| Entry |
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| Name |
inosine diphosphate phosphatase;
(deoxy)inosine diphosphatase;
NUDT16
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| Class |
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
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| Sysname |
inosine diphosphate phosphatase
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| Reaction(IUBMB) |
(1) IDP + H2O = IMP + phosphate [RN: R00961];
(2) dIDP + H2O = dIMP + phosphate [RN: R10235]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The human enzyme also hydrolyses GDP and dGDP, and to a lesser extent ITP, dITP and XTP.
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| History |
EC 3.6.1.64 created 2013
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| Pathway |
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| Orthology |
| K16855 | U8 snoRNA-decapping enzyme |
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| Genes |
| GGO: | 101147310(NUDT16) 109026149 |
| PPYG: | 129033983 129033984 |
| MCC: | 717914(NUDT16) 717946 |
| MTHB: | 126947206 126947217 |
| MNI: | 105490392 105490393(NUDT16) |
| CATY: | 105586448 105586449(NUDT16) |
| TGE: | 112617211 112617516 112619589(NUDT16) |
| CJC: | 100406671 100410770(NUDT16) |
| SBQ: | 101048719(NUDT16) 101049032 |
| CIMI: | 108290368 108290369 |
| MMUR: | 105872684(NUDT16) 105872691 |
| LCAT: | 123628745 123641286 |
| ERUF: | 138385796 138386686(NUDT16) |
| PCOQ: | 105825726 105826030 |
| MMU: | 73532(Nudt16l2) 75686(Nudt16) |
| MCAL: | 110301710(Nudt16) 110301971 |
| MPAH: | 110328254(Nudt16) 110328480 |
| RNO: | 363129(Nudt16) 688828(Nudt16l2) |
| MCOC: | 116072234 116072424 |
| ASYL: | 127688623 127688624 |
| CGE: | 100768978(Nudt16) 100769259 |
| MAUA: | 101823712 101840553 |
| PROB: | 127213387 127237494 |
| PLEU: | 114693512 114693567 |
| MORG: | 121464346 121464538 |
| MFOT: | 126494427 126499963 126500041 |
| AAMP: | 119809466 119809737 |
| HGL: | 101709761(Nudt16) 101717221 |
| CPOC: | 100718426 100718706 |
| NCAR: | 124992878 124993228 |
| MMMA: | 107143162 107143400 |
| AML: | 100482941(NUDT16) 117795062 |
| SANH: | 107657028 107671960 |
| CCAR: | 109088229 109093414 |
| CAUA: | 113069121 113071070 113094762 |
| CGIB: | 127944396 128011039 |
| PTET: | 122328442(zgc:103759) |
| LROH: | 127154263(zgc:103759) |
| OMC: | 131532141(zgc:103759) |
| PPRM: | 120462816(zgc:103759) |
| RKG: | 130081669(zgc:103759) |
| MAMB: | 125260652(zgc:103759) |
| CIDE: | 127505480(zgc:103759) |
| CERY: | 137009476(zgc:103759) |
| MASI: | 127419383 127420109 |
| TROS: | 130545186(zgc:103759) |
| TDW: | 130409569(zgc:103759) |
| IPU: | 108276081(zgc:103759) |
| IFU: | 128619791(zgc:103759) |
| SMEO: | 124398601(zgc:103759) |
| TFD: | 113658117(zgc:103759) |
| TVC: | 132862746(zgc:103759) |
| CGAR: | 128510615(zgc:103759) |
| NGRA: | 132896934(zgc:103759) |
| TRN: | 134333534(zgc:103759) |
| AMEX: | 103041050(zgc:103759) |
| CMAO: | 118822016(zgc:103759) |
| CHAR: | 105894127(zgc:103759) |
| SPIL: | 134087312(zgc:103759) |
| ASAD: | 121713667(zgc:103759) |
| TBEN: | 117493976(zgc:103759) |
