KEGG   ORTHOLOGY: K17547
Entry
K17547                      KO                                     
Symbol
SGK196
Name
glycoprotein-mannosyl O6-kinase [EC:2.7.1.183]
Pathway
map00515  Mannose type O-glycan biosynthesis
map01100  Metabolic pathways
Module
M00872  O-glycan biosynthesis, mannose type (core M3)
Disease
H00120  Muscular dystrophy-dystroglycanopathy type A
H01959  Muscular dystrophy-dystroglycanopathy type C
H02307  Muscular dystrophy-dystroglycanopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00515 Mannose type O-glycan biosynthesis
    K17547  SGK196; glycoprotein-mannosyl O6-kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K17547  SGK196; glycoprotein-mannosyl O6-kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.183  glycoprotein-mannosyl O6-kinase
     K17547  SGK196; glycoprotein-mannosyl O6-kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  Other
   K17547  SGK196; glycoprotein-mannosyl O6-kinase
Other DBs
RN: R11400 R12293
Genes
HSA: 84197(POMK)
PTR: 464154(POMK)
PPS: 100985143(POMK)
GGO: 101148209(POMK)
PON: 100446965(POMK)
NLE: 100593922(POMK)
MCC: 706318(POMK)
MCF: 102126456(POMK)
CSAB: 103215702(POMK)
CATY: 105595742(POMK)
PANU: 101024701(POMK)
TGE: 112630262(POMK)
RRO: 104668311(POMK)
RBB: 108534355(POMK)
TFN: 117095885(POMK)
PTEH: 111544084(POMK)
CJC: 100403123(POMK) 108590132
SBQ: 101052644(POMK)
CSYR: 103274594
MMUR: 105878131(POMK)
LCAT: 123626595(POMK)
OGA: 100951684(POMK)
MMU: 74653(Pomk)
MCAL: 110299993(Pomk)
MPAH: 110336756(Pomk)
RNO: 306549(Pomk)
MCOC: 116069072(Pomk)
MUN: 110566310(Pomk)
CGE: 100771074(Pomk)
MAUA: 101844716(Pomk)
PLEU: 114681357(Pomk)
MORG: 121462112(Pomk)
AAMP: 119813639(Pomk)
NGI: 103728518(Pomk)
HGL: 101699969(Pomk)
CPOC: 100718330(Pomk)
CCAN: 109699825(Pomk)
DORD: 106002029(Pomk)
DSP: 122107682(Pomk)
NCAR: 124982626
OCU: 100346922(POMK)
OPI: 101535715(POMK)
TUP: 102493452(POMK)
CFA: 482834(POMK)
CLUD: 112658415(POMK)
VVP: 112916169(POMK)
VLG: 121489599(POMK)
AML: 100469245(POMK)
UMR: 103677043(POMK)
UAH: 113245578(POMK)
UAR: 123780309(POMK)
ELK: 111144525
LLV: 125092814
MPUF: 101690834(POMK)
ORO: 101370967(POMK)
EJU: 114224858(POMK)
ZCA: 113925750(POMK)
MLX: 118009907(POMK)
FCA: 102902090(POMK)
PYU: 121010370(POMK)
PBG: 122472821(POMK)
PTG: 102958518(POMK)
PPAD: 109262248(POMK)
AJU: 106990023(POMK)
HHV: 120234023(POMK)
BTA: 514490(POMK)
BOM: 102270881(POMK)
BIU: 109553500(POMK)
BBUB: 102404277(POMK)
CHX: 102191304(POMK)
OAS: 105605250(POMK)
ODA: 120865868(POMK)
CCAD: 122426731 122432247(POMK)
CFR: 116660062(POMK)
CBAI: 105071098(POMK)
VPC: 102525840(POMK)
BACU: 103009793(POMK)
LVE: 103085701(POMK)
OOR: 101288878(POMK)
DLE: 111173564(POMK)
PCAD: 102996084(POMK)
PSIU: 116746716(POMK)
ECB: 100053457(POMK)
EPZ: 103541353(POMK)
EAI: 106828970(POMK)
MYB: 102242789(POMK)
MYD: 102769516(POMK)
MMYO: 118651705(POMK)
MLF: 102436905(POMK)
MNA: 107523904(POMK)
PKL: 118729222(POMK)
HAI: 109386257(POMK)
DRO: 112321487(POMK)
SHON: 118993222(POMK)
