KEGG   ORTHOLOGY: K17217
Entry
K17217                      KO                                     
Symbol
mccB
Name
cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2]
Pathway
map00260  Glycine, serine and threonine metabolism
map00270  Cysteine and methionine metabolism
map00670  One carbon pool by folate
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Module
M00609  Cysteine biosynthesis, methionine => cysteine
Reaction
R00782  L-cysteine hydrogen-sulfide-lyase (deaminating; pyruvate-forming)
R01001  L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
R01283  L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
R02408  L-cystine thiocysteine-lyase (deaminating; pyruvate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
   00270 Cysteine and methionine metabolism
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
Enzymes [BR:ko01000]
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.1  cystathionine gamma-lyase
     K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
    4.4.1.2  homocysteine desulfhydrase
     K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
Other DBs
COG: COG0626
GO: 0004123 0047982
Genes
PPAV: LOZ86_14560
GKN: PVT67_04235
PBEJ: PSH84_04400
PTHV: CE140_19790
SDO: SD1155_04930
BOMB: GT348_03645
DAL: Dalk_0849
DVR: Dvar_76790
MVH: ACN6A1_31845
OLE: K0B96_16580
PBOR: BSF38_05025(mccB)
GMA: AciX8_2098
GRB: GOB94_03575
EDA: GWR55_01120
EDG: H7846_07325
EPL: P4G45_05325
ORP: MOP44_12640
TGI: RBB81_19085
TEMP: RBB75_01515
TPSC: RBB77_09505
SCOR: J3U87_06265
CPI: Cpin_1963
CBAE: COR50_21245
CHIT: FW415_09465
CHIH: GWR21_25265
CFIL: MYF79_09760
CHOR: MKQ68_15740
CSAC: SIO70_11175
CHII: UNH65_02980
NIA: A8C56_12875
RHOZ: GXP67_11625
FLI: Fleli_0126
HAEI: MUN82_11060
CHK: D4L85_07900
FMM: LVD15_06280
FUA: LVD17_07615
FLW: LVD16_02685
TPEL: P0M28_21480
FPSZ: AMR72_00130
FAT: DVK85_10105
FKI: FK004_10650
FPAL: HYN49_09540
FALB: HYN59_11470
FAK: FUA48_15650
COC: Coch_1685
COL: AM608_00910
CAPN: CBG49_00030
CSPU: CGC55_09095
MARM: YQ22_16555
MART: BTR34_16640
AIC: JK629_00045
AEQU: QCQ61_09660
NUL: R1T42_07130
MYR: MYRA21_1478(mccB)
MOD: AS202_07005
AUE: C5O00_08315 C5O00_10905
SINH: LS482_14990
FCX: ABT310_12925
FAW: ABWH94_13985
SAHN: JRG66_13300
SAZS: VS868_01250
FBQ: D1817_07655
APIB: G8C43_00490
BPI: BPLAN_072(metB)
BBQ: BLBBOR_564
BLU: K645_2681
BLAD: G9C01_00035
OHO: Oweho_2590
SRU: SRU_1368
SRM: SRM_01563(metB)
BSU: BSU27250(yrhB)
