KEGG   ORTHOLOGY: K17217
Entry
K17217                      KO                                     
Symbol
mccB
Name
cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2]
Pathway
map00260  Glycine, serine and threonine metabolism
map00270  Cysteine and methionine metabolism
map00920  Sulfur metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
Module
M00609  Cysteine biosynthesis, methionine => cysteine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
   00270 Cysteine and methionine metabolism
    K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
Enzymes [BR:ko01000]
 4. Lyases
  4.4  Carbon-sulfur lyases
   4.4.1  Carbon-sulfur lyases (only sub-subclass identified to date)
    4.4.1.1  cystathionine gamma-lyase
     K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
    4.4.1.2  homocysteine desulfhydrase
     K17217  mccB; cystathionine gamma-lyase / homocysteine desulfhydrase
Other DBs
RN: R00782 R01001 R01283 R02408
COG: COG0626
GO: 0004123 0047982
Genes
PPAV: LOZ86_14560
PFE: PSF113_4197
PBC: CD58_21630
PYM: AK972_5187
PZA: HU749_021595
MBS: MRBBS_2486(mdeA)
MPQ: ABA45_11705
DAL: Dalk_0849
SDO: SD1155_04930
BOMB: GT348_03645
BSU: BSU27250(yrhB)
BSR: I33_2767(yrhB)
BSL: A7A1_0367
BSH: BSU6051_27250(mccB)
BSUT: BSUB_02907(mccB)
BSUL: BSUA_02907(mccB)
BSUS: Q433_14680
BSO: BSNT_09119(yrhB)
BSQ: B657_27250(mccB)
BSX: C663_2562(mccB)
BSS: BSUW23_13180(mccB)
BST: GYO_2965(yrhB)
BLI: BL02018(yrhB)
BLD: BLi02853(mccB)
BLH: BaLi_c29540(mccB)
BAQ: BACAU_2449(yrhB)
BYA: BANAU_2593(yrhB)
BAMP: B938_12585
BAML: BAM5036_2375(mccB)
BAMA: RBAU_2572(mccB)
BAMN: BASU_2378(mccB)
BAMB: BAPNAU_1127(yrhB)
BAMT: AJ82_13760
BAMY: V529_27190(yrhB)
BMP: NG74_02557(mccB)
BAO: BAMF_2533(mccB)
BAZ: BAMTA208_13370(mccB)
BQL: LL3_02811(mccB)
BXH: BAXH7_02735(yrhB)
BAMI: KSO_007200
BAMC: U471_25270
BAMF: U722_13215
BSON: S101395_01638(mccB)
BMOJ: HC660_25280(mccB)
BAN: BA_4600
BAR: GBAA_4600
BAT: BAS4268
BAI: BAA_4620
BANT: A16_45980
BANR: A16R_60345
BANS: BAPAT_4415
BANV: DJ46_3277(mccB)
BCE: BC4366
BCA: BCE_4454(metC)
BCZ: BCE33L4116(metC)
BCQ: BCQ_4156(metC)
BCX: BCA_4484
BAL: BACI_c43580(metC2)
BNC: BCN_4282
BCF: bcf_21745
BCER: BCK_13335
BTK: BT9727_4105(metC)
BTL: BALH_3957(metC)
BTT: HD73_4680
BTHI: BTK_23050
BTM: MC28_3663
BTG: BTB_c45120(mccB)
BTI: BTG_27215
BTW: BF38_126(mccB)
BWW: bwei_0567(mccB)
BMYO: BG05_1654
BMYC: DJ92_1469(mccB)
BPU: BPUM_2360
BPUM: BW16_12815
