KEGG   ORTHOLOGY: K17104
Entry
K17104                      KO                                     
Symbol
E2.5.1.41
Name
phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41]
Pathway
map00564  Glycerophospholipid metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K17104  E2.5.1.41; phosphoglycerol geranylgeranyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.41  phosphoglycerol geranylgeranyltransferase
     K17104  E2.5.1.41; phosphoglycerol geranylgeranyltransferase
Other DBs
RN: R04158
COG: COG1646
GO: 0047294
Genes
SVD: CP969_30850
SPRA: CP972_01495
MJA: MJ_1250
MFE: Mefer_0372
MVU: Metvu_0909
MFS: MFS40622_0685
MIF: Metin_0740
MJH: JH146_0475
MESG: MLAUSG7_1285
MESA: MLASG1_0491
MMP: MMP0007
MMD: GYY_00040
MMAD: MMJJ_10930
MAE: Maeo_1165
MVO: Mvol_1417
MTH: MTH_552
METC: MTCT_0480
METE: tca_00524(pcrB)
MTEE: MTTB_09860
MST: Msp_1291(pcrB)
MRU: mru_1102
MSI: Msm_0124
MEB: Abm4_0883
MMIL: sm9_0933
MEYE: TL18_05650
MOL: YLM1_0765
METH: MBMB1_0428
MFC: BRM9_1833
MCUB: MCBB_0391
MFV: Mfer_0282
MKA: MK0642
AFU: AF_0403
FPL: Ferp_2022
GAC: GACE_1575
GAH: GAH_00156
PFU: PF1039
PFI: PFC_04430
PHO: PH1124(PH1124)
PAB: PAB0735
PYN: PNA2_1786
PYS: Py04_0956
TKO: TK1026
TON: TON_1065
TGA: TGAM_1175(gggPS)
TSI: TSIB_0683
THE: GQS_10240
THA: TAM4_2030
THM: CL1_1622
TLT: OCC_02732
THS: TES1_1095
TNU: BD01_0972
TEU: TEU_10660
PPAC: PAP_08105
MBAR: MSBR2_3210
MBAK: MSBR3_3195
MAC: MA_3969
MMA: MM_0943
MMAC: MSMAC_0379
METM: MSMTP_0421
MTHR: MSTHT_1546
MTHE: MSTHC_1743
MHOR: MSHOH_0454
MBU: Mbur_1652
MMET: MCMEM_2137
MMH: Mmah_1962
MPY: Mpsy_1329
MTP: Mthe_1238
MCJ: MCON_1916
MHI: Mhar_0199
MHU: Mhun_1010
MLA: Mlab_1138
MEMA: MMAB1_3107
MPI: Mpet_1935
MBN: Mboo_0860
MPL: Mpal_1300
MEZ: Mtc_2486
HSL: OE_1398R(pcrB1) OE_3699R(pcrB2)
HHB: Hhub_1410(pcrB)
HALH: HTSR_1475
HHSR: HSR6_1547
HARA: AArcS_2630(pcrB)
HMA: rrnAC1650(pcrB)
HHI: HAH_2191(pcrB)
NPH: NP_1224A(pcrB)
NMO: Nmlp_2072(pcrB)
HUT: Huta_2960
HTI: HTIA_2549
HALL: LC1Hm_2400(pcrB)
HDS: HSR122_1249(pcrB)
HWA: HQ_1269A(pcrB)
HWC: Hqrw_1298(pcrB)
HVO: HVO_0680(pcrB1) HVO_1086(pcrB2)
HLA: Hlac_0199
NMG: Nmag_1070(pcrB1) Nmag_2771(pcrB2)
NAT: NJ7G_1988
SALI: L593_04125
MELU: MTLP_01470
TAC: Ta0995
TVO: TVG0750626(TVG0750626)
PTO: PTO0183
FAI: FAD_1427
CDIV: CPM_1185
MARC: AR505_1588
ABI: Aboo_0770
ACJ: ACAM_0473
SMR: Smar_0993
IHO: Igni_0425
IIS: EYM_04315
DKA: DKAM_1191
TAG: Tagg_0823
IAG: Igag_0058
HBU: Hbut_0005
STO: STK_03100
