KEGG   ORTHOLOGY: K17839
Entry
K17839                      KO                                     
Symbol
PAO4, PAO3, PAO2
Name
polyamine oxidase [EC:1.5.3.17 1.5.3.-]
Pathway
map00330  Arginine and proline metabolism
map00410  beta-Alanine metabolism
map00770  Pantothenate and CoA biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K17839  PAO4, PAO3, PAO2; polyamine oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K17839  PAO4, PAO3, PAO2; polyamine oxidase
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K17839  PAO4, PAO3, PAO2; polyamine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.17  non-specific polyamine oxidase
     K17839  PAO4, PAO3, PAO2; polyamine oxidase
    1.5.3.-
     K17839  PAO4, PAO3, PAO2; polyamine oxidase
Other DBs
RN: R09076 R09077
Genes
AJM: 119038304 119044760
PCAN: 112562815
BGT: 106052168
GAE: 121377312
HRF: 124147842
HRJ: 124281237
CRG: 105337353 117680768
MYI: 110458005
PMAX: 117316825
MMER: 123532668
OBI: 106875493
OSN: 115223386
ATH: AT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
TCC: 18612191
LJA: Lj2g3v3070870.2(Lj2g3v3070870.2) Lj6g3v0366930.1(Lj6g3v0366930.1) Lj6g3v0933770.1(Lj6g3v0933770.1)
ZJU: 107416625
MNT: 21395916
DOSA: Os04t0623300-01(Os04g0623300) Os04t0671200-01(Os04g0671200) Os04t0671300-01(Os04g0671300)
MMI: MMAR_1387
MSHG: MSG_01342
MBAI: MB901379_01280(pao)
MSEO: MSEO_01560
MMOR: MMOR_21900
MAIC: MAIC_40090
MGAD: MGAD_55070
MHEV: MHEL_07170
MPOF: MPOR_44830
 » show all
Reference
PMID:18583528 (PAO3/1.5.3.17)
  Authors
Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA
  Title
Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
  Journal
Plant Physiol 147:1845-57 (2008)
DOI:10.1104/pp.108.123802
  Sequence
[ath:AT3G59050]
LinkDB

KEGG   ORTHOLOGY: K13367
Entry
K13367                      KO                                     
Symbol
FMS1
Name
polyamine oxidase [EC:1.5.3.17]
Pathway
map00330  Arginine and proline metabolism
map00410  beta-Alanine metabolism
map00770  Pantothenate and CoA biosynthesis
map01100  Metabolic pathways
map01240  Biosynthesis of cofactors
Module
M00913  Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K13367  FMS1; polyamine oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K13367  FMS1; polyamine oxidase
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    K13367  FMS1; polyamine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.17  non-specific polyamine oxidase
     K13367  FMS1; polyamine oxidase
Other DBs
RN: R03899 R09074 R09076 R09077
GO: 0046592
Genes
SCE: YMR020W(FMS1)
SEUB: DI49_4107
SPAO: SPAR_M01440
AGO: AGOS_ABR057W
ERC: Ecym_4580
KLA: KLLA0_E07789g
KMX: KLMA_40378(FMS1)
LTH: KLTH0D07942g
ZRO: ZYRO0E06314g
CGR: CAGL0M07612g
NCS: NCAS_0A12730(NCAS0A12730)
NDI: NDAI_0B01530(NDAI0B01530)
TDL: TDEL_0B06550(TDEL0B06550)
KAF: KAFR_0A02140(KAFR0A02140)
KNG: KNAG_0M02130(KNAG0M02130)
CAL: CAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
SLB: AWJ20_1654(FMS1) AWJ20_390(FMS1) AWJ20_4168(FMS1)
MBE: MBM_07212
 » show all
Reference
  Authors
Landry J, Sternglanz R
  Title
Yeast Fms1 is a FAD-utilizing polyamine oxidase.