AJM: 119063071(POMK)
PDIC: 114508520(POMK)
PHAS: 123807632(POMK)
MMF: 118622665(POMK)
RFQ: 117021646(POMK)
PALE: 102890250(POMK)
PGIG: 120595664(POMK)
PVP: 105300659(POMK)
RAY: 107501363(POMK)
MJV: 108396029(POMK)
TOD: 119257864(POMK)
LAV: 100654599(POMK)
TMU: 101344402
DNM: 101440148(POMK)
MDO: 100030275(POMK)
GAS: 123234842(POMK)
SHR: 100924613(POMK)
PCW: 110196409(POMK)
OAA: 100082420(POMK)
GGA: 422491(POMK)
PCOC: 116238088(POMK)
MGP: 100538885(POMK)
CJO: 107313218(POMK)
NMEL: 110397665(POMK)
APLA: 101801929(POMK)
ACYG: 106035193(POMK)
AFUL: 116489168(POMK)
TGU: 100231168(POMK)
LSR: 110471717(POMK)
SCAN: 103825994(POMK)
PMOA: 120502697(POMK)
OTC: 121331452(POMK)
PRUF: 121360190(POMK)
GFR: 102033758(POMK)
FAB: 101811138(POMK)
PHI: 102112849(POMK)
PMAJ: 107202634(POMK)
CCAE: 111927790(POMK)
CCW: 104697134(POMK)
CBRC: 103617338(POMK)
ETL: 114062190(POMK)
ZAB: 102063824(POMK)
FPG: 101910645(POMK)
FCH: 102059878(POMK)
CLV: 102088245(POMK)
EGZ: 104135539(POMK)
NNI: 104021153(POMK)
PLET: 104627328(POMK)
PCRI: 104025085(POMK)
ACUN: 113479861(POMK)
TALA: 104368531(POMK)
PADL: 103925419(POMK)
ACHC: 115339485(POMK)
HALD: 104317846(POMK)
CCRI: 104161231(POMK)
CSTI: 104549119(POMK)
EHS: 104503411(POMK)
FGA: 104074713(POMK)
GSTE: 104256305(POMK)
LDI: 104352380(POMK)
MNB: 103775806(POMK)
AAM: 106484357(POMK)
AROW: 112972166(POMK)
NPD: 112953460(POMK)
DNE: 112993247(POMK)
ASN: 102374161(POMK)
AMJ: 102567007(POMK)
CPOO: 109309428(POMK)
GGN: 109301227(POMK)
PSS: 102445972(POMK)
CMY: 102947718(POMK)
CPIC: 101949171(POMK)
TST: 117877944(POMK)
CABI: 116834477(POMK)
MRV: 120406732(POMK)
ACS: 100560387(pomk)
PVT: 110086322(POMK)
SUND: 121917884 121932988(POMK)
PBI: 103068088(POMK)
PMUR: 107302375(POMK)
TSR: 106550224(POMK)
PGUT: 117664778(POMK)
VKO: 123031849(POMK)
ZVI: 118079270 118094855(POMK)
GJA: 107107431(POMK)
XLA: 496338(pomk.L)
XTR: 100497421(pomk)
NPR: 108804921(POMK)
RTEM: 120914558(POMK)
BBUF: 120989665(POMK)
BGAR: 122945703(POMK)
DRE: 492773(pomk)
SANH: 107678554
PPRM: 120479678(pomk)
MAMB: 125276601(pomk)
IPU: 108263618(pomk)
PHYP: 113542784(pomk)
SMEO: 124394813(pomk)
TFD: 113639743(pomk)
AMEX: 103039966(pomk)
EEE: 113585802(pomk)
TRU: 101062833(pomk)
NCC: 104947920(pomk)
ELY: 117269211(pomk)
EFO: 125905840(pomk)
PLEP: 121960031(pomk)
SLUC: 116041376(pomk)
ECRA: 117958862(pomk)
PFLV: 114571045(pomk)
GAT: 120831507(pomk)
PPUG: 119226242(pomk)
MSAM: 119914310(pomk)
CUD: 121525343(pomk)
ALAT: 119030297(pomk)
MZE: 101481202(pomk)
ONL: 100700536(pomk)
OAU: 116319162(pomk)
OLA: 101164276(pomk)
OML: 112140349(pomk)
XMA: 106700026(pomk)
XCO: 114150255(pomk)
XHE: 116724754(pomk)
PRET: 103473164(pomk)
PFOR: 103152298(pomk)
PLAI: 106947027(pomk)
PMEI: 106922492(pomk)
GAF: 122847279(pomk)
CVG: 107098491(pomk)
CTUL: 119797753(pomk)
GMU: 124872308(pomk)
NFU: 107395076(pomk)
KMR: 108246453(pomk)
ALIM: 106522200(pomk)
NWH: 119424393(pomk)
AOCE: 111579159(pomk)
MCEP: 124996365(pomk)
CSEM: 103389221(pomk)
