KEGG ORTHOLOGY: K16901

ORTHOLOGY: K16901

Entry

K16901                      KO

Symbol

K16901

Name

anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]

Pathway

map00350

Tyrosine metabolism

map00380

Tryptophan metabolism

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Reaction

R02698

4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)

R03299

3-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)

R09517

anthranilate,FAD:oxygen oxidoreductase (3-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
   00380 Tryptophan metabolism
    K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.8  anthranilate 3-monooxygenase (FAD)
     K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase
    1.14.14.9  4-hydroxyphenylacetate 3-monooxygenase
     K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase

Other DBs

GO:

0052881

Genes

MLAN:

BCA:

BCX:

BCF:

BCER:

BCEF:

BTL:

BMYC:

BTRO:

BNT:	GSN03_10105

BFD:	NCTC4823_00762 NCTC4823_00782

GST:	HW35_13010

BASD:

BACV:

BAAZ:

BABD:

BHK:	B4U37_13975

BMQ:	BMQ_3596(hpaB)

BMD:	BMD_3581(hpaB)

BMEG:

BG04_470

LYZ:	DCE79_01715

LYQ:	MY533_20320

LYO:	NV349_18730

BSJ:	UP17_10485

PASA:

BAOM_0489

PFRI:

L8956_11350

PERJ:

JNUCC41_20285

RUE:	DT065_13750

NCM:	QNK12_05460

NNV:	QNH39_24840

MSEM:

GMB29_08290

ROSS:

V2W31_07705

BOU:	I5818_04760

GAJ:	MY490_08530

MSUT:

LC048_10460

FPN:	ABE65_004705

FAR:	ABE41_004850

GTN:

GTNG_3160

HYI:	K2M58_04815

BBE:	BBR47_29710

BFM:	BP422_09685

BHUI:

LOK74_00560

BAYD:

BSPP4475_07420(hpaB)

BBOR:

RFB14_22195

ASED:

IRT44_17665

PCEL:

HUB94_10140 HUB94_23490

PMAH:

PTQ21_18440

PAMY:

P9222_14865

PWN:	QNH46_03550

PPAB:

PEZZ:

PTUN:

PTAC:

ANX:	ACH33_11740

ATHE:

K3F53_07200

AUD:	PO771_07515

COHL:

AACO:

ACYC:

SPOH:

MMAG:

MMAT:

MYH:	QU592_07890

RHZP:

HYG77_15420(hpaB)

SCYE:

R2B67_12015

STUI:

GCM10017668_02130

SVD:	CP969_28360

SACT:

DMT42_33040

SPRF:

K4G22_02725

STYI:

C9F11_36140(hpaH)

STGO:

MBET:

ACIT:

AGEG:

ARTQ:

GPR:	JQN66_16275

GNC:	QQS42_16500

CCYC:

SCMU_01870

PAEY:

KUF55_15835

PDX:

Psed_0216

PBRO:

HOP40_33130(hpaB) HOP40_33375(hpaB)

PPEL:

H6H00_18695(hpaB)

» show all

Reference

PMID:19942660

Authors

Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L

Title

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Journal

Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0

Sequence

[gtn:GTNG_3160]

LinkDB

ORTHOLOGY: K16902

Entry

K16902                      KO

Symbol

E1.5.1.45

Name

FAD reductase [NAD(P)H] [EC:1.5.1.45]

Pathway

map00350

Tyrosine metabolism

map00380

Tryptophan metabolism

map00740

Riboflavin metabolism

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

Reaction

R02698

4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)

R03299

3-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating)

R09517

anthranilate,FAD:oxygen oxidoreductase (3-hydroxylating)

R09520

FADH2:NADP+ oxidoreductase

R09748

FADH2:NAD+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K16902  E1.5.1.45; FAD reductase [NAD(P)H]
   00380 Tryptophan metabolism
    K16902  E1.5.1.45; FAD reductase [NAD(P)H]
  09108 Metabolism of cofactors and vitamins
   00740 Riboflavin metabolism
    K16902  E1.5.1.45; FAD reductase [NAD(P)H]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.45  FAD reductase [NAD(P)H]
     K16902  E1.5.1.45; FAD reductase [NAD(P)H]

