KEGG   ORTHOLOGY: K17876
Entry
K17876                      KO                                     
Symbol
CYP105D
Name
pentalenic acid synthase [EC:1.14.15.11]
Pathway
map00998  Biosynthesis of various antibiotics
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K17876  CYP105D; pentalenic acid synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17876  CYP105D; pentalenic acid synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.11  pentalenic acid synthase
     K17876  CYP105D; pentalenic acid synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP105 family
   K17876  CYP105D; pentalenic acid synthase
Other DBs
RN: R10158
COG: COG2124
Genes
SCO: SCO0774(3SCF60.06c)
SMA: SAVERM_412(pteD) SAVERM_7469(cyp28)
SGR: SGR_264
SGB: WQO_33270
SFI: SFUL_245
SANL: KZO11_37305
SHY: SHJG_8085
SHO: SHJGH_7847
SRC: M271_21650
SALS: SLNWT_4127
SCI: B446_32515
SLV: SLIV_34060(cyp105D1)
SVT: SVTN_38445
STRE: GZL_02304
SLD: T261_1672
SLC: SL103_24245
STRM: M444_05600
SCZ: ABE83_34380
SCX: AS200_06365
SRW: TUE45_00316
SLE: cxm22(cxm22)
SPAV: Spa2297_29860
STRT: A8713_29350
SGS: AVL59_17445
STSI: A4E84_37695
SALW: CP975_28665
SLS: SLINC_7705
SNR: SNOUR_10640(cyp105D1)
SALU: DC74_6505
SALL: SAZ_33560
SPLU: LK06_001175
STRD: NI25_02520
SSIA: A7J05_08355
SVU: B1H20_09560 B1H20_33895
SPUN: BFF78_03950 BFF78_04520
SGV: B1H19_32610
SLAU: SLA_0051 SLA_5925
SALF: SMD44_00535
SALJ: SMD11_2051
SLX: SLAV_33310
STRO: STRMOE7_31215
SFK: KY5_6369c
SNZ: DC008_31425
SGE: DWG14_00955
SRJ: SRO_0741 SRO_7230
SDX: C4B68_03290
SGD: ELQ87_02990
SCYA: EJ357_03310
SNQ: CP978_04335
SKA: CP970_09160
SGZ: C0216_18325
SVN: CP980_30305
SHAW: CEB94_37830
SRK: FGW37_23265 FGW37_32980
SFIC: EIZ62_12265
SFY: GFH48_05350
SAQU: EJC51_41390
SGF: HEP81_00723 HEP81_07558
SCAV: CVT27_00135
SSEO: D0Z67_27665
SRIM: CP984_07040
SSUB: CP968_30310
SCIN: CP977_05600
SPAC: B1H29_03325
SCHA: CP983_03125
SCOE: CP976_39075
SSPB: CP982_40055
SNF: JYK04_00068
SPLA: CP981_31765
SBRO: GQF42_39235
STUI: GCM10017668_04600
SATA: C5746_37845
SHUN: DWB77_06677
SCYG: S1361_35215
SFEU: IM697_20530
SDW: K7C20_30200
SCAL: I6J39_09775
SAUH: SU9_028810
SMOB: J7W19_23060
SROI: IAG44_00120 IAG44_36795
SHK: J2N69_29845
SANU: K7396_06825
STRY: EQG64_00380
SDD: D9753_02950
SACT: DMT42_34835
SINE: KI385_35940
SLF: JEQ17_04200
SAOV: G3H79_38180
SDUR: M4V62_10655
STAA: LDH80_02085
SNIG: HEK616_46830
SSPN: LXH13_35860
SXT: KPP03845_100983
SLON: LGI35_39285
SDRZ: NEH16_13335
STUD: STRTU_001148
SENG: OJ254_27990
SGK: PET44_04170
SYUN: MOV08_10425
SARG: HKX69_02805
SJN: RI060_02630
SCT: SCAT_0296(CYP105D)
SCY: SCATT_03050
NEX: NE857_24315
NCX: Nocox_12645
FRE: Franean1_3470 Franean1_3475
APRT: MUY14_00590
KUT: JJ691_53750
VMA: VAB18032_16385 VAB18032_16485
MCRA: ID554_15940
VER: HUT12_01280 HUT12_01985
 » show all
Reference
PMID:21081950 (CYP105D7)
  Authors
Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H
  Title
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
  Journal
J Antibiot (Tokyo) 64:65-71 (2011)
DOI:10.1038/ja.2010.135
  Sequence
[sma:SAVERM_7469]
LinkDB

