Entry
Name
non-specific polyamine oxidase;
polyamine oxidase (ambiguous);
Fms1;
AtPAO3
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming)
Reaction(IUBMB)
(1) spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:
R09076 ];
(2) spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [RN:
R09077 ];
(3) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:
R03899 ];
(4) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:
R09074 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1].
The specific polyamine oxidases are classified as EC
1.5.3.13 (N1-acetylpolyamine oxidase), EC
1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC
1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC
1.5.3.16 (spermine oxidase).
History
EC 1.5.3.17 created 2009
Pathway
ec00330 Arginine and proline metabolism
ec00770 Pantothenate and CoA biosynthesis
Orthology
Genes
ATH : AT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
ALY : 9314325 9316084 9323048
CRB : 17887258 17890473 17895855
CSAT : 104699419 104701179 104750367 104781816 104782814 104785057 104787599 104788143 104792182
EUS : EUTSA_v10005954mg EUTSA_v10016573mg EUTSA_v10018447mg
BRP : 103830193 103852299 103858041 103866035 103866687
BNA : 106351654 106353169 106381329 106385479 106391704 106421166 106428226 106441217 125606860
BOE : 106296723 106318716 106333466 106336574 106336734
RSZ : 108812262 108820199 108831364 108845973 108855756
THJ : 104803407 104805661 104821208 104822137
CPAP : 110815049 110815461
CIC : CICLE_v10011567mg CICLE_v10031239mg
PVY : 116114956 116117567 116124566
MINC : 123207207 123207209 123216015 123224129 123224436 123226440
GHI : 107916881 107925953 107944271 107945473
HSYR : 120118597 120122885 120144425 120147743 120172501 120179021 120188566 120209029
GMX : 100782576 100785056 100790521 100791090 100798561 100799631 100806878 100811255
GSJ : 114382235 114384726 114385073 114396367 114396607 114397655 114401509 114423310
PVU : 137817662 137823986 137826003 137831089 137831637
VRA : 106753045 106765160 106765271 106776036
VAR : 108337267 108338488 108343091 108343161
VUN : 114187577 114187960 114193147 114194688
VUM : 124830148 124830736 124835321 124847382
CCAJ : 109790272 109795185 109795282
APRC : 113846073 113849409 113855937 113874455
MTR : 11426561 11435419 25490550
TPRA : 123913461 123917285 123921186
CAM : 101488772 101489745 101514322
PSAT : 127084296 127085245 127117812
VVO : 131615889 131622090 131625806 131662101 131662508
LJA : 130722377 130723139 130733275
ADU : 107458090 107480998 107496522
AHF : 112702079 112702606 112733789 112766845 112767401 112791693
LANG : 109330188 109339566 109356838
PCIN : 129296051 129301525 129303997 129317176
QSA : O6P43_014219 O6P43_014740 O6P43_020520 O6P43_021014
PMUM : 103327360 103328951
PAVI : 110765111 110765925
PDUL : 117621412 117622174
MDM : 103405136 103405900 103443150 103444375
MSYL : 126582117 126583428 126611129 126612521
PXB : 103933878 103947391 103956795 103956798 103959927 103965587
MCHA : 111005782 111008343
CMAX : 111477047 111480387 111482955
CMOS : 111437612 111442764 111445809
CPEP : 111788589 111797083 111810933
MEAN : 126677646 126677683
JCU : 105634456 105634459 105636130
HBR : 110638926 110654238 110666897
MESC : 110600153 110604601 110608659
POP : 18106497 7464825 7468334 7468715
PEU : 105112050 105115960 105126880 105131456 105135278
PALZ : 118030279 118037141 118049224 118061712
PNZ : 133671607 133692190 133694684 133699086
JRE : 108986807 108988145 108993577 109010094
CILL : 122304197 122306141 122307122
CAVE : 132180819 132181091
TWL : 119984189 119994994 120003801 120013808
VRI : 117904754 117912466 117926581
SLY : 101252005 101258232 101260014 101264170
SPEN : 107007559 107011311 107012957 107026194
SOT : 102591553 102594410 102598184 102605222
SSTN : 125848666 125860850 125861216 125875918
SDUL : 129870221 129872808 129892275 129896640
CANN : 107841896 107859655 107878076