Other DBs

COG:

COG0431

Genes

BMET:

BMMGA3_15280

GST:	HW35_13015

BACO:

OXB_0115

BASB:

M662_01960

BACV:

I7V34_08055

NTX:	NQZ71_16505

NIL:	L8T27_005470

NTGC:

BMQ:

BMD:

BMEG:

BKO:	CKF48_21905

CSOA:

LIS82_16125

BDA:	FSZ17_13420

OJD:	NP439_16250

OON:	NP440_15125

LYP:	MTP04_05370 MTP04_06180

LYR:	AB9L17_02440

HNZ:	P9989_01650 P9989_02080

HSAN:

MUN89_21615

HSHI:

MUO14_14530

HAMY:

MUO15_11750 MUO15_12285

VNT:	OLD84_18510

VIK:	KFZ58_18400

VSS:	PD280_20005

SAPL:

APAK:

BMUR:

PASA:

PFRI:

PERI:

PERJ:

PESI:

RAX:	KO561_06640 KO561_15520

PPSN:

NOCE:

MLIT:

MENL:

MEBZ:

RSJ:	V1502_10140

BVJ:	I5776_05115

BOU:	I5818_06410

HSPO:

JGZ69_11790

MSUT:

LC048_10450

DOM:	RRU94_06045 RRU94_18790

GTN:

GTNG_3158

GMC:	GY4MC1_3653

PTL:	AOT13_04015

BHUI:

LOK74_00570 LOK74_23405

BAYD:

BBOR:

BRUM:

ASED:

BREP:

PBJ:	VN24_18680 VN24_25630

PNP:	IJ22_33750

PTHI:

NDS46_13530

PMAH:

PTQ21_20410

PDY:	QJQ58_08510

PSPN:

PPAB:

PEZZ:

PTAC:

PLIG:

EFF:	skT53_06260

SSIL:

SOLI23_13720

STHO:

QNH10_00625

STRB:

QWT68_10895

SOW:	QWT69_02010

SJT:	PGH26_01330

UTH:	DKZ56_04195

PALQ:

ACTY:

HSAI:

NARA:

Reference

PMID:19942660

Authors

Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L

Title

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Journal

Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0

Sequence

[gtn:GTNG_3158]

LinkDB

ENZYME: 1.14.14.8

Entry

EC 1.14.14.8                Enzyme

Name

anthranilate 3-monooxygenase (FAD);
anthranilate 3-hydroxylase;
anthranilate hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

anthranilate,FADH2:oxygen oxidoreductase (3-hydroxylating)

Reaction(IUBMB)

anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O [RN:R09517]

Reaction(KEGG)

R09517

Substrate

anthranilate [CPD:C00108];
FADH2 [CPD:C01352];
O2 [CPD:C00007]

Product

3-hydroxyanthranilate [CPD:C00632];
FAD [CPD:C00016];
H2O [CPD:C00001]

Comment

This enzyme, isolated from the bacterium Geobacillus thermodenitrificans, participates in the pathway of tryptophan degradation. The enzyme is part of a system that also includes a bifunctional riboflavin kinase/FMN adenylyltransferase and an FAD reductase, which ensures ample supply of FAD to the monooxygenase.

