KEGG   ORTHOLOGY: K17747
Entry
K17747                      KO                                     
Symbol
ptlF
Name
1-deoxy-11beta-hydroxypentalenate dehydrogenase [EC:1.1.1.340]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Reaction
R10156  1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K17747  ptlF; 1-deoxy-11beta-hydroxypentalenate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.340  1-deoxy-11beta-hydroxypentalenate dehydrogenase
     K17747  ptlF; 1-deoxy-11beta-hydroxypentalenate dehydrogenase
Genes
SMA: SAVERM_2993(ptlF)
SBH: SBI_09675
SCI: B446_29675
SCW: TU94_27385
SLE: sle_13200(sle_13200)
SSIA: A7J05_09260
SGJ: IAG43_27135
SHK: J2N69_35825
Reference
PMID:17178094
  Authors
You Z, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.
  Journal
Arch Biochem Biophys 459:233-40 (2007)
DOI:10.1016/j.abb.2006.11.016
  Sequence
[sma:SAVERM_2993]
LinkDB

KEGG   ENZYME: 1.1.1.340
Entry
EC 1.1.1.340                Enzyme                                 
Name
1-deoxy-11beta-hydroxypentalenate dehydrogenase;
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase;
ptlF (gene name);
penF (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Reaction(IUBMB)
1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ [RN:R10156]
Reaction(KEGG)
R10156
Substrate
1-deoxy-11beta-hydroxypentalenate [CPD:C20403];
NAD+ [CPD:C00003]
Product
1-deoxy-11-oxopentalenate [CPD:C20400];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
History
EC 1.1.1.340 created 2012
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17747  1-deoxy-11beta-hydroxypentalenate dehydrogenase
Genes
SMA: SAVERM_2993(ptlF)
SBH: SBI_09675
SCI: B446_29675
SCW: TU94_27385
SLE: sle_13200(sle_13200)
SSIA: A7J05_09260
SGJ: IAG43_27135
SHK: J2N69_35825
Reference
1  [PMID:17178094]
  Authors
You Z, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.
  Journal
Arch Biochem Biophys 459:233-40 (2007)
DOI:10.1016/j.abb.2006.11.016
  Sequence
[sma:SAVERM_2993]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.340
IUBMB Enzyme Nomenclature: 1.1.1.340
ExPASy - ENZYME nomenclature database: 1.1.1.340
BRENDA, the Enzyme Database: 1.1.1.340
LinkDB

KEGG   REACTION: R10156
Entry
R10156                      Reaction                               
Name
1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Definition
1-Deoxy-11beta-hydroxypentalenate + NAD+ <=> 1-Deoxy-11-oxopentalenate + NADH + H+
Equation
C20403 + C00003 <=> C20400 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00154  C20400_C20403
Enzyme
1.1.1.340
Pathway
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.340
     R10156  1-Deoxy-11beta-hydroxypentalenate + NAD+ <=> 1-Deoxy-11-oxopentalenate + NADH + H+
Orthology
K17747  1-deoxy-11beta-hydroxypentalenate dehydrogenase [EC:1.1.1.340]
Other DBs
RHEA: 34562
LinkDB

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