BSR: I33_2767(yrhB)
BSL: A7A1_0367
BSH: BSU6051_27250(mccB)
BSY: I653_12940
BSUT: BSUB_02907(mccB)
BSUL: BSUA_02907(mccB)
BSUS: Q433_14680
BSO: BSNT_09119(yrhB)
BSN: BSn5_04410
BSQ: B657_27250(mccB)
BSX: C663_2562(mccB)
BSP: U712_13395
BSS: BSUW23_13180(mccB)
BST: GYO_2965(yrhB)
BIT: BIS30_03010
BLI: BL02018(yrhB)
BLD: BLi02853(mccB)
BLH: BaLi_c29540(mccB)
BAY: RBAM_024350
BAQ: BACAU_2449(yrhB)
BYA: BANAU_2593(yrhB)
BAMP: B938_12585
BAML: BAM5036_2375(mccB)
BAMA: RBAU_2572(mccB)
BAMN: BASU_2378(mccB)
BAMB: BAPNAU_1127(yrhB)
BAMT: AJ82_13760
BAMY: V529_27190(yrhB)
BMP: NG74_02557(mccB)
BAO: BAMF_2533(mccB)
BAZ: BAMTA208_13370(mccB)
BQL: LL3_02811(mccB)
BXH: BAXH7_02735(yrhB)
BAMI: KSO_007200
BAMC: U471_25270
BAMF: U722_13215
BSIA: CWD84_08705
BAE: BATR1942_11340
BVM: B9C48_12455
BSON: S101395_01638(mccB)
BHT: DIC78_18030
BMOJ: HC660_25280(mccB)
BTEQ: G4P54_13885
BIQ: AN935_13310
BSTR: QI003_16790(mccB)
BAN: BA_4600
BAR: GBAA_4600
BAT: BAS4268
BAH: BAMEG_4637
BAI: BAA_4620
BAX: H9401_4389
BANT: A16_45980
BANR: A16R_60345
BANS: BAPAT_4415
BANH: HYU01_22435
BANV: DJ46_3277(mccB)
BAL: BACI_c43580(metC2)
BCE: BC4366
BCA: BCE_4454(metC)
BCZ: BCE33L4116(metC)
BCR: BCAH187_A4505
BCB: BCB4264_A4491
BCU: BCAH820_4452
BCG: BCG9842_B0745
BCQ: BCQ_4156(metC)
BCX: BCA_4484
BNC: BCN_4282
BCF: bcf_21745
BCER: BCK_13335
BCEF: BcrFT9_03441
BCY: Bcer98_3084
BTK: BT9727_4105(metC)
BTL: BALH_3957(metC)
BTB: BMB171_C4033
BTT: HD73_4680
BTHR: YBT1520_23210
BTHI: BTK_23050
BTC: CT43_CH4389
BTF: YBT020_21535
BTM: MC28_3663
BTG: BTB_c45120(mccB)
BTI: BTG_27215
BTN: BTF1_20465
BTHT: H175_ch4458
BTHU: YBT1518_24315
BTW: BF38_126(mccB)
BTHY: AQ980_07960
BWE: BcerKBAB4_4219
BWW: bwei_0567(mccB)
BMYO: BG05_1654
BTY: Btoyo_1609
BMYC: DJ92_1469(mccB)
BBY: CY96_21035
BWD: CT694_23485
BTRO: FJR70_15650
BMOB: MLA2C4_22810
BNT: GSN03_20800
BPAC: LMD38_05145
BPAN: NLJ82_21250
BALU: QRY64_24755
BAAP: BGI23_21110
BPAM: AABL52_05600
BPU: BPUM_2360
BPUM: BW16_12815
BPUS: UP12_11885
BIF: N288_18655
BMET: BMMGA3_12170(mccB)
BSM: BSM4216_1794
BGY: BGLY_3172(mccB)
BXI: BK049_15170
BALT: CFN77_12615
BAER: BAE_00305
BSAF: BSL056_12965
BSHI: LGQ02_13715
BCAB: EFK13_13835
BRY: M0696_13610
BJS: MY9_2706
BACI: B1NLA3E_16320
GST: HW35_04705
BACW: QR42_11960
BACP: SB24_16520
BACB: OY17_15455
BACY: QF06_11815
BACL: BS34A_29730(yrhB)
BALM: BsLM_2694
BACS: AUL54_17640
BACA: FAY30_17470
BAQU: K6959_18320
BZH: NF868_10630
BHAI: KJK41_15815
BCAO: LC087_07935