BPUS: UP12_11885
BJS: MY9_2706
BMET: BMMGA3_12170(mccB)
BACW: QR42_11960
BACP: SB24_16520
BACB: OY17_15455
BACY: QF06_11815
BACL: BS34A_29730(yrhB)
BALM: BsLM_2694
BGY: BGLY_3172(mccB)
BMQ: BMQ_4594(mccB)
BMD: BMD_4580(mccB)
BEO: BEH_16500
BAG: Bcoa_1961
BCOA: BF29_1572(mccB)
BCL: ABC1945
OIH: OB1109(metC)
GKA: GK2540
GTN: GTNG_2473
GGH: GHH_c26140(mcc)
GEA: GARCT_02594(mccB)
PCAL: BV455_02801(mccB)
AFL: Aflv_0761
AAMY: GFC30_2789
HHD: HBHAL_2023(mccB)
HLI: HLI_06375
PASA: BAOM_3878(mccB)
PSYO: PB01_15150
BLEN: NCTC4824_00046(mccB)
SAU: SA0419(metB)
SAV: SAV0460(yrhB)
SAW: SAHV_0458(yrhB)
SAM: MW0415(metB)
SAS: SAS0418
SAR: SAR0460
SAC: SACOL0503
SAA: SAUSA300_0434(metB)
SAE: NWMN_0425(metB)
SAD: SAAV_0403
SUE: SAOV_0478
SUJ: SAA6159_00410(metB)
SUK: SAA6008_00464(metB)
SUC: ECTR2_394
SUZ: MS7_0434(mccB)
SUG: SAPIG0526
SAUA: SAAG_00915
SAUS: SA40_0399
SAUU: SA957_0414
SAUG: SA268_0412
SAUT: SAI1T1_2003360(yrhB)
SAUJ: SAI2T2_1003360(yrhB)
SAUK: SAI3T3_1003360(yrhB)
SAUQ: SAI4T8_1003360(yrhB)
SAUV: SAI7S6_1003360(metB)
SAUW: SAI5S5_1003350(metB)
SAUX: SAI6T6_1003360(metB)
SAUY: SAI8T7_1003360(metB)
SAUF: X998_0487
SAB: SAB0410
SUY: SA2981_0436(metB)
SAUB: C248_0510
SAUM: BN843_4430
SAUC: CA347_454(mccB)
SAUR: SABB_02175(mccB)
SAUI: AZ30_02230
SAUD: CH52_03550
SAMS: NI36_02155
SER: SERP0095
SEP: SE_2323
SEPP: SEB_02318
SEPS: DP17_1515
SHA: SH2548(metB)
SHH: ShL2_02333(metB_2)
SSP: SSP0253
SCA: SCA_0087(metC)
SDT: SPSE_2355(metB2)
SDP: NCTC12225_02561(metB2)
SPAS: STP1_1535
SXO: SXYL_00285(metB)
SHU: SHYC_11450(mccB)
SCAP: AYP1020_2183(mccB)
SSCH: LH95_11030
SSCZ: RN70_11795
SAGQ: EP23_10730
SPIC: SAMEA4384060_2443(metC_1)
SSH: NCTC13712_00386(mccB)
SSIM: SAMEA4384339_0378(mccB)
SSTE: SAMEA4384403_2191(metB2)
MCL: MCCL_1790
MCAK: MCCS_23060(mccB)
ESI: Exig_2343
EAN: Eab7_2188
BBE: BBR47_47850(mccB)
PPY: PPE_02107
PPM: PPSC2_11035(yrhB)
PPO: PPM_2116(yrhB)
PPOL: X809_11380
PPOY: RE92_01315
ASOC: CB4_01041(mccB_2)
JEO: JMA_30770
CRN: CAR_c05790(yrhB)
CAE: SMB_G0947(mccB)
SAY: TPY_1267(metC)
CTHM: CFE_0259
STED: SPTER_12980(mccB_2)
PBOR: BSF38_05025(mccB)
SRU: SRU_1368
SRM: SRM_01563(metB)
CPI: Cpin_1963
COC: Coch_1685
MARM: YQ22_16555
MYR: MYRA21_1478(mccB)
BPI: BPLAN_072(metB)
BLU: K645_2681
 » show all
Reference
  Authors
Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I
  Title
Conversion of methionine to cysteine in Bacillus subtilis and its regulation.
