KEGG ORTHOLOGY: K17982

ORTHOLOGY: K17982

Entry

K17982                      KO

Symbol

TPS04, GES

Name

geranyllinalool synthase [EC:4.2.3.144]

Pathway

map00904

Diterpenoid biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R10533

geranylgeranyl-diphosphate diphosphate-lyase [(E,E)-geranyllinalool-forming]

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K17982  TPS04, GES; geranyllinalool synthase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.144  geranyllinalool synthase
     K17982  TPS04, GES; geranyllinalool synthase

Other DBs

GO:

0080013

Genes

ATH:	AT1G61120(TPS04)

ALY:

9322626

CRB:

17894892

CSAT:

104716016 104754111

EUS:	EUTSA_v10023261mg

BRP:

103838542

BNA:	106394830 106421978

BOE:

106317451

RSZ:	108825402 108828927

THJ:

104819156

CIT:

102615273

CIC:	CICLE_v10014262mg

PVY:

MINC:

TCC:

HSYR:

DZI:

RARG:

GMX:	100801909(TPS17)

GSJ:

114375850

VUM:

124833890

APRC:

113852067 113859895

QSA:	O6P43_012599

PDUL:

MSYL:

MNT:

CSAV:

HLP:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:	108980512 108980515

CILL:

122275634 122277255

CAVE:

132168887 132169898 132172888

AGLU:

133869539 133869600 133869615

CSAA:

142635117

TWL:	119987749 119989959

VVI:	100255330 100264943

VRI:	117923513 117924119 117924226 117924269 117924274

SLY:

SPEN:

SOT:

SSTN:

SDUL:

LBB:

ITR:

SSPL:

121742651 121744697 121789493

SMIL:

SHIS:

APAN:

PEBU:

PTAB:

CARB:

113721941 113723890 113730933

BHW:	143568266 143581233 143614071

ECAD:

122582386

AGRV:

141679606 141695287 141695288

CSIN:

114267916 114295608 114295609 114318211

RVL:	131312085 131312779 131312780 131317277

AEW:	130782577 130795146

DLT:

127795391

ATRI:

130816048

MOF:	131145713 131145715 131145718 131153769

MING:

122075207

TSS:

122650729

ZOF:	121972243 121978100

MSIN:

131221945 131221946 131221957 131221960 131221962 131241231 131241232

» show all

Reference

PMID:18398052

Authors

Herde M, Gartner K, Kollner TG, Fode B, Boland W, Gershenzon J, Gatz C, Tholl D

Title

Identification and regulation of TPS04/GES, an Arabidopsis geranyllinalool synthase catalyzing the first step in the formation of the insect-induced volatile C16-homoterpene TMTT.

Journal

Plant Cell 20:1152-68 (2008)
DOI:10.1105/tpc.106.049478

Sequence

[ath:AT1G61120]

LinkDB

ENZYME: 4.2.3.144

Entry

EC 4.2.3.144                Enzyme

Name

geranyllinalool synthase;
TPS04/GES;
GES

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranylgeranyl-diphosphate diphosphate-lyase [(E,E)-geranyllinalool-forming]

Reaction(IUBMB)

geranylgeranyl diphosphate + H2O = (6E,10E)-geranyllinalool + diphosphate [RN:R10533]

Reaction(KEGG)

R10533

Substrate

geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]

Product

(6E,10E)-geranyllinalool [CPD:C20681];
diphosphate [CPD:C00013]

Comment

The enzyme is a component of the herbivore-induced indirect defense system. The product, (E,E)-geranyllinalool, is a precursor to the volatile compound 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT), which is released by many plants in response to damage.

