KEGG ORTHOLOGY: K18050

ORTHOLOGY: K18050

Entry

K18050                      KO

Symbol

PRKCE

Name

novel protein kinase C epsilon type [EC:2.7.11.13]

Pathway

map04022

cGMP-PKG signaling pathway

map04071

Sphingolipid signaling pathway

map04270

Vascular smooth muscle contraction

map04371

Apelin signaling pathway

map04530

Tight junction

map04666

Fc gamma R-mediated phagocytosis

map04750

Inflammatory mediator regulation of TRP channels

map04925

Aldosterone synthesis and secretion

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04933

AGE-RAGE signaling pathway in diabetic complications

map05131

Shigellosis

map05206

MicroRNAs in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K18050  PRKCE; novel protein kinase C epsilon type
   04071 Sphingolipid signaling pathway
    K18050  PRKCE; novel protein kinase C epsilon type
   04022 cGMP-PKG signaling pathway
    K18050  PRKCE; novel protein kinase C epsilon type
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K18050  PRKCE; novel protein kinase C epsilon type
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K18050  PRKCE; novel protein kinase C epsilon type
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K18050  PRKCE; novel protein kinase C epsilon type
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K18050  PRKCE; novel protein kinase C epsilon type
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K18050  PRKCE; novel protein kinase C epsilon type
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K18050  PRKCE; novel protein kinase C epsilon type
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K18050  PRKCE; novel protein kinase C epsilon type
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K18050  PRKCE; novel protein kinase C epsilon type
   04931 Insulin resistance
    K18050  PRKCE; novel protein kinase C epsilon type
   04933 AGE-RAGE signaling pathway in diabetic complications
    K18050  PRKCE; novel protein kinase C epsilon type
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K18050  PRKCE; novel protein kinase C epsilon type
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K18050  PRKCE; novel protein kinase C epsilon type
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  PKC family [OT]
   K18050  PRKCE; novel protein kinase C epsilon type

Other DBs

GO:

0004699

Genes

HSA:	5581(PRKCE)

PTR:	459203(PRKCE)

PPS:	100974922(PRKCE)

GGO:	101133595(PRKCE)

PON:	100440778(PRKCE)

PPYG:

129025414(PRKCE)

NLE:	100606298(PRKCE)

HMH:	116483166(PRKCE)

SSYN:

129461973(PRKCE)

MCC:	714533(PRKCE)

MCF:	102127282(PRKCE)

MTHB:

126933879

MNI:	105464958(PRKCE)

CSAB:

103220351(PRKCE)

CATY:

105590592(PRKCE)

PANU:

101022026(PRKCE)

TGE:	112604800(PRKCE)

MLEU:

105528827(PRKCE)

RRO:	104663184(PRKCE)

RBB:	108522504(PRKCE)

TFN:	117062364(PRKCE)

PTEH:

111550425(PRKCE)

CANG:

105507408(PRKCE)

CJC:	100388620(PRKCE)

SBQ:	101053832(PRKCE)

CIMI:

108292079(PRKCE)

ANAN:

105716048(PRKCE)

CSYR:

103272114

MMUR:

105866526(PRKCE)

LCAT:

123636878(PRKCE)

PCOQ:

105818012(PRKCE)

OGA:	100943756(PRKCE)

MMU:	18754(Prkce)

MCAL:

110312510(Prkce)

MPAH:

110336160(Prkce)

RNO:	29340(Prkce)

MCOC:

116080908(Prkce)

ANU:	117717018(Prkce)

MUN:	110552342(Prkce)

CGE:	100763552(Prkce)

MAUA:

101839221(Prkce)

PROB:

127214920(Prkce)

PLEU:

114709090(Prkce)

MORG:

121432846(Prkce)

MFOT:

126504040

AAMP:

119807809(Prkce)

NGI:	103725757(Prkce)

HGL:	101700837(Prkce)

CPOC:

100721814(Prkce)

CCAN:

109689908

DORD:

105986806(Prkce)

DSP:	122104544(Prkce)

PLOP:

125356479(Prkce)

NCAR:

124962983

MMMA:

107137311(Prkce)

OCU:	100009103(PRKCE)

OPI:	101520570(PRKCE)

TUP:	102502025(PRKCE)

GVR:	103592021(PRKCE)

CFA:	609934(PRKCE)

CLUD:

112671518(PRKCE)

VVP:	112915218(PRKCE)

VLG:	121490590(PRKCE)

NPO:	129511727(PRKCE)

AML:	100468967(PRKCE)

UMR:	103671225(PRKCE)

UAH:	113246159(PRKCE)

UAR:	123785895(PRKCE)

ELK:

111155859

LLV:

125109503

MPUF:

101678238(PRKCE)

MNP:	132021606(PRKCE)

MLK:	131808516(PRKCE)

NVS:	122916358(PRKCE)

ORO:	101362539(PRKCE)

EJU:	114209682(PRKCE)

ZCA:	113937273(PRKCE)

MLX:	118008176(PRKCE)

NSU:	110590351(PRKCE)

LWW:	102749878(PRKCE)

FCA:	101100958(PRKCE)

PYU:	121016336(PRKCE)

PCOO:

112869711(PRKCE)

PBG:	122496797(PRKCE)

PVIV:

