KEGG   ORTHOLOGY: K17644
Entry
K17644                      KO                                     
Symbol
AFLD, NOR-1
Name
norsolorinic acid ketoreductase [EC:1.1.1.349]
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Reaction
R10309  (1'S)-averantin:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17644  AFLD, NOR-1; norsolorinic acid ketoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.349  norsolorinic acid ketoreductase
     K17644  AFLD, NOR-1; norsolorinic acid ketoreductase
Other DBs
COG: COG1028
GO: 0140393
Genes
PAN: PODANSg8566
PBEL: QC761_207200 QC761_207370(NOR1)
PPSD: QC762_207200 QC762_207370(NOR1)
PPSP: QC763_207200 QC763_207370(NOR1)
PPSA: QC764_207200 QC764_207370(NOR1)
TTT: THITE_2147584
MGR: MGG_10274
PPEI: PpBr36_02616 PpBr36_09608
PGRI: PgNI_02173 PgNI_10101
TMN: UCRPA7_6053
FVN: FVRRES_07755 FVRRES_10990
FVR: FVEG_09885
FOX: FOXG_15212
NHE: NECHADRAFT_19049 NECHADRAFT_44851 NECHADRAFT_94977
FFC: NCS54_00901400 NCS54_00908600 NCS54_00917600 NCS54_00932700
FKR: NCS57_00920500 NCS57_00926800 NCS57_00952200 NCS57_01357800
FMU: J7337_000075
TRE: TRIREDRAFT_103113 TRIREDRAFT_105884
TRR: M419DRAFT_7213 M419DRAFT_88601
TATV: 25785678(TrAtP1_010597) 25786313(TrAtP1_005361)
TASP: 36609116(TrAFT101_011820) 36618684(TrAFT101_010637)
VAL: VDBG_02925 VDBG_06335
VDA: VDAG_03485
CFJ: CFIO01_09694 CFIO01_11244
CLUP: CLUP02_11195 CLUP02_13454 CLUP02_15568
CHIG: CH63R_01668 CH63R_08584
ELA: UCREL1_771 UCREL1_8646
PFY: PFICI_02604 PFICI_13483 PFICI_14974
BFU: BCIN_09g00680 BCIN_13g02220
PSCO: LY89DRAFT_589972 LY89DRAFT_642918
GLZ: GLAREA_06058 GLAREA_09658 GLAREA_12088
ANI: ANIA_07821
AFM: AFUA_5G14120
NFI: NFIA_072850
AOR: AO090023000875 AO090026000011 AO090038000063
ANG: An02g01090 An12g03210 An12g06400
AFV: AFLA_006309 AFLA_007227 AFLA_012318
ALUC: AKAW2_80215A
ACHE: ACHE_50053S
APUU: APUU_12296S APUU_20041S APUU_61047A
PCS: N7525_000969
PDP: PDIP_02390
POU: POX_f08371
URE: UREG_06504
PNO: SNOG_15959
PTE: PTT_11290
BSC: COCSADRAFT_103200
AALT: CC77DRAFT_1088875 CC77DRAFT_546209
ARAB: EKO05_0010085
FFU: CLAFUR5_14299
CBET: CB0940_10641
NPA: UCRNP2_9593
KMG: 30166162(I203_104045) 30166689(I203_106626)
KNE: 92178403(IAR55_001144) 92178404(IAR55_001145) 92183621(IAR55_006363)
SCM: SCHCO_02748978(SCHCODRAFT_02748978)
AG: AAA58798(nor-1)
 » show all
Reference
PMID:7993094
  Authors
Trail F, Chang PK, Cary J, Linz JE
  Title
Structural and functional analysis of the nor-1 gene involved in the biosynthesis of aflatoxins by Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 60:4078-85 (1994)
DOI:10.1128/AEM.60.11.4078-4085.1994
  Sequence
[ag:AAA58798]
Reference
PMID:10584035
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
LinkDB

