KEGG   ORTHOLOGY: K17876
Entry
K17876                      KO                                     
Symbol
CYP105D
Name
pentalenic acid synthase [EC:1.14.15.11]
Pathway
map00998  Biosynthesis of various antibiotics
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K17876  CYP105D; pentalenic acid synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17876  CYP105D; pentalenic acid synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.11  pentalenic acid synthase
     K17876  CYP105D; pentalenic acid synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP105 family
   K17876  CYP105D; pentalenic acid synthase
Other DBs
RN: R10158
COG: COG2124
Genes
SCO: SCO0774(3SCF60.06c)
SMA: SAVERM_412(pteD) SAVERM_7469(cyp28)
SGR: SGR_264
SGB: WQO_33270
SHY: SHJG_8085
SHO: SHJGH_7847
SRC: M271_21650
SCT: SCAT_0296(CYP105D)
SCY: SCATT_03050
SALS: SLNWT_4127
SFI: SFUL_245
SALU: DC74_6505
SALL: SAZ_33560
SLV: SLIV_34060(cyp105D1)
STRE: GZL_02304
SLD: T261_1672
STRM: M444_05600
SLE: cxm22(cxm22)
SNR: SNOUR_10640(cyp105D1)
STRD: NI25_02520
SALJ: SMD11_2051
SFK: KY5_6369c
SAUH: SU9_028810
 » show all
Reference
PMID:21081950 (CYP105D7)
  Authors
Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H
  Title
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
  Journal
J Antibiot (Tokyo) 64:65-71 (2011)
DOI:10.1038/ja.2010.135
  Sequence
LinkDB

KEGG   ENZYME: 1.14.15.11
Entry
EC 1.14.15.11               Enzyme                                 
Name
pentalenic acid synthase;
CYP105D7;
sav7469 (gene name);
1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase
Reaction(IUBMB)
1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O [RN:R10158]
Reaction(KEGG)
R10158
Substrate
1-deoxypentalenate [CPD:C20404];
reduced ferredoxin [CPD:C00138];
O2 [CPD:C00007]
Product
pentalenate [CPD:C20405];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.
History
EC 1.14.15.11 created 2012
Pathway
ec00998  Biosynthesis of various antibiotics
ec01110  Biosynthesis of secondary metabolites
Orthology
K17876  pentalenic acid synthase
Genes
SCOSCO0774(3SCF60.06c)
SMASAVERM_412(pteD) SAVERM_7469(cyp28)
SGRSGR_264
SGBWQO_33270
SHYSHJG_8085
SHOSHJGH_7847
SRCM271_21650
SCTSCAT_0296(CYP105D)
SCYSCATT_03050
SALSSLNWT_4127
SFISFUL_245
SCIB446_32515
SALUDC74_6505
SALLSAZ_33560
SLVSLIV_34060(cyp105D1)
SVTSVTN_38445
STREGZL_02304
SLDT261_1672
SLCSL103_24245
STRMM444_05600
SCZABE83_34380
SCXAS200_06365
SRWTUE45_00316
SLEcxm22(cxm22)
SPAVSpa2297_29860
STRTA8713_29350
SGSAVL59_17445
STSIA4E84_37695
SALWCP975_28665
SLSSLINC_7705
SNRSNOUR_10640(cyp105D1)
SPLULK06_001175
STRDNI25_02520
SSIAA7J05_08355
SVUB1H20_09560 B1H20_33895
SPUNBFF78_03950 BFF78_04520
SGVB1H19_32610
SLAUSLA_0051 SLA_5925
SALFSMD44_00535
SALJSMD11_2051
SLXSLAV_33310
STROSTRMOE7_31215
SFKKY5_6369c
SNZDC008_31425
SGEDWG14_00955
SRJSRO_0741 SRO_7230
SDXC4B68_03290
SGDELQ87_02990
SCYAEJ357_03310
SNQCP978_04335
SKACP970_09160
SGZC0216_18325
SVNCP980_30305
SHAWCEB94_37830
SRKFGW37_23265 FGW37_32980
SFICEIZ62_12265
SFYGFH48_05350
SAQUEJC51_41390
SGFHEP81_00723 HEP81_07558
SCAVCVT27_00135
SSEOD0Z67_27665
SRIMCP984_07040
SSUBCP968_30310
SCINCP977_05600
SPACB1H29_03325
SCHACP983_03125
SCOECP976_39075
SSPBCP982_40055
SNFJYK04_00068
SPLACP981_31765
SBROGQF42_39235
STUIGCM10017668_04600
SATAC5746_37845
SHUNDWB77_06677
SCYGS1361_35215
SFEUIM697_20530
SDWK7C20_30200
SCALI6J39_09775
SAUHSU9_028810
SMOBJ7W19_23060
SROIIAG44_00120 IAG44_36795
SHKJ2N69_29845
SANUK7396_06825
STRYEQG64_00380
SDDD9753_02950
SACTDMT42_34835
NCXNocox_12645
FREFranean1_3470 Franean1_3475
VMAVAB18032_16385 VAB18032_16485
MCRAID554_15940
VERHUT12_01280 HUT12_01985
 » show all
Reference
1  [PMID:21081950]
  Authors
Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H
  Title
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
  Journal
J Antibiot (Tokyo) 64:65-71 (2011)
DOI:10.1038/ja.2010.135
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.11
IUBMB Enzyme Nomenclature: 1.14.15.11
ExPASy - ENZYME nomenclature database: 1.14.15.11
BRENDA, the Enzyme Database: 1.14.15.11
LinkDB

KEGG   REACTION: R10158
Entry
R10158                      Reaction                               
Name
1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase
Definition
1-Deoxypentalenate + Reduced ferredoxin + Oxygen <=> Pentalenate + Oxidized ferredoxin + H2O
Equation
Reaction class
RC01993  C20404_C20405
Enzyme
Pathway
rn00998  Biosynthesis of various antibiotics
rn01110  Biosynthesis of secondary metabolites
Orthology
K17876  pentalenic acid synthase [EC:1.14.15.11]
Other DBs
RHEA: 34502
LinkDB

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