LBB : 132612873 132616613 132623904 132625063 132636706
NTA : 107761719 107762338 107775720 107775961 107799822 107800087 107812697 107831274(T361)
NSY : 104210410 104213745 104226820 104230337
NTO : 104086117 104093043 104097366 104107681
NAU : 109226965 109228574 109240600 109243515
INI : 109167577 109172637 109187541
ITR : 116010319 116013313 116021265
SIND : 105167429 105175973 105178573
OEU : 111372349 111378096 111390976 111400284 111400605
SSPL : 121742052 121744847 121755793 121758703 121785048 121785220 121786259 121787529
SMIL : 131009452 131012736 131012795 131023738
SHIS : 125188165 125194139 125211044 125214141
APAN : 127247546 127253966 127262074
HAN : 110882585 110912497 110921258
ECAD : 122579583 122587045 122595094
LSV : 111884410 111898938 111914638
CCAV : 112515135 112522951 112527605
DCR : 108192953 108204744 108210485
CSIN : 114294840 114318666
AEW : 130750968 130758255 130778145 130778154 130790095
CQI : 110691948 110701998 110708250 110711120
ATRI : 130806122 130806580 130817602
NNU : 104588475 104607001 104610796
MING : 122064936 122071825 122074521 122080019
TSS : 122646703 122651308 122664493
PSOM : 113287329 113288317 113295350 113298295 113300769 113303219
OSA : 4337046 4337359 4337360
OBR : 102710582 102711526 102711798
OGL : 127770370 127771328 127771985
BDI : 100824039 100840588 100841193
ATS : 109734611 109739586 109759728
TDC : 119356520 119357039 119357042 119365716 119366305 119366306
TAES : 123046773 123047325 123047326 123054629 123055127 123055128 123190477 123190981 123190982
TUA : 125527638 125539728 125539768
LPER : 127337065 127337225 127337227
LRD : 124669336 124670462 124672478 124675898 124676624 124678600
SBI : 8074727 8082588 8082590
ZMA : 100191603 100384522 101027113 103631209 103642073
MFLO : 136491471 136492492 136492700 136492738 136497517 136497519 136497931 136497933 136497938 136497940
SITA : 101753072 101753473 101768863
SVS : 117850298 117850301 117863481
PVIR : 120641827 120642828 120642829 120680766 120681805 120683566
PHAI : 112899574 112900150 112900151
PDA : 103703721 103705589 103717571 103723706
EGU : 105035498 105035697 105058904 105059362
MUS : 135584561 135611954 135617498 135626638
ZOF : 121969490 121974620 121989686 121998634 122034451
DCT : 110099374 110101011 110103987
PEQ : 110019083 110020947 110023934
MSIN : 131220731 131236929
ACAK : 137938190 137944061 137951697 137953363
NCOL : 116247370 116267545
SMO : SELMODRAFT_22558 SELMODRAFT_22584 SELMODRAFT_270153 SELMODRAFT_271685 SELMODRAFT_439374 SELMODRAFT_440258
PPP : 112286660 112286662 112292916
CGR : 2891729(GVI51_M07601)
NCS : NCAS_0A12730(NCAS0A12730)
NDI : NDAI_0B01530(NDAI0B01530)
TDL : TDEL_0B06550(TDEL0B06550)
KAF : KAFR_0A02140(KAFR0A02140)
KNG : KNAG_0M02130(KNAG0M02130)
PIC : PICST_28515(CPB2) PICST_57813
SPAA : SPAPADRAFT_59154 SPAPADRAFT_72688
LBG : 92210198(LODBEIA_P50020)
CAL : CAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
CTP : CTRG_00245 CTRG_05911
COT : CORT_0G01470 CORT_0G01480
CDU : CD36_34620(CBP1) CD36_41930
CLU : CLUG_02138 CLUG_02198
CLUS : A9F13_02g01056 A9F13_02g01573
PPA : PAS_chr3_0922 PAS_chr4_0823
PKZ : C5L36_0A11360 C5L36_0E03350 C5L36_0E04060
BNN : FOA43_000015 FOA43_002928
BBRX : BRETT_001103 BRETT_005227
OPA : HPODL_01448 HPODL_01779 HPODL_03198
YLI : 2906855(YALI2_C00609g)
SLB : AWJ20_1654(FMS1) AWJ20_390(FMS1) AWJ20_4168(FMS1)
MBAI : MB901379_01280(pao)
» show all
Taxonomy
Reference
Authors
Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA
Title
Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
Journal
Sequence
Reference
Authors
Muller S, Walter RD
Title
Purification and characterization of polyamine oxidase from Ascaris suum.
Journal
Reference
Authors
Landry J, Sternglanz R
Title
Yeast Fms1 is a FAD-utilizing polyamine oxidase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.17
ExPASy - ENZYME nomenclature database: 1.5.3.17
LinkDB
All DBs