125162095(PRKCE)

LRUF:

124502915

PTG:	102956451(PRKCE)

PPAD:

109278788(PRKCE)

PUC:

125936002

AJU:

106977232

HHV:	120224286(PRKCE)

BTA:	507041(PRKCE)

BOM:	102266941(PRKCE) 102283594

BIU:	109566044(PRKCE)

BBUB:

102404606(PRKCE)

BBIS:

104987605(PRKCE)

CHX:	102169016(PRKCE)

OAS:	101110314(PRKCE)

BTAX:

128055243(PRKCE)

ODA:	120851733(PRKCE)

CCAD:

122441637(PRKCE)

MBEZ:

129539824(PRKCE)

SSC:	100524932(PRKCE)

CFR:	102509837(PRKCE)

CBAI:

105079021(PRKCE)

CDK:	105103566(PRKCE)

VPC:	102533967(PRKCE)

BACU:

103006250(PRKCE)

BMUS:

118905913(PRKCE)

LVE:	103068913(PRKCE)

OOR:	101276402(PRKCE)

DLE:	111174803(PRKCE)

PCAD:

102988770(PRKCE)

PSIU:

116764149(PRKCE)

NASI:

112405267(PRKCE)

ECB:	100053394(PRKCE)

EPZ:	103549602(PRKCE)

EAI:	106826113(PRKCE)

MYB:	102263707(PRKCE)

MYD:	102759931(PRKCE)

MMYO:

118669039(PRKCE)

MLF:	102435274(PRKCE)

MDT:	132213400(PRKCE)

PKL:	118717316(PRKCE)

EFUS:

103305423

MNA:

107530341

DRO:	112297947(PRKCE)

SHON:

119001241(PRKCE)

AJM:	119060907(PRKCE)

PDIC:

114499237(PRKCE)

PHAS:

123811487(PRKCE)

MMF:	118630650(PRKCE)

PPAM:

129065757(PRKCE)

HAI:	109393868(PRKCE)

RFQ:	117033065(PRKCE)

PALE:

102894641(PRKCE)

PGIG:

120621691(PRKCE)

PVP:	105292973(PRKCE)

RAY:	107509571(PRKCE)

MJV:	108406405(PRKCE)

TOD:	119259343(PRKCE)

SARA:

101543045(PRKCE)

SETR:

126023927(PRKCE)

LAV:	100655386(PRKCE)

TMU:

101349247

ETF:	101645703(PRKCE)

DNM:	101447884(PRKCE)

MDO:	100032210(PRKCE)

GAS:	123236843(PRKCE)

SHR:	100921656(PRKCE)

AFZ:

127548045

PCW:	110218526(PRKCE)

TVP:	118841865(PRKCE)

OAA:	103168168(PRKCE)

GGA:	421409(PRKCE)

PCOC:

116229894(PRKCE)

MGP:	100543758(PRKCE)

CJO:	107311186(PRKCE)

TPAI:

128081808(PRKCE)

LMUT:

125689059(PRKCE)

NMEL:

110395486(PRKCE)

APLA:

101795629(PRKCE)

ACYG:

106029794(PRKCE)

CATA:

118255097(PRKCE)

AFUL:

116487192(PRKCE)

TGU:	100230589(PRKCE)

LSR:	110480403(PRKCE)

SCAN:

103817167(PRKCE)

PMOA:

120496950(PRKCE)

OTC:	121340667(PRKCE)

PRUF:

121358709(PRKCE)

GFR:	102031365(PRKCE)

FAB:	101815711(PRKCE)

OMA:	130251296(PRKCE)

PHI:	102110578(PRKCE)

PMAJ:

107202015(PRKCE)

CCAE:

111927602(PRKCE)

CCW:	104685689(PRKCE)

CBRC:

103622726(PRKCE)

ETL:

114067530

ZAB:	102065634(PRKCE)

ZLE:	135445849(PRKCE)

ACHL:

103807831(PRKCE)

SVG:	106853788(PRKCE)

MMEA:

130578213(PRKCE)

HRT:	120750148(PRKCE)

SATI:

136359441(PRKCE)

FPG:	101917755(PRKCE)

FCH:	102059448(PRKCE)

CCRI:

104155932

NNT:	104406853(PRKCE)

SHAB:

115613721(PRKCE)

ACUN:

113478353(PRKCE)

TALA:

104361523(PRKCE)

ACHC:

115350386(PRKCE)

HALD:

104319501(PRKCE)

HLE:	104837397(PRKCE)

AGEN:

GCL:

LDI:

DPUB:

AVIT:

104271105(PRKCE)

EGZ:	104123423(PRKCE)

NNI:	104019696(PRKCE)

PCAO:

104046507(PRKCE)

PADL:

103914308(PRKCE) 103918098

AFOR:

103904812(PRKCE)

FGA:	104075887(PRKCE)

CLV:	102096207(PRKCE)

PLET:

104628209(PRKCE)

EHS:

104503759

CUCA:

104056824(PRKCE)

BREG:

104634121(PRKCE)

OHA:	104333589(PRKCE)

CPEA:

104395276(PRKCE)

CVF:	104282541(PRKCE)

RTD:	128907859(PRKCE)

AAM:	106485510(PRKCE)

AROW:

