KEGG   ORTHOLOGY: K17683
Entry
K17683            Tight     KO                                     
Symbol
CYP2A6
Name
cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
Pathway
map00232  Caffeine metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07945  
R08225  
R08324  
R08325  
R08326  
R08327  
R08390  
R08391  
R08392  
R09408  
R09421  
R09423  
R09424  
R09425  
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00982 Drug metabolism - cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
   00983 Drug metabolism - other enzymes
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17683  CYP2A6; cytochrome P450 family 2 subfamily A6
Genes
HSA: 1548(CYP2A6) 1549(CYP2A7)
PTR: 107966456(CYP2A7)
PPS: 100975509(CYP2A7)
GGO: 101146638
PON: 100457048
PPYG: 129019418
MCF: 102122745(CYP2A24)
TGE: 112611969
Reference
PMID:2726448 (CYP2A6)
  Authors
Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR
  Title
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
  Journal
Nucleic Acids Res 17:2907-17 (1989)
DOI:10.1093/nar/17.8.2907
  Sequence
[hsa:1548]
Reference
PMID:7668294 (CYP2A7)
  Authors
Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al.
  Title
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
  Journal
Am J Hum Genet 57:651-60 (1995)
  Sequence
[hsa:1549]
Reference
  Authors
Xu C, Goodz S, Sellers EM, Tyndale RF
  Title
CYP2A6 genetic variation and potential consequences.
  Journal
Adv Drug Deliv Rev 54:1245-56 (2002)
DOI:10.1016/S0169-409X(02)00065-0
LinkDB

KEGG   ORTHOLOGY: K07411
Entry
K07411                      KO                                     
Symbol
CYP2A
Name
cytochrome P450 family 2 subfamily A [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
Reaction
R08390  
R08391  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07411  CYP2A; cytochrome P450 family 2 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07411  CYP2A; cytochrome P450 family 2 subfamily A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07411  CYP2A; cytochrome P450 family 2 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07411  CYP2A; cytochrome P450 family 2 subfamily A
Genes
MLEU: 105542587
CSYR: 103249340
MMUR: 105876749
LCAT: 123624224 123624295 123624296
ERUF: 138374920
PCOQ: 105820607
OGA: 100953114
MMU: 13085(Cyp2a12) 13086(Cyp2a4) 13087(Cyp2a5) 233005(Cyp2a22)
MCAL: 110297420
MPAH: 110315448
RNO: 24299(Cyp2a3) 24894(Cyp2a1) 24895(Cyp2a2)
CGE: 100689033(Cyp2a14) 100689034(Cyp2a17) 100689035(Cyp2a15) 100772358
MMMA: 107151438
OCU: 100328596(CYP2A11)
OPI: 101534346
OCZ: 121153846
TUP: 102485364
GVR: 103600499
CFA: 484493(CYP2A7) 484494(CYP2A13)
MPUF: 101681178
FCA: 101089561(CYP2A25) 101089816(CYP2A13)
PCOO: 112851420
BTA: 540707(CYP2A13)
BOM: 102281503
BIU: 109572736
BBUB: 102401344
BBIS: 104995374
CHX: 102168381
OAS: 100568289(CYP2A6)
BTAX: 128063606
CSUM: 138095858
ODA: 120872402
CCAD: 122421546
MREE: 136158784
OVR: 110148802
MBEZ: 129546792
SSC: 403149(CYP2A19)
CFR: 102507471
CBAI: 105062872
CDK: 105093359
VPC: 102541022
BMUS: 118885279
PPHC: 136140232
MNA: 107534173
DRO: 112320011
RFQ: 117035077
MJV: 108397726
SETR: 126028127
ETF: 101647240
DNM: 101416547
PCW: 110203005
OAA: 100075646(CYP2A.B) 100089063
TACU: 119945683
AROW: 112961606
CTIG: 120316365
PTEX: 113450319
NSS: 113425563
VKO: 123026164
ZVI: 118086690
RTEM: 120913358
ACAT: 141107725
PADS: 140343581
DTC: 141051696
DALB: 135902500
RSAN: 119382954
RMP: 119162174
ABRU: 129964017
MAEA: 128206032
AG: AAA37068(CYP2A8) BAA25259(CYP2A9) BAA85463(CYP2A16)
 » show all
Reference
PMID:3818621 (CYP2A1)
  Authors
Nagata K, Matsunaga T, Gillette J, Gelboin HV, Gonzalez FJ
  Title
Rat testosterone 7 alpha-hydroxylase. Isolation, sequence, and expression of cDNA and its developmental regulation and induction by 3-methylcholanthrene.