BARD: QRY57_21565
BAEI: RE735_07970
BASB: M662_04705
BACF: AM500_08780
BAFC: K3G25_05245
BASD: LCG60_02945
BHAM: ABN702_04040
BACV: I7V34_10320
BAEZ: DPQ26_24790
BAZS: BZ167_16845
BACH: BSZ43_14115
BACJ: CJO35_14220
BAWR: D9C22_14580
BAAZ: GD442_21445
BACN: GNK04_15330
BABD: EKQ63_23400
BHK: B4U37_15535
BCOH: BC6307_15895
BCIR: C2I06_10455
NTX: NQZ71_07960
NIL: L8T27_013795
NTGC: AB3U99_16130
BMQ: BMQ_4594(mccB)
BMD: BMD_4580(mccB)
BMEG: BG04_1586 BG04_4883
BEO: BEH_16500
BFX: BC359_04745
PKS: IE339_19400
BCL: ABC1945
BLE: BleG1_1700
SHUA: PQ477_17365
BGI: BGM20_07520
BON: A361_02835
BKO: CKF48_17425
CGOT: J1899_15725
CFIR: NAF01_02895
CSOA: LIS82_19845
CSPG: LS684_14025
CPSS: M5V91_19240
CSUA: IM538_17675
OIH: OB1109(metC)
OCN: CUC15_07025
OKM: ACN6MR_05315
HHD: HBHAL_2023(mccB)
HMN: HM131_16225
HLI: HLI_06375
HNZ: P9989_05815
HSAN: MUN89_17580
HSHI: MUO14_19475
HAMY: MUO15_07760
TAP: GZ22_04630
TAID: KS242_05465
VIR: X953_04960
VHL: BME96_04135
VIL: CFK37_01100
VNE: CFK40_17135
VIM: GWK91_05705
VNT: OLD84_06875
VIK: KFZ58_06635
LEX: Len3610_01585
BSJ: UP17_16915
BMUR: ABE28_015665
PBUT: DTO10_03730
PASA: BAOM_3878(mccB)
PPSR: I6J18_20135
PFRI: L8956_17555
PERI: RE409_19370
PERJ: JNUCC41_26475
PERS: ACJ9PY_18000
PESI: V1500_19435
AQT: FN924_05330
RAX: KO561_05555
BTHV: CQJ30_10390
PSYH: D0S48_17720
PSYO: PB01_15150
PSYB: KD050_05310
PPSN: ACQCPR_14590
GRC: GI584_17700
GCS: MUN88_11630
GSM: MUN87_07235
POF: GS400_02555
PCHU: QNI29_02085
PONA: IMZ31_01975
NTM: BTDUT50_12135
NDT: L1999_22110
NCM: QNK12_23485
NNV: QNH39_19435
NOCE: V1499_15305
MSEM: GMB29_13390
MDG: K8L98_18130
MSEE: WCV65_13970
MHRF: QLQ22_18290
BLEN: NCTC4824_00046(mccB)
SEDD: ERJ70_04085
BVQ: FHE72_15530
RMF: D5E69_15360
RAZ: U9J35_15730
ROD: P8596_16230
ROSS: V2W31_15735
RSJ: V1502_08320
BCK: BCO26_2430
BAG: Bcoa_1961
BCOA: BF29_1572(mccB)
BVJ: I5776_17570
BOU: I5818_21615
HSPO: JGZ69_02890
CTHU: HUR95_16170
MCUI: G8O30_08385
PSUA: FLK61_25195
SLMS: MM221_11375
MJO: FOF60_09740
MSUT: LC048_11955
ECTO: MUG87_08350
ALKG: MOJ78_14250
PMAF: V1498_06115
PEST: V1501_15235
FPN: ABE65_014675
FAR: ABE41_013445
FEC: QNH15_16605
PNH: V1497_01585 V1497_12975
PHJ: LC071_04670
GKA: GK2540
GTE: GTCCBUS3UF5_28630
GTK: GT3570_12440
GTM: GT3921_06745
GLI: GLN3_05575
BCAL: CWI35_15570
GTN: GTNG_2473
GWC: GWCH70_2474
GYC: GYMC61_0979
GYA: GYMC52_2573
GCT: GC56T3_0952
GMC: GY4MC1_1027
GGH: GHH_c26140(mcc)
GJF: M493_13170
