KEGG   ORTHOLOGY: K16968
Entry
K16968                      KO                                     
Symbol
msmA
Name
methanesulfonate monooxygenase subunit alpha [EC:1.14.13.111]
Pathway
map00920  Sulfur metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K16968  msmA; methanesulfonate monooxygenase subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.111  methanesulfonate monooxygenase (NADH)
     K16968  msmA; methanesulfonate monooxygenase subunit alpha
Other DBs
RN: R09513
GO: 0018648
Genes
PQI: KH389_17555
CUH: BJN34_09325 BJN34_22320
BCT: GEM_5812
PPK: U875_05270
PPNO: DA70_22340
PRB: X636_04325
BPA: BPP0512
BBH: BN112_2904
BBR: BB0517
BBM: BN115_0496
BBX: BBS798_0510
BTRM: SAMEA390648701717(antA)
PUT: PT7_2466
PUD: G9Q38_01130
MPT: Mpe_A0919(msmS2)
METP: C1M51_13795
SPLB: SFPGR_26200
MNO: Mnod_2707 Mnod_8364
FIL: BN1229_v1_3549(msmA)
FIY: BN1229_v1_2374(msmA)
APB: SAR116_2102 SAR116_2109
AG: AAD26619(msmA)
 » show all
Reference
PMID:10094704
  Authors
de Marco P, Moradas-Ferreira P, Higgins TP, McDonald I, Kenna EM, Murrell JC
  Title
Molecular analysis of a novel methanesulfonic acid monooxygenase from the methylotroph Methylosulfonomonas methylovora.
  Journal
J Bacteriol 181:2244-51 (1999)
DOI:10.1128/JB.181.7.2244-2251.1999
  Sequence
[ag:AAD26619]
Reference
PMID:11772638
  Authors
Baxter NJ, Scanlan J, De Marco P, Wood AP, Murrell JC
  Title
Duplicate copies of genes encoding methanesulfonate monooxygenase in Marinosulfonomonas methylotropha strain TR3 and detection of methanesulfonate utilizers in the environment.
  Journal
Appl Environ Microbiol 68:289-96 (2002)
DOI:10.1128/AEM.68.1.289-296.2002
LinkDB

KEGG   ORTHOLOGY: K16969
Entry
K16969                      KO                                     
Symbol
msmB
Name
methanesulfonate monooxygenase subunit beta [EC:1.14.13.111]
Pathway
map00920  Sulfur metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K16969  msmB; methanesulfonate monooxygenase subunit beta
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.111  methanesulfonate monooxygenase (NADH)
     K16969  msmB; methanesulfonate monooxygenase subunit beta
Other DBs
RN: R09513
GO: 0018648
Genes
PQI: KH389_17550
CUH: BJN34_09330
BCT: GEM_5811
BUE: BRPE67_FCDS01800
PPK: U875_05275
PPNO: DA70_22345
PRB: X636_04320
BPA: BPP0513
BBH: BN112_2903
BBR: BB0518
BBM: BN115_0497
BBX: BBS798_0511
PUT: PT7_2465
PUD: G9Q38_01125
MPT: Mpe_A0920(msmB)
SPLB: SFPGR_26190
MNO: Mnod_2708 Mnod_8365
FIL: BN1229_v1_3548(msmB)
FIY: BN1229_v1_2375(msmB)
APB: SAR116_2103
AG: AAD26620(msmB)
 » show all
Reference
PMID:10094704
  Authors
de Marco P, Moradas-Ferreira P, Higgins TP, McDonald I, Kenna EM, Murrell JC
  Title
Molecular analysis of a novel methanesulfonic acid monooxygenase from the methylotroph Methylosulfonomonas methylovora.
  Journal
J Bacteriol 181:2244-51 (1999)
DOI:10.1128/JB.181.7.2244-2251.1999
  Sequence
[ag:AAD26620]
Reference
PMID:11772638
  Authors
Baxter NJ, Scanlan J, De Marco P, Wood AP, Murrell JC
  Title
Duplicate copies of genes encoding methanesulfonate monooxygenase in Marinosulfonomonas methylotropha strain TR3 and detection of methanesulfonate utilizers in the environment.