POV: 109637637(pomk)
SSEN: 122761047(pomk)
HHIP: 117771427(pomk)
HSP: 118098074(pomk)
LCF: 108877752(pomk)
SDU: 111221209(pomk)
SLAL: 111659623(pomk)
XGL: 120806638(pomk)
HCQ: 109530012(pomk)
BPEC: 110161849(pomk)
MALB: 109960745(pomk)
BSPL: 114867242(pomk)
SASA: 100306734(pomk)
OTW: 112262119(pomk)
OMY: 110498207(pomk)
OGO: 124001569(pomk)
ONE: 115146469(pomk)
SALP: 111968961(pomk)
SNH: 120059807(pomk)
CCLU: 121538738(pomk)
ELS: 105015966(pomk)
SFM: 108920894(pomk)
PKI: 111833170(pomk)
AANG: 118226785(pomk)
LOC: 102694538(pomk)
PSPA: 121294710(pomk)
ARUT: 117408772(pomk) 117420431
LCM: 102349350(POMK)
CMK: 103191503(pomk)
RTP: 109935288(pomk)
APLC: 110983381
SKO: 100366379
BTAB: 109043533
FOC: 113213134
TPAL: 117647322
PVM: 113825371
PJA: 122253449
PCHN: 125026273
HAME: 121859183
PPOI: 119107979
DSV: 119459675
RSAN: 119379176
RMP: 119175867
VDE: 111249089
VJA: 111265098
TUT: 107367514
DPTE: 113799300
DFR: 124496257
PTEP: 107438133
SDM: 118198420
PCAN: 112563976
BGT: 106072675
GAE: 121384009
MYI: 110462321
PMAX: 117340008
OBI: 106868601
OSN: 115219475
NVE: 5520898
EPA: 110236958
ATEN: 116292519
ADF: 107334959
PDAM: 113681644
SPIS: 111329972
DGT: 114515738
XEN: 124443858
HMG: 100206145
 » show all
Reference
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:84197]
LinkDB

KEGG   ENZYME: 2.7.1.183
Entry
EC 2.7.1.183                Enzyme                                 
Name
glycoprotein-mannosyl O6-kinase;
SGK196;
protein O-mannose kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
Reaction(IUBMB)
ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein] [RN:R11400 R12293]
Reaction(KEGG)
R11400 R12293(G)
Substrate
ATP [CPD:C00002];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein]
Product
ADP [CPD:C00008];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]
Comment
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
History
EC 2.7.1.183 created 2014
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K17547  glycoprotein-mannosyl O6-kinase
Genes
HSA84197(POMK)
PTR464154(POMK)
PPS100985143(POMK)
GGO101148209(POMK)
PON100446965(POMK)
NLE100593922(POMK)
MCC706318(POMK)
MCF102126456(POMK)
CSAB103215702(POMK)
CATY105595742(POMK)
PANU101024701(POMK)
TGE112630262(POMK)
RRO104668311(POMK)
RBB108534355(POMK)
TFN117095885(POMK)
PTEH111544084(POMK)
CJC100403123(POMK) 108590132
SBQ101052644(POMK)
CSYR103274594
MMUR105878131(POMK)
LCAT123626595(POMK)
OGA100951684(POMK)
MMU74653(Pomk)
MCAL110299993(Pomk)
MPAH110336756(Pomk)
RNO306549(Pomk)
MCOC116069072(Pomk)
MUN110566310(Pomk)
CGE100771074(Pomk)
MAUA101844716(Pomk)
PLEU114681357(Pomk)
MORG121462112(Pomk)
AAMP119813639(Pomk)
NGI103728518(Pomk)
HGL101699969(Pomk)
CPOC100718330(Pomk)
CCAN109699825(Pomk)
DORD106002029(Pomk)
DSP122107682(Pomk)
NCAR124982626
OCU100346922(POMK)
OPI101535715(POMK)
TUP102493452(POMK)
CFA482834(POMK)
CLUD112658415(POMK)
VVP112916169(POMK)
VLG121489599(POMK)
AML100469245(POMK)
UMR103677043(POMK)
UAH113245578(POMK)
UAR123780309(POMK)