GEA: GARCT_02594(mccB)
GEL: IB49_04570
GSE: GT50_04120
GSR: GS3922_03475
GEJ: A0V43_10570
GZA: IC807_08840
GTH: Geoth_1097
PTL: AOT13_17155
PTB: DER53_00265
PARG: PspKH34_09440
PCAL: BV455_02801(mccB)
AFL: Aflv_0761
AGN: AFK25_10605
ANM: GFC28_3612
ANL: GFC29_1821
AND: GRQ40_13470
AAYD: B379_11395
ACAI: ISX45_10945
AAMY: GFC30_2789
STEA: C0679_09625
SAU: SA0419(metB)
SAV: SAV0460(yrhB)
SAW: SAHV_0458(yrhB)
SAH: SaurJH1_0495
SAJ: SaurJH9_0482
SAM: MW0415(metB)
SAS: SAS0418
SAR: SAR0460
SAC: SACOL0503
SAA: SAUSA300_0434(metB)
SAO: SAOUHSC_00422
SAE: NWMN_0425(metB)
SAD: SAAV_0403
SUU: M013TW_0425
SUV: SAVC_01890
SUE: SAOV_0478
SUJ: SAA6159_00410
SUK: SAA6008_00464(metB)
SUC: ECTR2_394
SUT: SAT0131_00500
SUQ: HMPREF0772_10062
SUZ: MS7_0434(mccB)
SUD: ST398NM01_0526
SUX: SAEMRSA15_03860
SUW: SATW20_05290
SUG: SAPIG0526
SUF: SARLGA251_03940
SAUA: SAAG_00915
SAUE: RSAU_000393
SAUN: SAKOR_00444
SAUS: SA40_0399
SAUU: SA957_0414
SAUG: SA268_0412
SAUZ: SAZ172_0462
SAUT: SAI1T1_2003360(yrhB)
SAUJ: SAI2T2_1003360(yrhB)
SAUK: SAI3T3_1003360(yrhB)
SAUQ: SAI4T8_1003360(yrhB)
SAUV: SAI7S6_1003360(metB)
SAUW: SAI5S5_1003350(metB)
SAUX: SAI6T6_1003360(metB)
SAUY: SAI8T7_1003360(metB)
SAUF: X998_0487
SAB: SAB0410
SUY: SA2981_0436(metB)
SAUB: C248_0510
SAUM: BN843_4430
SAUC: CA347_454(mccB)
SAUR: SABB_02175(mccB)
SAUI: AZ30_02230
SAUD: CH52_03550
SAMS: NI36_02155
SUH: SAMSHR1132_04050
SER: SERP0095
SEP: SE_2323
SEPP: SEB_02318
SEPS: DP17_1515
SHA: SH2548(metB)
SHH: ShL2_02333(metB_2)
SSP: SSP0253
SCA: SCA_0087(metC)
SLG: SLGD_02456
SLN: SLUG_23510
SSD: SPSINT_0116
SDT: SPSE_2355(metB2)
SDP: NCTC12225_02561(metB2)
SWA: A284_11085
SPAS: STP1_1535
SXY: BE24_10690
SXL: SXYLSMQ121_0281
SXO: SXYL_00285(metB)
SHU: SHYC_11450(mccB)
SCAP: AYP1020_2183(mccB)
SSCH: LH95_11030
SSCZ: RN70_11795
SAGQ: EP23_10730
SEQO: SE1039_22900
SSIF: AL483_09470
SCV: A4G25_07300
SLZ: B5P37_06600
SKL: C7J89_03245
SFQ: C7J90_02460
SHOM: EGX58_04080
SMUS: C7J88_06865
SCAR: DWB96_12385
SCHR: DWB92_11605
SPIC: SAMEA4384060_2443(metC_1)
SSH: NCTC13712_00386(mccB)
SSIM: SAMEA4384339_0378(mccB)
SDB: CNQ82_00630
SLLO: ISP08_02060
SAUL: I6G39_10115
SRAI: LN051_10780
SPSD: JMB28_01925
STAS: HYI43_11695
SEDA: MNY58_01480
SCAQ: QMO72_01560
SDEV: Q2T90_07425
SROT: ML435_01985
STAP: AOB58_2111
SHSI: QQM35_02135
SGAI: K3U27_07695
SSUC: ACSSAF_01480
SSCU: CEP64_10520
SFF: FOB90_08365
SSTE: SAMEA4384403_2191(metB2)
MVT: I6J10_00355
MACR: BHM04_11955