  Journal
J Bacteriol 189:187-97 (2007)
DOI:10.1128/JB.01273-06
LinkDB

KEGG   ENZYME: 4.4.1.2
Entry
EC 4.4.1.2                  Enzyme                                 
Name
homocysteine desulfhydrase;
homocysteine desulfurase;
L-homocysteine hydrogen-sulfide-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
Reaction(IUBMB)
L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate (overall reaction) [RN:R01283];
(1a) L-homocysteine = hydrogen sulfide + 2-aminobut-2-enoate [RN:R08633];
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
R01283 R08633
Substrate
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Product
hydrogen sulfide [CPD:C00283];
NH3 [CPD:C00014];
2-oxobutanoate [CPD:C00109];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing hydrogen sulfide and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase
History
EC 4.4.1.2 created 1961
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
Orthology
K17217  cystathionine gamma-lyase / homocysteine desulfhydrase
Genes
PPAVLOZ86_14560
PFEPSF113_4197
PBCCD58_21630
PYMAK972_5187
PZAHU749_021595
MBSMRBBS_2486(mdeA)
MPQABA45_11705
DALDalk_0849
SDOSD1155_04930
BOMBGT348_03645
ECOGFIV45_10075
BSUBSU27250(yrhB)
BSRI33_2767(yrhB)
BSLA7A1_0367
BSHBSU6051_27250(mccB)
BSYI653_12940
BSUTBSUB_02907(mccB)
BSULBSUA_02907(mccB)
BSUSQ433_14680
BSOBSNT_09119(yrhB)
BSNBSn5_04410
BSQB657_27250(mccB)
BSXC663_2562(mccB)
BSPU712_13395
BSSBSUW23_13180(mccB)
BSTGYO_2965(yrhB)
BLIBL02018(yrhB)
BLDBLi02853(mccB)
BLHBaLi_c29540(mccB)
BAYRBAM_024350
BAQBACAU_2449(yrhB)
BYABANAU_2593(yrhB)
BAMPB938_12585
BAMLBAM5036_2375(mccB)
BAMARBAU_2572(mccB)
BAMNBASU_2378(mccB)
BAMBBAPNAU_1127(yrhB)
BAMTAJ82_13760
BAMYV529_27190(yrhB)
BMPNG74_02557(mccB)
BAOBAMF_2533(mccB)
BAZBAMTA208_13370(mccB)
BQLLL3_02811(mccB)
BXHBAXH7_02735(yrhB)
BAMIKSO_007200
BAMCU471_25270
BAMFU722_13215
BSIACWD84_08705
BAEBATR1942_11340
BVMB9C48_12455
BSONS101395_01638(mccB)
BHTDIC78_18030
BMOJHC660_25280(mccB)
BTEQG4P54_13885
BIQAN935_13310
BANBA_4600
BARGBAA_4600
BATBAS4268
BAHBAMEG_4637
BAIBAA_4620
BAXH9401_4389
BANTA16_45980
BANRA16R_60345
BANSBAPAT_4415
BANHHYU01_22435
BANVDJ46_3277(mccB)
BCEBC4366
BCABCE_4454(metC)
BCZBCE33L4116(metC)
BCRBCAH187_A4505
BCBBCB4264_A4491
BCUBCAH820_4452
BCGBCG9842_B0745
BCQBCQ_4156(metC)
BCXBCA_4484
BALBACI_c43580(metC2)
BNCBCN_4282
BCFbcf_21745
BCERBCK_13335
BCEFBcrFT9_03441
BCYBcer98_3084
BTKBT9727_4105(metC)
BTLBALH_3957(metC)
BTBBMB171_C4033
BTTHD73_4680
BTHRYBT1520_23210
BTHIBTK_23050
BTCCT43_CH4389
BTFYBT020_21535
BTMMC28_3663
BTGBTB_c45120(mccB)
BTIBTG_27215
BTNBTF1_20465
BTHTH175_ch4458
BTHUYBT1518_24315
BTWBF38_126(mccB)
BTHYAQ980_07960
BWEBcerKBAB4_4219
BWWbwei_0567(mccB)
BMYOBG05_1654
BTYBtoyo_1609
BMYCDJ92_1469(mccB)
BBYCY96_21035
BWDCT694_23485
BTROFJR70_15650
BMOBMLA2C4_22810
BNTGSN03_20800
BPACLMD38_05145
BPUBPUM_2360
BPUMBW16_12815
BPUSUP12_11885
BJSMY9_2706
BACIB1NLA3E_16320
BIFN288_18655
BMETBMMGA3_12170(mccB)
GSTHW35_04705
BACWQR42_11960
BACPSB24_16520
BACBOY17_15455