KEGG   ENZYME: 1.1.1.349
Entry
EC 1.1.1.349                Enzyme                                 
Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
R10309
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17644  norsolorinic acid ketoreductase
Genes
PAN: PODANSg8566
PBEL: QC761_207200 QC761_207370(NOR1)
PPSD: QC762_207200 QC762_207370(NOR1)
PPSP: QC763_207200 QC763_207370(NOR1)
PPSA: QC764_207200 QC764_207370(NOR1)
TTT: THITE_2147584
MGR: MGG_10274
PPEI: PpBr36_02616 PpBr36_09608
PGRI: PgNI_02173 PgNI_10101
TMN: UCRPA7_6053
FVN: FVRRES_07755 FVRRES_10990
FVR: FVEG_09885
FOX: FOXG_15212
NHE: NECHADRAFT_19049 NECHADRAFT_44851 NECHADRAFT_94977
FFC: NCS54_00901400 NCS54_00908600 NCS54_00917600 NCS54_00932700
FKR: NCS57_00920500 NCS57_00926800 NCS57_00952200 NCS57_01357800
FMU: J7337_000075
TRE: TRIREDRAFT_103113 TRIREDRAFT_105884
TRR: M419DRAFT_7213 M419DRAFT_88601
TATV: 25785678(TrAtP1_010597) 25786313(TrAtP1_005361)
TASP: 36609116(TrAFT101_011820) 36618684(TrAFT101_010637)
VAL: VDBG_02925 VDBG_06335
VDA: VDAG_03485
CFJ: CFIO01_09694 CFIO01_11244
CLUP: CLUP02_11195 CLUP02_13454 CLUP02_15568
CHIG: CH63R_01668 CH63R_08584
ELA: UCREL1_771 UCREL1_8646
PFY: PFICI_02604 PFICI_13483 PFICI_14974
BFU: BCIN_09g00680 BCIN_13g02220
PSCO: LY89DRAFT_589972 LY89DRAFT_642918
GLZ: GLAREA_06058 GLAREA_09658 GLAREA_12088
ANI: ANIA_07821
AFM: AFUA_5G14120
NFI: NFIA_072850
AOR: AO090023000875 AO090026000011 AO090038000063
ANG: An02g01090 An12g03210 An12g06400
AFV: AFLA_006309 AFLA_007227 AFLA_012318
ALUC: AKAW2_80215A
ACHE: ACHE_50053S
APUU: APUU_12296S APUU_20041S APUU_61047A
PCS: N7525_000969
PDP: PDIP_02390
POU: POX_f08371
URE: UREG_06504
PNO: SNOG_15959
PTE: PTT_11290
BSC: COCSADRAFT_103200
AALT: CC77DRAFT_1088875 CC77DRAFT_546209
ARAB: EKO05_0010085
FFU: CLAFUR5_14299
CBET: CB0940_10641
NPA: UCRNP2_9593
KMG: 30166162(I203_104045) 30166689(I203_106626)
KNE: 92178403(IAR55_001144) 92178404(IAR55_001145) 92183621(IAR55_006363)
SCM: SCHCO_02748978(SCHCODRAFT_02748978)
 » show all
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
DOI:10.1128/AEM.59.8.2486-2492.1993
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
DOI:10.1128/AEM.65.12.5639-5641.1999
  Sequence
[ag:AAA58798]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349
LinkDB

KEGG   REACTION: R10309
Entry
R10309                      Reaction                               
Name
(1'S)-averantin:NADP+ oxidoreductase
Definition
(1'S)-Averantin + NADP+ <=> Norsolorinic acid + NADPH + H+
Equation
C20499 + C00006 <=> C20452 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC01491  C20452_C20499
Enzyme
1.1.1.349
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.349
     R10309  (1'S)-Averantin + NADP+ <=> Norsolorinic acid + NADPH + H+
Orthology
K17644  norsolorinic acid ketoreductase [EC:1.1.1.349]
Other DBs
RHEA: 35450
LinkDB

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