KEGG   ORTHOLOGY: K17648
Entry
K17648                      KO                                     
Symbol
ESTA
Name
versiconal hemiacetal acetate esterase [EC:3.1.1.94]
Pathway
map00254  Aflatoxin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Reaction
R10398  versiconol acetate O-acetylhydrolase
R10401  versiconal-hemiacetal-acetate O-acetylhydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00254 Aflatoxin biosynthesis
    K17648  ESTA; versiconal hemiacetal acetate esterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.94  versiconal hemiacetal acetate esterase
     K17648  ESTA; versiconal hemiacetal acetate esterase
Other DBs
COG: COG0657
GO: 0140397
Genes
PAN: PODANSg8561
PBEL: QC761_207320
PPSD: QC762_207320
PPSP: QC763_207320
PPSA: QC764_207320
MTM: MYCTH_54712
PGRI: PgNI_02164
FGR: FGSG_09112
FVR: FVEG_03630 FVEG_07643
FOX: FOXG_04573 FOXG_05758
NHE: NECHADRAFT_44040
FFC: NCS54_00871400
FKR: NCS57_00911800
FMU: J7337_003641 J7337_010341
TASP: 36611238(TrAFT101_002308)
MBRN: 26243644(est1)
PTKZ: JDV02_003531
SAPO: SAPIO_CDS0298 SAPIO_CDS8256
SSL: SS1G_01703
BFU: BCIN_02g03480
MBE: MBM_02254
PSCO: LY89DRAFT_594986
GLZ: GLAREA_08109
ANI: ANIA_05565 ANIA_07816
ACT: ACLA_062700
AOR: AO090026000017
ANG: An11g08610
AFV: AFLA_006302
APUU: APUU_10059S APUU_20047S
PCS: N7525_004428
PNO: SNOG_09866
PTE: PTT_13757
PTRR: 6348579(PtrM4_076080)
BZE: COCCADRAFT_3427
BSC: COCSADRAFT_131207
BOR: COCMIDRAFT_32193
AALT: CC77DRAFT_1033655
ZTR: MYCGRDRAFT_77854
PFJ: MYCFIDRAFT_42424 MYCFIDRAFT_49459
FFU: CLAFUR5_14256
CBET: CB0940_05528 CB0940_05991
BCOM: BAUCODRAFT_148152 BAUCODRAFT_307726
AG: AAS66011(estA)
 » show all
Reference
PMID:15184162
  Authors
Chang PK, Yabe K, Yu J
  Title
The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 70:3593-9 (2004)
DOI:10.1128/AEM.70.6.3593-3599.2004
  Sequence
[ag:AAS66011]
LinkDB

KEGG   ENZYME: 3.1.1.94
Entry
EC 3.1.1.94                 Enzyme                                 
Name
versiconal hemiacetal acetate esterase;
VHA esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
versiconal-hemiacetal-acetate O-acetylhydrolase
Reaction(IUBMB)
(1) versiconal hemiacetal acetate + H2O = versiconal + acetate [RN:R10401];
(2) versiconol acetate + H2O = versiconol + acetate [RN:R10398]
Reaction(KEGG)
R10398 R10401
Substrate
versiconal hemiacetal acetate [CPD:C20505];
H2O [CPD:C00001];
versiconol acetate [CPD:C20506]
Product
versiconal [CPD:C20507];
acetate [CPD:C00033];
versiconol [CPD:C20508]
Comment
Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.
History
EC 3.1.1.94 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17648  versiconal hemiacetal acetate esterase
Genes
PAN: PODANSg8561
PBEL: QC761_207320
PPSD: QC762_207320
PPSP: QC763_207320
PPSA: QC764_207320
MTM: MYCTH_54712
PGRI: PgNI_02164
FGR: FGSG_09112
FVR: FVEG_03630 FVEG_07643
FOX: FOXG_04573 FOXG_05758
NHE: NECHADRAFT_44040
FFC: NCS54_00871400
FKR: NCS57_00911800
FMU: J7337_003641 J7337_010341
TASP: 36611238(TrAFT101_002308)
MBRN: 26243644(est1)
PTKZ: JDV02_003531
SAPO: SAPIO_CDS0298 SAPIO_CDS8256
SSL: SS1G_01703
BFU: BCIN_02g03480
MBE: MBM_02254
PSCO: LY89DRAFT_594986
GLZ: GLAREA_08109
ANI: ANIA_05565 ANIA_07816
ACT: ACLA_062700
AOR: AO090026000017
ANG: An11g08610
AFV: AFLA_006302
APUU: APUU_10059S APUU_20047S
PCS: N7525_004428
PNO: SNOG_09866
PTE: PTT_13757
PTRR: 6348579(PtrM4_076080)
BZE: COCCADRAFT_3427
BSC: COCSADRAFT_131207
BOR: COCMIDRAFT_32193
AALT: CC77DRAFT_1033655
ZTR: MYCGRDRAFT_77854
PFJ: MYCFIDRAFT_42424 MYCFIDRAFT_49459
FFU: CLAFUR5_14256
CBET: CB0940_05528 CB0940_05991
BCOM: BAUCODRAFT_148152 BAUCODRAFT_307726
 » show all
Reference
1  [PMID:8776851]
  Authors
Kusumoto K, Hsieh DP
  Title
Purification and characterization of the esterases involved in aflatoxin biosynthesis in Aspergillus parasiticus.
  Journal
Can J Microbiol 42:804-10 (1996)
DOI:10.1139/m96-101
Reference
2  [PMID:15184162]
  Authors
Chang PK, Yabe K, Yu J
  Title
The Aspergillus parasiticus estA-encoded esterase converts versiconal hemiacetal acetate to versiconal and versiconol acetate to versiconol in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 70:3593-9 (2004)
DOI:10.1128/AEM.70.6.3593-3599.2004
  Sequence
[ag:AAS66011]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.94
IUBMB Enzyme Nomenclature: 3.1.1.94
ExPASy - ENZYME nomenclature database: 3.1.1.94
BRENDA, the Enzyme Database: 3.1.1.94
LinkDB

KEGG   REACTION: R10401
Entry
R10401                      Reaction                               
Name
versiconal-hemiacetal-acetate O-acetylhydrolase
Definition
Versiconal hemiacetal acetate + H2O <=> Versiconal + Acetate
Equation
C20505 + C00001 <=> C20507 + C00033
Reaction class
RC00020  C00033_C20505
RC00041  C20505_C20507
Enzyme
3.1.1.94
Pathway
rn00254  Aflatoxin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.94
     R10401  Versiconal hemiacetal acetate + H2O <=> Versiconal + Acetate
Orthology
K17648  versiconal hemiacetal acetate esterase [EC:3.1.1.94]
Other DBs
RHEA: 35718
LinkDB

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