SSO: SSO0259
SOL: Ssol_1237
SSOA: SULA_1279
SSOL: SULB_1280
SSOF: SULC_1278
SCAS: SACC_01720
SAI: Saci_0728
SID: M164_1886
SII: LD85_2100
SIH: SiH_1816
SIR: SiRe_1736
SIC: SiL_1728
MSE: Msed_2291
MCN: Mcup_2034
AHO: Ahos_0786
ACIH: HS5_21600
CSTY: KN1_18710
STEP: IC006_1789
SAHS: HS7_07230
PAI: PAE3045
PIS: Pisl_0443
PCL: Pcal_0985
PAS: Pars_1793
PYR: P186_1474
POG: Pogu_0338
TNE: Tneu_1677
CMA: Cmaq_0928
TTN: TTX_1714
TUZ: TUZN_1798
VDI: Vdis_0768
VMO: VMUT_1616
TPE: Tpen_0633
ASC: ASAC_1045
ACIA: SE86_06355
NMR: Nmar_1795
NCT: NMSP_1711
NEV: NTE_00080
TAA: NMY3_00623(pcrB)
NCV: NCAV_1797
NBV: T478_1498
NDV: NDEV_0006
CCAI: NAS2_1641
KCR: Kcr_1391
BARC: AOA65_2367
BARB: AOA66_1442
MARH: Mia14_0378
 » show all
Reference
  Authors
Soderberg T, Chen A, Poulter CD
  Title
Geranylgeranylglyceryl phosphate synthase. Characterization of the recombinant enzyme from Methanobacterium thermoautotrophicum.
  Journal
Biochemistry 40:14847-54 (2001)
DOI:10.1021/bi0111799
  Sequence
[mth:MTH_552]
LinkDB

KEGG   ENZYME: 2.5.1.41
Entry
EC 2.5.1.41                 Enzyme                                 
Name
phosphoglycerol geranylgeranyltransferase;
glycerol phosphate geranylgeranyltransferase;
geranylgeranyl-transferase (ambiguous);
prenyltransferase (ambiguous);
(S)-3-O-geranylgeranylglyceryl phosphate synthase;
(S)-geranylgeranylglyceryl phosphate synthase;
GGGP synthase;
(S)-GGGP synthase;
GGGPS;
geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase;
geranylgeranyl diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
geranylgeranyl-diphosphate:sn-glycerol-1-phosphate geranylgeranyltransferase
Reaction(IUBMB)
geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [RN:R04158]
Reaction(KEGG)
R04158
Substrate
geranylgeranyl diphosphate [CPD:C00353];
sn-glycerol 1-phosphate [CPD:C00623]
Product
diphosphate [CPD:C00013];
3-(O-geranylgeranyl)-sn-glycerol 1-phosphate [CPD:C04590]
Comment
This cytosolic enzyme catalyses the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria [2]. Requires Mg2+ for maximal activity [2]. It catalyses the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate [2]. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 1.1.1.261 (sn-glycerol-1-phosphate dehydrogenase), EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase) and EC 2.7.7.67 (CDP-archaeol synthase), which lead to the formation of CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [5].