  Journal
Biochem Biophys Res Commun 303:771-6 (2003)
DOI:10.1016/S0006-291X(03)00416-9
  Sequence
[sce:YMR020W]
LinkDB

KEGG   ENZYME: 1.5.3.17
Entry
EC 1.5.3.17                 Enzyme                                 
Name
non-specific polyamine oxidase;
polyamine oxidase (ambiguous);
Fms1;
AtPAO3
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
Sysname
polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming)
Reaction(IUBMB)
(1) spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076];
(2) spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [RN:R09077];
(3) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899];
(4) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074]
Reaction(KEGG)
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001];
spermidine [CPD:C00315];
N1-acetylspermine [CPD:C02567];
N1-acetylspermidine [CPD:C00612]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027];
putrescine [CPD:C00134];
3-acetamidopropanal [CPD:C18170]
Comment
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1].
The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase).
History
EC 1.5.3.17 created 2009
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K13367  polyamine oxidase
K17839  polyamine oxidase
Genes
AJM119038304 119044760
PCAN112562815
BGT106052168
GAE121377312
HRF124147842
HRJ124281237
CRG105337353 117680768
MYI110458005
PMAX117316825
MMER123532668
OBI106875493
OSN115223386
ATHAT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
ALY9314325 9316084 9323048
CRB17887258 17890473 17895855
CSAT104699419 104701179 104750367 104781816 104782814 104785057 104787599 104788143 104792182
EUSEUTSA_v10005954mg EUTSA_v10016573mg EUTSA_v10018447mg
BRP103830193 103852299 103858041 103866035 103866687
BNA106351646 106351654 106353169 106381329 106385479 106391704 106421166 106428226 106434498 106441217 111211981
BOE106296723 106318716 106333466 106336574 106336734
RSZ108812262 108820199 108831364 108833605 108845973 108855756
THJ104803407 104805661 104821208 104822137
CPAP110815049 110815461
CIT102624788 102627867
CICCICLE_v10011567mg CICLE_v10031239mg
PVY116114956 116117567 116124566
MINC123207207 123207209 123216015 123224129 123224436 123226440
TCC18612191
GRA105763643 105790392
GHI107916881 107925953 107944271 107945473
GAB108469685 108483444
DZI111291899 111305825
EGR104422211 104442425
GMX100782576 100785056 100790521 100791090 100798561 100799631 100806878 100811255
GSJ114382235 114384726 114385073 114396367 114396607 114397655 114401509 114423310
PVUPHAVU_006G028600g PHAVU_006G085900g PHAVU_008G196900g PHAVU_008G241700g
VRA106753045 106765160 106765271 106776036
VAR108337267 108338488 108343091 108343161
VUN114187577 114187960 114193147 114194688
CCAJ109790272 109795185 109795282
APRC113846073 113849409 113855937 113874455
MTRMTR_3g064370 MTR_3g449620 MTR_5g090300
CAM101488772 101489745 101514322
LJALj2g3v3070870.2(Lj2g3v3070870.2) Lj6g3v0366930.1(Lj6g3v0366930.1) Lj6g3v0933770.1(Lj6g3v0933770.1)
ADU107458090 107480998 107496522
AIP107610087 107631405
AHF112702079 112702606 112733789 112766845 112767401 112791693
LANG109330188 109339566 109356838
FVE101293234 101293991