MARY: LAU42_10670
MBRU: MGG13_10090
MEPI: KFV12_11885
MEQU: KFV11_10180
MBOC: QSV55_10290
MPSH: QA539_09630
MAEQ: ACMGE4_00195
MANM: ACMGE9_07895
MCL: MCCL_1790
MCAK: MCCS_23060(mccB)
MBOE: HT586_11100
SBAC: BVH56_07765
ESI: Exig_2343
EAT: EAT1b_0608
EAN: Eab7_2188
EXM: U719_00325 U719_12900
EXU: ESP131_15010
EAP: KB235_07395
EACE: KKI46_12845
EAUR: NMQ00_06115
EMM: PTI97_08760
EPF: OE059_05815
EXI: A0126_11525
EXH: HNY42_13465
EMEX: ACNOIU_05700
BBE: BBR47_47850(mccB)
BLR: BRLA_c040910
BFM: BP422_19710
BAGR: BA6348_07560
BRW: GOP56_13100
BCHS: JNE38_25755
BCOP: JD108_05020
BPAB: PSE45_22780
BHUI: LOK74_16635
BAYD: BSPP4475_03825
BBOR: RFB14_05025
BRUM: NDK47_05855
BREH: HP435_23350
ASED: IRT44_02020
BREP: M655_005620
BGEL: AAFJ72_17500
PJD: Pjdr2_5104
PPY: PPE_02107
PPM: PPSC2_11035(yrhB)
PPO: PPM_2116(yrhB)
PPOL: X809_11380
PPQ: PPSQR21_021960
PPOY: RE92_01315
PTA: HPL003_19390
PBJ: VN24_22970
PIH: UB51_24975
PPEO: ABE82_11210
PBV: AR543_13270
PXL: BS614_24800
PKB: B4V02_14230
PAIH: ASL14_00325
PPRT: ET464_13385
PKA: PQ456_10635
PAMY: P9222_15305
PNK: AASFL403_08255
PLZH: C0638_22160
PACL: DCC85_10010
PASZ: KAI36_02254(mccB)
ANX: ACH33_03440
ASOC: CB4_01041(mccB_2)
ATHE: K3F53_15475
AUD: PO771_03285
ANEU: PP175_21035
PLN: Plano_2471
PKU: AUO94_03270
PRT: AUC31_13730
PLL: I858_010425
PANA: BBH88_06555
PDG: BCM40_02840
PHC: BBI08_09600
PMAR: B0X71_15400
PPLA: BBI15_08580
PFAE: AJGP001_14280
PLX: CW734_14630
PMAT: BBI11_14200
PDEC: H1Q58_13505
PLAY: DNR44_007335
PLIQ: QWY22_15895
PSHE: QWY16_15790
PSHX: QWY21_15930
JEO: JMA_30770
SPSY: AZE41_06760
SPOO: J3U78_10515
SPOH: GGGNBK_16595(metC)
RST: ATY39_01120
PAEK: D3873_09800
PANC: E2636_04660
VIJ: JNUCC6_21815
NTR: B0W44_09000
LFB: C1X05_03180
TVU: AB849_002175
KPUL: GXN76_04270
KEB: GXN75_04830
PABS: JIR001_06880
CMIC: caldi_03410(metC)
ACAE: HYG86_02780
SAY: TPY_1267(metC)
SAP: Sulac_2385
HFV: R50_0413(mccB) R50_0742(mccB)
CTHM: CFE_0259
THEZ: OEI98_001812
BACG: D2962_10705
STED: SPTER_12980(mccB_2)
SCAO: SCACP_12010(mccB_1)
SVE: SVEN_3489 SVEN_6204
ACTR: Asp14428_15180
LEPT: JVX88_00190
FVA: FV113G1_02250
MEME: HYG87_01500
MEER: NKF70_14295
 » show all
Reference
PMID:17056751
  Authors
Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I
  Title
Conversion of methionine to cysteine in Bacillus subtilis and its regulation.
  Journal
J Bacteriol 189:187-97 (2007)
DOI:10.1128/JB.01273-06
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