History

EC 4.2.3.144 created 2013

Pathway

ec00904

Diterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K17982

geranyllinalool synthase

Genes

ATH:	AT1G61120(TPS04)

ALY:

9322626

CRB:

17894892

CSAT:

104716016 104754111

EUS:	EUTSA_v10023261mg

BRP:

103838542

BNA:	106394830 106421978

BOE:

106317451

RSZ:	108825402 108828927

THJ:

104819156

CIT:

102615273

CIC:	CICLE_v10014262mg

PVY:

116145933

MINC:

123218154 123218155

TCC:

18596906

HSYR:

120121786 120192372

DZI:

111318761

RARG:

115739675 115739816

GMX:	100801909(TPS17)

GSJ:

114375850

VUM:

124833890

APRC:

113852067 113859895

QSA:	O6P43_012599

PDUL:

117621951

MSYL:

126610088

MNT:

21395364

CSAV:

115696241 115696242

HLP:

133821775

MEAN:

126679178

JCU:

105649498

HBR:

110643009

MESC:

110605412

POP:

7494350

PEU:

105128087

PALZ:

118047351 118058321

PNZ:

133698479

JRE:	108980512 108980515

CILL:

122275634 122277255

CAVE:

132168887 132169898 132172888

AGLU:

133869539 133869600 133869615

CSAA:

142635117

TWL:	119987749 119989959

VVI:	100255330 100264943

VRI:	117923513 117924119 117924226 117924269 117924274

SLY:

101262489

SPEN:

107015071

SOT:

102599238

SSTN:

125860537

SDUL:

129896507

LBB:

132618871

ITR:

116028365

SSPL:

121742651 121744697 121789493

SMIL:

130985542

SHIS:

125187743 125209176

APAN:

127249780

PEBU:

140836031

PTAB:

142522661

CARB:

113721941 113723890 113730933

BHW:	143568266 143581233 143614071

ECAD:

122582386

AGRV:

141679606 141695287 141695288

CSIN:

114267916 114295608 114295609 114318211

RVL:	131312085 131312779 131312780 131317277

AEW:	130782577 130795146

DLT:

127795391

ATRI:

130816048

MOF:	131145713 131145715 131145718 131153769

MING:

122075207

TSS:

122650729

ZOF:	121972243 121978100

MSIN:

131221945 131221946 131221957 131221960 131221962 131241231 131241232

» show all

Reference

1 [PMID:18398052]

Authors

Herde M, Gartner K, Kollner TG, Fode B, Boland W, Gershenzon J, Gatz C, Tholl D

Title

Identification and regulation of TPS04/GES, an Arabidopsis geranyllinalool synthase catalyzing the first step in the formation of the insect-induced volatile C16-homoterpene TMTT.

Journal

Plant Cell 20:1152-68 (2008)
DOI:10.1105/tpc.106.049478

Sequence

[ath:AT1G61120]

Reference

2 [PMID:18842097]

Authors

Attaran E, Rostas M, Zeier J

Title

Pseudomonas syringae elicits emission of the terpenoid (E,E)-4,8,12-trimethyl-1,3,7,11-tridecatetraene in Arabidopsis leaves via jasmonate signaling and expression of the terpene synthase TPS4.

Journal

Mol Plant Microbe Interact 21:1482-97 (2008)
DOI:10.1094/MPMI-21-11-1482

Sequence

[ath:AT1G61120]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.144

IUBMB Enzyme Nomenclature:

4.2.3.144

ExPASy - ENZYME nomenclature database:

4.2.3.144

BRENDA, the Enzyme Database:

4.2.3.144

LinkDB

REACTION: R10533

Entry

R10533                      Reaction

Name

geranylgeranyl-diphosphate diphosphate-lyase [(E,E)-geranyllinalool-forming]

Definition

Geranylgeranyl diphosphate + H2O <=> (E,E)-Geranyllinalool + Diphosphate

Equation

C00353 + C00001 <=> C20681 + C00013

Reaction class

RC01821

C00353_C20681

Enzyme

4.2.3.144

Pathway

rn00904

Diterpenoid biosynthesis

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.144
     R10533  Geranylgeranyl diphosphate + H2O <=> (E,E)-Geranyllinalool + Diphosphate

Orthology

K17982

geranyllinalool synthase [EC:4.2.3.144]

Other DBs

RHEA:

38158

LinkDB

DBGET integrated database retrieval system