History
EC 2.5.1.41 created 1992, modified 2009
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K17104  phosphoglycerol geranylgeranyltransferase
Genes
SVDCP969_30850
SPRACP972_01495
MJAMJ_1250
MFEMefer_0372
MVUMetvu_0909
MFSMFS40622_0685
MIFMetin_0740
MJHJH146_0475
MESGMLAUSG7_1285
MESAMLASG1_0491
MIGMetig_1082
MMPMMP0007
MMQMmarC5_1677
MMXMmarC6_0942
MMZMmarC7_1004
MMDGYY_00040
MMAKMMKA1_00070
MMAOMMOS7_00070
MMADMMJJ_10930
MAEMaeo_1165
MVNMevan_1213
MVOMvol_1417
MOKMetok_0736
METFCFE53_04705
MTHMTH_552
MMGMTBMA_c09410
METCMTCT_0480
MWOMWSIV6_0917
METEtca_00524(pcrB)
METZMETMT2_0829
METKFVF72_08760
MTHMFZP57_04400
METJFZP68_04865
MTEEMTTB_09860
MSTMsp_1291(pcrB)
METBAW729_09185
MRUmru_1102
MSIMsm_0124
MEBAbm4_0883
MMILsm9_0933
MEYETL18_05650
MOLYLM1_0765
MAROMarbSA_02470
MELMetbo_2269
MEWMSWAN_0376
METHMBMB1_0428
MFCBRM9_1833
MFIDSM1535_0016
MCUBMCBB_0391
MSUBBK009_00180
METNBK008_07970
METTCIT01_10475
METOCIT02_04670
MEMEHYG87_00325
MFVMfer_0282
MKAMK0642
AFUAF_0403
AFGAFULGI_00004070
APOArcpr_0988
AVEArcve_0345
ASTAsulf_00438
FPLFerp_2022
GACGACE_1575
GAHGAH_00156
PFUPF1039
PFIPFC_04430
PHOPH1124(PH1124)
PABPAB0735
PYNPNA2_1786
PYAPYCH_06020
PYSPy04_0956
PYCTQ32_06100
TKOTK1026
TONTON_1065
TGATGAM_1175(gggPS)
TSITSIB_0683
TBATERMP_01020
THEGQS_10240
THATAM4_2030
THMCL1_1622
TLTOCC_02732
THSTES1_1095
TNUBD01_0972
TEUTEU_10660
TGYX802_09560
THVADU37_CDS06810
TCHCHITON_1469
TPEPA0127_00030
TPIEA7C91_00815
TGGA3K92_02365
TCEA3L02_05075
TBSA3L01_06055
THHCDI07_06010
TSLA3L11_10070
TTDA3L14_08455
TPRFA3L09_04095
TRLA3L10_00545
TPAFA3L08_09200
THYA3L12_06710
TICFH039_08020
TCQTIRI35C_1523
THEMFPV09_01420
PPACPAP_08105
MBAMbar_A0675
MBYMSBRM_3248
MBWMSBRW_0328
MBARMSBR2_3210
MBAKMSBR3_3195
MACMA_3969
MMAMM_0943
MMAZMmTuc01_0970
MMJMSMAS_0361
MMACMSMAC_0379
MVCMSVAZ_3248
MEKMSKOL_3213
MLSMSLAZ_0576
METMMSMTP_0421
MEFMSWH1_2769
MEQMSWHS_2267
MSJMSSAC_3705
MSZMSSIH_3241
MSWMSSIT_3312
MTHRMSTHT_1546
MTHEMSTHC_1743
MHORMSHOH_0454
MFZAOB57_006815
MBUMbur_1652
MMETMCMEM_2137
MELOJ7W08_09650
MMHMmah_1962
MHAZBHR79_03825
MEVMetev_1519
MZHMzhil_0369
MPYMpsy_1329
MZIHWN40_02045
MHZMetho_0329
MTPMthe_1238
MCJMCON_1916
MHIMhar_0199
MHUMhun_1010
MRTJKHC33_11900
MLAMlab_1138
MEMMemar_0769
MBGBN140_2339
MEMAMMAB1_3107
MCHKMchiMG62_08940
MPIMpet_1935
MBNMboo_0860
MFOMetfor_2140
MPLMpal_1300
MPDMCP_0258 MCP_2780
MEZMtc_2486
RCIRCIX581 RCIX582
HALVNG_0252C VNG_1918C
HSLOE_1398R(pcrB1) OE_3699R(pcrB2)
HDLHALDL1_05460 HALDL1_09625
HHBHhub_1410(pcrB)
HAGSJT689_02430 JT689_09055
HABOJRZ79_00935 JRZ79_07465
HNOLT974_02075
HLULT972_01815 LT972_11520
HANRLJ422_01145 LJ422_07725
HJEHacjB3_02500 HacjB3_13025 HacjB3_18758
HALHHTSR_1475
HHSRHSR6_1547
HSUHLASF_0583
HSFHLASA_0579
SALRFQU85_02410
HALREFA46_005885
HARAAArcS_2630(pcrB)