ELK111144525
LLV125092814
MPUF101690834(POMK)
ORO101370967(POMK)
EJU114224858(POMK)
ZCA113925750(POMK)
MLX118009907(POMK)
FCA102902090(POMK)
PYU121010370(POMK)
PBG122472821(POMK)
PTG102958518(POMK)
PPAD109262248(POMK)
AJU106990023(POMK)
HHV120234023(POMK)
BTA514490(POMK)
BOM102270881(POMK)
BIU109553500(POMK)
BBUB102404277(POMK)
CHX102191304(POMK)
OAS105605250(POMK)
ODA120865868(POMK)
CCAD122426731 122432247(POMK)
CFR116660062(POMK)
CBAI105071098(POMK)
VPC102525840(POMK)
BACU103009793(POMK)
LVE103085701(POMK)
OOR101288878(POMK)
DLE111173564(POMK)
PCAD102996084(POMK)
PSIU116746716(POMK)
ECB100053457(POMK)
EPZ103541353(POMK)
EAI106828970(POMK)
MYB102242789(POMK)
MYD102769516(POMK)
MMYO118651705(POMK)
MLF102436905(POMK)
MNA107523904(POMK)
PKL118729222(POMK)
HAI109386257(POMK)
DRO112321487(POMK)
SHON118993222(POMK)
AJM119063071(POMK)
PDIC114508520(POMK)
PHAS123807632(POMK)
MMF118622665(POMK)
RFQ117021646(POMK)
PALE102890250(POMK)
PGIG120595664(POMK)
PVP105300659(POMK)
RAY107501363(POMK)
MJV108396029(POMK)
TOD119257864(POMK)
LAV100654599(POMK)
TMU101344402
DNM101440148(POMK)
MDO100030275(POMK)
GAS123234842(POMK)
SHR100924613(POMK)
PCW110196409(POMK)
OAA100082420(POMK)
GGA422491(POMK)
PCOC116238088(POMK)
MGP100538885(POMK)
CJO107313218(POMK)
NMEL110397665(POMK)
APLA101801929(POMK)
ACYG106035193(POMK)
AFUL116489168(POMK)
TGU100231168(POMK)
LSR110471717(POMK)
SCAN103825994(POMK)
PMOA120502697(POMK)
OTC121331452(POMK)
PRUF121360190(POMK)
GFR102033758(POMK)
FAB101811138(POMK)
PHI102112849(POMK)
PMAJ107202634(POMK)
CCAE111927790(POMK)
CCW104697134(POMK)
CBRC103617338(POMK)
ETL114062190(POMK)
ZAB102063824(POMK)
FPG101910645(POMK)
FCH102059878(POMK)
CLV102088245(POMK)
EGZ104135539(POMK)
NNI104021153(POMK)
PLET104627328(POMK)
PCRI104025085(POMK)
ACUN113479861(POMK)
TALA104368531(POMK)
PADL103925419(POMK)
ACHC115339485(POMK)
HALD104317846(POMK)
CCRI104161231(POMK)
CSTI104549119(POMK)
EHS104503411(POMK)
FGA104074713(POMK)
GSTE104256305(POMK)
LDI104352380(POMK)
MNB103775806(POMK)
AAM106484357(POMK)
AROW112972166(POMK)
NPD112953460(POMK)
DNE112993247(POMK)
ASN102374161(POMK)
AMJ102567007(POMK)
CPOO109309428(POMK)
GGN109301227(POMK)
PSS102445972(POMK)
CMY102947718(POMK)
CPIC101949171(POMK)
TST117877944(POMK)
CABI116834477(POMK)
MRV120406732(POMK)
ACS100560387(pomk)
PVT110086322(POMK)
SUND121917884 121932988(POMK)
PBI103068088(POMK)
PMUR107302375(POMK)
TSR106550224(POMK)
PGUT117664778(POMK)
VKO123031849(POMK)
PMUA114581527 114581529
ZVI118079270 118094855(POMK)
GJA107107431(POMK)
XLA496338(pomk.L)
XTR100497421(pomk)
NPR108804921(POMK)
RTEM120914558(POMK)
BBUF120989665(POMK)
BGAR122945703(POMK)
DRE492773(pomk)
SRX107708470 107733691
SANH107678554
SGH107567859 107582561
CCAR109061611 109065618
CAUA113057034 113078215
PPRM120479678(pomk)
MAMB125276601(pomk)
IPU108263618(pomk)
PHYP113542784(pomk)
SMEO124394813(pomk)
TFD113639743(pomk)
AMEX103039966(pomk)
EEE113585802(pomk)
TRU101062833(pomk)
TNGGSTEN00000504G001 GSTEN00013652G001
