KEGG ORTHOLOGY: K17826

ORTHOLOGY: K17826

Entry

K17826                      KO

Symbol

FTMG, CYP5067A

Name

fumitremorgin C monooxygenase [EC:1.14.14.119]

Pathway

map00404

Staurosporine biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00786

Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A

Reaction

R10414

fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.119  fumitremorgin C monooxygenase
     K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, fungi type
  CYP5067 family
   K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase

Other DBs

COG:

COG2124

Genes

AFM:	AFUA_8G00240

NFI:	NFIA_093750

Reference

PMID:19226505

Authors

Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H

Title

Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.

Journal

Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787

Sequence

[afm:AFUA_8G00240]

LinkDB

ENZYME: 1.14.14.119

Entry

EC 1.14.14.119              Enzyme

Name

fumitremorgin C monooxygenase;
ftmG (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)

Reaction(IUBMB)

fumitremorgin C + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R10414]

Reaction(KEGG)

R10414

Substrate

fumitremorgin C [CPD:C20604];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]

Product

12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]

Comment

A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.

History

EC 1.14.14.119 created 2013 as EC 1.14.13.177, transferred 2018 to EC 1.14.14.119

Pathway

ec00404

Staurosporine biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17826

fumitremorgin C monooxygenase

Genes

AFM:	AFUA_8G00240

NFI:	NFIA_093750

Reference

1 [PMID:19226505]

Authors

Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H

Title

Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.

Journal

Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787

Sequence

[afm:AFUA_8G00240]

Other DBs

ExplorEnz - The Enzyme Database:

1.14.14.119

IUBMB Enzyme Nomenclature:

1.14.14.119

ExPASy - ENZYME nomenclature database:

1.14.14.119

BRENDA, the Enzyme Database:

1.14.14.119

LinkDB

REACTION: R10414

Entry

R10414                      Reaction

Name

fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)

Definition

Fumitremorgin C + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> 12alpha,13alpha-Dihydroxyfumitremorgin C + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O

Equation

C20604 + 2 C03024 + 2 C00007 <=> C20605 + 2 C03161 + 2 C00001

Reaction class

RC03173

C20604_C20605

Enzyme

1.14.14.119

Pathway

rn00404

Staurosporine biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00786

Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.119
     R10414  Fumitremorgin C + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> 12alpha,13alpha-Dihydroxyfumitremorgin C + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O

Orthology

K17826

fumitremorgin C monooxygenase [EC:1.14.14.119]

Other DBs

RHEA:

35970

LinkDB

DBGET integrated database retrieval system