RCN112186479 112191920
PPER18782544 18782903
PMUM103327360 103328951
PAVI110765111 110765925
PDUL117621412 117622174
MDM103405136 103405900 103443150 103444375
PXB103933878 103947391 103956795 103956798 103959927 103965587
ZJU107416625
MNT21395916
CSV101205765 101213852
CMO103493008 103502485
BHJ120085574 120086274
MCHA111005782 111008343
CMAX111477047 111480387 111482955
CMOS111437612 111442764 111445809
CPEP111788589 111797083 111810933
RCU8273410 8277860
JCU105634456 105634459 105636130
HBR110638926 110654238 110666897
MESC110600153 110604601 110608659
POP18106497 7464825 7468334 7468715
PEU105112050 105115960 105126880 105131456 105135278
PALZ118030279 118037141 118049224 118061712
JRE108986807 108988145 108993577 109010094
QSU112030214 112039554
QLO115976191 115984102
TWL119984189 119994994 120003801 120013808
VVI100245491 100250153
VRI117904754 117912466 117926581
SLY101252005 101258232 101260014 101264170
SPEN107007559 107011311 107012957 107026194
SOT102591553 102594410 102598184 102605222
SSTN125848666 125860850 125861216 125875918
CANN107841896 107859655 107878076
NTA107761719 107762338 107775720 107775961 107799822 107800087 107812697 107831274(T361)
NSY104210410 104213745 104226820 104230337
NTO104086117 104093043 104097366 104107681
NAU109226965 109228574 109240600 109243515
INI109167577 109172637 109187541
ITR116010319 116013313 116021265
SIND105167429 105175973 105178573
OEU111372349 111378096 111390976 111400284 111400605
EGT105951963 105961838
SSPL121742052 121744847 121755793 121758703 121785048 121785220 121786259 121787529
HAN110882585 110912497 110921258
ECAD122579583 122587045 122595094
LSV111884410 111898938 111914638
CCAV112515135 112522951 112527605
DCR108192953 108204744 108210485
CSIN114294840 114318666
BVG104891257 104902678
SOE110785198 110798217
CQI110691948 110701998 110708250 110711120
NNU104588475 104607001 104610796
MING122064936 122071825 122074521 122080019
TSS122646703 122651308 122664493
PSOM113287329 113288317 113295350 113298295 113300769 113303219
NCOL116247370 116267545
OSA4337046 4337359 4337360
DOSAOs04t0623300-01(Os04g0623300) Os04t0671200-01(Os04g0671200) Os04t0671300-01(Os04g0671300)
OBR102710582 102711526 102711798
BDI100824039 100840588 100841193
ATS109734611 109739586 109759728
TDC119356520 119357039 119357042 119365716 119366305 119366306
TAES123046773 123047325 123047326 123054629 123055127 123055128 123190477 123190981 123190982
TUA125527638 125539728 125539768
SBI8074727 8082588 8082590
ZMA100191603 100384522 101027113 103631209 103642073
SITA101753072 101753473 101768863
SVS117850298 117850301 117863481
PVIR120641827 120642828 120642829 120680766 120681805 120683566
PHAI112899574 112900150 112900151
PDA103703721 103705589 103717571 103723706
EGU105035498 105035697 105058904 105059362
MUS103971799 103973550 103983690 103998527
DCT110099374 110101011 110103987
PEQ110019083 110020947 110023934
AOF109827207 109845387
ATR18427217 18437742
SMOSELMODRAFT_22558 SELMODRAFT_22584 SELMODRAFT_270153 SELMODRAFT_271685 SELMODRAFT_439374 SELMODRAFT_440258
PPP112286660 112286662 112292916
SCEYMR020W(FMS1)
SEUBDI49_4107
SPAOSPAR_M01440
AGOAGOS_ABR057W
ERCEcym_4580
KLAKLLA0_E07789g