| GACU: | 117532873(zgc:103759) |
| EMAC: | 134880947(zgc:103759) |
| ELY: | 117257952(zgc:103759) |
| EFO: | 125891238(zgc:103759) |
| PLEP: | 121946612(zgc:103759) |
| SLUC: | 116041066(zgc:103759) |
| ECRA: | 117948020(zgc:103759) |
| GAT: | 120828900(zgc:103759) |
| PPUG: | 119223307(zgc:103759) |
| AFB: | 129100264(zgc:103759) |
| CLUM: | 117733683(zgc:103759) |
| PSWI: | 130198938(zgc:103759) |
| CANA: | 137800494(zgc:103759) |
| CVE: | 137889040(zgc:103759) |
| MSAM: | 119881932 119916776 119918505 |
| SCHU: | 122882682(zgc:103759) |
| CUD: | 121516982(zgc:103759) |
| LMIX: | 132990231(zgc:103759) |
| ALAT: | 119022848(zgc:103759) |
| ASTR: | 137608159(zgc:103759) |
| OAU: | 116315623(zgc:103759) |
| OML: | 112159327(zgc:103759) |
| CSAI: | 133457499(zgc:103759) |
| GAF: | 122831977(zgc:103759) |
| PPRL: | 129371752(zgc:103759) |
| CTUL: | 119772913(zgc:103759) |
| GMU: | 124872305(zgc:103759) |
| KMR: | 108233051(zgc:103759) |
| NWH: | 119417186(zgc:103759) |
| AOCE: | 111568682(zgc:103759) |
| MCEP: | 125015508(zgc:103759) |
| SSEN: | 122776679(zgc:103759) |
| SSOE: | 131468425(zgc:103759) |
| HHIP: | 117764281(zgc:103759) |
| HSP: | 118111677(zgc:103759) |
| PPLT: | 128442108(zgc:103759) |
| SMAU: | 118316662(zgc:103759) |
| LCF: | 108882689(zgc:103759) |
| XGL: | 120804372(zgc:103759) |
| SSCV: | 125988174(zgc:103759) |
| SBIA: | 133507849(zgc:103759) |
| PEE: | 133406554(zgc:103759) |
| PTAO: | 133481809(zgc:103759) |
| BSPL: | 114859118(zgc:103759) |
| SJO: | 128357344(zgc:103759) |
| SSCO: | 133987633(zgc:103759) |
| TTY: | 137184073(zgc:103759) |
| OTW: | 112224924(zgc:103759) |
| OMY: | 110501384(zgc:103759) |
| OGO: | 124043699(zgc:103759) |
| OKE: | 118386106(zgc:103759) |
| OMM: | 135547285(zgc:103759) |
| SNH: | 120063810(zgc:103759) |
| SFON: | 129816160(zgc:103759) |
| CCLU: | 121553256(zgc:103759) |
| OEP: | 134019447(zgc:103759) |
| AANG: | 118211242(zgc:103759) |
| AROT: | 135238520(zgc:103759) |
| CCOG: | 133110335(zgc:103759) |
| PSPA: | 121329068(zgc:103759) |
| PSEX: | 120542304(zgc:103759) 120542590 |
| CMK: | 103191283(zgc:103759) |
| RTP: | 125488267(zgc:103759) |
| CPLA: | 122545443(zgc:103759) |
| SCAU: | 119961414(zgc:103759) |
| LERI: | 129694063(zgc:103759) |
| CLEP: | 143451700 143464834 |
| CLEC: | 106661250 106669818 |
| HHAL: | 106678633 106678639 106683938 |
| PHU: | Phum_PHUM040630 Phum_PHUM040640 |
| PTRU: | 123512954 123513332 |
| TUT: | 107363439 107364909 107365057 |
| CSCU: | 111626039 111626044 |
| PCAN: | 112571937 112572589 |
| PMAX: | 117321138 117332919 |
| RPHI: | 132742214 132742215 |
| LAK: | 106179938 106179941 106179942 106181443 |
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| Reference |
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| Authors |
Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y |
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| Title |
NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.1.64 |
| ExPASy - ENZYME nomenclature database: | 3.6.1.64 |
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| LinkDB |
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