KEGG   ORTHOLOGY: K17625
Entry
K17625                      KO                                     
Symbol
novS
Name
dTDP-4-keto-6-deoxyhexose reductase [EC:1.1.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00795  dTDP-beta-L-noviose biosynthesis
Reaction
R10459  dTDP-5-dimethyl-L-lyxose:NAD+ 4-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K17625  novS; dTDP-4-keto-6-deoxyhexose reductase
Genes
TALX: FOF52_07600(rfbD)
NGV: CDO52_02240(rfbD)
SPIQ: OHA34_29485(rfbD)
AG: AAF67512(novS) AAG29801(couS) AAN65241(cloS)
Reference
PMID:15752721
  Authors
Thuy TT, Lee HC, Kim CG, Heide L, Sohng JK
  Title
Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides.
  Journal
Arch Biochem Biophys 436:161-7 (2005)
DOI:10.1016/j.abb.2005.01.012
Reference
PMID:10770754
  Authors
Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L
  Title
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
  Journal
Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000
  Sequence
[ag:AAF67512]
LinkDB

KEGG   REACTION: R10459
Entry
R10459                      Reaction                               
Name
dTDP-5-dimethyl-L-lyxose:NAD+ 4-oxidoreductase
Definition
dTDP-4-oxo-5-C-methyl-L-rhamnose + NADH + H+ <=> dTDP-5-dimethyl-L-lyxose + NAD+
Equation
C11460 + C00004 + C00080 <=> C12481 + C00003
Comment
4-ketoreductase, NovS CloS CouS
Reaction class
RC00001  C00003_C00004
RC00261  C11460_C12481
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00795  dTDP-beta-L-noviose biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R10459  dTDP-4-oxo-5-C-methyl-L-rhamnose + NADH + H+ <=> dTDP-5-dimethyl-L-lyxose + NAD+
Orthology
K17625  dTDP-4-keto-6-deoxyhexose reductase [EC:1.1.1.-]
LinkDB

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