BACYQF06_11815
BACLBS34A_29730(yrhB)
BALMBsLM_2694
BSMBSM4216_1794
BGYBGLY_3172(mccB)
BXIBK049_15170
BALTCFN77_12615
BACSAUL54_17640
BSAFBSL056_12965
BITBIS30_03010
BSHILGQ02_13715
BHKB4U37_15535
BCOHBC6307_15895
BCIRC2I06_10455
BMQBMQ_4594(mccB)
BMDBMD_4580(mccB)
BMEGBG04_1586 BG04_4883
BEOBEH_16500
BFXBC359_04745
PKSIE339_19400
BCKBCO26_2430
BAGBcoa_1961
BCOABF29_1572(mccB)
BCLABC1945
BLEBleG1_1700
BGIBGM20_07520
BONA361_02835
BKOCKF48_17425
CGOTJ1899_15725
OIHOB1109(metC)
OCNCUC15_07025
GKAGK2540
GTEGTCCBUS3UF5_28630
GTKGT3570_12440
GTMGT3921_06745
GLIGLN3_05575
GTNGTNG_2473
GWCGWCH70_2474
GYCGYMC61_0979
GYAGYMC52_2573
GCTGC56T3_0952
GMCGY4MC1_1027
GGHGHH_c26140(mcc)
GJFM493_13170
GEAGARCT_02594(mccB)
GELIB49_04570
GSEGT50_04120
GSRGS3922_03475
GEJA0V43_10570
GZAIC807_08840
GTHGeoth_1097
PTLAOT13_17155
PTBDER53_00265
PCALBV455_02801(mccB)
AFLAflv_0761
AGNAFK25_10605
ANMGFC28_3612
AAMYGFC30_2789
ANLGFC29_1821
ANDGRQ40_13470
ACAIISX45_10945
ASEDIRT44_02020
HHDHBHAL_2023(mccB)
HMNHM131_16225
HLIHLI_06375
TAPGZ22_04630
TAIDKS242_05465
VIRX953_04960
VHLBME96_04135
VILCFK37_01100
VNECFK40_17135
VIMGWK91_05705
FPNABE65_014675
FARABE41_013445
BSJUP17_16915
BMURABE28_015665
PBUTDTO10_03730
PASABAOM_3878(mccB)
PPSRI6J18_20135
AQTFN924_05330
BTHVCQJ30_10390
PSYHD0S48_17720
PSYOPB01_15150
GRCGI584_17700
POFGS400_02555
NTMBTDUT50_12135
MSEMGMB29_13390
MDGK8L98_18130
BLENNCTC4824_00046(mccB)
SEDDERJ70_04085
BVQFHE72_15530
RMFD5E69_15360
BVJI5776_17570
BOUI5818_21615
CTHUHUR95_16170
MCUIG8O30_08385
STEAC0679_09625
SAUSA0419(metB)
SAVSAV0460(yrhB)
SAWSAHV_0458(yrhB)
SAHSaurJH1_0495
SAJSaurJH9_0482
SAMMW0415(metB)
SASSAS0418
SARSAR0460
SACSACOL0503
SAASAUSA300_0434(metB)
SAOSAOUHSC_00422
SAENWMN_0425(metB)
SADSAAV_0403
SUUM013TW_0425
SUVSAVC_01890
SUESAOV_0478
SUJSAA6159_00410(metB)
SUKSAA6008_00464(metB)
SUCECTR2_394
SUTSAT0131_00500
SUQHMPREF0772_10062
SUZMS7_0434(mccB)
SUDST398NM01_0526
SUXSAEMRSA15_03860
SUWSATW20_05290
SUGSAPIG0526
SUFSARLGA251_03940
SAUASAAG_00915
SAUERSAU_000393
SAUNSAKOR_00444
SAUSSA40_0399
SAUUSA957_0414
SAUGSA268_0412
SAUZSAZ172_0462
SAUTSAI1T1_2003360(yrhB)
SAUJSAI2T2_1003360(yrhB)
SAUKSAI3T3_1003360(yrhB)
SAUQSAI4T8_1003360(yrhB)
SAUVSAI7S6_1003360(metB)
SAUWSAI5S5_1003350(metB)
SAUXSAI6T6_1003360(metB)
SAUYSAI8T7_1003360(metB)
SAUFX998_0487
SABSAB0410
SUYSA2981_0436(metB)
SAUBC248_0510
SAUMBN843_4430
SAUCCA347_454(mccB)
SAURSABB_02175(mccB)
SAUIAZ30_02230
SAUDCH52_03550
SAMSNI36_02155
SUHSAMSHR1132_04050
SERSERP0095
SEPSE_2323
SEPPSEB_02318
SEPSDP17_1515
SHASH2548(metB)
SHHShL2_02333(metB_2)
SSPSSP0253
SCASCA_0087(metC)
SLGSLGD_02456
SLNSLUG_23510
SSDSPSINT_0116
SDTSPSE_2355(metB2)
SDPNCTC12225_02561(metB2)
SWAA284_11085
SPASSTP1_1535
SXYBE24_10690
SXLSXYLSMQ121_0281
SXOSXYL_00285(metB)
SHUSHYC_11450(mccB)
SCAPAYP1020_2183(mccB)
SSCHLH95_11030
SSCZRN70_11795
SAGQEP23_10730
SEQOSE1039_22900
SSIFAL483_09470
SCVA4G25_07300
SLZB5P37_06600
SKLC7J89_03245
SFQC7J90_02460
SHOMEGX58_04080
SMUSC7J88_06865
SCARDWB96_12385
SCHRDWB92_11605
