KEGG   ORTHOLOGY: K17689
Entry
K17689            Tight     KO                                     
Symbol
CYP3A4
Name
cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Reaction
R02356  
R03408  
R05727  quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08256  
R08257  
R08264  
R08268  
R08269  
R08271  
R08272  
R08274  
R08275  
R08276  
R08277  
R08285  
R08286  
R08287  
R08293  
R08294  
R08303  
R08304  
R08312  
R08313  
R08318  
R08339  
R08340  
R08341  
R08342  
R08343  
R08390  
R08391  
R08392  
R09404  
R09408  
R09423  
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00591 Linoleic acid metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00982 Drug metabolism - cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00983 Drug metabolism - other enzymes
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   05207 Chemical carcinogenesis - receptor activation
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.55  quinine 3-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.56  1,8-cineole 2-exo-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.57  taurochenodeoxycholate 6alpha-hydroxylase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Other DBs
GO: 0047638 0033780 0050591
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899(CYP3A4)
GGO: 101149513
PON: 100436782
PPYG: 129041698
NLE: 100593175
SSYN: 129489604
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A4)
MTHB: 126950475
MNI: 105497389
CSAB: 103246766
CATY: 105584402
PANU: 101026757
TGE: 112621193
MLEU: 105543708
RRO: 104673585
RBB: 108538168
TFN: 117072034
PTEH: 111530171 111534893
CANG: 105513064
CJC: 100404344(CYP3A4)
SBQ: 101037403
CIMI: 108308036(CYP3A4)
ANAN: 105719456(CYP3A4)
CSYR: 103252931
MMUR: 105868328 105868331
LCAT: 123631591 123631593
PCOQ: 105806078
OGA: 100948865
 » show all
Reference
PMID:3267210 (CYP3A4)
  Authors
Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR
  Title
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
  Journal
DNA 7:79-86 (1988)
DOI:10.1089/dna.1988.7.79
  Sequence
[hsa:1576]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
Reference
PMID:9056237 (CYP3A21)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100404344]
LinkDB

KEGG   REACTION: R08256
Entry
R08256                      Reaction                               
Definition
Irinotecan <=> APC
Equation
C16641 <=> C16542
Comment
CYP3A4
incomplete reaction
multi-step reaction
Reaction class
RC02266  C16542_C16641
Enzyme
1.14.14.-
Pathway
rn00983  Drug metabolism - other enzymes
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     R08256  Irinotecan <=> APC
Orthology
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
LinkDB

KEGG   REACTION: R08257
Entry
R08257                      Reaction                               
Definition
Irinotecan + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> NPC + Glutaral + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C16641 + 2 C03024 + 2 C00007 <=> C16543 + C12518 + 2 C03161 + 2 C00001
Comment
CYP3A4
Reaction class
RC02267  C16543_C16641
RC02298  C12518_C16641
Enzyme
1.14.14.-
Pathway
rn00983  Drug metabolism - other enzymes
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     R08257  Irinotecan + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> NPC + Glutaral + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Orthology
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
LinkDB

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