112962912(PRKCE)

NPD:	112953217(PRKCE)

DNE:	112995937(PRKCE)

SCAM:

104144993(PRKCE)

ASN:	102368989(PRKCE)

AMJ:	102576791(PRKCE)

CPOO:

109319646(PRKCE)

GGN:	109296774(PRKCE)

PSS:	102452906(PRKCE)

CMY:	102936130(PRKCE)

CCAY:

125633553(PRKCE)

DCC:	119853443(PRKCE)

CPIC:

101951149(PRKCE)

TST:	117874374(PRKCE)

CABI:

116815013(PRKCE)

MRV:	120401443(PRKCE)

ACS:	100567346(prkce)

ASAO:

132761494(PRKCE)

PVT:

110080748

SUND:

121924436(PRKCE)

PBI:	103053780 103060295(PRKCE)

PMUR:

107287861(PRKCE)

CTIG:

120309857(PRKCE)

TSR:	106547762(PRKCE)

PGUT:

117671626(PRKCE)

APRI:

131189216(PRKCE)

PTEX:

113433329(PRKCE)

NSS:	113422569(PRKCE)

VKO:	123023205(PRKCE)

PMUA:

114594748(PRKCE)

PRAF:

128411222(PRKCE)

ZVI:	118083100(PRKCE)

HCG:	128351997(PRKCE)

GJA:	107115714 107125702

STOW:

125425192(PRKCE)

EMC:	129332684(PRKCE)

XLA:	108716426 108717735

XTR:	100135720(prkce)

NPR:	108804505(PRKCE)

RTEM:

120937971(PRKCE)

BBUF:

120999440(PRKCE)

BGAR:

122935079(PRKCE)

MUO:	115465374(PRKCE)

GSH:	117356490(PRKCE)

DRE:	100005075(prkcea) 100332055(prkceb)

SRX:	107708403 107727364 107739250 107749378

SANH:

107678509(prkce) 107698816 107699301

SGH:	107550054 107582770 107586499 107590020(prkce)

CCAR:

109069787 109083439 109099594 109100163 109113084

CAUA:

113056147 113057224 113111553 113113025

CGIB:

127969319 127970423 128025283 128026453

PTET:

122355618(prkcea) 122356745(prkceb)

LROH:

127174107(prkcea) 127174825(prkceb)

OMC:	131550962(prkcea) 131552387(prkceb)

PPRM:

120468589 120471522(prkcea)

RKG:	130088695(prkcea) 130106384(prkceb)

MAMB:

125255135(prkcea) 125277255(prkceb)

CIDE:

127523898 127523910 127524763

CERY:

137008347(prkcea) 137020871(prkceb)

MASI:

127412171 127413761 127423589 127427261

TROS:

130559103(prkceb) 130568813(prkcea)

TDW:	130431487(prkceb) 130438918(prkcea)

MANU:

129416206(prkceb) 129420780(prkcea)

IPU:	108263296(prkceb) 108274197(prkcea)

IFU:	128605415(prkceb) 128616532(prkcea) 128622627

PHYP:

113527396 113543727(prkce)

SMEO:

124388742(prkcea) 124399767(prkceb)

TFD:	113644992(prkceb) 113645377 113645394 113653498(prkcea) 113656571 113657868

TVC:	132843324 132847138(prkceb) 132850560 132850561 132853428 132855741 132856634 132863297(prkcea)

TRN:	134315058(prkceb) 134321243(prkcea)

AMEX:

103032491(prkceb) 103034301(prkcea)

CMAO:

118809266(prkcea) 118810223(prkceb)

EEE:	113572717 113572795

CHAR:

105900023(prkceb) 105904120

TRU:	101067313 101073327(prkce)

TFS:	130533229(prkcea) 130534076

TNG:	GSTEN00009554G001 GSTEN00018762G001

LCO:	104922490(prkce) 104931840

NCC:	104949865 104951027(prkce)

TBEN:

117473508(prkcea) 117487103

CGOB:

115019831 115024247(prkce)

PGEO:

117443136 117464447(prkcea)

GACU:

117541597 117544213(prkcea)

EMAC:

134859003 134870934(prkcea)

ELY:	117247057(prkcea) 117272631

EFO:	125881102(prkcea) 125903350

PLEP:

121958543(prkcea)

SLUC:

116061400(prkcea) 116061689

ECRA:

117936430(prkcea) 117960301

ESP:	116671724(prkce) 116705557

PFLV:

114548088(prkce) 114571931

GAT:	120818998(prkcea) 120821024

PPUG:

119212824(prkcea) 119214162

AFB:	129090911(prkcea) 129092029

CLUM:

117743861 117748961(prkcea)

PSWI:

130203303(prkcea) 130207122

MSAM:

119912380 119916371(prkcea)

SCHU:

122867302(prkcea) 122884321

CUD:	121510997 121528149(prkcea)

ALAT:

119010144(prkcea) 119033782

ASTR:

137588085(prkcea)

MZE:	101468101 101486794

ONL:	100692040 100695466

OAU:	116309925 116328797

OLA:	101168247(prkce) 101172355

OML:	112154223(prkcea) 112161503

CSAI:

133419631(prkcea) 133463220

XMA:	102224280 102236119(prkce)