  Journal
J Biol Chem 262:2787-93 (1987)
  Sequence
[rno:24894]
Reference
PMID:3192524 (CYP2A2)
  Authors
Matsunaga T, Nagata K, Holsztynska EJ, Lapenson DP, Smith A, Kato R, Gelboin HV, Waxman DJ, Gonzalez FJ
  Title
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase.
  Journal
J Biol Chem 263:17995-8002 (1988)
  Sequence
[rno:24895]
Reference
PMID:2751996 (CYP2A3)
  Authors
Kimura S, Kozak CA, Gonzalez FJ
  Title
Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene.
  Journal
Biochemistry 28:3798-803 (1989)
DOI:10.1021/bi00435a026
  Sequence
[rno:24299]
Reference
PMID:2703500 (CYP2A4)
  Authors
Lindberg R, Burkhart B, Ichikawa T, Negishi M
  Title
The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.
  Journal
J Biol Chem 264:6465-71 (1989)
  Sequence
[mmu:13087]
Reference
PMID:2275554 (CYP2A8)
  Authors
Lai TS, Chiang JY
  Title
Cloning and characterization of two major 3-methylcholanthrene inducible hamster liver cytochrome P450s.
  Journal
Arch Biochem Biophys 283:429-39 (1990)
DOI:10.1016/0003-9861(90)90664-K
  Sequence
Reference
PMID:9500848 (CYP2A9)
  Authors
Kurose K, Tohkin M, Ushio F, Fukuhara M
  Title
Cloning and characterization of Syrian hamster testosterone 7 alpha-hydroxylase, CYP2A9.
  Journal
Arch Biochem Biophys 351:60-5 (1998)
DOI:10.1006/abbi.1997.0544
  Sequence
Reference
PMID:8349611 (CYP2A10 CYP2A11)
  Authors
Peng HM, Ding X, Coon MJ
  Title
Isolation and heterologous expression of cloned cDNAs for two rabbit nasal microsomal proteins, CYP2A10 and CYP2A11, that are related to nasal microsomal cytochrome P450 form a.
  Journal
J Biol Chem 268:17253-60 (1993)
  Sequence
[ocu:100328596]
Reference
PMID:10524222 (CYP2A16)
  Authors
Tohkin M, Kurose K, Isozaki E, Fukuhara M
  Title
Molecular cloning, heterologous expression, and characterization of a novel member of CYP2A in the Syrian hamster.