KMXKLMA_40378(FMS1)
LTHKLTH0D07942g
ZROZYRO0E06314g
CGRCAGL0M07612g
NCSNCAS_0A12730(NCAS0A12730)
NDINDAI_0B01530(NDAI0B01530)
TDLTDEL_0B06550(TDEL0B06550)
TGBHG536_0G01210
KAFKAFR_0A02140(KAFR0A02140)
KNGKNAG_0M02130(KNAG0M02130)
ZMKHG535_0G03510
PPAPAS_chr3_0922 PAS_chr4_0823
DHADEHA2A02552g
PICPICST_28515(CPB2) PICST_57813
PGUPGUG_01595
SPAASPAPADRAFT_59154 SPAPADRAFT_72688
LELLELG_04349
CALCAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
CTPCTRG_00245 CTRG_05911
COTCORT_0G01470 CORT_0G01480
CDUCD36_34620(CBP1) CD36_41930
CTENCANTEDRAFT_112827
YLIYALI0B23430g
CLUCLUG_02138 CLUG_02198
CLUSA9F13_02g01056 A9F13_02g01573
CAURCJI97_004945
SLBAWJ20_1654(FMS1) AWJ20_390(FMS1) AWJ20_4168(FMS1)
PKZC5L36_0A11360 C5L36_0E03350 C5L36_0E04060
BNNFOA43_000015 FOA43_002928
BBRXBRETT_001103 BRETT_005227
OPAHPODL_01448 HPODL_01779 HPODL_03198
SLUDSCDLUD_004183
FVRFVEG_09930
SSLSS1G_07267
BFUBCIN_10g01880
MBEMBM_07212
PSCOLY89DRAFT_680191
PCSPc13g13670
PDPPDIP_27570
ZTRMYCGRDRAFT_110027
PFJMYCFIDRAFT_86444
FFUCLAFUR5_09476
SREPTSG_06229
FCYFRACYDRAFT_240044
PIFPITG_04877
AGCBSY240_941
BRND1F64_13355
LABRCHH27_06980
MMIMMAR_1387
MMAEMMARE11_13540
MYEAB431_22575
MSHGMSG_01342
MBAIMB901379_01280(pao)
MSEOMSEO_01560
MRHMycrhN_3787
MMORMMOR_21900
MAICMAIC_40090
MTYMTOK_01650
MGADMGAD_55070
MHEVMHEL_07170
MPOFMPOR_44830
MIMAKG07_02330
MICRBMW26_06900
MFOLDXT68_06775
 » show all
Reference
1  [PMID:18583528]
  Authors
Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA
  Title
Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
  Journal
Plant Physiol 147:1845-57 (2008)
DOI:10.1104/pp.108.123802
  Sequence
[ath:AT3G59050]
Reference
2  [PMID:1567380]
  Authors
Muller S, Walter RD
  Title
Purification and characterization of polyamine oxidase from Ascaris suum.
  Journal
Biochem J 283 ( Pt 1):75-80 (1992)
DOI:10.1042/bj2830075
Reference
3  [PMID:12670477]
  Authors
Landry J, Sternglanz R
  Title
Yeast Fms1 is a FAD-utilizing polyamine oxidase.
  Journal
Biochem Biophys Res Commun 303:771-6 (2003)
DOI:10.1016/S0006-291X(03)00416-9
  Sequence
[sce:YMR020W]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.17
IUBMB Enzyme Nomenclature: 1.5.3.17
ExPASy - ENZYME nomenclature database: 1.5.3.17
BRENDA, the Enzyme Database: 1.5.3.17
LinkDB

KEGG   REACTION: R09076
Entry
R09076                      Reaction                               
Name
spermidine:oxygen oxidoreductase (spermidine-forming)
Definition
Spermine + Oxygen + H2O <=> Spermidine + 3-Aminopropanal + Hydrogen peroxide
Equation
Reaction class
RC00053  C00315_C00750
RC00225  C00750_C05665
RC02755  C00007_C00027
Enzyme
1.5.3.16        1.5.3.17
Pathway
rn00330  Arginine and proline metabolism
rn00410  beta-Alanine metabolism
rn00770  Pantothenate and CoA biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00913  Pantothenate biosynthesis, 2-oxoisovalerate/spermine => pantothenate
Orthology
K12259  spermine oxidase [EC:1.5.3.16 1.5.3.-]
K13366  polyamine oxidase [EC:1.5.3.14 1.5.3.16 1.5.3.-]
K13367  polyamine oxidase [EC:1.5.3.17]
K17839  polyamine oxidase [EC:1.5.3.17 1.5.3.-]
Other DBs
RHEA: 25807
LinkDB

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