XCO:	114137801 114151921(prkce)

XHE:	116712859 116726861(prkce)

PRET:

103476621 103481826(prkce)

PFOR:

103145135(prkce) 103155522

PLAI:

106940220 106948767

PMEI:

106904308(prkce) 106908205

GAF:	122823820(prkcea) 122842574

PPRL:

129353970 129367963(prkcea)

CVG:	107085540(prkce) 107090628

CTUL:

119781897(prkcea) 119795240

GMU:	124858840 124875100(prkcea)

NFU:	107387753(prkce)

KMR:	108249079(prkcea)

ALIM:

106516627(prkce)

NWH:	119424048(prkcea)

AOCE:

111562817 111577888(prkce)

MCEP:

125018826 125022292(prkcea)

CSEM:

103381531(prkce) 103387794

POV:	109627017 109635952

SSEN:

122759157(prkcea)

HHIP:

117752974(prkcea) 117775705

HSP:	118100742(prkcea) 118118579

PPLT:

128426397(prkcea) 128453657

SMAU:

118283545 118287636(prkcea)

LCF:	108872883 108882782(prkcea)

SDU:	111219758(prkce) 111223864

SLAL:

111645457 111655236(prkce)

XGL:	120794674(prkcea) 120796188

HCQ:	109510070 109530172(prkce)

SSCV:

125990884

SBIA:

133495401(prkcea) 133509501

PEE:	133409489 133418078(prkcea)

PTAO:

133469277(prkcea) 133485977

BPEC:

110162858 110174578(prkce)

MALB:

109963057(prkce) 109963810

BSPL:

114845652(prkcea)

SJO:	128373305 128381755(prkcea)

SASA:

106589411 106589721(prkce) 106591157 106611052

STRU:

115152826 115201192 115201530(prkce)

OTW:	112224299 112224582 112261469

OMY:	110498742 110499309 110503000

OGO:	124038633 124040057 124040294

ONE:	115144077 115144498(prkce)

OKI:	109869986 109870171(prkce) 109898971

OKE:	118357702 118357744 118378942

SALP:

111967801 111968048 111968262 111978759

SNH:	120029376 120029801 120045351

CCLU:

121547367 121547663 121556241 121586923

ELS:	105006029 105021252(prkce)

SFM:	108918044(prkce)

PKI:	111839985(prkce)

AANG:

118218235 118221346

LOC:	102694770(prkce)

PSPA:

121316343 121316681

ARUT:

117403245 117411020

PSEX:

120516604(prkcea)

LCM:

102363817

CMK:	103180812 103185381(prkcha)

RTP:

109930871

CPLA:

122552746(prkcea) 122553462(prkcha)

HOC:	132818369(prkcha) 132819714

LERI:

129699659 129700114

PMRN:

116947747 116948332 116953858

LRJ:	133341414 133352798 133356189 133356190

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG1954(Pkc98E)

DER:

6555094

DSE:

6612641

DSI:	Dsimw501_GD21405(Dsim_GD21405)

DYA:	Dyak_GE23824

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24186

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108372482 108374017 108382512

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ020037

CPII:

120413782

CNS:	116339603 116339700

BCOO:

LLL:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105674898(Pkc98E)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	103313855 663551(Pkc98E)

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

DCOR:

135799755(Pkc98E)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212831

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106684731(Pkc98E)

NLU:

111046812

HVI:

124373655

MQU:

128986716

PHU:	Phum_PHUM513980

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_301963

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:	136855902(Pkc98E)

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129223741 129224358

SDM:

118199924

LPOL:

106462674 106464630

PMEO:

129584930 129584932

CEL:	CELE_F57F5.5(pkc-1)

CBR:	CBG_23354(Cbr-pkc-1)

CRQ:	GCK72_018163

NAI:	NECAME_11125

BMY:	BM_BM4529(Bma-pkc-1)

LOA:	LOAG_04164

TSP:

Tsp_08348

HRO:	HELRODRAFT_64769 HELRODRAFT_78764

LGI:	LOTGIDRAFT_127378

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_131700

SHX:	MS3_00000224(PRKC2_1)

OVI:	T265_10146

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:	107331208 107357650

AMIL:

114962843

PDAM:

113681488

SPIS:

111329101

DGT:	114520044 114542531

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_30067

AQU:

100633428

SOM:	SOMG_01504(pck2)

NCE:	NCER_101503

MBR:	MONBRDRAFT_20766 MONBRDRAFT_21555

SRE:	PTSG_01655 PTSG_11595

» show all

Reference

PMID:2917656

Authors

Schaap D, Parker PJ, Bristol A, Kriz R, Knopf J

Title

Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity.