  Journal
Appl Environ Microbiol 68:289-96 (2002)
DOI:10.1128/AEM.68.1.289-296.2002
LinkDB

KEGG   ORTHOLOGY: K15762
Entry
K15762                      KO                                     
Symbol
tmoC, tbuB, touC
Name
toluene monooxygenase system ferredoxin subunit
Pathway
map00623  Toluene degradation
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15762  tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15762  tmoC, tbuB, touC; toluene monooxygenase system ferredoxin subunit
Other DBs
RN: R02550 R03562 R05666 R09513
Genes
PSD: DSC_04395
MCA: MCA0225 MCA0586
METU: GNH96_03875 GNH96_15290
MMAI: sS8_4250 sS8_5417 sS8_5458
CZA: CYCME_2096
THIS: HZT40_03315
HAZ: A9404_01470
SINI: GT972_13800
TBN: TBH_C0917
VFF: VITFI_CDS2832
RPI: Rpic_4634
RPF: Rpic12D_3558
CNC: CNE_BB1p12340(tbcC)
CUH: BJN34_22335
REU: Reut_B5677
RME: Rmet_1314(tmoC)
BCON: NL30_24545
BSTL: BBJ41_10545
BUG: BC1001_PA6408(tmoC)
BUE: BRPE67_FCDS01820
BGE: BC1002_6840
BPX: BUPH_05040
PARB: CJU94_38150
PGP: CUJ91_31710
PPK: U875_01865
PRB: X636_07605
BHO: D560_1527
BHM: D558_1518
PNA: Pnap_2045
HPSE: HPF_01795(tmoC)
HTN: KI616_01915
MPT: Mpe_A0816(tbuB) Mpe_A0922(msmC) Mpe_A2541(tbuB)
METP: C1M51_13810 C1M51_16285
IDC: LRM40_19620 LRM40_20510
SPLB: SFPGR_21440 SFPGR_26170
RBU: PG1C_06400 PG1C_06870
DAR: Daro_3818
DEY: HYN24_09690
FLE: KI610_08745
AZO: azo2601
AOA: dqs_2762
ACOM: CEW83_16210
AZD: CDA09_10205
AZR: CJ010_11510 CJ010_16420
THK: CCZ27_06380
ACIB: ACBT_0271(tmoC)
LLU: AKJ09_01042
BRA: BRADO3598
BBT: BBta_1596 BBta_4027
AOL: S58_10650 S58_37600
BRO: BRAD285_3000 BRAD285_3721
XAU: Xaut_4301
XDI: EZH22_10100 EZH22_20215
BID: Bind_2847
HMC: HYPMC_2243(tmoC)
MSC: BN69_2679
MBRY: B1812_07855
MROS: EHO51_16965
MTW: CQW49_04205
AFI: Acife_1627
AFJ: AFERRID_23190
BTS: Btus_2067
SAY: TPY_0637
SAP: Sulac_3002
MSHG: MSG_02602
MFJ: MFLOJ_53280
MSTO: MSTO_08240
MSAK: MSAS_06400
MPHL: MPHLCCUG_04539(tmoC)
MLL: B1R94_25135
MHAS: MHAS_04835(tmoC)
MMAG: MMAD_01690(nirD)
MMOR: MMOR_05350
MANY: MANY_23690
MTER: 4434518_03548(tmoC)
MHIB: MHIB_29680
CCYC: SCMU_04680
NFR: ERS450000_00317(tmoC)
ROA: Pd630_LPD03570
RKO: JWS14_48095
GPO: GPOL_c08460
PHW: G7075_19685
FRA: Francci3_0213
AMQ: AMETH_6106
AMYC: CU254_12400
AACD: LWP59_25955 LWP59_38060
PDX: Psed_0811 Psed_1157 Psed_1440 Psed_6060
PBRO: HOP40_29375
TRO: trd_A0921
NAJ: B1756_14065
SSO: SSO1230(tmoC)
SOL: Ssol_2198
SSOA: SULA_2231
SSOL: SULB_2232
SSOF: SULC_2229
SSHI: J5U23_02016
SIS: LS215_0423
SID: M164_0422
SIN: YN1551_2654
SII: LD85_0413
SIH: SiH_0429
SIR: SiRe_0387
SULA: BFU36_13260
SULE: GFS03_03535
SULO: GFS33_07685
SULL: EWF20_11135
AMAN: B6F84_00800
ABRI: DFR85_14350
PAS: Pars_0544
AG: AAA26001(tmoC)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
  Sequence
[ag:AAA26001]
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