History

EC 1.14.14.8 created 2010

Pathway

ec00380

Tryptophan metabolism

ec01100

Metabolic pathways

Orthology

K16901

anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase

Genes

MLAN:

JY572_02720

BCA:

BCE_2148

BCX:

BCA_2146

BCF:

bcf_10170

BCER:

BCK_24265

BCEF:

BcrFT9_01682

BTL:

BALH_1835

BMYC:

DJ92_4629

BTRO:

FJR70_09265

BNT:	GSN03_10105

BFD:	NCTC4823_00762 NCTC4823_00782

GST:	HW35_13010

BASD:

LCG60_12305

BACV:

I7V34_08065

BAAZ:

GD442_12120

BABD:

EKQ63_13795

BHK:	B4U37_13975

BMQ:	BMQ_3596(hpaB)

BMD:	BMD_3581(hpaB)

BMEG:

BG04_470

LYZ:	DCE79_01715

LYQ:	MY533_20320

LYO:	NV349_18730

BSJ:	UP17_10485

PASA:

BAOM_0489

PFRI:

L8956_11350

PERJ:

JNUCC41_20285

RUE:	DT065_13750

NCM:	QNK12_05460

NNV:	QNH39_24840

MSEM:

GMB29_08290

ROSS:

V2W31_07705

BOU:	I5818_04760

GAJ:	MY490_08530

MSUT:

LC048_10460

FPN:	ABE65_004705

FAR:	ABE41_004850

GTN:

GTNG_3160

HYI:	K2M58_04815

BBE:	BBR47_29710

BFM:	BP422_09685

BHUI:

LOK74_00560

BAYD:

BSPP4475_07420(hpaB)

BBOR:

RFB14_22195

ASED:

IRT44_17665

PCEL:

HUB94_10140 HUB94_23490

PMAH:

PTQ21_18440

PAMY:

P9222_14865

PWN:	QNH46_03550

PPAB:

KET34_14640

PEZZ:

HW560_24985

PTUN:

V6W81_12905

PTAC:

ACJYJG_13525

ANX:	ACH33_11740

ATHE:

K3F53_07200

AUD:	PO771_07515

COHL:

J4772_07980

AACO:

K1I37_05145

ACYC:

JI721_10660

SPOH:

GGGNBK_09075

MMAG:

MMAD_31860

MMAT:

MMAGJ_45110

MYH:	QU592_07890

RHZP:

HYG77_15420(hpaB)

SCYE:

R2B67_12015

STUI:

GCM10017668_02130

SVD:	CP969_28360

SACT:

DMT42_33040

SPRF:

K4G22_02725

STYI:

C9F11_36140(hpaH)

STGO:

KBP30_11445

MBET:

N8K70_15960

ACIT:

HPK19_02390

AGEG:

MUG94_16705

ARTQ:

CGQ24_03165

GPR:	JQN66_16275

GNC:	QQS42_16500

CCYC:

SCMU_01870

PAEY:

KUF55_15835

PDX:

Psed_0216

PBRO:

HOP40_33130(hpaB) HOP40_33375(hpaB)

PPEL:

H6H00_18695(hpaB)

» show all

Reference

1 [PMID:19942660]

Authors

Liu X, Dong Y, Li X, Ren Y, Li Y, Wang W, Wang L, Feng L

Title

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Journal

Microbiology 156:589-95 (2010)
DOI:10.1099/mic.0.031880-0

Sequence

[gtn:GTNG_3160]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.8

IUBMB Enzyme Nomenclature:

1.14.14.8

ExPASy - ENZYME nomenclature database:

1.14.14.8

BRENDA, the Enzyme Database:

1.14.14.8

LinkDB

REACTION: R09517

Entry

R09517                      Reaction

Name

anthranilate,FAD:oxygen oxidoreductase (3-hydroxylating)

Definition

Anthranilate + FADH2 + Oxygen <=> 3-Hydroxyanthranilate + FAD + H2O

Equation

C00108 + C01352 + C00007 <=> C00632 + C00016 + C00001

Reaction class

RC00046

C00108_C00632

RC00126

C00016_C01352

Enzyme

1.14.14.8

Pathway

rn00380

Tryptophan metabolism

rn01100

Metabolic pathways

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.8
     R09517  Anthranilate + FADH2 + Oxygen <=> 3-Hydroxyanthranilate + FAD + H2O

Orthology

K16901

anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]

K16902

FAD reductase [NAD(P)H] [EC:1.5.1.45]

Other DBs

RHEA:

27549

LinkDB

DBGET integrated database retrieval system