Journal

FEBS Lett 243:351-7 (1989)
DOI:10.1016/0014-5793(89)80160-7

Sequence

[mmu:18754]

LinkDB

ORTHOLOGY: K06068

Entry

K06068                      KO

Symbol

PRKCD

Name

novel protein kinase C delta type [EC:2.7.11.13]

Pathway

map04062

Chemokine signaling pathway

map04140

Autophagy - animal

map04270

Vascular smooth muscle contraction

map04361

Axon regeneration

map04621

NOD-like receptor signaling pathway

map04625

C-type lectin receptor signaling pathway

map04666

Fc gamma R-mediated phagocytosis

map04722

Neurotrophin signaling pathway

map04750

Inflammatory mediator regulation of TRP channels

map04912

GnRH signaling pathway

map04915

Estrogen signaling pathway

map04930

Type II diabetes mellitus

map04931

Insulin resistance

map04933

AGE-RAGE signaling pathway in diabetic complications

map05020

Prion disease

map05131

Shigellosis

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Disease

H00108

Autoimmune lymphoproliferative syndromes

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K06068  PRKCD; novel protein kinase C delta type
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
   04625 C-type lectin receptor signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
   04666 Fc gamma R-mediated phagocytosis
    K06068  PRKCD; novel protein kinase C delta type
   04062 Chemokine signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
  09152 Endocrine system
   04912 GnRH signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
   04915 Estrogen signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K06068  PRKCD; novel protein kinase C delta type
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06068  PRKCD; novel protein kinase C delta type
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K06068  PRKCD; novel protein kinase C delta type
  09158 Development and regeneration
   04361 Axon regeneration
    K06068  PRKCD; novel protein kinase C delta type
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K06068  PRKCD; novel protein kinase C delta type
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K06068  PRKCD; novel protein kinase C delta type
  09164 Neurodegenerative disease
   05020 Prion disease
    K06068  PRKCD; novel protein kinase C delta type
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K06068  PRKCD; novel protein kinase C delta type
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K06068  PRKCD; novel protein kinase C delta type
   04931 Insulin resistance
    K06068  PRKCD; novel protein kinase C delta type
   04933 AGE-RAGE signaling pathway in diabetic complications
    K06068  PRKCD; novel protein kinase C delta type
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06068  PRKCD; novel protein kinase C delta type
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.13  protein kinase C
     K06068  PRKCD; novel protein kinase C delta type
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  PKC family [OT]
   K06068  PRKCD; novel protein kinase C delta type

Other DBs

GO:

0004699

Genes

HSA:	5580(PRKCD)

PTR:	460442(PRKCD)

PPS:	100978487(PRKCD)

GGO:	101133370(PRKCD)

PON:	100452668(PRKCD)

PPYG:

129034252(PRKCD)

NLE:	100591028(PRKCD)

HMH:	116473376(PRKCD)

SSYN:

129480500(PRKCD)

MCC:	694656(PRKCD)

MCF:	102136158(PRKCD)

MTHB:

126948783

MNI:	105480568(PRKCD)

CSAB:

103227755(PRKCD)

CATY:

105585581(PRKCD)

PANU:

101003920(PRKCD)

TGE:	112619188(PRKCD)

MLEU:

105543983(PRKCD)

RRO:	104672393(PRKCD)

RBB:	108515204(PRKCD)

TFN:	117082999(PRKCD)

PTEH:

111524359(PRKCD)

CANG:

105515446(PRKCD)

CJC:	100395399(PRKCD)

SBQ:	101044546(PRKCD)

CIMI:

108304989(PRKCD)

ANAN:

105722920(PRKCD)

CSYR:

103268097(PRKCD)

MMUR:

105875067(PRKCD)

LCAT:

123623170(PRKCD)

PCOQ:

105805862(PRKCD)

OGA:	100951664(PRKCD)

MMU:	18753(Prkcd)

MCAL:

110309154(Prkcd)

MPAH:

110326026(Prkcd)

RNO:	170538(Prkcd)

MCOC:

116085415(Prkcd)

ANU:	117705965(Prkcd)

MUN:	110547587(Prkcd)

CGE:	100774348(Prkcd)

MAUA:

101842470(Prkcd)

PROB:

127236861(Prkcd)

PLEU:

114708186(Prkcd)

MORG:

121455195(Prkcd)

MFOT:

126511136

AAMP:

119827346(Prkcd)

NGI:	103749021(Prkcd)

HGL:	101718422(Prkcd)

CPOC:

100726624(Prkcd)

CCAN:

109693718(Prkcd)

DORD:

105996605(Prkcd)

DSP:	122107987(Prkcd)

PLOP:

125358588(Prkcd)

NCAR:

124968791

MMMA:

107149626(Prkcd)

OCU:

100008966

OPI:	101523591(PRKCD)

TUP:	102487574(PRKCD)

GVR:	103598537(PRKCD)

CFA:	494005(PRKCD)

CLUD:

112665911(PRKCD)

VVP:	112910129(PRKCD)

VLG:	121495996(PRKCD)

NPO:	129522341(PRKCD)

AML:	100481918(PRKCD)

UMR:	103674744(PRKCD)

UAH:	113256975(PRKCD)

UAR:	123798757(PRKCD)

ELK:

111144045

LLV:

125078754

MPUF:

101675130(PRKCD)

MNP:	132011420(PRKCD)

MLK:	131824034(PRKCD)

NVS:	122909342(PRKCD)

ORO:	101385728(PRKCD)

EJU:	114225007(PRKCD)

ZCA:	113918529(PRKCD)

MLX:	118005176(PRKCD)

NSU:	110584785(PRKCD)

LWW:	102730196 102751076

FCA:	101087716(PRKCD)

PYU:	121016847(PRKCD)

PCOO:

112852480(PRKCD)

PBG:	122487327(PRKCD)