LinkDB

KEGG   ORTHOLOGY: K15765
Entry
K15765                      KO                                     
Symbol
tmoF, tbuC, touF
Name
toluene monooxygenase electron transfer component [EC:1.18.1.3]
Pathway
map00623  Toluene degradation
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00538  Toluene degradation, toluene => benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.18  Acting on iron-sulfur proteins as donors
   1.18.1  With NAD+ or NADP+ as acceptor
    1.18.1.3  ferredoxin---NAD+ reductase
     K15765  tmoF, tbuC, touF; toluene monooxygenase electron transfer component
Other DBs
RN: R02550 R03562 R05666 R09513
Genes
PSD: DSC_04380
PPSE: BN5_3604
MBS: MRBBS_1308(tmoF)
MSR: AU15_20760
CYQ: Q91_2220
CZA: CYCME_2538
CYY: CPC19_01700
THIS: HZT40_03300
APAC: S7S_13335
MGEO: CFI10_14575 CFI10_17775
SINI: GT972_13815
GBI: PG2T_00920
TBN: TBH_C0920
VFF: VITFI_CDS2835
RPI: Rpic_4637
RPF: Rpic12D_3561
CNC: CNE_BB1p12310(tmoF)
CUH: BJN34_09360 BJN34_22330
REU: Reut_B5674
RME: Rmet_1311
CCUP: BKK81_02070
CUU: BKK79_10805
BCT: GEM_5810
BCON: NL30_24560
BUG: BC1001_PA6405(tmoF)
BYI: BYI23_D008210
BUE: BRPE67_DCDS10130 BRPE67_FCDS01810
BUQ: AC233_11115
PARB: CJU94_38165
PGP: CUJ91_31715
PACS: FAZ98_33525
PPK: U875_01850 U875_05305
PPNO: DA70_22375
PRB: X636_04295 X636_07620
BUO: BRPE64_DCDS03530
BPE: BP0066
BPC: BPTD_0064
BPER: BN118_3398
BPET: B1917_0069
BPEU: Q425_690
BPA: BPP0517
BBH: BN112_2899
BBR: BB0522
BBM: BN115_0501
BBX: BBS798_0515
BTRM: SAMEA390648701722(dmpP_1)
PUT: PT7_2459
ACID: CBP33_05305
ACIP: CBP36_05755
ACIN: CBP34_05140
ACIS: CBP35_13190
DEL: DelCs14_1741
LIM: L103DPR2_00189(carAd)
HPSE: HPF_01780(tmoF)
HTN: KI616_01900
DIH: G7047_13310
MPT: Mpe_A0819(tbuC) Mpe_A0921(msmD)
METP: C1M51_13805 C1M51_16300
MASW: AM586_27385 AM586_27565
SPLB: SFPGR_26180
RBU: PG1C_04260
DAR: Daro_3815
DEY: HYN24_09705
FLE: KI610_08760
AZD: CDA09_10220
AZR: CJ010_11495
THK: CCZ27_06365
EMX: FKV68_30105
BBT: BBta_1593
AOL: S58_10620
BRO: BRAD285_2997
OCA: OCAR_6789
OCG: OCA5_c12870
OCO: OCA4_c12870
MNO: Mnod_2710 Mnod_8367
FIL: BN1229_v1_3546(msmD)
FIY: BN1229_v1_2377(msmD)
HDI: HDIA_4247(carAd)
SGI: SGRAN_2803(thnA4)
CNA: AB433_10445
BTS: Btus_2064
NFR: ERS450000_00316(tmoF)
ROA: Pd630_LPD03567
PHW: G7075_19670
AMYC: CU254_12395
PBRO: HOP40_29380
TRO: trd_A0924
AG: AAA26004(tmoF)
 » show all
Reference
PMID:1885512
  Authors
Yen KM, Karl MR, Blatt LM, Simon MJ, Winter RB, Fausset PR, Lu HS, Harcourt AA, Chen KK
  Title
Cloning and characterization of a Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 173:5315-27 (1991)
DOI:10.1128/JB.173.17.5315-5327.1991
Reference
PMID:1429451
  Authors
Yen KM, Karl MR
  Title
Identification of a new gene, tmoF, in the Pseudomonas mendocina KR1 gene cluster encoding toluene-4-monooxygenase.