  Journal
Biochim Biophys Acta 1446:438-42 (1999)
DOI:10.1016/S0167-4781(99)00109-8
  Sequence
LinkDB

KEGG   ORTHOLOGY: K17709
Entry
K17709                      KO                                     
Symbol
CYP2B6
Name
cytochrome P450 family 2 subfamily B6 [EC:1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map05207  Chemical carcinogenesis - receptor activation
map05417  Lipid and atherosclerosis
Reaction
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07048  
R07050  
R07051  
R07052  
R08275  
R08285  
R08286  
R08287  
R08313  
R08324  
R08325  
R08326  
R08390  
R08391  
R08392  
R09441  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
   00982 Drug metabolism - cytochrome P450
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17709  CYP2B6; cytochrome P450 family 2 subfamily B6
Genes
HSA: 1555(CYP2B6)
PTR: 104003379(CYP2B6) 456052
PPS: 100984180(CYP2B6)
GGO: 101151678
PON: 100457779 100458142
PPYG: 129020761 129020845
NLE: 101179527
HMH: 116480657
SSYN: 129466954
MCC: 114675607 678687(CYP2B6)
MCF: 102124427(CYP2B6)
MTHB: 126942029
MNI: 105495315
CSAB: 103234720
CATY: 105597999
PANU: 101001292
MLEU: 105542145
TFN: 117087868
PTEH: 111554026
CANG: 105507826
CJC: 100405958
SBQ: 101041829
CIMI: 108285668(CYP2B6)
ANAN: 105723440(CYP2B6)
CSYR: 103268360
ERUF: 138374640
CSUM: 138096812
MDO: 100018958
GAS: 123242991
SHR: 100931571
AFZ: 127556219
PCW: 110204171
TVP: 118837766
PBRV: 138153845
MLAO: 141509523
OAA: 100074363
TACU: 119946069
 » show all
Reference
PMID:2573390
  Authors
Yamano S, Nhamburo PT, Aoyama T, Meyer UA, Inaba T, Kalow W, Gelboin HV, McBride OW, Gonzalez FJ
  Title
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver.
  Journal
Biochemistry 28:7340-8 (1989)
DOI:10.1021/bi00444a029
  Sequence
[hsa:1555]
LinkDB

KEGG   ORTHOLOGY: K07412
Entry
K07412                      KO                                     
Symbol
CYP2B
Name
cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map05207  Chemical carcinogenesis - receptor activation
Reaction
R03408  
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07048  
R07050  
R07051  
R07052  
R08390  
R08391  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
   00590 Arachidonic acid metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07412  CYP2B; cytochrome P450 family 2 subfamily B
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07412  CYP2B; cytochrome P450 family 2 subfamily B
Genes
ERUF: 138374639 138374643 138374644 138374921
PCOQ: 105820475 105820477 105820598
OGA: 105888244
MMU: 13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 243881(Cyp2b23)
MCAL: 110288440 110288965 110297861 110298448 110298729 110298847
MPAH: 110336742
RNO: 103691072(Cyp2b14) 103691092 24300(Cyp2b1) 286953(Cyp2b3) 292728(Cyp2b21) 29295(Cyp2b12) 361523(Cyp2b2) 685222(Cyp2b15)
MCOC: 116100420 116101862 116101866
ANU: 117710642 117710646 117714125
ASYL: 127665036 127673060 127683018 127683025 127683051 127683058 127683066 127683070
OPI: 101530662
GVR: 103600497
CFA: 474177(CYP2B6)
CLUD: 112645436
VVP: 112928354
VLG: 121485519
NPO: 129499612
EJU: 114202558
MLX: 118022638
NSU: 110590260
FCA: 105259649(CYP2B6) 105260134
PCOO: 112851322
PPAD: 109261476
PUC: 125915742
HHV: 120243430
BTA: 504769(CYP2B6) 530571(CYP2B39)
MBEZ: 129546790
SSC: 102165015 403104(CYP2B22)
MYB: 102245131
MYD: 102751643
MMYO: 118674745
MDT: 132216860
PKL: 118702365
EFUS: 103284293
DRO: 112319965
AJM: 119042877
PDIC: 114511724
PHAS: 123823834
MMF: 118639252
PPAM: 129076628
RFQ: 117035075
PGIG: 120595325
RAY: 107521826
MJV: 108405662
TMU: 101341442
MDO: 100018927
GAS: 123242992
SHR: 105749943
PBRV: 138154621
LKP: 140902153
CABI: 116833843
ASAO: 132780095
ACAT: 141107689
AJJ: 139968188
PCHN: 125047440
HAME: 121875618
PCLA: 123773186
PPOI: 119094960
DALB: 135909661
ABRU: 129968506
CANU: 128178189
OED: 130048152
AIRR: 138326995
YBA: 132557564
RPHI: 132737651
 » show all
Reference
PMID:6306654 (CYP2B2)
  Authors
Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y
  Title
Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.