PVIV:

125160334(PRKCD)

LRUF:

124523091

PTG:	102959855(PRKCD)

PPAD:

109247926(PRKCD)

PUC:

125929472

AJU:

106987049

HHV:	120239415(PRKCD)

BTA:	505708(PRKCD)

BOM:	102273901(PRKCD)

BIU:	109576388(PRKCD)

BBUB:

102407491(PRKCD)

BBIS:

104997117(PRKCD)

CHX:	102171471(PRKCD)

OAS:	101107639(PRKCD)

BTAX:

128044536(PRKCD)

ODA:	120868385(PRKCD)

CCAD:

122424790(PRKCD)

MBEZ:

129547928(PRKCD)

SSC:	100622955(PRKCD)

CFR:	102511255(PRKCD)

CBAI:

105080156(PRKCD)

CDK:	105093214(PRKCD)

VPC:	102537750(PRKCD)

BACU:

103000809(PRKCD)

BMUS:

118904172(PRKCD)

LVE:	103073166(PRKCD)

OOR:	101275504(PRKCD)

DLE:	111174287(PRKCD)

PCAD:

102984279(PRKCD)

PSIU:

116762083(PRKCD)

NASI:

112400532(PRKCD)

ECB:	100051333(PRKCD)

EPZ:	103546514(PRKCD)

EAI:	106822994(PRKCD)

MYB:	102256501(PRKCD)

MYD:	102760591(PRKCD)

MMYO:

118667983(PRKCD)

MLF:	102431901(PRKCD)

MDT:	132215291(PRKCD)

PKL:	118715126(PRKCD)

EFUS:

103290422(PRKCD)

MNA:	107534935(PRKCD)

DRO:	112301220(PRKCD)

SHON:

118983341(PRKCD)

AJM:	119041430(PRKCD)

PDIC:

114501653(PRKCD)

PHAS:

123814537(PRKCD)

MMF:	118633138(PRKCD)

PPAM:

129087905(PRKCD)

HAI:	109395953(PRKCD)

RFQ:	117037221(PRKCD)

PALE:

102888600(PRKCD)

PGIG:

120606307(PRKCD)

PVP:	105304348(PRKCD)

RAY:	107516555(PRKCD)

MJV:	108408298(PRKCD)

TOD:	119261357(PRKCD)

SARA:

101547708(PRKCD)

SETR:

126013204(PRKCD)

LAV:	100659245(PRKCD)

TMU:

101355651

ETF:	101650810(PRKCD)

DNM:	101440758(PRKCD)

MDO:	100030722(PRKCD)

GAS:	123230752(PRKCD)

SHR:	100925245(PRKCD)

AFZ:

127553769

PCW:	110197529(PRKCD)

TVP:	118831538(PRKCD)

OAA:	100088214(PRKCD)

GGA:	415905(PRKCD)

PCOC:

116232318(PRKCD)

MGP:	100541931(PRKCD)

CJO:	107319581(PRKCD)

TPAI:

128078325(PRKCD)

LMUT:

125698774(PRKCD)

NMEL:

110404811(PRKCD)

APLA:

101796703(PRKCD)

ACYG:

106042845(PRKCD)

CATA:

118248261(PRKCD)

AFUL:

116492904(PRKCD)

TGU:	100230711(PRKCD)

LSR:	110469913(PRKCD)

SCAN:

103816971(PRKCD)

PMOA:

120495685(PRKCD)

OTC:	121347200(PRKCD)

PRUF:

121352257(PRKCD)

GFR:	102031450(PRKCD)

FAB:	101806370(PRKCD)

OMA:	130258495(PRKCD)

PHI:	102111760(PRKCD)

PMAJ:

107210274(PRKCD)

CCAE:

111935183(PRKCD)

CCW:	104683217(PRKCD)

CBRC:

103614258(PRKCD)

ETL:	114058791(PRKCD)

ZAB:	102071110(PRKCD)

ACHL:

103807716(PRKCD)

SVG:	106849217(PRKCD)

MMEA:

130574657(PRKCD)

HRT:	120758436(PRKCD)

SATI:

136366040(PRKCD)

FPG:	101920231(PRKCD)

FCH:	102049783(PRKCD)

CCRI:

104163194(PRKCD)

NNT:	104410700(PRKCD)

SHAB:

115614174(PRKCD)

ACUN:

113484720(PRKCD)

TALA:

104365907(PRKCD)

ACHC:

115333335(PRKCD)

HALD:

104316544(PRKCD)

HLE:	104828117(PRKCD)

AGEN:

126049843

GCL:

127021552

CSTI:

104557431(PRKCD)

LDI:	104345396(PRKCD)

MNB:

103772630

DPUB:

104300397(PRKCD)

AVIT:

104276937(PRKCD)

BRHI:

104490479(PRKCD)

EGZ:	104126756(PRKCD)

NNI:	104008710(PRKCD)

PCRI:

104037225(PRKCD)

PCAO:

104039912(PRKCD)

PADL:

103915063(PRKCD)

AFOR:

103898254(PRKCD)

FGA:	104083293(PRKCD)

GSTE:

104261920(PRKCD)

CLV:	102091654(PRKCD)

MUI:	104537245(PRKCD)

PGUU:

104468186(PRKCD)

PLET:

104626476(PRKCD)

EHS:	104514754(PRKCD)

CMAC:

104485786

CUCA:

104066690(PRKCD)

TEO:	104374033(PRKCD)

BREG:

104637745(PRKCD)

OHA:	104336617(PRKCD)

ACAR:

104520783(PRKCD)

CPEA:

104398486(PRKCD)

CVF:	104291943(PRKCD)

RTD:	128915653(PRKCD)

AAM:	106485957(PRKCD)

AROW:

112972980(PRKCD)

NPD:	112953052(PRKCD)

TGT:	104565251(PRKCD)

DNE:	112986206(PRKCD)

SCAM:

104147015(PRKCD)

ASN:	102387772(PRKCD)

AMJ:	102571623(PRKCD)

CPOO:

109318287(PRKCD)

GGN:	109289214(PRKCD)

PSS:	102451674(PRKCD)

CMY:	102945932(PRKCD)

CCAY:

125639345(PRKCD)

DCC:	119858806(PRKCD)

CPIC:

101951475(PRKCD)

TST:	117880659(PRKCD)

CABI:

116820430(PRKCD)

MRV:	120368642(PRKCD)

ACS:	100553700(prkcd)

ASAO:

132769200(PRKCD)

PVT:	110080620(PRKCD)

SUND:

121922638(PRKCD)

PBI:	103054205(PRKCD)

PMUR:

107293197(PRKCD)

CTIG:

120310129(PRKCD)

PGUT:

117678118(PRKCD)

APRI:

131190993(PRKCD)

PTEX:

113453193(PRKCD)

NSS:	113420561(PRKCD)

VKO:	123034075(PRKCD)

PMUA:

114589765 114591604(PRKCD)

PRAF:

128408224(PRKCD)

ZVI:	118080644(PRKCD)

HCG:	128347886(PRKCD)

GJA:	107115526(PRKCD)

STOW:

125429841(PRKCD)

EMC:	129328205(PRKCD)

XTR:	116407520 116412350 733756(prkcd)

NPR:	108797915(PRKCD)

RTEM:

120916072 120945346(PRKCD)

BGAR:

122919785 122919786 122920081 122923544 122925678 122925680 122925772 122941981 122942138 122942140 122942146 122943261(PRKCD)

MUO:	115471962(PRKCD)

GSH:	117351358(PRKCD)

DRE:	100150844(prkcdb) 334571(prkcda)

SRX:	107712078 107721176 107728641 107746897

SANH:

107656045 107667398 107673500 107696837

SGH:	107558893(prkcd) 107582675 107600299

CCAR:

109054463 109063612

CAUA:

113050390 113055278 113094825 113110979

CGIB:

127959544 127968130 128015769 128022413

PTET:

122347182(prkcda) 122354305(prkcdb)

LROH:

127167169(prkcda) 127173261(prkcdb)

OMC:	131542112(prkcda) 131549725(prkcdb)

PPRM:

120480498(prkcdb) 120491486(prkcda)

RKG:	130086710(prkcdb) 130087502(prkcda)

MAMB:

125256482(prkcdb) 125273755(prkcda)

CIDE:

127514019 127522064

CERY:

137010734(prkcda) 137021605(prkcdb)

MASI:

127426272 127427978 127446241 127449299

TROS:

130556827(prkcda) 130571351(prkcdb)

TDW:	130409928(prkcdb) 130424967(prkcda)

MANU:

129427730(prkcdb) 129450529(prkcda)

IPU:	108254977(prkcdb) 108271968(prkcda)

IFU:	128614961(prkcda) 128625003(prkcdb)

PHYP:

113534377 113539572(prkcd)

SMEO:

124390632(prkcda) 124402367(prkcdb)

TFD:	113642794(prkcda) 113661884(prkcdb)

TVC:	132837939(prkcdb) 132844432(prkcda)

TRN:	134302104(prkcdb) 134316601(prkcda)

AMEX:

103030273(prkcda) 103036366(prkcdb)

CMAO:

118799424(prkcdb) 118808294(prkcda)

EEE:	113576010(prkcd)

CHAR:

105907752(prkcda) 105912157(prkcdb)

TRU:	101062863(prkcd)

TFS:	130524056(prkcda)

TNG:	GSTEN00004810G001 GSTEN00027270G001

LCO:

104933455

NCC:	104944044(prkcd)

TBEN:

117475452 117489552(prkcda)

CGOB:

115008352 115008519(prkcd)

PGEO:

117446645(prkcdb) 117447434(prkcda)

GACU:

117543783(prkcdb) 117551113(prkcda)

EMAC:

134882874 134882887(prkcda)

ELY:	117257453(prkcda)

EFO:	125891431 125891930(prkcda)

PLEP:

121955918(prkcda)

SLUC:

116041697(prkcda)

ECRA:

117943700(prkcda) 117944105(prkcdb)

ESP:	116688371 116688666

PFLV:

114553915 114554679(prkcd)

GAT:	120834638(prkcda)

PPUG:

119193971(prkcda) 119230203

AFB:	129105230 129106484(prkcda)

CLUM:

117730323 117730620(prkcda)

PSWI:

130208665 130208821(prkcda)

MSAM:

119886414(prkcda)