SPICSAMEA4384060_2443(metC_1)
SSHNCTC13712_00386(mccB)
SSIMSAMEA4384339_0378(mccB)
SDBCNQ82_00630
SLLOISP08_02060
SAULI6G39_10115
SSCUCEP64_10520
SFFFOB90_08365
SSTESAMEA4384403_2191(metB2)
MVTI6J10_00355
MCLMCCL_1790
MCAKMCCS_23060(mccB)
MACRBHM04_11955
MBOEHT586_11100
MARYLAU42_10670
SBACBVH56_07765
ESIExig_2343
EATEAT1b_0608
EANEab7_2188
EXMU719_00325 U719_12900
EXUESP131_15010
EAPKB235_07395
EACEKKI46_12845
BBEBBR47_47850(mccB)
BLRBRLA_c040910
BFMBP422_19710
BAGRBA6348_07560
BRWGOP56_13100
BCHSJNE38_25755
BCOPJD108_05020
PJDPjdr2_5104
PPYPPE_02107
PPMPPSC2_11035(yrhB)
PPOPPM_2116(yrhB)
PPOLX809_11380
PPQPPSQR21_021960
PPOYRE92_01315
PTAHPL003_19390
PBJVN24_22970
PIHUB51_24975
PPEOABE82_11210
PBVAR543_13270
PXLBS614_24800
PKBB4V02_14230
PAIHASL14_00325
PPRTET464_13385
ANXACH33_03440
ASOCCB4_01041(mccB_2)
ATHEK3F53_15475
PLNPlano_2471
PKUAUO94_03270
PRTAUC31_13730
PLLI858_010425
PANABBH88_06555
PDGBCM40_02840
PHCBBI08_09600
PMARB0X71_15400
PPLABBI15_08580
PFAEAJGP001_14280
PLXCW734_14630
PMATBBI11_14200
PDECH1Q58_13505
JEOJMA_30770
SPSYAZE41_06760
RSTATY39_01120
PAEKD3873_09800
PANCE2636_04660
PLAYDNR44_007335
VIJJNUCC6_21815
NTRB0W44_09000
LFBC1X05_03180
TVUAB849_002175
KPULGXN76_04270
KEBGXN75_04830
PABSJIR001_06880
CRNCAR_c05790(yrhB)
CAESMB_G0947(mccB)
ACAEHYG86_02780
SAYTPY_1267(metC)
SAPSulac_2385
CTHMCFE_0259
STEDSPTER_12980(mccB_2)
SVESVEN_3489 SVEN_6204
OLEK0B96_16580
PBORBSF38_05025(mccB)
GMAAciX8_2098
EDAGWR55_01120
SCORJ3U87_06265
FVAFV113G1_02250
SRUSRU_1368
SRMSRM_01563(metB)
CPICpin_1963
CBAECOR50_21245
CHITFW415_09465
CHIHGWR21_25265
NIAA8C56_12875
RHOZGXP67_11625
FLIFleli_0126
CHKD4L85_07900
FPSZAMR72_00130
FATDVK85_10105
FKIFK004_10650
FPALHYN49_09540
FALBHYN59_11470
FAKFUA48_15650
COCCoch_1685
COLAM608_00910
CAPNCBG49_00030
CSPUCGC55_09095
MARMYQ22_16555
MARTBTR34_16640
AICJK629_00045
MYRMYRA21_1478(mccB)
MODAS202_07005
AUEC5O00_08315 C5O00_10905
SINHLS482_14990
APIBG8C43_00490
BPIBPLAN_072(metB)
BBQBLBBOR_564
BLUK645_2681
OHOOweho_2590
MEMEHYG87_01500
 » show all
Reference
1  [PMID:14917685]
  Authors
KALLIO RE.
  Title
Function of pyridoxal phosphate in desulfhydrase systems of Proteus morganii.
  Journal
J Biol Chem 192:371-7 (1951)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.2
IUBMB Enzyme Nomenclature: 4.4.1.2
ExPASy - ENZYME nomenclature database: 4.4.1.2
BRENDA, the Enzyme Database: 4.4.1.2
CAS: 9024-41-3
LinkDB

KEGG   REACTION: R01283
Entry
R01283                      Reaction                               
Name
L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
Definition
L-Homocysteine + H2O <=> Hydrogen sulfide + Ammonia + 2-Oxobutanoate
Equation
Comment
multi-step reaction (see R08633+R08637)
Reaction class
RC00487  C00109_C00155
RC02814  C00155_C00283
Enzyme
Pathway
rn00920  Sulfur metabolism
rn01100  Metabolic pathways
Orthology
K17217  cystathionine gamma-lyase / homocysteine desulfhydrase [EC:4.4.1.1 4.4.1.2]
Other DBs
RHEA: 14504
LinkDB

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