  Journal
J Bacteriol 174:7253-61 (1992)
DOI:10.1128/JB.174.22.7253-7261.1992
  Sequence
[ag:AAA26004]
LinkDB

KEGG   ENZYME: 1.14.13.111
Entry
EC 1.14.13.111              Enzyme                                 
Name
methanesulfonate monooxygenase (NADH);
mesylate monooxygenase;
mesylate,reduced-FMN:oxygen oxidoreductase;
MsmABC;
methanesulfonic acid monooxygenase;
MSA monooxygenase;
MSAMO
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methanesulfonate,NADH:oxygen oxidoreductase
Reaction(IUBMB)
methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O [RN:R09513]
Reaction(KEGG)
R09513
Substrate
methanesulfonate [CPD:C11145];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
formaldehyde [CPD:C00067];
NAD+ [CPD:C00003];
sulfite [CPD:C00094];
H2O [CPD:C00001]
Comment
A flavoprotein. Methanesulfonate is the simplest of the sulfonates and is a substrate for the growth of certain methylotrophic microorganisms. Compared with EC 1.14.14.5, alkanesulfonate monooxygenase, this enzyme has a restricted substrate range that includes only the short-chain aliphatic sulfonates (methanesulfonate to butanesulfonate) and excludes all larger molecules, such as arylsulfonates [1]. The enzyme from the bacterium Methylosulfonomonas methylovora is a multicomponent system comprising a hydroxylase, a reductase (MsmD) and a ferredoxin (MsmC). The hydroxylase has both large (MsmA) and small (MsmB) subunits, with each large subunit containing a Rieske-type [2Fe-2S] cluster. cf. EC 1.14.14.34, methanesulfonate monooxygenase (FMNH2).
History
EC 1.14.13.111 created 2009 as EC 1.14.14.6, transferred 2010 to EC 1.14.13.111, modified 2016
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K16968  methanesulfonate monooxygenase subunit alpha
K16969  methanesulfonate monooxygenase subunit beta
Genes
PQI: KH389_17550 KH389_17555
CUH: BJN34_09325 BJN34_09330 BJN34_22320
BCT: GEM_5811 GEM_5812
BUE: BRPE67_FCDS01800
PPK: U875_05270 U875_05275
PPNO: DA70_22340 DA70_22345
PRB: X636_04320 X636_04325
BPA: BPP0512 BPP0513
BBH: BN112_2903 BN112_2904
BBR: BB0517 BB0518
BBM: BN115_0496 BN115_0497
BBX: BBS798_0510 BBS798_0511
BTRM: SAMEA390648701717(antA)
PUT: PT7_2465 PT7_2466
PUD: G9Q38_01125 G9Q38_01130
MPT: Mpe_A0919(msmS2) Mpe_A0920(msmB)
METP: C1M51_13795
SPLB: SFPGR_26190 SFPGR_26200
MNO: Mnod_2707 Mnod_2708 Mnod_8364 Mnod_8365
FIL: BN1229_v1_3548(msmB) BN1229_v1_3549(msmA)
FIY: BN1229_v1_2374(msmA) BN1229_v1_2375(msmB)
APB: SAR116_2102 SAR116_2103 SAR116_2109
 » show all
Reference
1  [PMID:10094704]
  Authors
de Marco P, Moradas-Ferreira P, Higgins TP, McDonald I, Kenna EM, Murrell JC
  Title
Molecular analysis of a novel methanesulfonic acid monooxygenase from the methylotroph Methylosulfonomonas methylovora.
  Journal
J Bacteriol 181:2244-51 (1999)
DOI:10.1128/JB.181.7.2244-2251.1999
  Sequence
[ag:AAD26619 AAD26620]
Reference
2  [PMID:8932698]
  Authors
Higgins TP, Davey M, Trickett J, Kelly DP, Murrell JC
  Title
Metabolism of methanesulfonic acid involves a multicomponent monooxygenase enzyme.
  Journal
Microbiology 142 ( Pt 2):251-60 (1996)
DOI:10.1099/13500872-142-2-251
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.111
IUBMB Enzyme Nomenclature: 1.14.13.111
ExPASy - ENZYME nomenclature database: 1.14.13.111
UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.111
BRENDA, the Enzyme Database: 1.14.13.111
LinkDB

KEGG   REACTION: R09513
Entry
R09513                      Reaction                               
Name
methanesulfonate,NADH:oxygen oxidoreductase
Definition
Methanesulfonic acid + NADH + H+ + Oxygen <=> Formaldehyde + NAD+ + Sulfite + H2O
Equation
C11145 + C00004 + C00080 + C00007 <=> C00067 + C00003 + C00094 + C00001
Reaction class
RC00001  C00003_C00004
RC02556  C00067_C11145
Enzyme
1.14.13.111
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
Orthology
K15762  toluene monooxygenase system ferredoxin subunit
K15765  toluene monooxygenase electron transfer component [EC:1.18.1.3]
K16968  methanesulfonate monooxygenase subunit alpha [EC:1.14.13.111]
K16969  methanesulfonate monooxygenase subunit beta [EC:1.14.13.111]
Other DBs
RHEA: 26080
LinkDB

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