NCC104947920(pomk)
ELY117269211(pomk)
EFO125905840(pomk)
PLEP121960031(pomk)
SLUC116041376(pomk)
ECRA117958862(pomk)
PFLV114571045(pomk)
GAT120831507(pomk)
PPUG119226242(pomk)
MSAM119914310(pomk)
CUD121525343(pomk)
ALAT119030297(pomk)
MZE101481202(pomk)
ONL100700536(pomk)
OAU116319162(pomk)
OLA101164276(pomk)
OML112140349(pomk)
XMA106700026(pomk)
XCO114150255(pomk)
XHE116724754(pomk)
PRET103473164(pomk)
PFOR103152298(pomk)
PLAI106947027(pomk)
PMEI106922492(pomk)
GAF122847279(pomk)
CVG107098491(pomk)
CTUL119797753(pomk)
GMU124872308(pomk)
NFU107395076(pomk)
KMR108246453(pomk)
ALIM106522200(pomk)
NWH119424393(pomk)
AOCE111579159(pomk)
MCEP124996365(pomk)
CSEM103389221(pomk)
POV109637637(pomk)
SSEN122761047(pomk)
HHIP117771427(pomk)
HSP118098074(pomk)
LCF108877752(pomk)
SDU111221209(pomk)
SLAL111659623(pomk)
XGL120806638(pomk)
HCQ109530012(pomk)
BPEC110161849(pomk)
MALB109960745(pomk)
BSPL114867242(pomk)
SASA100306734(pomk)
OTW112262119(pomk)
OMY110498207(pomk)
OGO124001569(pomk)
ONE115146469(pomk)
SALP111968961(pomk)
SNH120059807(pomk)
CCLU121538738(pomk)
ELS105015966(pomk)
SFM108920894(pomk)
PKI111833170(pomk)
AANG118226785(pomk)
LOC102694538(pomk)
PSPA121294710(pomk)
ARUT117408772(pomk) 117420431
LCM102349350(POMK)
CMK103191503(pomk)
RTP109935288(pomk)
BFO118412857 118413332 118426113
BBEL109462232 109462249 109462276 109463158 109463207 109466369 109469120 109475484 109475485
CIN100180020 100180094
SCLV120335512 120336072 120336720
APLC110983381
SKO100366379
BTAB109043533
NLU111056326 120350971
FOC113213134
TPAL117647322
PVM113825371
PJA122253449
PCHN125026273
HAME121859183
PPOI119107979
ISCIscW_ISCW021504
DSV119459675
RSAN119379176
RMP119175867
VDE111249089
VJA111265098
TUT107367514
DPTE113799300
DFR124496257
PTEP107438133
SDM118198420
LGILOTGIDRAFT_123453
PCAN112563976
BGT106072675
GAE121384009
CRG105333495 105333837 105333838 105343841 117690447
MYI110462321
PMAX117340008
OBI106868601
OSN115219475
LAK106159752 106164523
NVE5520898
EPA110236958
ATEN116292519
ADF107334959
AMIL114953313 114976608
PDAM113681644
SPIS111329972
DGT114515738
XEN124443858
HMG100206145
TADTRIADDRAFT_32494
SREPTSG_04862
 » show all
Reference
1  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science 341:896-9 (2013)
DOI:10.1126/science.1239951
  Sequence
[hsa:84197]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.183
IUBMB Enzyme Nomenclature: 2.7.1.183
ExPASy - ENZYME nomenclature database: 2.7.1.183
BRENDA, the Enzyme Database: 2.7.1.183
LinkDB

KEGG   REACTION: R12293
Entry
R12293                      Reaction                               
Definition
O-mannose core M3 + ATP <=> Phospho-core M3 + ADP
Equation
Enzyme
Pathway
rn00515  Mannose type O-glycan biosynthesis
rn01100  Metabolic pathways
Module
M00872  O-glycan biosynthesis, mannose type (core M3)
Orthology
K17547  glycoprotein-mannosyl O6-kinase [EC:2.7.1.183]
Other DBs
RHEA: 52619
LinkDB

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