HAADMW046_08620
HALXM0R89_10565 M0R89_11495
HMArrnAC1650(pcrB)
HHIHAH_2191(pcrB)
HHNHISP_11165
HABSG26_03535 SG26_19305
HTABVU17_10680
HALJG9465_07155
HSINKDQ40_02435
NPHNP_1224A(pcrB)
NMONmlp_2072(pcrB)
NHOHWV23_12105
NSALHWV07_06090
HUTHuta_2960
HTIHTIA_2549
HALAHrd1104_04755
HMUHmuk_0293 Hmuk_3016
HALZE5139_02350 E5139_04750
HALLLC1Hm_2400(pcrB)
HAZPGBQ70_02350 GBQ70_04745
HALIBV210_05505
HSNDV733_16670
HDSHSR122_1249(pcrB)
HRRHZS55_08765 HZS55_21180
HPELHZS54_09880 HZS54_24710
HLTI7X12_05240 I7X12_12865
HARCHARCEL1_00260
HDOMUK72_05205
HWAHQ_1269A(pcrB)
HWCHqrw_1298(pcrB)
HVOHVO_0680(pcrB1) HVO_1086(pcrB2)
HMEHFX_0542 HFX_0642
HGIABY42_03240
HALEG3A49_03460
HBOHbor_22430 Hbor_25380
HAQDU484_06795
HAJDU500_07065
HAERDU502_04730 DU502_10580
HRAEI982_09010
HLMDV707_12695
HALMFCF25_10385
HLAHlac_0199
HALPDOS48_00985
HALBEKH57_10395
HEZZEO776_01025
HALQHrr1229_005920
HSSJ7656_00150
HSAIHPS36_05665
HAZZKI388_14710
SRUBC2R22_04090
HAEhalTADL_1085
HALNB4589_004795 B4589_008105
HALGHUG10_14840
HALUHUG12_01355
HMPK6T50_11055
HREK6T36_10845
HRMK6T25_05200
HACBHbl1158_03290
HDFAArcSl_2174 AArcSl_2191(pcrB)
HAHHalar_2377 Halar_3226
HTUHtur_1301 Htur_2683
HDABB347_02560 BB347_08760
HJTDVR14_14030
HALYHYG82_09055
HSALJMJ58_02305 JMJ58_15430
HLOJ0X27_05125
HAKZJ0X25_01645 J0X25_13355
NMGNmag_1070(pcrB1) Nmag_2771(pcrB2)
HXAHalxa_2474 Halxa_4034
NATNJ7G_1988
NPENatpe_0946
NVRFEJ81_04880
NPLFGF80_05970
NAYHYG81_05975
NGENatgr_0591 Natgr_1269 Natgr_2083
HRUHalru_0157
NOUNatoc_0656 Natoc_2675
SALIL593_04125
SAIMK0C01_03090
HLRHALLA_07705 HALLA_12930
HLCCHINAEXTREME00365 CHINAEXTREME09750
NAJB1756_06220 B1756_12310
NAGAArcMg_0535 AArcMg_0918
NANAArc1_0548 AArc1_2828
NBGDV706_01315 DV706_10880 DV706_15955
NASGCU68_01215 GCU68_12380
MELUMTLP_01470
MEAMMU439_00360
TACTa0995
TVOTVG0750626(TVG0750626)
PTOPTO0183
FACFACI_IFERC01G0508
FAIFAD_1427
CDIVCPM_1185
TARTALC_00272
MAXMMALV_02560
MERMMINT_05980
MEARMpt1_c10950
MARCAR505_1588
ABIAboo_0770
ACFAciM339_0296
APEAPE_0621.1
ACJACAM_0473
SMRSmar_0993
SHCShell_1468
IHOIgni_0425
IISEYM_04315
DKADKAM_1191
DFDDesfe_1302
DMUDesmu_1195
TAGTagg_0823
IAGIgag_0058
THGTCELL_0313
HBUHbut_0005
PFMPyrfu_0154
PDLPyrde_0546
STOSTK_03100
SOHD1869_01095
SSOSSO0259
SOLSsol_1237
SSOASULA_1279
SSOLSULB_1280
SSOFSULC_1278
SSHIJ5U23_03207
SCASSACC_01720
SAISaci_0728
SACNSacN8_03530
SACRSacRon12I_03515
SACSSUSAZ_03285
SISLS215_1988
SIAM1425_1879
SIMM1627_1956
SIDM164_1886
SIYYG5714_1955
SINYN1551_0965
SIILD85_2100
SIHSiH_1816
SIRSiRe_1736
SICSiL_1728
SULABFU36_04740
SULEGFS03_10290
SULOGFS33_02105
SULLEWF20_02560
MSEMsed_2291
MCNMcup_2034
MHKDFR87_06930
MPRUDFR88_06730
MTENGWK48_05230
MJNMjAS7_0580
AHOAhos_0786
AMANB6F84_07390
ABRIDFR85_07535
ASULDFR86_06445
AAMBD1866_11765
ACIHHS5_21600