KEGG   ENZYME: 1.14.15.11
Entry
EC 1.14.15.11               Enzyme                                 
Name
pentalenic acid synthase;
CYP105D7;
sav7469 (gene name);
1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase
Reaction(IUBMB)
1-deoxypentalenate + reduced ferredoxin + O2 = pentalenate + oxidized ferredoxin + H2O [RN:R10158]
Reaction(KEGG)
R10158
Substrate
1-deoxypentalenate [CPD:C20404];
reduced ferredoxin [CPD:C00138];
O2 [CPD:C00007]
Product
pentalenate [CPD:C20405];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Comment
A heme-thiolate enzyme (P-450). Isolated from the bacterium Streptomyces avermitilis. The product, pentalenate, is a co-metabolite from pentalenolactone biosynthesis.
History
EC 1.14.15.11 created 2012
Pathway
ec00998  Biosynthesis of various antibiotics
ec01110  Biosynthesis of secondary metabolites
Orthology
K17876  pentalenic acid synthase
Genes
SCO: SCO0774(3SCF60.06c)
SMA: SAVERM_412(pteD) SAVERM_7469(cyp28)
SGR: SGR_264
SGB: WQO_33270
SFI: SFUL_245
SANL: KZO11_37305
SHY: SHJG_8085
SHO: SHJGH_7847
SRC: M271_21650
SALS: SLNWT_4127
SCI: B446_32515
SLV: SLIV_34060(cyp105D1)
SVT: SVTN_38445
STRE: GZL_02304
SLD: T261_1672
SLC: SL103_24245
STRM: M444_05600
SCZ: ABE83_34380
SCX: AS200_06365
SRW: TUE45_00316
SLE: cxm22(cxm22)
SPAV: Spa2297_29860
STRT: A8713_29350
SGS: AVL59_17445
STSI: A4E84_37695
SALW: CP975_28665
SLS: SLINC_7705
SNR: SNOUR_10640(cyp105D1)
SALU: DC74_6505
SALL: SAZ_33560
SPLU: LK06_001175
STRD: NI25_02520
SSIA: A7J05_08355
SVU: B1H20_09560 B1H20_33895
SPUN: BFF78_03950 BFF78_04520
SGV: B1H19_32610
SLAU: SLA_0051 SLA_5925
SALF: SMD44_00535
SALJ: SMD11_2051
SLX: SLAV_33310
STRO: STRMOE7_31215
SFK: KY5_6369c
SNZ: DC008_31425
SGE: DWG14_00955
SRJ: SRO_0741 SRO_7230
SDX: C4B68_03290
SGD: ELQ87_02990
SCYA: EJ357_03310
SNQ: CP978_04335
SKA: CP970_09160
SGZ: C0216_18325
SVN: CP980_30305
SHAW: CEB94_37830
SRK: FGW37_23265 FGW37_32980
SFIC: EIZ62_12265
SFY: GFH48_05350
SAQU: EJC51_41390
SGF: HEP81_00723 HEP81_07558
SCAV: CVT27_00135
SSEO: D0Z67_27665
SRIM: CP984_07040
SSUB: CP968_30310
SCIN: CP977_05600
SPAC: B1H29_03325
SCHA: CP983_03125
SCOE: CP976_39075
SSPB: CP982_40055
SNF: JYK04_00068
SPLA: CP981_31765
SBRO: GQF42_39235
STUI: GCM10017668_04600
SATA: C5746_37845
SHUN: DWB77_06677
SCYG: S1361_35215
SFEU: IM697_20530
SDW: K7C20_30200
SCAL: I6J39_09775
SAUH: SU9_028810
SMOB: J7W19_23060
SROI: IAG44_00120 IAG44_36795
SHK: J2N69_29845
SANU: K7396_06825
STRY: EQG64_00380
SDD: D9753_02950
SACT: DMT42_34835
SINE: KI385_35940
SLF: JEQ17_04200
SAOV: G3H79_38180
SDUR: M4V62_10655
STAA: LDH80_02085
SNIG: HEK616_46830
SSPN: LXH13_35860
SXT: KPP03845_100983
SLON: LGI35_39285
SDRZ: NEH16_13335
STUD: STRTU_001148
SENG: OJ254_27990
SGK: PET44_04170
SYUN: MOV08_10425
SARG: HKX69_02805
SJN: RI060_02630
SCT: SCAT_0296(CYP105D)
SCY: SCATT_03050
NEX: NE857_24315
NCX: Nocox_12645
FRE: Franean1_3470 Franean1_3475
APRT: MUY14_00590
KUT: JJ691_53750
VMA: VAB18032_16385 VAB18032_16485
MCRA: ID554_15940
VER: HUT12_01280 HUT12_01985
 » show all
Reference
1  [PMID:21081950]
  Authors
Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H
  Title
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis.
  Journal
J Antibiot (Tokyo) 64:65-71 (2011)
DOI:10.1038/ja.2010.135
  Sequence
[sma:SAVERM_7469]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.15.11
IUBMB Enzyme Nomenclature: 1.14.15.11
ExPASy - ENZYME nomenclature database: 1.14.15.11
BRENDA, the Enzyme Database: 1.14.15.11
LinkDB

KEGG   REACTION: R10158
Entry
R10158                      Reaction                               
Name
1-deoxypentalenate,reduced ferredoxin:oxygen oxidoreductase
Definition
1-Deoxypentalenate + Reduced ferredoxin + Oxygen <=> Pentalenate + Oxidized ferredoxin + H2O
Equation
C20404 + C00138 + C00007 <=> C20405 + C00139 + C00001
Reaction class
RC01993  C20404_C20405
Enzyme
1.14.15.11
Pathway
rn00998  Biosynthesis of various antibiotics
rn01110  Biosynthesis of secondary metabolites
Orthology
K17876  pentalenic acid synthase [EC:1.14.15.11]
Other DBs
RHEA: 34502
LinkDB

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