SCHU:

122865392 122866851(prkcda)

CUD:	121507580(prkcda)

ALAT:

119021732(prkcda)

ASTR:

137595443(prkcda) 137595594

MZE:	101471530(prkcd)

ONL:	100698031(prkcd)

OAU:	116333821(prkcda)

OLA:	101174016(prkcd)

OML:	112145195(prkcda)

CSAI:

133448765(prkcda)

XMA:	102232189(prkcd)

XCO:	114135620(prkcd)

XHE:	116710982(prkcd)

PRET:

103465249(prkcd)

PFOR:

103143216 103145765

PLAI:

106963883(prkcd) 106965019

PMEI:

106931356 106931995(prkcd)

GAF:	122834698(prkcda)

PPRL:

129358120(prkcda) 129358207

CVG:	107094023(prkcd)

CTUL:

119776675(prkcda)

GMU:	124856448(prkcda)

NFU:	107385705(prkcd)

KMR:	108235712(prkcda)

ALIM:

106518011(prkcd)

NWH:	119411922(prkcda)

AOCE:

111566615(prkcd)

MCEP:

125006281(prkcda)

CSEM:

103385936(prkcd)

POV:	109629305(prkcd)

SSEN:

122768025(prkcda)

HHIP:

117761354(prkcda)

HSP:	118105172(prkcda)

PPLT:

128425234(prkcda) 128453300

SMAU:

118309613 118309678(prkcda)

LCF:	108881487(prkcda)

SDU:	111221681(prkcd) 111221709

SLAL:

111667849(prkcd) 111670988

XGL:	120807519(prkcda)

HCQ:

109522455

SSCV:

125977529 125977811

SBIA:

133506921 133507552(prkcda)

PEE:	133408426 133408622(prkcda)

PTAO:

133483033 133483847(prkcda)

BPEC:

110168367(prkcd)

MALB:

109964491

BSPL:

114855205(prkcda)

SJO:	128354994 128355592(prkcda)

SASA:

100195900(kpcd) 106565545 106565827 106583214(KPCD) 106595901

STRU:

115150559 115150786 115207643 115207853

OTW:	112217414(prkcda) 112219327 112254422 112254618

OMY:	110494302(prkcda) 110494510 110527955 110528134

OGO:	124002983 124016910 124031271 124031434

ONE:	115138121 115143158 115143328

OKI:	109891002 109891155 109895618 109897123

OKE:	118388418 118388586(prkcda) 118399847 118400310

SALP:

111966617 111968570 111969929 111970102

SNH:	120025310(prkcda) 120059307 120065197 120065610

CCLU:

121574964 121575240(prkcda) 121577601 121578203

ELS:	105017197(prkcd) 105017308

SFM:	108923432 108936999

PKI:	111839856 111840581

AANG:

118207526 118207872 118210592

LOC:	102698207(prkcd)

PSPA:

121298104 121328340

ARUT:

117412065 117962609

PSEX:

120540466

LCM:	102367474(PRKCD)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116942323 116952362 116952762

LRJ:	133349514 133355397 133356643

BFO:

BBEL:

SCLV:

LPIC:

ARUN:

AJC:

DME:	Dmel_CG42349(Pkcdelta)

DER:

6551361

DSI:	Dsimw501_GD17078(Dsim_GD17078)

DYA:	Dyak_GE17008

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21641

DAZ:

DHE:

CCAT:

BDR:

RZE:

TDA:

LCQ:

LSQ:

CQU:	CpipJ_CPIJ019407

TCA:

658064

SOY:	115886471 115886576

CSET:

LDC:

APLN:

PPYR:

OTU:

LGLY:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

DCI:

HHAL:

106692631(Pkcdelta)

NLU:	120353949 120353950 120353989

MQU:

128994256

PHU:	Phum_PHUM544690

TPAL:

IEL:

DMK:

DPZ:

LSM:

PPOI:

DFR:

CVS:	136975667 136989827

UDV:

129231853

LPOL:

106458922 106467740 106471012

CEL:	CELE_B0545.1(tpa-1)

CBR:	CBG_01645(Cbr-tpa-1)

CRQ:	GCK72_014663

TSP:

PVUL:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111107462 111107852

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LLON:

ATEN:

XEN:

HSY:

RES:

NCOL:

VNX:	VNE69_03317

» show all

Reference

PMID:21103796

Authors

Basu A, Pal D

Title

Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death.

Journal

ScientificWorldJournal 10:2272-84 (2010)
DOI:10.1100/tsw.2010.214

Reference

PMID:12473183

Authors

Kikkawa U, Matsuzaki H, Yamamoto T

Title

Protein kinase C delta (PKC delta): activation mechanisms and functions.

Journal

J Biochem 132:831-9 (2002)
DOI:10.1093/oxfordjournals.jbchem.a003294

Reference

PMID:8357834

Authors

Aris JP, Basta PV, Holmes WD, Ballas LM, Moomaw C, Rankl NB, Blobel G, Loomis CR, Burns DJ

Title

Molecular and biochemical characterization of a recombinant human PKC-delta family member.

Journal

Biochim Biophys Acta 1174:171-81 (1993)
DOI:10.1016/0167-4781(93)90111-P

Sequence

[hsa:5580]

LinkDB

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