  Journal
Proc Natl Acad Sci U S A 80:3958-62 (1983)
DOI:10.1073/pnas.80.13.3958
  Sequence
[rno:361523]
Reference
PMID:3396451 (CYP2B3)
  Authors
Labbe D, Jean A, Anderson A
  Title
A constitutive member of the rat cytochrome P450IIB subfamily: full-length coding sequence of the P450IIB3 cDNA.
  Journal
DNA 7:253-60 (1988)
DOI:10.1089/dna.1988.7.253
  Sequence
[rno:286953]
Reference
PMID:3219345 (CYP2B9 CYP2B10)
  Authors
Noshiro M, Lakso M, Kawajiri K, Negishi M
  Title
Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.
  Journal
Biochemistry 27:6434-43 (1988)
DOI:10.1021/bi00417a035
  Sequence
[mmu:13094 13088]
Reference
PMID:2116765 (CYP2B11)
  Authors
Graves PE, Elhag GA, Ciaccio PJ, Bourque DP, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
  Journal
Arch Biochem Biophys 281:106-15 (1990)
DOI:10.1016/0003-9861(90)90419-y
  Sequence
[cfa:474177]
Reference
PMID:1445240 (CYP2B12)
  Authors
Friedberg T, Grassow MA, Bartlomowicz-Oesch B, Siegert P, Arand M, Adesnik M, Oesch F
  Title
Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver.
  Journal
Biochem J 287 ( Pt 3):775-83 (1992)
DOI:10.1042/bj2870775
  Sequence
[rno:29295]
Reference
PMID:8294026 (CYP2B15)
  Authors
Nakayama K, Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y
  Title
Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene.
  Journal
Gene 136:333-6 (1993)
DOI:10.1016/0378-1119(93)90490-t
  Sequence
[rno:685222]
Reference
PMID:9799616 (CYP2B19)
  Authors
Keeney DS
  Title
The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes.
  Journal
Genomics 53:417-9 (1998)
DOI:10.1006/geno.1998.5533
  Sequence
[mmu:13090]
Reference
PMID:11159754 (CYP2B21)
  Authors
Brookman-Amissah N, Mackay AG, Swann PF
  Title
Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.
  Journal
Carcinogenesis 22:155-60 (2001)
DOI:10.1093/carcin/22.1.155
  Sequence
[rno:292728]
Reference
PMID:16315095 (CYP2B22)
  Authors
Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y
  Title
Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants.
  Journal
Transgenic Res 14:907-17 (2005)
DOI:10.1007/s11248-005-0199-x
  Sequence
[ssc:403104]
LinkDB

KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     
Symbol
CYP2C8
Name
cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07042  
R07043  
R07048  
R07050  
R07055  
R07056  
R08312  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379(CYP2C8)
GGO: 101127173
PON: 100447840(CYP2C8)
PPYG: 129006200
NLE: 100602226
HMH: 116457254
SSYN: 129462752
MCC: 100534648(CYP2C93) 678683(CYP2C8) 702239
MCF: 102116849 102117212(CYP2C8) 102119308(CYP2C93)
CSAB: 103216303(CYP2C8) 103216308
PANU: 101022842(CYP2C8) 101023648
RRO: 104665592
RBB: 108541196
TFN: 117069764
PTEH: 111529253
CJC: 100390915(CYP2C8) 100402764
SBQ: 101041387
CIMI: 108281688(CYP2C8)
ANAN: 105708272(CYP2C8)
CSYR: 103260641
PCOQ: 105822696
ASAO: 132781291
SUND: 121921666
PCAE: 139312564
APRI: 131192456
PRAF: 128407606
DTC: 141052000
GSH: 117365670
HOC: 132836750
DALB: 135903504
RMP: 119168129
CRG: 105344043
CANU: 128177588
CVN: 111128571
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]
LinkDB

KEGG   ORTHOLOGY: K17719
Entry
K17719                      KO                                     
Symbol
CYP2C9
Name
cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07048  
R07050  
R07051  
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08267  
R08275  
R08285  
R08324  
R08325  
R08326  
R08390  
R08392  
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1559(CYP2C9)
