Metin_1437
MJH: JH146_0454
MESG: MLAUSG7_0025(hacB)
MESA: MLASG1_1205(hacB)
MIG: Metig_0050 Metig_1570
MMP: MMP0381
MMQ: MmarC5_1257
MMX: MmarC6_0529
MMZ: MmarC7_1379
MMAK: MMKA1_04000(leuD)
MMAO: MMOS7_03940(leuD)
MMAD: MMJJ_06580(dmdB_1)
MAE: Maeo_0652
MVN: Mevan_1368
MVO: Mvol_1671
MOK: Metok_0567
METF: CFE53_04745
MTH: MTH_829
MMG: MTBMA_c12270(leuD1)
METC: MTCT_0743
MWO: MWSIV6_1206(hacB)
METE: tca_00796(DmdB_1)
METZ: METMT2_0903
METK: FVF72_07395
MTHM: FZP57_05725
METJ: FZP68_00480
MST: Msp_0374(leuD2)
METB: AW729_05200
MRU: mru_1689(aksE)
MSI: Msm_0847
MEB: Abm4_0514(aksE)
MMIL: sm9_1773(aksE)
MEYE: TL18_07930
MOL: YLM1_1157
MARO: MarbSA_18800
MEL: Metbo_1944
MEW: MSWAN_0676
METH: MBMB1_0696(leuD1)
MFC: BRM9_1499(aksE)
MFI: DSM1535_2193(leuD1)
MCUB: MCBB_0707(hacB)
MSUB: BK009_01700
METN: BK008_09225
METT: CIT01_01955
METO: CIT02_03290
MEME: HYG87_03480
MFV: Mfer_0205
MKA: MK1206(leuD_2)
MBA: Mbar_A0244 Mbar_A2270
MBY: MSBRM_1355 MSBRM_2710
MBW: MSBRW_0751 MSBRW_2476
MBAR: MSBR2_1054 MSBR2_2666
MBAK: MSBR3_1018 MSBR3_2760
MAC: MA_1223(leuC) MA_3751(leuD)
MMA: MM_0645
MMAZ: MmTuc01_0660
MMJ: MSMAS_0664
MMAC: MSMAC_0666
MVC: MSVAZ_0690 MSVAZ_2221
MEK: MSKOL_0668 MSKOL_2220
MLS: MSLAZ_2434
METM: MSMTP_0731
MEF: MSWH1_0826
MEQ: MSWHS_0885
MSJ: MSSAC_3368 MSSAC_3559
MSZ: MSSIH_2894 MSSIH_3101
MSW: MSSIT_2938 MSSIT_3158
MTHR: MSTHT_2374
MTHE: MSTHC_0906
MHOR: MSHOH_0786
MFZ: AOB57_003550
MBU: Mbur_1578
MMET: MCMEM_2089
MELO: J7W08_09410
MMH: Mmah_0127
MHAZ: BHR79_02815
MEV: Metev_1312
MZH: Mzhil_1660
MPY: Mpsy_2354
MZI: HWN40_10575
MHZ: Metho_0481
MTP: Mthe_0853
MCJ: MCON_1922(leuD1)
MHI: Mhar_2395
MHU: Mhun_1799
MRTJ: KHC33_05415
MLA: Mlab_0234
MEM: Memar_0635
MBG: BN140_1716(leuD3)
MCHK: MchiMG62_07650
MPI: Mpet_2490
MBN: Mboo_0600
MFO: Metfor_2591
MPL: Mpal_2144
MPD: MCP_1962
MEZ: Mtc_1558(leuD-2)
RCI: RCIX2645(leuD-2)
CDIV: CPM_1676
 » show all
Reference
PMID:18765671
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1271]
LinkDB

KEGG   REACTION: R09720
Entry
R09720                      Reaction                               
Name
(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming]
Definition
(R)-2-Hydroxybutane-1,2,4-tricarboxylate <=> Homoisocitrate
Equation
C01251 <=> C05662
Comment
two-step reaction (see R03444+R04371)
Reaction class
RC00497  C01251_C05662
Enzyme
4.2.1.114
Pathway
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
Other DBs
RHEA: 32306
LinkDB

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