SACDHS1genome_0144
SAZOD1868_01885
CSTYKN1_18710
STEPIC006_1789
SAHSHS7_07230
PAIPAE3045
PISPisl_0443
PCLPcal_0985
PASPars_1793
PYRP186_1474
POGPogu_0338
TNETneu_1677
PYWPYWP30_01805
CMACmaq_0928
TTNTTX_1714
TUZTUZN_1798
VDIVdis_0768
VMOVMUT_1616
TPETpen_0633
THBN186_04510
TCBTCARB_1929
THFMA03_05950
THELIG193_04075
ASCASAC_1045
ACIASE86_06355
CLGCalag_0530
FFOFFONT_0864
NMRNmar_1795
NIRNSED_09615
NKRNKOR_09545
NIDNPIRD3C_0251
NINNADRNF5_0072
NIWNisw_05030
NCLC5F47_09295
NOXC5F49_09180
NUEC5F50_12615
NIPNsoK4_09320
NCTNMSP_1711
NICDSQ20_10180
CSYCENSYa_1828
NGANgar_c35980
NVNNVIE_020530
NEVNTE_00080
TAANMY3_00623(pcrB)
NFNNFRAN_1692
NCVNCAV_1797
CSUCSUB_C1094
NBVT478_1498
TAHSU86_006215
NIUDSQ19_10505
NDVNDEV_0006
CCAINAS2_1641
KCRKcr_1391
BARCAOA65_2367
BARBAOA66_1442
MARHMia14_0378
FLTSv326_1238
MIYMicr_00713
LOKILokiarch_51250
AGWQT03_C0001G1125
 » show all
Reference
1
  Authors
Zhang, D.-L., Daniels, L. and Poulter, C.D.
  Title
Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction.
  Journal
J Am Chem Soc 112:1264-1265 (1990)
Reference
2  [PMID:8408023]
  Authors
Chen A, Zhang D, Poulter CD
  Title
(S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis.
  Journal
J Biol Chem 268:21701-5 (1993)
  Sequence
Reference
3  [PMID:12801917]
  Authors
Nemoto N, Oshima T, Yamagishi A
  Title
Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum.
  Journal
J Biochem 133:651-7 (2003)
DOI:10.1093/jb/mvg083
  Sequence
[tac:Ta0995]
Reference
4  [PMID:16377641]
  Authors
Payandeh J, Fujihashi M, Gillon W, Pai EF
  Title
The crystal structure of (S)-3-O-geranylgeranylglyceryl phosphate synthase reveals an ancient fold for an ancient enzyme.
  Journal
J Biol Chem 281:6070-8 (2006)
DOI:10.1074/jbc.M509377200
  Sequence
[afu:AF_0403]
Reference
5  [PMID:10960477]
  Authors
Morii H, Nishihara M, Koga Y
  Title
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus.
  Journal
J Biol Chem 275:36568-74 (2000)
DOI:10.1074/jbc.M005925200
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.41
IUBMB Enzyme Nomenclature: 2.5.1.41
ExPASy - ENZYME nomenclature database: 2.5.1.41
BRENDA, the Enzyme Database: 2.5.1.41
CAS: 124650-69-7
LinkDB

KEGG   REACTION: R04158
Entry
R04158                      Reaction                               
Name
geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase
Definition
Geranylgeranyl diphosphate + sn-Glycerol 1-phosphate <=> Diphosphate + 3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
Equation
Reaction class
RC01091  C00623_C04590
Enzyme
Pathway
rn00564  Glycerophospholipid metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K17104  phosphoglycerol geranylgeranyltransferase [EC:2.5.1.41]
Other DBs
RHEA: 23407
LinkDB

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