PTR: 100616515(CYP2C9)
PPS: 100996034(CYP2C9)
GGO: 101126456
PON: 100450749(CYP2C9)
PPYG: 129006530
NLE: 100591471
HMH: 116457268
SSYN: 129468897
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
DORD: 106001520
NCAR: 124985776
SFUM: 130029818
 » show all
Reference
PMID:3196692
  Authors
Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP
  Title
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
  Journal
Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039
  Sequence
[hsa:1559]
LinkDB

KEGG   ORTHOLOGY: K17720
Entry
K17720                      KO                                     
Symbol
CYP2C18
Name
cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Genes
HSA: 1562(CYP2C18)
GGO: 134756383
HMH: 116480603
MCC: 701855(CYP2C18)
MCF: 102145601(CYP2C18)
MTHB: 126962034 126962041
MNI: 105479956
CSAB: 103216300(CYP2C18)
CATY: 105586945
PANU: 101021773
TGE: 112631551
MLEU: 105545510
CJC: 100389345(CYP2C18)
SBQ: 101042223
CIMI: 108298685(CYP2C18)
ANAN: 105718959(CYP2C18)
CSYR: 103277155
MMUR: 105872416
LCAT: 123649683
PCOQ: 105822660
PLEU: 114689432
MFOT: 126511071
MMMA: 107149729
OCZ: 121164027
SHON: 118988004
MMF: 118632033
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1562]
LinkDB

KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R03408  
R07042  
R07043  
R07048  
R07050  
R07051  
R07052  
R07054  
R07055  
R07056  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Genes
PON: 100449185
PPYG: 129006201
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76) 135965165
MTHB: 126962035 126962036
MNI: 105470210
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
MLEU: 105553702 105553718
CANG: 105527570
CJC: 100391987
SBQ: 101040831
CIMI: 108282285(CYP2C76)
ANAN: 105708280(CYP2C76)
MMU: 100043108(Cyp2c69) 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 545288(Cyp2c67) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
RNO: 100361492(Cyp2c55) 100361547(Cyp2c7l1) 100911718 100912265(Cyp2c66) 120093077 120098584 134483996 134485234 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
PMAV: 102913528
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
CFA: 100688697 415122(CYP2C18)
FCA: 101089396(CYP2C41) 101089804
BTA: 505468(CYP2C88) 510380(CYP2C89) 511498(CYP2C23) 535243(CYP2C90) 616593(CYP2C87) 785540(CYP2C281)
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
BACU: 103017669
BMUS: 118882389
LVE: 103084494
GMF: 115857893
DDP: 132439707
DLE: 111172397
PPHC: 136136240
NASI: 112392977
DRO: 112300219
AJM: 119064549
PALE: 102891905
PVP: 105301394
MJV: 108409895
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
NMEL: 110399446
PMOA: 120499733
ETL: 114065370
ACHL: 103805798
MMEA: 130581013
HRT: 120748109
HALD: 104315668
HLE: 104831888
HHAR: 128147453
BBUT: 142030640
CSTI: 104561375
MNB: 103771400
AVIT: 104273142
BRHI: 104492082
CBOR: 142091170
MUI: 104534424
CMAC: 104476783
TEO: 104374656
OHA: 104329922
ACAR: 104529274
TGT: 104566795
CPOO: 109315166
CMY: 102931882
CCAY: 125621101
NDS: 141999079
TSR: 106538299
PGUT: 117659140
HCG: 128343349
EMC: 129324116
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
CPLA: 122542870
CPUN: 140454488
HOC: 132836798
BFO: 118416246
BBEL: 109470437
AJJ: 139973304
MNZ: 135219059
HAZT: 108665260
OOT: 143038011
RSAN: 119373421
HRF: 124113633
CRG: 105333836
CANU: 128179353
RPHI: 132743744
OSN: 115231110
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]
LinkDB

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